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Conserved domains on  [gi|49176397|ref|YP_026242|]
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putative glucosamine-6-phosphate deaminase YieK [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

glucosamine/galactosamine-6-phosphate isomerase/deaminase family protein( domain architecture ID 10013934)

glucosamine/galactosamine-6-phosphate isomerase/deaminase family protein similar to Escherichia coli protein YieK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-228 1.49e-156

glucosamine-6-phosphate deaminase;


:

Pssm-ID: 183470  Cd Length: 239  Bit Score: 433.79  E-value: 1.49e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397    1 MKLIITEDYQEMSRVAAHHLLGYMSKTRRVNLAITAGSTPKGMYEYLTTLVKGKPWYDNCYFYNFDEIPFRGKEGEGVTI 80
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYMSKTKRVNLAITAGSTPKGMYEYLITLVKGKAWYDNVHYYNFDEIPFRGKEGEGVTI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397   81 TNLRNLFFTPAGIKEENIQKLTIDNYREHDQKLAREGGLDLVVLGLGADGHFCGNLPNTTHFHEQTVEFPIQGEMVDIVA 160
Cdd:PRK12358  81 TNLRNLFFTPAGIKEENIHKLTIDNYREHDQKLARDGGLDLVVLGLGADGHFCGNLPGTTHFHDETVEVPIQGEMVDIVA 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49176397  161 HGELGGDFSLVPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEDVPASVLQLHPSLMVI 228
Cdd:PRK12358 161 HGELGGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLTVI 228
 
Name Accession Description Interval E-value
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-228 1.49e-156

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 433.79  E-value: 1.49e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397    1 MKLIITEDYQEMSRVAAHHLLGYMSKTRRVNLAITAGSTPKGMYEYLTTLVKGKPWYDNCYFYNFDEIPFRGKEGEGVTI 80
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYMSKTKRVNLAITAGSTPKGMYEYLITLVKGKAWYDNVHYYNFDEIPFRGKEGEGVTI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397   81 TNLRNLFFTPAGIKEENIQKLTIDNYREHDQKLAREGGLDLVVLGLGADGHFCGNLPNTTHFHEQTVEFPIQGEMVDIVA 160
Cdd:PRK12358  81 TNLRNLFFTPAGIKEENIHKLTIDNYREHDQKLARDGGLDLVVLGLGADGHFCGNLPGTTHFHDETVEVPIQGEMVDIVA 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49176397  161 HGELGGDFSLVPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEDVPASVLQLHPSLMVI 228
Cdd:PRK12358 161 HGELGGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLTVI 228
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-228 1.40e-76

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 230.83  E-value: 1.40e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397  10 QEMSRVAAHHLLGYMSKTRRVNLAITAGSTPKGMYEYLTTLVK-GKPWYDNCYFYNFDEIPFRGKEGEGVTITNLRNLFF 88
Cdd:cd01399   1 EEMSEAAAELIAELIREKPPAVLGLATGSTPLGVYEELIELHKeGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397  89 TPAGIKEENIQKLT------IDNYREHDQKLAREGGLDLVVLGLGADGHFCGNLPNTTHFHE-QTVEFpiqgEMVDIVAH 161
Cdd:cd01399  81 DHIDIKPENIHIPDgnaadlEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRtRVVTL----DESTRQAN 156

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49176397 162 GELGGDFSLVPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEDVPASVLQLHPSLMVI 228
Cdd:cd01399 157 ARFFDGDEDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVI 223
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-228 3.27e-48

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 159.17  E-value: 3.27e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397   1 MKLIITEDYQEMSRVAAHHLLGYMSKT----RRVNLAITAGSTPKGMYEYLTTLVKGK--PWyDNCYFYNFDE---IP-- 69
Cdd:COG0363   2 MRVIIFPDAEELAAAAAERAAERIAEAiaekGRAVLGLAGGSTPLGLYEELARLHKEGglDW-SRVHVFNLDEyvgLPpd 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397  70 ----FRgkegegvtiTNLRNLFFTPAGIKEENI-----QKLTIDNY-REHDQKLAREGGLDLVVLGLGADGHFCGNLPNT 139
Cdd:COG0363  81 hpqsNR---------RFMREALLDHVDIPPENIhipdgEAEDPEAAaARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGS 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397 140 tHFHEQTvEFPIQGEMVDIVAHGELGGDFSLVPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEDVPASVL 219
Cdd:COG0363 152 -PFLSET-DRVVTLDESTRQANARFFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASIL 229


                ....*....
gi 49176397 220 QLHPSLMVI 228
Cdd:COG0363 230 QGHPNVTWF 238
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
7-222 8.72e-18

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 78.82  E-value: 8.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397     7 EDYQEMSRVAAHHLLGYMSKT----RRVNLAITAGSTPKGMYEYLTTLVKGKPWyDNCYFYNFDE--IP-------FRgk 73
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAAlaerGRFTLALSGGSTPKPLYELLAAAPARLDW-SRVHVFWGDErcVPpddpdsnYG-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397    74 egegvtitNLRNLFFTPAGIKEENIqkLTIDNY--------REHDQKLAREGG------LDLVVLGLGADGHFCGNLPNT 139
Cdd:pfam01182  78 --------MAREALLSHVPIPASNV--HPIPASaadpeeaaAAYEAELRELLPdlelpvFDLVLLGMGPDGHTASLFPGS 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397   140 THFHEQTvefpiqgemvDIVAHgelggdfslVPDSY------VTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVtED 213
Cdd:pfam01182 148 PALEETD----------RLVVA---------VTDSPkppperITLTLPVLNAARRVWFLVTGAGKADALRRALAGDP-DP 207


                  ....*....
gi 49176397   214 VPASVLQLH 222
Cdd:pfam01182 208 LPAALVRPG 216
 
Name Accession Description Interval E-value
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-228 1.49e-156

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 433.79  E-value: 1.49e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397    1 MKLIITEDYQEMSRVAAHHLLGYMSKTRRVNLAITAGSTPKGMYEYLTTLVKGKPWYDNCYFYNFDEIPFRGKEGEGVTI 80
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYMSKTKRVNLAITAGSTPKGMYEYLITLVKGKAWYDNVHYYNFDEIPFRGKEGEGVTI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397   81 TNLRNLFFTPAGIKEENIQKLTIDNYREHDQKLAREGGLDLVVLGLGADGHFCGNLPNTTHFHEQTVEFPIQGEMVDIVA 160
Cdd:PRK12358  81 TNLRNLFFTPAGIKEENIHKLTIDNYREHDQKLARDGGLDLVVLGLGADGHFCGNLPGTTHFHDETVEVPIQGEMVDIVA 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49176397  161 HGELGGDFSLVPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEDVPASVLQLHPSLMVI 228
Cdd:PRK12358 161 HGELGGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLTVI 228
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-228 1.40e-76

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 230.83  E-value: 1.40e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397  10 QEMSRVAAHHLLGYMSKTRRVNLAITAGSTPKGMYEYLTTLVK-GKPWYDNCYFYNFDEIPFRGKEGEGVTITNLRNLFF 88
Cdd:cd01399   1 EEMSEAAAELIAELIREKPPAVLGLATGSTPLGVYEELIELHKeGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397  89 TPAGIKEENIQKLT------IDNYREHDQKLAREGGLDLVVLGLGADGHFCGNLPNTTHFHE-QTVEFpiqgEMVDIVAH 161
Cdd:cd01399  81 DHIDIKPENIHIPDgnaadlEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRtRVVTL----DESTRQAN 156

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49176397 162 GELGGDFSLVPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEDVPASVLQLHPSLMVI 228
Cdd:cd01399 157 ARFFDGDEDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVI 223
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-228 3.27e-48

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 159.17  E-value: 3.27e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397   1 MKLIITEDYQEMSRVAAHHLLGYMSKT----RRVNLAITAGSTPKGMYEYLTTLVKGK--PWyDNCYFYNFDE---IP-- 69
Cdd:COG0363   2 MRVIIFPDAEELAAAAAERAAERIAEAiaekGRAVLGLAGGSTPLGLYEELARLHKEGglDW-SRVHVFNLDEyvgLPpd 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397  70 ----FRgkegegvtiTNLRNLFFTPAGIKEENI-----QKLTIDNY-REHDQKLAREGGLDLVVLGLGADGHFCGNLPNT 139
Cdd:COG0363  81 hpqsNR---------RFMREALLDHVDIPPENIhipdgEAEDPEAAaARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGS 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397 140 tHFHEQTvEFPIQGEMVDIVAHGELGGDFSLVPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEDVPASVL 219
Cdd:COG0363 152 -PFLSET-DRVVTLDESTRQANARFFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASIL 229


                ....*....
gi 49176397 220 QLHPSLMVI 228
Cdd:COG0363 230 QGHPNVTWF 238
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-228 1.79e-37

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 131.88  E-value: 1.79e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397    1 MKLIITEDYQEMSRVAAHHLLGYM-----SKTRRVNLAITAGSTPKGMYEYLTTLVK-GKPWYDNCYFYNFDE---IP-- 69
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRInaflpTKERPFVLGLATGSSPLETYKALIELHKaGKVDFSRVTTFNLDEyvgLPad 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397   70 ----FRgkegegvtiTNLRNLFFTPAGIKEENIQKL---TIDNYRE---HDQKLAREGGLDLVVLGLGADGHFCGNLPNT 139
Cdd:PRK00443  81 hpesYR---------YFMRENFFDHVDIPPENINLLngnAPDPEAEcrrYEEKIKSAGGIDLQILGIGENGHIAFNEPGS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397  140 -----THFHEQTVEFPIQGEMVDivahgelGGDFSLVPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEDV 214
Cdd:PRK00443 152 sfasrTRIKTLTEDTRIANSRFF-------DGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMW 224

                        250
                 ....*....|....
gi 49176397  215 PASVLQLHPSLMVI 228
Cdd:PRK00443 225 PASILQLHPKATLV 238
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 1-223 6.11e-24

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 95.67  E-value: 6.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397    1 MKLIITEDYQEMSRVAAHHLLGYMSKTRRVNLAITAGSTPKGMYEYLTTLVKGKP-WYDNCYFYNFDEIPFRGKEGEGVT 79
Cdd:PRK09762   1 QTLQQVENYTALSERASEYLLAVIRSKPDAVICLATGATPLLTYHYLVEKIHQQQvDVSQLTFVKLDEWVDLPLTMPGTC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397   80 ITNLRNLFFTPAGIKEENIQKLTIDNYREHD-----QKLAREGGLDLVVLGLGADGHFCGNLP--------NTTHFHEQT 146
Cdd:PRK09762  81 ETFLQQHIVQPLGLREDQLISFRSEEINETEcervtNLIARKGGLDLCVLGLGKNGHLGLNEPgeslqpacHISQLDART 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49176397  147 VEFP-IQGEMVDivahgelggdfslvPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEDVPASVLQLHP 223
Cdd:PRK09762 161 QQHEmLKTAGRP--------------VTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHS 224
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 4-228 1.15e-22

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 96.25  E-value: 1.15e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397    4 IITEDYQEMSRVAAHHLLGYMSKTRRVN----LAITAGSTPKGMYEYLTTLVK--GKPWYDNCYFyNFDEIPFRGKEGEG 77
Cdd:PRK02122  31 DIFESSEEASRAVAQEIATLIRERQAEGkpcvLGLATGSSPIGVYAELIRMHReeGLSFKNVITF-NLDEYYPMQPDSLQ 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397   78 VTITNLRNLFFTPAGIKEENI-------QKLTIDNY-REHDQKLAREGGLDLVVLGLGADGHFCGNLPNTthfHEQTVEF 149
Cdd:PRK02122 110 SYHRFMKENLFDHVDIPPENIhipdgtiPKEEIDEYcRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGS---GRNSRTR 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397  150 PIqgeMVDIVAHGELGGDF---SLVPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEDVPASVLQLHPSLM 226
Cdd:PRK02122 187 LV---TLDHITRRDAASDFfgeENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNAT 263


                 ..
gi 49176397  227 VI 228
Cdd:PRK02122 264 FV 265
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-224 2.98e-21

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 89.05  E-value: 2.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397    1 MKLIITEDyqemSRVAAHHLLGYMSKtrRVN-----------LAITAGSTPKGMYEYLTTLVK-GKPWYDNCYFYNFDE- 67
Cdd:PTZ00285   1 MRIVISED----ADAVADYTSNYIIK--RINdfkptsdrpfvLGLPTGSTPLPTYQELIRAYReGRVSFSNVVTFNMDEy 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397   68 --IPFRGKEGEGVTI-TNlrnlFFTPAGIKEENIQKL--TIDNY----REHDQKLAREGGLDLVVLGLGADGHFCGNLPN 138
Cdd:PTZ00285  75 vgLPRDHPQSYHYFMkEN----FFDHVDIKEENRHILngTAPDLeeecRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397  139 TTHFHEQTVEFPIQGEmvdIVAHGEL-GGDFSLVPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEDVPAS 217
Cdd:PTZ00285 151 SSLDSRTRVKSLNQET---IDANARFfGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPAS 227


                 ....*..
gi 49176397  218 VLQLHPS 224
Cdd:PTZ00285 228 ALQMHPA 234
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
7-222 8.72e-18

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 78.82  E-value: 8.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397     7 EDYQEMSRVAAHHLLGYMSKT----RRVNLAITAGSTPKGMYEYLTTLVKGKPWyDNCYFYNFDE--IP-------FRgk 73
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAAlaerGRFTLALSGGSTPKPLYELLAAAPARLDW-SRVHVFWGDErcVPpddpdsnYG-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397    74 egegvtitNLRNLFFTPAGIKEENIqkLTIDNY--------REHDQKLAREGG------LDLVVLGLGADGHFCGNLPNT 139
Cdd:pfam01182  78 --------MAREALLSHVPIPASNV--HPIPASaadpeeaaAAYEAELRELLPdlelpvFDLVLLGMGPDGHTASLFPGS 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397   140 THFHEQTvefpiqgemvDIVAHgelggdfslVPDSY------VTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVtED 213
Cdd:pfam01182 148 PALEETD----------RLVVA---------VTDSPkppperITLTLPVLNAARRVWFLVTGAGKADALRRALAGDP-DP 207


                  ....*....
gi 49176397   214 VPASVLQLH 222
Cdd:pfam01182 208 LPAALVRPG 216
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 10-223 2.67e-16

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 74.91  E-value: 2.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397  10 QEMSRVAAHHLLG----YMSKTRRVNLAITAGSTPKGMYEYLTTLvKGKPWyDNCYFYNFDE--IPFrgkEGEGVTITNL 83
Cdd:cd01400   1 EALAEALADRIAEalaaAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDW-SKVHVFLGDErcVPP---DDPDSNYRLA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397  84 RNLFFTPAGIKEENIQKLTIDNY-----REHDQKLAREGG----LDLVVLGLGADGHFCGNLPNTTHFHEQTvefpiqGE 154
Cdd:cd01400  76 REALLSHVAIPAANIHPIPTELGpedaaAAYEKELRALFGgvppFDLVLLGMGPDGHTASLFPGHPALLEET------DR 149

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49176397 155 MVdIVAHGElggdfSLVPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEDVPASVLQLHP 223
Cdd:cd01400 150 LV-VAVTDS-----PKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRP 212
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 120-220 2.40e-03

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 38.30  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176397  120 DLVVLGLGADGHFCGNLPNTTHFHEQTvefpiqgEMVDIVAhgelggDFSLVPDSYVTMGPKSIMAAKNLLIIVSGAGKA 199
Cdd:PLN02360 152 DLILLGMGSDGHVASLFPNHPALEEKD-------DWVTFIT------DSPKPPPERITFTLPVINSASNVAVVATGESKA 218

                         90       100
                 ....*....|....*....|....*
gi 49176397  200 QA----LKNVLQGPVTEDVPASVLQ 220
Cdd:PLN02360 219 NAvhlaIDDVTEGPDAPSLPARMVQ 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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