4PMT: The structure of TrkA kinase bound to the inhibitor N~4~-(4-morpholin-4-ylphenyl)-N~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6-diamine

PDB ID: 4PMTDownload
MMDB ID: 120853
PDB Deposition Date: 2014/5/22
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 4PMT: monomeric; determined by author
Molecular Components in 4PMT
Label Count Molecule
Protein (1 molecule)
1
High Affinity Nerve Growth Factor Receptor
(Gene symbol: NTRK1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
N~4~-[4-(morpholin-4-yl)phenyl]-N~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6-diamineN~4~-[4-(morpholin-4-yl)phenyl]-N~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6-diamine
2
1
CHLORIDE IONCHLORIDE ION
3
3
ACETATE IONACETATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303