4YNE: (R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors

PDB ID: 4YNEDownload
MMDB ID: 129783
PDB Deposition Date: 2015/3/9
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.0229  Å
Source Organism:
Similar Structures:
Biological Unit for 4YNE: monomeric; determined by author
Molecular Components in 4YNE
Label Count Molecule
Protein (1 molecule)
1
High Affinity Nerve Growth Factor Receptor
(Gene symbol: NTRK1)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-(pyridin-2-yl)imidazo[1,2-b]pyridazine6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-(pyridin-2-yl)imidazo[1,2-b]pyridazine
2
5
SULFATE IONSULFATE ION
3
1
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303