6F6Z: Mouse Thymidylate Synthase Cocrystallized with N(4)OHdCMP and Soaked in Methylenetetrahydrofolate

PDB ID: 6F6ZDownload
MMDB ID: 171690
PDB Deposition Date: 2017/12/6
Updated in MMDB: 2019/02
Experimental Method:
x-ray diffraction
Resolution: 2.127  Å
Source Organism:
Similar Structures:
Biological Unit for 6F6Z: dimeric; determined by author and by software (PISA)
Molecular Components in 6F6Z
Label Count Molecule
Proteins (2 molecules)
2
Thymidylate Synthase
(Gene symbol: Tyms)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate)2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate)
2
2
(2~{S})-2-[[4-[[(6~{R})-2-azanyl-4-oxidanylidene-5,6,7,8-tetrahydro-1~{H}-pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid(2~{S})-2-[[4-[[(6~{R})-2-azanyl-4-oxidanylidene-5,6,7,8-tetrahydro-1~{H}-pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303