|
Name |
Accession |
Description |
Interval |
E-value |
| RHS_core |
NF041261 |
RHS element core protein; |
1-1247 |
0e+00 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 2519.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1 MSGKPAARQGDMTQYGGSIVQGSAGVRIGAPTGVACSVCPGGVTSGHPVNPLLGAKVLPGETDIALPGPLPFILSRTYSS 80
Cdd:NF041261 1 MSGKPAARQGDMTQYGGPIVQGSAGVRIGAPTGVACSVCPGGMTSGNPVNPLLGAKVLPGETDIALPGPLPFILSRTYSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 81 YRTKTPAPVGSLGPGWKMPADIRLQLRDNTLILSDNGGRSLYFEHLFPGEDGYSRSESLWLVRGGVAKLDEGHRLAALWQ 160
Cdd:NF041261 81 YRTRTPAPVGVFGPGWKAPSDIRLQLRDDGLILNDNGGRSIHFEPLFPGEAVYSRSESLWLVRGGVAAQPDGHTLAALWQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 161 ALPEELRLSPHRYLATNSPQGPWWLLGWCERVPEADEVLPAPLPPYRVLTGLVDRFGRTQTFHREAAGEFSGEITGVTDG 240
Cdd:NF041261 161 ALPEDIRLSPHLYLATNSAQGPWWILGWSERVPGADEVLPAPLPPYRVLTGMVDRFGRTLTFHREAAGDLAGEITGVTDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 241 AWRHFRLVLTTQAQRAEEARQQAISGGTEP--------SAFPDTLPGYTEYGRDNGIRLSAVWLTHDPEYPENLPAAPLV 312
Cdd:NF041261 241 AGREFRLVLTTQAQRAEEARKQRTSSLSSPdgprplssSAFPDTLPGGTEYGPDNGIRLSAVWLTHDPAYPESLPAAPLV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 313 RYGWTPRGELAVVYDRSGKQVRSFTYDDKYRGRMVAHRHTGRPEIRYRYDSDGRVTEQLNPAGLSYTYQYEKDRITITDS 392
Cdd:NF041261 321 RYTYTEAGELLAVYDRSNTQVRAFTYDAQHPGRMVAHRYAGRPEMCYRYDDTGRVTEQLNPAGLSYRYQYEQDRITITDS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 393 LDRREVLHTQGEAGLKRVVKKEHADGSVTQSQFDAVGRLRAQTDAAGRTTEYSPDVVTGLITRITTPDGRASAFYYNHHN 472
Cdd:NF041261 401 LNRREVLHTEGEGGLKRVVKKEHADGSVTRSGYDAAGRLTAQTDAAGRRTEYSLNVVSGDITDITTPDGRETKFYYNDGN 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 473 QLTSATGPDGLELRREYDELGRLIQETAPDGDITRYRYDNPHSDLPCATEDATGSRKTMTWSRYGQLLSFTDCSGYVTRY 552
Cdd:NF041261 481 QLTSVTSPDGLESRREYDEPGRLVSETSRSGETTRYRYDDPHSELPATTTDATGSTKQMTWSRYGQLLAFTDCSGYQTRY 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 553 DHDRFGQMTAVHREEGLSQYRAYDSRGQLIAVKDTQGHETRYEYNIAGDLTAVIAPDGSRNGTQYDAWGKAVRTTQGGLT 632
Cdd:NF041261 561 EYDRFGQMTAVHREEGISTYRRYDNRGQLTSVKDAQGRETRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQGGLT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 633 RSMEYDAAGRVIRLTSENGSHTTFRYDVLDRLIQETGFDGRTQRYHHDLTGKLIRSEDEGLVTHWHYDEADRLTHRTVKG 712
Cdd:NF041261 641 RSMEYDAAGRITTLTNENGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTGKLTQSEDEGLVTLWHYDESDRITHRTVNG 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 713 ETAERWQYDERGWLTDISHISEGHRVAVHYRYDEKGRLTGERQTVHHPQTEALLWQHETRHAYNAQGLANRCIPDSLPAV 792
Cdd:NF041261 721 EPAEQWQYDEHGWLTDISHLSEGHRVAVHYGYDDKGRLTGERQTVENPETGELLWQHETGHAYNEQGLANRVTPDSLPPV 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 793 EWLTYGSGYLAGMKLGDTPLVEYTRDRLHRETLRSFG------RYELTTAYTPAGQLQSQHLNSLLSDRDYTWNDNGELI 866
Cdd:NF041261 801 EWLTYGSGYLAGMKLGGTPLVEYTRDRLHRETVRSFGgagsnaAYELTTAYTPAGQLQSQHLNSLVYDRDYTWNDNGDLV 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 867 RISSPRQTRSYSYSTTGRLTGVHTTAANLDIRIPYATDPAGNRLPDPELHPDSTLSMWPDNRIARDAHYLYRYDRHGRLT 946
Cdd:NF041261 881 RISGPRQTREYGYSATGRLTGVHTTAANLDIRIPYATDPAGNRLPDPELHPDSTLTAWPDNRIAEDAHYVYRYDEYGRLT 960
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 947 EKTDLIPEGVIRTDDERTHRYHYDSQHRLVHYTRTQYEEPLVESRYLYDPLGRRVAKRVWRRERDLTGWMSLSRKPQVTW 1026
Cdd:NF041261 961 EKTDRIPEGVIRTDDERTHHYHYDSQHRLVFYTRIQHGEPLVESRYLYDPLGRRMAKRVWRRERDLTGWMSLSRKPEVTW 1040
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1027 YGWDGDRLTTIQNDRSRIQTIYQPGSFTPLIRVETATGELAKTQRRSLADALQQSGGEDGGSVVFPPVLVQMLDRLESEI 1106
Cdd:NF041261 1041 YGWDGDRLTTVQTDTTRIQTVYQPGSFTPLIRVETENGERAKAQRRSLAETLQQEGSENGHGVVFPAELVRMLDRLEEEI 1120
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1107 LADRVSEESRRWLASCGLTVEQMQNQMDPVYTPARKIHLYHCDHRGLPLALISTEGATAWCAEYDEWGNLLNEENPHQLQ 1186
Cdd:NF041261 1121 RADRVSEESRAWLAQCGLTVEQMARQVEPEYTPARKLHLYHCDHRGLPLALISEEGNTAWQGEYDEWGNLLNEENPHHLQ 1200
|
1210 1220 1230 1240 1250 1260
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 49176361 1187 QLIRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNLYGYQLNPISDIDPLGL 1247
Cdd:NF041261 1201 QPYRLPGQQYDEESGLYYNRNRYYDPLQGRYITQDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
|
|
| DUF4329 |
pfam14220 |
Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found ... |
1280-1396 |
3.13e-43 |
|
Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found in bacteria and eukaryotes, and is approximately 130 amino acids in length. It is often found in association with pfam05593 and pfam03527. There is a single completely conserved residue D and a highly conserved HTH motif which may be functionally important.
Pssm-ID: 433783 Cd Length: 114 Bit Score: 152.92 E-value: 3.13e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1280 STAYDALNKINSQSICEDKEFAGLICKDNSGRYFSTAPNRGERKGSypFNSPCPNGTEKVSAYHTHGADSHGeYWDEIFS 1359
Cdd:pfam14220 1 DAAKDALEEYNGRSIRENREYCGFILTDDEGKYVYTAPTRGGEASS--GNPPVPNGQTVVASYHTHGAYDSN-YDSEVFS 77
|
90 100 110
....*....|....*....|....*....|....*..
gi 49176361 1360 GKDEKIVKSKDNNIKSFYLGTPSGNFKAIDNHGKEIT 1396
Cdd:pfam14220 78 VQDKKIVLSDMQNGVNGYVATPGGRLWYIDPSRSYAR 114
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
133-1250 |
1.39e-32 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 137.97 E-value: 1.39e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 133 YSRSESLWLVRGGVAKLDEGHRLAALWQALPEELRLSPHRYLATNSPQGPWWLLGWCERVPEADEVLPAPLPPYRVLTGL 212
Cdd:COG3209 61 STTDVVGTLTGAGGTSAGGVTALGDASAAGGGYVGGAAAGGGATLTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGAT 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 213 VDRFGRTQTFHREAAGEFSGEITGVTDGAWRHFRLVLTTQAQRAEEARQQAISGGTepSAFPDTLPGYTEYGRDNGIRLS 292
Cdd:COG3209 141 AGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLATGLA--GSALLALGSGAILGGLAGAYSG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 293 AVWLTHDPEYPENLPAAPLVRYGWTPRGELAVVYDRSGKQVRSFTYDDKYRGRMVAHRHTGRPEIRYRYDSDGRVTEQLN 372
Cdd:COG3209 219 SATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGA 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 373 PAGLSYTYQYEKDRITITDSLDRREVLHTQGEAGLKRVVKKEHADGSVTQSQFDAVGRLRAQTDAAGRTTEYSPDVVTGL 452
Cdd:COG3209 299 GLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGST 378
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 453 ITRITTPDGRASAFYYNHHNQLTSATGPDGLELRREYDELGRLIQETAPDGDITRYRYDNPHSDLPCATEDATGSRKTMT 532
Cdd:COG3209 379 SGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGGAGAS 458
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 533 WSRYGQLLSFTDCSGYVTRYDHDRFGQMTAVHREEGLSQYRAYDSRGQLIAVKDTQGHETRYEYNIAGDLTAVIAPDGSR 612
Cdd:COG3209 459 GTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTTTAGARGLVVTTGTTLTLGTTTTATLS 538
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 613 NGTQYDAWGKAVRTTQGGLTRSmEYDAAGRVIRLTSENGSHTTFRYDVLDRLIQETGFDGRTQRYHHDLTGKLIRSEDEG 692
Cdd:COG3209 539 ATDATGTGDTTTTGTVGTGTST-GTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAG 617
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 693 LVTHWHYDEADRLTHRTVKGETAERWQYDERGWLTDISHISEGHRVAVHYRYDEKGRLTGERQTVHHPQTEALLWQHETR 772
Cdd:COG3209 618 LTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGA 697
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 773 HAYNAQGLANRCIPDSLPAVEWLTYGSGYLAGMKLGDTPLVEYTRDRLHRETLRSFGRYELTTAYTPAGQLQSQHLNSLL 852
Cdd:COG3209 698 TTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLTSETTPGGV 777
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 853 SDRD----YTWNDNGELIRISSPR-QTRSYSYSTTGRLTGVHTTAANLDIRIpyatdpagnrlpdpelhpdstlsmwpdn 927
Cdd:COG3209 778 TQGTyttrYTYDALGRLTSVTYPDgETVTYTYDALGRLTSVITVGSGGGTDL---------------------------- 829
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 928 riardAHYLYRYDRHGRLTEKTDLIPEGvirtddERTHRYHYDSQHRLvhytrTQYEEPLVESRYLYDPLGRRVAKRVWr 1007
Cdd:COG3209 830 -----QDRTYTYDAAGNITSITDALRAG------TLTQTYTYDALGRL-----TSATDPGTTESYTYDANGNLTSRTDG- 892
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1008 rerdltgwmslsrkpQVTWYGWDG-DRLTTIQNDrsriqtiyqpgsftplirvetatgelaktqrrsladalqqsggeDG 1086
Cdd:COG3209 893 ---------------GTTTYTYDAlGRLVSVTKP--------------------------------------------DG 913
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1087 GSVVFppvlvqmldrleseiladrvseesrrwlascgltveqmqnqmdpVYTParkihLYHCDHRGLPLALISTEGATAW 1166
Cdd:COG3209 914 TTTTY--------------------------------------------TYDA-----LGHTDHLGSVRALTDASGQVVW 944
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1167 CAEYDEWGNLLNEENPHQLQQLiRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNLYGYQL-NPISDIDPL 1245
Cdd:COG3209 945 RYDYDPFGNLLAETSGAAANPL-RFTGQEYDAETGLYYNGARYYDPALGRFLSPDPIGLAGGLNLYAYVGnNPVNYVDPL 1023
|
....*
gi 49176361 1246 GLSMW 1250
Cdd:COG3209 1024 GLAAL 1028
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
1170-1247 |
1.27e-30 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 115.68 E-value: 1.27e-30
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49176361 1170 YDEWGNLLNEENPhqLQQLIRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNLYGY-QLNPISDIDPLGL 1247
Cdd:TIGR03696 1 YDPYGEVLSESGA--APNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPDPIGLGGGLNLYAYvGNNPVNWVDPLGL 77
|
|
| DUF6531 |
pfam20148 |
Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins. |
46-123 |
2.94e-18 |
|
Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins.
Pssm-ID: 466309 [Multi-domain] Cd Length: 74 Bit Score: 80.27 E-value: 2.94e-18
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49176361 46 GHPVNPLLGAKVLPgETDIALPGPLPFILSRTYSSYRTKTpapvGSLGPGWKMPADIRLQLR-DNTLILSDNGGRSLYF 123
Cdd:pfam20148 1 GDPVNVATGNKVLE-ETDFSLPGPLPLVWTRTYNSSSERD----GPLGPGWSHPYDQRLELEgDGGVVYIDADGREVTF 74
|
|
| PAAR_2 |
cd14738 |
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR ... |
1-29 |
8.44e-08 |
|
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR (proline-alanine-alanine-arginine) repeat family, where it forms a sharp conical extension on the VgrG spike, a trimeric protein complex of the bacterial type VI secretion system (T6SS). The T6SS is responsible for translocation of a wide variety of toxic effector molecules, allowing predatory cells to kill prokaryotic as well as eukaryotic prey cells. The pointed tip of the PAAR domain is stabilized by a zinc atom positioned close to the cone's vertex and is likely to be important for its integrity during penetration of the target cell envelope. VgrG proteins are orthologous to the central baseplate spikes of bacteriophages with contractile tails, and genes encoding proteins with PAAR motifs have been frequently found immediately downstream from vgrG-like genes. It has been shown that PAAR proteins are essential for T6SS-mediated secretion and target cell killing by Vibrio cholerae (encodes two PAAR proteins) and Acinetobacter baylyi (encodes three PAAR proteins); inactivation of all these PAAR genes results in inactivation of Hcp secretion as well as T6SS-dependent killing of E. coli.
Pssm-ID: 269823 Cd Length: 94 Bit Score: 51.48 E-value: 8.44e-08
10 20
....*....|....*....|....*....
gi 49176361 1 MSGKPAARQGDMTQYGGSIVQGSAGVRIG 29
Cdd:cd14738 66 IGGKPAARMGDSTAHGGVIVSGVPTVLIG 94
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RHS_core |
NF041261 |
RHS element core protein; |
1-1247 |
0e+00 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 2519.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1 MSGKPAARQGDMTQYGGSIVQGSAGVRIGAPTGVACSVCPGGVTSGHPVNPLLGAKVLPGETDIALPGPLPFILSRTYSS 80
Cdd:NF041261 1 MSGKPAARQGDMTQYGGPIVQGSAGVRIGAPTGVACSVCPGGMTSGNPVNPLLGAKVLPGETDIALPGPLPFILSRTYSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 81 YRTKTPAPVGSLGPGWKMPADIRLQLRDNTLILSDNGGRSLYFEHLFPGEDGYSRSESLWLVRGGVAKLDEGHRLAALWQ 160
Cdd:NF041261 81 YRTRTPAPVGVFGPGWKAPSDIRLQLRDDGLILNDNGGRSIHFEPLFPGEAVYSRSESLWLVRGGVAAQPDGHTLAALWQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 161 ALPEELRLSPHRYLATNSPQGPWWLLGWCERVPEADEVLPAPLPPYRVLTGLVDRFGRTQTFHREAAGEFSGEITGVTDG 240
Cdd:NF041261 161 ALPEDIRLSPHLYLATNSAQGPWWILGWSERVPGADEVLPAPLPPYRVLTGMVDRFGRTLTFHREAAGDLAGEITGVTDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 241 AWRHFRLVLTTQAQRAEEARQQAISGGTEP--------SAFPDTLPGYTEYGRDNGIRLSAVWLTHDPEYPENLPAAPLV 312
Cdd:NF041261 241 AGREFRLVLTTQAQRAEEARKQRTSSLSSPdgprplssSAFPDTLPGGTEYGPDNGIRLSAVWLTHDPAYPESLPAAPLV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 313 RYGWTPRGELAVVYDRSGKQVRSFTYDDKYRGRMVAHRHTGRPEIRYRYDSDGRVTEQLNPAGLSYTYQYEKDRITITDS 392
Cdd:NF041261 321 RYTYTEAGELLAVYDRSNTQVRAFTYDAQHPGRMVAHRYAGRPEMCYRYDDTGRVTEQLNPAGLSYRYQYEQDRITITDS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 393 LDRREVLHTQGEAGLKRVVKKEHADGSVTQSQFDAVGRLRAQTDAAGRTTEYSPDVVTGLITRITTPDGRASAFYYNHHN 472
Cdd:NF041261 401 LNRREVLHTEGEGGLKRVVKKEHADGSVTRSGYDAAGRLTAQTDAAGRRTEYSLNVVSGDITDITTPDGRETKFYYNDGN 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 473 QLTSATGPDGLELRREYDELGRLIQETAPDGDITRYRYDNPHSDLPCATEDATGSRKTMTWSRYGQLLSFTDCSGYVTRY 552
Cdd:NF041261 481 QLTSVTSPDGLESRREYDEPGRLVSETSRSGETTRYRYDDPHSELPATTTDATGSTKQMTWSRYGQLLAFTDCSGYQTRY 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 553 DHDRFGQMTAVHREEGLSQYRAYDSRGQLIAVKDTQGHETRYEYNIAGDLTAVIAPDGSRNGTQYDAWGKAVRTTQGGLT 632
Cdd:NF041261 561 EYDRFGQMTAVHREEGISTYRRYDNRGQLTSVKDAQGRETRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQGGLT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 633 RSMEYDAAGRVIRLTSENGSHTTFRYDVLDRLIQETGFDGRTQRYHHDLTGKLIRSEDEGLVTHWHYDEADRLTHRTVKG 712
Cdd:NF041261 641 RSMEYDAAGRITTLTNENGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTGKLTQSEDEGLVTLWHYDESDRITHRTVNG 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 713 ETAERWQYDERGWLTDISHISEGHRVAVHYRYDEKGRLTGERQTVHHPQTEALLWQHETRHAYNAQGLANRCIPDSLPAV 792
Cdd:NF041261 721 EPAEQWQYDEHGWLTDISHLSEGHRVAVHYGYDDKGRLTGERQTVENPETGELLWQHETGHAYNEQGLANRVTPDSLPPV 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 793 EWLTYGSGYLAGMKLGDTPLVEYTRDRLHRETLRSFG------RYELTTAYTPAGQLQSQHLNSLLSDRDYTWNDNGELI 866
Cdd:NF041261 801 EWLTYGSGYLAGMKLGGTPLVEYTRDRLHRETVRSFGgagsnaAYELTTAYTPAGQLQSQHLNSLVYDRDYTWNDNGDLV 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 867 RISSPRQTRSYSYSTTGRLTGVHTTAANLDIRIPYATDPAGNRLPDPELHPDSTLSMWPDNRIARDAHYLYRYDRHGRLT 946
Cdd:NF041261 881 RISGPRQTREYGYSATGRLTGVHTTAANLDIRIPYATDPAGNRLPDPELHPDSTLTAWPDNRIAEDAHYVYRYDEYGRLT 960
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 947 EKTDLIPEGVIRTDDERTHRYHYDSQHRLVHYTRTQYEEPLVESRYLYDPLGRRVAKRVWRRERDLTGWMSLSRKPQVTW 1026
Cdd:NF041261 961 EKTDRIPEGVIRTDDERTHHYHYDSQHRLVFYTRIQHGEPLVESRYLYDPLGRRMAKRVWRRERDLTGWMSLSRKPEVTW 1040
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1027 YGWDGDRLTTIQNDRSRIQTIYQPGSFTPLIRVETATGELAKTQRRSLADALQQSGGEDGGSVVFPPVLVQMLDRLESEI 1106
Cdd:NF041261 1041 YGWDGDRLTTVQTDTTRIQTVYQPGSFTPLIRVETENGERAKAQRRSLAETLQQEGSENGHGVVFPAELVRMLDRLEEEI 1120
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1107 LADRVSEESRRWLASCGLTVEQMQNQMDPVYTPARKIHLYHCDHRGLPLALISTEGATAWCAEYDEWGNLLNEENPHQLQ 1186
Cdd:NF041261 1121 RADRVSEESRAWLAQCGLTVEQMARQVEPEYTPARKLHLYHCDHRGLPLALISEEGNTAWQGEYDEWGNLLNEENPHHLQ 1200
|
1210 1220 1230 1240 1250 1260
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 49176361 1187 QLIRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNLYGYQLNPISDIDPLGL 1247
Cdd:NF041261 1201 QPYRLPGQQYDEESGLYYNRNRYYDPLQGRYITQDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
|
|
| DUF4329 |
pfam14220 |
Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found ... |
1280-1396 |
3.13e-43 |
|
Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found in bacteria and eukaryotes, and is approximately 130 amino acids in length. It is often found in association with pfam05593 and pfam03527. There is a single completely conserved residue D and a highly conserved HTH motif which may be functionally important.
Pssm-ID: 433783 Cd Length: 114 Bit Score: 152.92 E-value: 3.13e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1280 STAYDALNKINSQSICEDKEFAGLICKDNSGRYFSTAPNRGERKGSypFNSPCPNGTEKVSAYHTHGADSHGeYWDEIFS 1359
Cdd:pfam14220 1 DAAKDALEEYNGRSIRENREYCGFILTDDEGKYVYTAPTRGGEASS--GNPPVPNGQTVVASYHTHGAYDSN-YDSEVFS 77
|
90 100 110
....*....|....*....|....*....|....*..
gi 49176361 1360 GKDEKIVKSKDNNIKSFYLGTPSGNFKAIDNHGKEIT 1396
Cdd:pfam14220 78 VQDKKIVLSDMQNGVNGYVATPGGRLWYIDPSRSYAR 114
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
133-1250 |
1.39e-32 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 137.97 E-value: 1.39e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 133 YSRSESLWLVRGGVAKLDEGHRLAALWQALPEELRLSPHRYLATNSPQGPWWLLGWCERVPEADEVLPAPLPPYRVLTGL 212
Cdd:COG3209 61 STTDVVGTLTGAGGTSAGGVTALGDASAAGGGYVGGAAAGGGATLTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGAT 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 213 VDRFGRTQTFHREAAGEFSGEITGVTDGAWRHFRLVLTTQAQRAEEARQQAISGGTepSAFPDTLPGYTEYGRDNGIRLS 292
Cdd:COG3209 141 AGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLATGLA--GSALLALGSGAILGGLAGAYSG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 293 AVWLTHDPEYPENLPAAPLVRYGWTPRGELAVVYDRSGKQVRSFTYDDKYRGRMVAHRHTGRPEIRYRYDSDGRVTEQLN 372
Cdd:COG3209 219 SATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGA 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 373 PAGLSYTYQYEKDRITITDSLDRREVLHTQGEAGLKRVVKKEHADGSVTQSQFDAVGRLRAQTDAAGRTTEYSPDVVTGL 452
Cdd:COG3209 299 GLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGST 378
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 453 ITRITTPDGRASAFYYNHHNQLTSATGPDGLELRREYDELGRLIQETAPDGDITRYRYDNPHSDLPCATEDATGSRKTMT 532
Cdd:COG3209 379 SGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGGAGAS 458
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 533 WSRYGQLLSFTDCSGYVTRYDHDRFGQMTAVHREEGLSQYRAYDSRGQLIAVKDTQGHETRYEYNIAGDLTAVIAPDGSR 612
Cdd:COG3209 459 GTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTTTAGARGLVVTTGTTLTLGTTTTATLS 538
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 613 NGTQYDAWGKAVRTTQGGLTRSmEYDAAGRVIRLTSENGSHTTFRYDVLDRLIQETGFDGRTQRYHHDLTGKLIRSEDEG 692
Cdd:COG3209 539 ATDATGTGDTTTTGTVGTGTST-GTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAG 617
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 693 LVTHWHYDEADRLTHRTVKGETAERWQYDERGWLTDISHISEGHRVAVHYRYDEKGRLTGERQTVHHPQTEALLWQHETR 772
Cdd:COG3209 618 LTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGA 697
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 773 HAYNAQGLANRCIPDSLPAVEWLTYGSGYLAGMKLGDTPLVEYTRDRLHRETLRSFGRYELTTAYTPAGQLQSQHLNSLL 852
Cdd:COG3209 698 TTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLTSETTPGGV 777
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 853 SDRD----YTWNDNGELIRISSPR-QTRSYSYSTTGRLTGVHTTAANLDIRIpyatdpagnrlpdpelhpdstlsmwpdn 927
Cdd:COG3209 778 TQGTyttrYTYDALGRLTSVTYPDgETVTYTYDALGRLTSVITVGSGGGTDL---------------------------- 829
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 928 riardAHYLYRYDRHGRLTEKTDLIPEGvirtddERTHRYHYDSQHRLvhytrTQYEEPLVESRYLYDPLGRRVAKRVWr 1007
Cdd:COG3209 830 -----QDRTYTYDAAGNITSITDALRAG------TLTQTYTYDALGRL-----TSATDPGTTESYTYDANGNLTSRTDG- 892
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1008 rerdltgwmslsrkpQVTWYGWDG-DRLTTIQNDrsriqtiyqpgsftplirvetatgelaktqrrsladalqqsggeDG 1086
Cdd:COG3209 893 ---------------GTTTYTYDAlGRLVSVTKP--------------------------------------------DG 913
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1087 GSVVFppvlvqmldrleseiladrvseesrrwlascgltveqmqnqmdpVYTParkihLYHCDHRGLPLALISTEGATAW 1166
Cdd:COG3209 914 TTTTY--------------------------------------------TYDA-----LGHTDHLGSVRALTDASGQVVW 944
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 1167 CAEYDEWGNLLNEENPHQLQQLiRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNLYGYQL-NPISDIDPL 1245
Cdd:COG3209 945 RYDYDPFGNLLAETSGAAANPL-RFTGQEYDAETGLYYNGARYYDPALGRFLSPDPIGLAGGLNLYAYVGnNPVNYVDPL 1023
|
....*
gi 49176361 1246 GLSMW 1250
Cdd:COG3209 1024 GLAAL 1028
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
1170-1247 |
1.27e-30 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 115.68 E-value: 1.27e-30
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49176361 1170 YDEWGNLLNEENPhqLQQLIRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNLYGY-QLNPISDIDPLGL 1247
Cdd:TIGR03696 1 YDPYGEVLSESGA--APNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPDPIGLGGGLNLYAYvGNNPVNWVDPLGL 77
|
|
| DUF6531 |
pfam20148 |
Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins. |
46-123 |
2.94e-18 |
|
Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins.
Pssm-ID: 466309 [Multi-domain] Cd Length: 74 Bit Score: 80.27 E-value: 2.94e-18
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49176361 46 GHPVNPLLGAKVLPgETDIALPGPLPFILSRTYSSYRTKTpapvGSLGPGWKMPADIRLQLR-DNTLILSDNGGRSLYF 123
Cdd:pfam20148 1 GDPVNVATGNKVLE-ETDFSLPGPLPLVWTRTYNSSSERD----GPLGPGWSHPYDQRLELEgDGGVVYIDADGREVTF 74
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
5-754 |
3.57e-18 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 90.97 E-value: 3.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 5 PAARQGDMTQYGGSIVQGSAGVRIGAPTGVACSVCPGGVTSGHPVNPLLGAKVLPGETDIALPGPLPFILSRTYSSYRTK 84
Cdd:COG3209 134 GGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLATGLAGSALLALGSGAILGGLA 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 85 TPAPVGSLGPGWKMPADIRLQLRDNTLILSDNGGRSLYFEHLFPGEDGYSRSESLWLVRGGVAKLDEGHRLAALWQALPE 164
Cdd:COG3209 214 GAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGAGLDASTGTGGAGGSNAAATAG 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 165 ELRLSPHRYLATNSPQGPwwllGWCERVPEADEVLPAPLPPYRVLTGLVDRFGRTQTFHREAAGEFSGEITGVTDGAWRH 244
Cdd:COG3209 294 GLGGAGLGSGGAGGGGTA----GGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTVGGGGSLTLGGYGAAGGLTTS 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 245 FRLVLTTQAQRAEEARQQAISGGTEPSAFPDTLPGYTEYGRDNGIRLSAVWLTHDPEYPENLPAAPLVRYGWTPRGELAV 324
Cdd:COG3209 370 VGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDAT 449
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 325 VYDRSGKQVRSFTYDDKYRGRMVAHRHTGRPEIRYRYDSDGRVTEQLNPAGLSYTYQYEKDRITITDSLDRREVLHTQGE 404
Cdd:COG3209 450 TTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTTTAGARGLVVTTGTTLTL 529
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 405 AGLKRVVKKEHADGSVTQSQFDAVGRLRAQTDAAGRTTEYSPDVVTGLITRITTPDGRASAFYYNHHNQLTSATGPDGLE 484
Cdd:COG3209 530 GTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTT 609
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 485 LRREYDELGRLIQETAPDGDITRYRYDNPHSDLPCATEDATGSRKTMTWSRYGQLLSFTDCSGYVTRYDHDRFGQMTAVH 564
Cdd:COG3209 610 TSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGT 689
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 565 REEGLSQYRAYDSRGQLIAVKDTQGHETRYEYNIAGDLTAVIAPDGSRNGTQYDAWGKAVRTTQGGLTRSMEYDAAGRVI 644
Cdd:COG3209 690 TSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLT 769
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176361 645 RLTSENGS-----HTTFRYDVLDRLIQETGFDGRTQRYHHDLTGKLIR-------SEDEGLVTHWHYDEADRLTHRT--- 709
Cdd:COG3209 770 SETTPGGVtqgtyTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSvitvgsgGGTDLQDRTYTYDAAGNITSITdal 849
|
730 740 750 760
....*....|....*....|....*....|....*....|....*
gi 49176361 710 VKGETAERWQYDERGWLTDIShiseGHRVAVHYRYDEKGRLTGER 754
Cdd:COG3209 850 RAGTLTQTYTYDALGRLTSAT----DPGTTESYTYDANGNLTSRT 890
|
|
| RHS |
pfam03527 |
RHS protein; |
1143-1180 |
7.25e-12 |
|
RHS protein;
Pssm-ID: 427349 [Multi-domain] Cd Length: 38 Bit Score: 61.17 E-value: 7.25e-12
10 20 30
....*....|....*....|....*....|....*...
gi 49176361 1143 IHLYHCDHRGLPLALISTEGATAWCAEYDEWGNLLNEE 1180
Cdd:pfam03527 1 IYYYHTDHLGTPEELTDEAGEIVWSAEYDAWGNVTEER 38
|
|
| PAAR_2 |
cd14738 |
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR ... |
1-29 |
8.44e-08 |
|
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR (proline-alanine-alanine-arginine) repeat family, where it forms a sharp conical extension on the VgrG spike, a trimeric protein complex of the bacterial type VI secretion system (T6SS). The T6SS is responsible for translocation of a wide variety of toxic effector molecules, allowing predatory cells to kill prokaryotic as well as eukaryotic prey cells. The pointed tip of the PAAR domain is stabilized by a zinc atom positioned close to the cone's vertex and is likely to be important for its integrity during penetration of the target cell envelope. VgrG proteins are orthologous to the central baseplate spikes of bacteriophages with contractile tails, and genes encoding proteins with PAAR motifs have been frequently found immediately downstream from vgrG-like genes. It has been shown that PAAR proteins are essential for T6SS-mediated secretion and target cell killing by Vibrio cholerae (encodes two PAAR proteins) and Acinetobacter baylyi (encodes three PAAR proteins); inactivation of all these PAAR genes results in inactivation of Hcp secretion as well as T6SS-dependent killing of E. coli.
Pssm-ID: 269823 Cd Length: 94 Bit Score: 51.48 E-value: 8.44e-08
10 20
....*....|....*....|....*....
gi 49176361 1 MSGKPAARQGDMTQYGGSIVQGSAGVRIG 29
Cdd:cd14738 66 IGGKPAARMGDSTAHGGVIVSGVPTVLIG 94
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
637-673 |
1.96e-06 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 45.67 E-value: 1.96e-06
10 20 30
....*....|....*....|....*....|....*..
gi 49176361 637 YDAAGRVIRLTSENGSHTTFRYDVLDRLIQETGFDGR 673
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
575-611 |
4.13e-06 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 44.90 E-value: 4.13e-06
10 20 30
....*....|....*....|....*....|....*..
gi 49176361 575 YDSRGQLIAVKDTQGHETRYEYNIAGDLTAVIAPDGS 611
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
468-504 |
1.42e-05 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 43.36 E-value: 1.42e-05
10 20 30
....*....|....*....|....*....|....*..
gi 49176361 468 YNHHNQLTSATGPDGLELRREYDELGRLIQETAPDGD 504
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| PAAR |
COG4104 |
Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion [Intracellular ... |
3-48 |
2.28e-05 |
|
Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 443280 Cd Length: 87 Bit Score: 44.04 E-value: 2.28e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 49176361 3 GKPAARQGDMTQYGGSIVQGSAGVRIG----APTG--VACSVC-PGGVTSGHP 48
Cdd:COG4104 2 PKPAARLGDKTSHGGPVISGSPTVLIGgrpaARVGdkVSCPKHgPDTIAEGSP 54
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
425-462 |
4.86e-05 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 41.82 E-value: 4.86e-05
10 20 30
....*....|....*....|....*....|....*...
gi 49176361 425 FDAVGRLRAQTDAAGRTTEYSPDvVTGLITRITTPDGR 462
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYD-AAGRLTAVTDPDGT 37
|
|
| PAAR |
COG4104 |
Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion [Intracellular ... |
3-29 |
5.50e-05 |
|
Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 443280 Cd Length: 87 Bit Score: 42.88 E-value: 5.50e-05
10 20
....*....|....*....|....*..
gi 49176361 3 GKPAARQGDMTQYGGSIVQGSAGVRIG 29
Cdd:COG4104 60 GKPAARVGDKTACGGTIISGSPTVLIG 86
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
575-612 |
7.56e-05 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 41.42 E-value: 7.56e-05
10 20 30
....*....|....*....|....*....|....*...
gi 49176361 575 YDSRGQLIAVKDTQGHETRYEYNIAGDLTAVIAPDGSR 612
Cdd:TIGR01643 1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGS 38
|
|
| PAAR_CT_1 |
cd14743 |
proline-alanine-alanine-arginine (PAAR) domain with C-terminal extension; This domain is found ... |
2-46 |
2.49e-04 |
|
proline-alanine-alanine-arginine (PAAR) domain with C-terminal extension; This domain is found in the PAAR (proline-alanine-alanine-arginine) repeat family of mostly gamma-proteobacteria, and forms a sharp conical extension on the VgrG spike, a trimeric protein complex of the bacterial type VI secretion system (T6SS). Some members contains C-terminal domain extensions corresponding to Rearrangement hotspot (Rhs) protein repeats and conserved Rhs repeat-associated unique core sequences as well as uncharacterized domains. However, these terminal domains are exposed to solution, and do not distort the binding site of VgrG. Rhs and related YD-peptide repeat proteins are widely distributed in bacteria. Rhs shares similar architecture with distantly related WapA proteins of Bacillus and Listeria species, suggesting intercellular growth inhibition as its primary function. Additionally, a plasmid-encoded Rhs protein has been implicated in bacteriocin production in Pseudomonas savastanoi. The pointed tip of the PAAR domain is stabilized by a zinc atom positioned close to the cone's vertex and is likely to be important for its integrity during penetration of the target cell envelope. VgrG proteins are orthologous to the central baseplate spikes of bacteriophages with contractile tails, and genes encoding proteins with PAAR motifs have been frequently found immediately downstream from vgrG-like genes.
Pssm-ID: 269828 Cd Length: 78 Bit Score: 41.13 E-value: 2.49e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 49176361 2 SGKPAARQGDMTQYGGSIVQGSAGVRI-GAPTGVACSV--CPGGVTSG 46
Cdd:cd14743 30 DGLPAARVGDKTSCGATIVSGSINVLInGKPAAVLGSTtsHGGVVIGG 77
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
533-568 |
1.35e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 37.58 E-value: 1.35e-03
10 20 30
....*....|....*....|....*....|....*.
gi 49176361 533 WSRYGQLLSFTDCSGYVTRYDHDRFGQMTAVHREEG 568
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
468-508 |
1.59e-03 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 37.57 E-value: 1.59e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 49176361 468 YNHHNQLTSATGPDGLELRREYDELGRLIQETAPDGDITRY 508
Cdd:TIGR01643 1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRY 41
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
637-678 |
1.85e-03 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 37.18 E-value: 1.85e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 49176361 637 YDAAGRVIRLTSENGSHTTFRYDVLDRLIQETGFDGRTQRYH 678
Cdd:TIGR01643 1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
|
|
| PAAR |
COG4104 |
Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion [Intracellular ... |
3-48 |
4.27e-03 |
|
Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 443280 Cd Length: 87 Bit Score: 37.87 E-value: 4.27e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 49176361 3 GKPAARQGDMTQYGG----SIVQGSAGVRIG----APTGVACSvCPGGVTSGHP 48
Cdd:COG4104 29 GRPAARVGDKVSCPKhgpdTIAEGSPTVLINgkpaARVGDKTA-CGGTIISGSP 81
|
|
| PAAR_RHS |
cd14742 |
proline-alanine-alanine-arginine (PAAR) domain, also containing C-terminal Rearrangement ... |
3-29 |
4.30e-03 |
|
proline-alanine-alanine-arginine (PAAR) domain, also containing C-terminal Rearrangement hotspot (Rhs) extensions; This PAAR (proline-alanine-alanine-arginine) repeat subfamily, which forms a sharp conical extension on the VgrG spike, a trimeric protein complex of the bacterial type VI secretion system (T6SS), contains C- and N-terminal domain extensions. These include Rearrangement hotspot (Rhs) protein repeats and conserved Rhs repeat-associated unique core sequences at the C-terminal, and various predicted functions at N- and C-terminal extensions. However, these terminal domains are exposed to solution, and do not distort the binding site of VgrG. Rhs and related YD-peptide repeat proteins are widely distributed in bacteria. Rhs shares similar architecture with distantly related WapA proteins of Bacillus and Listeria species, suggesting intercellular growth inhibition as its primary function. Additionally, a plasmid-encoded Rhs protein has been implicated in bacteriocin production in Pseudomonas savastanoi. The pointed tip of the PAAR domain is stabilized by a zinc atom positioned close to the cone's vertex and is likely to be important for its integrity during penetration of the target cell envelope. VgrG proteins are orthologous to the central baseplate spikes of bacteriophages with contractile tails, and genes encoding proteins with PAAR motifs have been frequently found immediately downstream from vgrG-like genes.
Pssm-ID: 269827 Cd Length: 86 Bit Score: 37.57 E-value: 4.30e-03
10 20
....*....|....*....|....*..
gi 49176361 3 GKPAARQGDMTQYGGSIVQGSAGVRIG 29
Cdd:cd14742 60 GQPAARKGDKTTCSAVISEGSPNVFIG 86
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
489-511 |
4.43e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 36.04 E-value: 4.43e-03
|
| PAAR_2 |
cd14738 |
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR ... |
3-29 |
7.97e-03 |
|
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR (proline-alanine-alanine-arginine) repeat family, where it forms a sharp conical extension on the VgrG spike, a trimeric protein complex of the bacterial type VI secretion system (T6SS). The T6SS is responsible for translocation of a wide variety of toxic effector molecules, allowing predatory cells to kill prokaryotic as well as eukaryotic prey cells. The pointed tip of the PAAR domain is stabilized by a zinc atom positioned close to the cone's vertex and is likely to be important for its integrity during penetration of the target cell envelope. VgrG proteins are orthologous to the central baseplate spikes of bacteriophages with contractile tails, and genes encoding proteins with PAAR motifs have been frequently found immediately downstream from vgrG-like genes. It has been shown that PAAR proteins are essential for T6SS-mediated secretion and target cell killing by Vibrio cholerae (encodes two PAAR proteins) and Acinetobacter baylyi (encodes three PAAR proteins); inactivation of all these PAAR genes results in inactivation of Hcp secretion as well as T6SS-dependent killing of E. coli.
Pssm-ID: 269823 Cd Length: 94 Bit Score: 37.23 E-value: 7.97e-03
10 20 30
....*....|....*....|....*....|
gi 49176361 3 GKPAARQGDMTQYGG---SIVQGSAGVRIG 29
Cdd:cd14738 38 GLPAARVGDMCVCVGppdTIVQGSSTVLIG 67
|
|
| PAAR_1 |
cd14737 |
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR ... |
3-29 |
8.67e-03 |
|
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR (proline-alanine-alanine-arginine) repeat family, where it forms a sharp conical extension on the VgrG spike, a trimeric protein complex of the bacterial type VI secretion system (T6SS). The T6SS is responsible for translocation of a wide variety of toxic effector molecules, allowing predatory cells to kill prokaryotic as well as eukaryotic prey cells. The pointed tip of the PAAR domain is stabilized by a zinc atom positioned close to the cone's vertex and is likely to be important for its integrity during penetration of the target cell envelope. VgrG proteins are orthologous to the central baseplate spikes of bacteriophages with contractile tails, and genes encoding proteins with PAAR motifs have been frequently found immediately downstream from vgrG-like genes. It has been shown that PAAR proteins are essential for T6SS-mediated secretion and target cell killing by Vibrio cholerae (encodes two PAAR proteins) and Acinetobacter baylyi (encodes three PAAR proteins); inactivation of all these PAAR genes results in inactivation of Hcp secretion as well as T6SS-dependent killing of E. coli.
Pssm-ID: 269822 Cd Length: 94 Bit Score: 36.87 E-value: 8.67e-03
10 20
....*....|....*....|....*..
gi 49176361 3 GKPAARQGDMTQYGGSIVQGSAGVRIG 29
Cdd:cd14737 68 GKPAARVGDPVSCGGTVAGGSPNVFIG 94
|
|
| |
