2FQI: dual binding modes of a novel series of DHODH inhibitors

PDB ID: 2FQIDownload
MMDB ID: 43780
PDB Deposition Date: 2006/1/18
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 1.95  Å
Source Organism:
Similar Structures:
Biological Unit for 2FQI: monomeric; determined by author
Molecular Components in 2FQI
Label Count Molecule
Protein (1 molecule)
1
Dihydroorotate Dehydrogenase, Mitochondrial
(Gene symbol: DHODH)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
2
SULFATE IONSULFATE ION
2
3
ACETATE IONACETATE ION
3
1
FLAVIN MONONUCLEOTIDEFLAVIN MONONUCLEOTIDE
4
1
OROTIC ACIDOROTIC ACID
5
1
2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303