6T8N: Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K3007

PDB ID: 6T8NDownload
MMDB ID: 181818
PDB Deposition Date: 2019/10/24
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 1.77  Å
Source Organism:
Similar Structures:
Biological Unit for 6T8N: monomeric; determined by author
Molecular Components in 6T8N
Label Count Molecule
Protein (1 molecule)
1
Activin Receptor Type I
(Gene symbol: ACVR1)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
1
SULFATE IONSULFATE ION
3
1
L(+)-TARTARIC ACIDL(+)-TARTARIC ACID
4
1
cyclopropyl-[4-[6-[5-(4-ethoxy-1-propan-2-yl-piperidin-4-yl)pyridin-2-yl]pyrrolo[1,2-b]pyridazin-4-yl]piperazin-1-yl]methanonecyclopropyl-[4-[6-[5-(4-ethoxy-1-propan-2-yl-piperidin-4-yl)pyridin-2-yl]pyrrolo[1,2-b]pyridazin-4-yl]piperazin-1-yl]methanone
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303