4QFS: Structure of AMPK in complex with Br2-A769662core activator and STAUROSPORINE inhibitor

PDB ID: 4QFSDownload
MMDB ID: 156757
PDB Deposition Date: 2014/5/21
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 3.55  Å
Source Organism:
Similar Structures:
Biological Unit for 4QFS: trimeric; determined by author and by software (PISA)
Molecular Components in 4QFS
Label Count Molecule
Proteins (3 molecules)
1
5'-amp-activated Protein Kinase Catalytic Subunit Alpha-1
(Gene symbol: Prkaa1)
Molecule annotation
1
5'-amp-activated Protein Kinase Subunit Beta-1
(Gene symbol: Prkab1)
Molecule annotation
1
5'-amp-activated Protein Kinase Subunit Gamma-1
(Gene symbol: Prkag1)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
1
STAUROSPORINESTAUROSPORINE
2
1
2-bromo-3-(4-bromophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile2-bromo-3-(4-bromophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
3
5
CHLORIDE IONCHLORIDE ION
4
1
ADENOSINE MONOPHOSPHATEADENOSINE MONOPHOSPHATE
5
2
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303