4BCF: Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor

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PDB ID: 4BCFDownload
MMDB ID: 175507
PDB Deposition Date: 2012/10/2
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 3.011  Å
Source Organism:
Similar Structures:
Biological Unit for 4BCF: dimeric; determined by software (PISA)
Molecular Graphic ?
4BCF: Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
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Interactions?
AA: CYCLIN-DEPENDENT KINASE 9BB: CYCLIN-T11T6Q: 2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile
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Molecular Components in 4BCF
Label Count Molecule
Proteins (2 molecules)
1
Cyclin-dependent Kinase 9
(Gene symbol: CDK9)
1 Protein
SS Diagram
3D Domains
175150225300331331 residues, click to see VAST similar structures.helix 62-73helix 124-144helix 210-222helix 235-245helix 287-297helix 306-313strand 19-29strand 31-40strand 44-51strand 81-88strand 99-105strand 108-111strand 145-149strand 155-160strand 162-167strand 171-175Domain 1 (1-106): click to see VAST similar structures1Domain 2 (107-331): click to see VAST similar structures2
1
Cyclin-t1
(Gene symbol: CCNT1)
1 Protein
SS Diagram
3D Domains
175150225260260 residues, click to see VAST similar structures.helix 16-23helix 32-53helix 57-73helix 82-96helix 102-113helix 125-145helix 155-165helix 169-185helix 194-209helix 232-248Domain 1 (1-150): click to see VAST similar structures1Domain 2 (151-259): click to see VAST similar structures2Domain 2 (151-260): click to see VAST similar structures2
Chemical and Non-standard biopolymers (1 molecule)
1
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