5LT7: Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives

PDB ID: 5LT7Download
MMDB ID: 143848
PDB Deposition Date: 2016/9/6
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 1.51  Å
Source Organism:
Similar Structures:
Biological Unit for 5LT7: monomeric; determined by software (PISA)
Molecular Components in 5LT7
Label Count Molecule
Protein (1 molecule)
1
Histone-lysine N-methyltransferase Setd2
(Gene symbol: SETD2)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
3
ZINC IONZINC ION
2
2
THIOCYANATE IONTHIOCYANATE ION
3
1
[(2~{S},5~{R})-1-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]-5-azaniumyl-6-oxidanyl-6-oxidanylidene-hexan-2-yl]-[(2~{R})-2-oxidanylpropyl]azanium[(2~{S},5~{R})-1-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]-5-azaniumyl-6-oxidanyl-6-oxidanylidene-hexan-2-yl]-[(2~{R})-2-oxidanylpropyl]azanium
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303