4UXL: Structure of Human ROS1 Kinase Domain in Complex with PF-06463922

PDB ID: 4UXLDownload
MMDB ID: 127709
PDB Deposition Date: 2014/8/25
Updated in MMDB: 2019/05
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 4UXL: dimeric; determined by author and by software (PISA)
Molecular Components in 4UXL
Label Count Molecule
Proteins (2 molecules)
2
Proto-oncogene Tyrosine-protein Kinase ROS
(Gene symbol: ROS1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
(10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile(10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303