5XZB: Mouse cGAS bound to the inhibitor RU365

PDB ID: 5XZBDownload
MMDB ID: 153557
PDB Deposition Date: 2017/7/12
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.13  Å
Source Organism:
Similar Structures:
Biological Unit for 5XZB: trimeric; determined by author and by software (PISA)
Molecular Components in 5XZB
Label Count Molecule
Protein (1 molecule)
1
Cyclic Gmp-amp Synthase
(Gene symbol: Cgas)
Molecule annotation
Nucleotides(2 molecules)
1
DNA (5'-d(*ap*ap*ap*tp*tp*gp*cp*cp*gp*ap*ap*gp*ap*cp*g)-3')
Molecule annotation
1
DNA (5'-d(p*cp*gp*tp*cp*tp*tp*cp*gp*gp*cp*ap*ap*tp*t)-3')
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
ZINC IONZINC ION
2
1
(3R)-3-[1-(1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-one(3R)-3-[1-(1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303