3WEK: Crystal structure of the human squalene synthase F288L mutant in complex with presqualene pyrophosphate

PDB ID: 3WEKDownload
MMDB ID: 117380
PDB Deposition Date: 2013/7/7
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.85  Å
Source Organism:
Similar Structures:
Biological Unit for 3WEK: monomeric; determined by author and by software (PISA)
Molecular Components in 3WEK
Label Count Molecule
Protein (1 molecule)
1
Squalene Synthase
(Gene symbol: FDFT1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
MAGNESIUM IONMAGNESIUM ION
2
1
{(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate{(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303