2F53: Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without apparent cross-reactivity

PDB ID: 2F53Download
MMDB ID: 38710
PDB Deposition Date: 2005/11/25
Updated in MMDB: 2021/10
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 2F53: pentameric; determined by author and by software (PISA)
Molecular Components in 2F53
Label Count Molecule
Proteins (5 molecules)
1
HLA Class I Histocompatibility Antigen
Molecule annotation
1
Beta-2-microglobulin
Molecule annotation
1
Cancer/testis Antigen 1B
Molecule annotation
1
T-cell Receptor, Alpha Chain
Molecule annotation
1
T-cell Receptor, Beta Chain
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
SODIUM IONSODIUM ION
2
4
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303