6MSB: Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

PDB ID: 6MSBDownload
MMDB ID: 171580
PDB Deposition Date: 2018/10/16
Updated in MMDB: 2022/11
Experimental Method:
electron microscopy
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 6MSB: 48-meric; determined by author
Molecular Components in 6MSB
Label Count Molecule
Proteins (48 molecules)
1
26S Proteasome Non-atpase Regulatory Subunit 1
(Gene symbol: PSMD1)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 3
(Gene symbol: PSMD3)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 12
(Gene symbol: PSMD12)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 11
(Gene symbol: PSMD11)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 6
(Gene symbol: PSMD6)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 7
(Gene symbol: PSMD7)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 13
(Gene symbol: PSMD13)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 4
(Gene symbol: PSMD4)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 14
(Gene symbol: PSMD14)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 8
(Gene symbol: PSMD8)
Molecule annotation
1
26S Proteasome Complex Subunit Sem1
(Gene symbol: SEM1)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 2
(Gene symbol: PSMD2)
Molecule annotation
1
26S Proteasome Regulatory Subunit 7
(Gene symbol: PSMC2)
Molecule annotation
1
26S Proteasome Regulatory Subunit 4
(Gene symbol: PSMC1)
Molecule annotation
1
26S Proteasome Regulatory Subunit 8
(Gene symbol: PSMC5)
Molecule annotation
1
26S Proteasome Regulatory Subunit 6B
(Gene symbol: PSMC4)
Molecule annotation
1
26S Proteasome Regulatory Subunit 10B
(Gene symbol: PSMC6)
Molecule annotation
1
26S Proteasome Regulatory Subunit 6A
(Gene symbol: PSMC3)
Molecule annotation
2
Ubiquitin
Molecule annotation
2
Proteasome Subunit Alpha Type-6
(Gene symbol: PSMA6)
Molecule annotation
2
Proteasome Subunit Alpha Type-2
(Gene symbol: PSMA2)
Molecule annotation
2
Proteasome Subunit Alpha Type-4
(Gene symbol: PSMA4)
Molecule annotation
2
Proteasome Subunit Alpha Type-7
(Gene symbol: PSMA7)
Molecule annotation
2
Proteasome Subunit Alpha Type-5
(Gene symbol: PSMA5)
Molecule annotation
2
Proteasome Subunit Alpha Type-1
(Gene symbol: PSMA1)
Molecule annotation
2
Proteasome Subunit Alpha Type-3
(Gene symbol: PSMA3)
Molecule annotation
2
Proteasome Subunit Beta Type-6
(Gene symbol: PSMB6)
Molecule annotation
2
Proteasome Subunit Beta Type-7
(Gene symbol: PSMB7)
Molecule annotation
2
Proteasome Subunit Beta Type-3
(Gene symbol: PSMB3)
Molecule annotation
2
Proteasome Subunit Beta Type-2
(Gene symbol: PSMB2)
Molecule annotation
2
Proteasome Subunit Beta Type-5
(Gene symbol: PSMB5)
Molecule annotation
2
Proteasome Subunit Beta Type-1
(Gene symbol: PSMB1)
Molecule annotation
2
Proteasome Subunit Beta Type-4
(Gene symbol: PSMB4)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
1
ZINC ION (Link to PubChem not yet available)ZINC ION
2
4
ADENOSINE-5'-TRIPHOSPHATE (Link to PubChem not yet available)ADENOSINE-5'-TRIPHOSPHATE
3
5
MAGNESIUM ION (Link to PubChem not yet available)MAGNESIUM ION
4
2
ADENOSINE-5'-DIPHOSPHATE (Link to PubChem not yet available)ADENOSINE-5'-DIPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303