2FPV: Dual binding mode of a novel series of DHODH inhibitors

PDB ID: 2FPVDownload
MMDB ID: 43773
PDB Deposition Date: 2006/1/17
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 2FPV: monomeric; determined by author
Molecular Components in 2FPV
Label Count Molecule
Protein (1 molecule)
1
Dihydroorotate Dehydrogenase, Mitochondrial
(Gene symbol: DHODH)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
2
ACETATE IONACETATE ION
2
4
SULFATE IONSULFATE ION
3
1
FLAVIN MONONUCLEOTIDEFLAVIN MONONUCLEOTIDE
4
1
OROTIC ACIDOROTIC ACID
5
1
3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303