1M63: Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

PDB ID: 1M63Download
MMDB ID: 20702
PDB Deposition Date: 2002/7/12
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 1M63: octameric; determined by software (PISA)
Molecular Components in 1M63
Label Count Molecule
Proteins (6 molecules)
2
Serine/threonine Protein Phosphatase 2B Catalytic Subunit, Alpha Isoform
(Gene symbol: PPP3CA)
Molecule annotation
2
Calcineurin B Subunit Isoform 1
(Gene symbol: PPP3R1)
Molecule annotation
2
Peptidyl-prolyl Cis-trans Isomerase a
(Gene symbol: PPIA)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
DH
2
CYCLOSPORIN A
1
2
ZINC IONZINC ION
2
2
FE (III) IONFE (III) ION
3
8
CALCIUM IONCALCIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303