NCBI
National Center for
Biotechnology Information
Search
2CNE:
Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B
PDB ID:
2CNE
Download
MMDB ID:
41379
PDB Deposition Date:
2006/5/21
Updated in MMDB:
2023/12
Experimental Method:
x-ray diffraction
Resolution:
1.8 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 2CNE: monomeric; determined by author and by software (PQS)
Molecular Components in 2CNE
Label
Count
Molecule
Protein (1 molecule)
A
1
Tyrosine-protein Phosphatase Non-receptor Type 1
(Gene symbol:
PTPN1
)
Chemicals and Non-standard biopolymers (4 molecules)
1
1
N-({4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL}ACETYL)-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE
2
2
SULFATE ION
3
1
octyl beta-D-glucopyranoside
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303