4ZTU: Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase

PDB ID: 4ZTUDownload
MMDB ID: 132879
PDB Deposition Date: 2015/5/15
Updated in MMDB: 2015/09
Experimental Method:
x-ray diffraction
Resolution: 3.299  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 4ZTU: pentameric; determined by author and by software (PISA)
Molecular Components in 4ZTU
Label Count Molecule
Proteins (3 molecules)
1
DNA Polymerase Subunit Gamma-1
Molecule annotation
2
DNA Polymerase Subunit Gamma-2, Mitochondrial
Molecule annotation
Nucleotides(2 molecules)
1
DNA (25-mer)
Molecule annotation
1
DNA (5'-d(p*ap*ap*gp*ap*cp*gp*ap*gp*gp*gp*cp*cp*ap*gp*tp*gp*cp*cp*gp*tp*ap*c)-3')
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
MAGNESIUM IONMAGNESIUM ION
2
1
2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303