3S91: Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1

PDB ID: 3S91Download
MMDB ID: 92032
PDB Deposition Date: 2011/5/31
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.06  Å
Source Organism:
Similar Structures:
Biological Unit for 3S91: dimeric; determined by author and by software (PISA)
Molecular Components in 3S91
Label Count Molecule
Proteins (2 molecules)
2
Bromodomain-containing Protein 3
(Gene symbol: BRD3)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
(6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium(6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium
2
2
ISOPROPYL ALCOHOLISOPROPYL ALCOHOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303