2FPY: Dual binding mode of a novel series of DHODH inhibitors

PDB ID: 2FPYDownload
MMDB ID: 43774
PDB Deposition Date: 2006/1/17
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 2FPY: monomeric; determined by author
Molecular Components in 2FPY
Label Count Molecule
Protein (1 molecule)
1
Dihydroorotate Dehydrogenase, Mitochondrial Precursor
(Gene symbol: DHODH)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
ACETATE IONACETATE ION
2
5
SULFATE IONSULFATE ION
3
1
FLAVIN MONONUCLEOTIDEFLAVIN MONONUCLEOTIDE
4
1
OROTIC ACIDOROTIC ACID
5
1
3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303