4I5L: Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation

PDB ID: 4I5LDownload
MMDB ID: 109894
PDB Deposition Date: 2012/11/28
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.43  Å
Source Organism:
Similar Structures:
Biological Unit for 4I5L: pentameric; determined by author
Molecular Components in 4I5L
Label Count Molecule
Proteins (3 molecules)
1
Serine/threonine-protein Phosphatase 2A 65 KDA Regulatory Subunit a Alpha Isoform
(Gene symbol: PPP2R1A)
Molecule annotation
1
Serine/threonine-protein Phosphatase 2A Regulatory Subunit B'' Subunit Beta - Cell Division Control Protein 6 Homolog Chimeric Construct
(Gene symbol: CDC6)
Molecule annotation
1
Serine/threonine-protein Phosphatase 2A Catalytic Subunit Alpha Isoform, Pp2a-alpha
(Gene symbol: PPP2CA)
Molecule annotation
Chemicals and Non-standard biopolymers (15 molecules)
GH
2
Microcystin-LR (MCLR) bound form
1
8
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
2
2
CALCIUM IONCALCIUM ION
3
2
MANGANESE (II) IONMANGANESE (II) ION
4
1
MALONATE IONMALONATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303