3N7S: Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism

PDB ID: 3N7SDownload
MMDB ID: 84835
PDB Deposition Date: 2010/5/27
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 3N7S: dimeric; determined by author and by software (PISA)
Molecular Components in 3N7S
Label Count Molecule
Proteins (2 molecules)
1
Calcitonin Gene-related Peptide Type 1 Receptor
(Gene symbol: CALCRL)
Molecule annotation
1
Receptor Activity-modifying Protein 1
(Gene symbol: RAMP1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamideN-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303