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4BCF:
Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
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PDB ID:
4BCF
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MMDB ID:
175507
PDB Deposition Date:
2012/10/2
Updated in MMDB:
2024/10
Experimental Method:
x-ray diffraction
Resolution:
3.011 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
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Biological Unit
Asymmetric Unit
Biological Unit for 4BCF: dimeric; determined by software (PISA)
Molecular Graphic
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3D view
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Interactions
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A
A: CYCLIN-DEPENDENT KINASE 9
B
B: CYCLIN-T1
1
T6Q: 2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile
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Format:
ASN.1 (Cn3D)
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Data Set:
alpha-Carbons
Single 3D structure
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Molecular Components in 4BCF
Label
Count
Molecule
Proteins (2 molecules)
A
1
Cyclin-dependent Kinase 9
(Gene symbol:
CDK9
)
1 Protein
SS Diagram
3D Domains
1
75
150
225
300
331
331 residues, click to see VAST similar structures.
helix 62-73
helix 124-144
helix 210-222
helix 235-245
helix 287-297
helix 306-313
strand 19-29
strand 31-40
strand 44-51
strand 81-88
strand 99-105
strand 108-111
strand 145-149
strand 155-160
strand 162-167
strand 171-175
Domain 1 (1-106): click to see VAST similar structures
1
Domain 2 (107-331): click to see VAST similar structures
2
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B
1
Cyclin-t1
(Gene symbol:
CCNT1
)
1 Protein
SS Diagram
3D Domains
1
75
150
225
260
260 residues, click to see VAST similar structures.
helix 16-23
helix 32-53
helix 57-73
helix 82-96
helix 102-113
helix 125-145
helix 155-165
helix 169-185
helix 194-209
helix 232-248
Domain 1 (1-150): click to see VAST similar structures
1
Domain 2 (151-259): click to see VAST similar structures
2
Domain 2 (151-260): click to see VAST similar structures
2
click domain graphic to toggle highlight of corresponding residues in 3D viewer
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile
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Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303
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