5EAK: Optimization of Microtubule Affinity Regulating Kinase (MARK) Inhibitors with Improved Physical Properties

PDB ID: 5EAKDownload
MMDB ID: 136591
PDB Deposition Date: 2015/10/16
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 5EAK: monomeric; determined by author
Molecular Components in 5EAK
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Mark2
(Gene symbol: MARK2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-[(1S,2R)-2-aminocyclohexyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamideN-[(1S,2R)-2-aminocyclohexyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303