2Y68: Structure-based design of a new series of D-glutamic acid-based inhibitors of bacterial MurD ligase

PDB ID: 2Y68Download
MMDB ID: 91142
PDB Deposition Date: 2011/1/20
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.49  Å
Source Organism:
Similar Structures:
Biological Unit for 2Y68: monomeric; determined by author and by software (PISA)
Molecular Components in 2Y68
Label Count Molecule
Protein (1 molecule)
1
Udp-n-acetylmuramoylalanine--d-glutamate Ligase
(Gene symbol: murD)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
1
2-[[2-fluoro-5-[[[4-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenyl]amino]methyl]phenyl]carbonylamino]pentanedioic acid2-[[2-fluoro-5-[[[4-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenyl]amino]methyl]phenyl]carbonylamino]pentanedioic acid
2
2
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
4
AZIDE IONAZIDE ION
4
4
SULFATE IONSULFATE ION
5
3
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303