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Conserved domains on  [gi|671743033|ref|YP_009049986|]
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SecY-independent transporter protein (mitochondrion) [Chlorella sorokiniana]

Protein Classification

TatC family protein( domain architecture ID 2169)

TatC family protein similar to twin-arginine translocase subunit TatC which is part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes

PubMed:  25494301

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TatC super family cl43276
Twin-arginine protein secretion pathway component TatC [Intracellular trafficking, secretion, ...
7-245 4.58e-19

Twin-arginine protein secretion pathway component TatC [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG0805:

Pssm-ID: 440568  Cd Length: 249  Bit Score: 83.24  E-value: 4.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033   7 HLFELKLRGFYLILSAITTFFICWNYQLEIVYILGRPFIQL---HQTFIFLELTEAFYTLVKISLILTLFLLLPLVLYHF 83
Cdd:COG0805   14 HLEELRKRLIRSLIAFLVGFIVGFFFADPIYDFLAAPLKAAlpeGVKLIATGPTEPFFTYLKVALLAGLILALPVILYQL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033  84 WCFLIPSFYQMERSGVNFLYGIFLLLVLSEFLFTYFFLLPKIFHFLLSFEMSsaslesftelskqplvSVEFNARIACYV 163
Cdd:COG0805   94 WAFIAPGLYRHERRLALPFVLASVLLFLAGAAFAYFVVLPLAFKFLLSFAPE----------------GVEPLLDISEYL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033 164 KLVVKIITTVLVLFQIPFGISLLYSKKMLKVSSFYFNRKYLAGTSLLVSAFIVPPDFSSQLGLAFLFYMLFEFLIFIGLF 243
Cdd:COG0805  158 SFVLKLLLAFGLAFELPVVLVLLNRLGIVTPETLRKKRRYAIVGIFVLAAILTPPDVISQLLLAIPLILLYELSILIARL 237

                 ..
gi 671743033 244 FE 245
Cdd:COG0805  238 VE 239
 
Name Accession Description Interval E-value
TatC COG0805
Twin-arginine protein secretion pathway component TatC [Intracellular trafficking, secretion, ...
7-245 4.58e-19

Twin-arginine protein secretion pathway component TatC [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440568  Cd Length: 249  Bit Score: 83.24  E-value: 4.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033   7 HLFELKLRGFYLILSAITTFFICWNYQLEIVYILGRPFIQL---HQTFIFLELTEAFYTLVKISLILTLFLLLPLVLYHF 83
Cdd:COG0805   14 HLEELRKRLIRSLIAFLVGFIVGFFFADPIYDFLAAPLKAAlpeGVKLIATGPTEPFFTYLKVALLAGLILALPVILYQL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033  84 WCFLIPSFYQMERSGVNFLYGIFLLLVLSEFLFTYFFLLPKIFHFLLSFEMSsaslesftelskqplvSVEFNARIACYV 163
Cdd:COG0805   94 WAFIAPGLYRHERRLALPFVLASVLLFLAGAAFAYFVVLPLAFKFLLSFAPE----------------GVEPLLDISEYL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033 164 KLVVKIITTVLVLFQIPFGISLLYSKKMLKVSSFYFNRKYLAGTSLLVSAFIVPPDFSSQLGLAFLFYMLFEFLIFIGLF 243
Cdd:COG0805  158 SFVLKLLLAFGLAFELPVVLVLLNRLGIVTPETLRKKRRYAIVGIFVLAAILTPPDVISQLLLAIPLILLYELSILIARL 237

                 ..
gi 671743033 244 FE 245
Cdd:COG0805  238 VE 239
tatC TIGR00945
Twin arginine targeting (Tat) protein translocase TatC; This model represents the TatC ...
7-234 1.07e-16

Twin arginine targeting (Tat) protein translocase TatC; This model represents the TatC translocase component of the Sec-independent protein translocation system. This system is responsible for translocation of folded proteins, often with bound cofactors across the periplasmic membrane. A related model (TIGR01912) represents the archaeal clade of this family. TatC is often found in a gene cluster with the two other components of the system, TatA/E (TIGR01411) and TatB (TIGR01410). A model also exists for the Twin-arginine signal sequence (TIGR01409). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273355  Cd Length: 215  Bit Score: 76.10  E-value: 1.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033    7 HLFELKLRGFYLILSAITTFFICWNYQLEIVYILGRPFIQLHQTFIFLELTEAFYTLVKISLILTLFLLLPLVLYHFWCF 86
Cdd:TIGR00945   4 HLEELRKRLLISLIAFLVAFFICFYFSKPIIELLQAPLLALGVTFIATSPTEPFFTYIKISLIVGIILASPVILYQIWAF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033   87 LIPSFYQMERSGVNFLYGIFLLLVLSEFLFTYFFLLPKIFHFLLsfemssasleSFTELSKQPLVSvefnarIACYVKLV 166
Cdd:TIGR00945  84 ILPGLYEHERRLLLPLLLGSILLFLAGLAFAYYVLFPAALNFLL----------TLGADVVEPLLS------IDQYFEFV 147
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 671743033  167 VKIITTVLVLFQIPFGISLLYSKKMLKVSSFYFNRKYLAGTSLLVSAFIVPPDFSSQLGLAFLFYMLF 234
Cdd:TIGR00945 148 LKLLFSFGVAFQVPVLQVLLGKLGIVTPEQLRSKRRYVIVGAFVIGAILTPPDPLSQILLAIPLLLLY 215
TatC pfam00902
Sec-independent protein translocase protein (TatC); The bacterial Tat system has a remarkable ...
7-227 1.21e-15

Sec-independent protein translocase protein (TatC); The bacterial Tat system has a remarkable ability to transport folded proteins even enzyme complexes across the cytoplasmic membrane. It is structurally and mechanistically similar to the Delta pH-driven thylakoidal protein import pathway. A functional Tat system or Delta pH-dependent pathway requires three integral membrane proteins: TatA/Tha4, TatB/Hcf106 and TatC/cpTatC. The TatC protein is essential for the function of both pathways. It might be involved in twin-arginine signal peptide recognition, protein translocation and proton translocation. Sequence analysis predicts that TatC contains six transmembrane helices (TMHs), and experimental data confirmed that N- and C-termini of TatC or cpTatC are exposed to the cytoplasmic or stromal face of the membrane. The cytoplasmic N-terminus and the first cytoplasmic loop region of the Escherichia coli TatC protein are essential for protein export. At least two TatC molecules co-exist within each Tat translocon.


Pssm-ID: 459989  Cd Length: 210  Bit Score: 73.23  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033    7 HLFELKLRGFYLILSAITTFFICWNYQLEIVYILGRPFIQLHQ-TFIFLELTEAFYTLVKISLILTLFLLLPLVLYHFWC 85
Cdd:pfam00902   2 HLEELRKRLIRSLIAIVVGFIVAFFFAEPIFDFLLAPLKAPEGvKLIATGPTEAFFTYLKVSLLAGLILALPVILYQLWA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033   86 FLIPSFYQMERSGVNFLYGIFLLLVLSEFLFTYFFLLPKIFHFLLSFEMSSAslesftelskqplvsVEFNARIACYVKL 165
Cdd:pfam00902  82 FIAPGLYKHERRYVLPFVFASVLLFLLGAAFAYFVVFPLALRFLLGFGVSAG---------------VVPMLSISEYLSF 146
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 671743033  166 VVKIITTVLVLFQIPFGISLLYSKKMLKVSSFYFNRKYLAGTSLLVSAFIVPPDFSSQLGLA 227
Cdd:pfam00902 147 VLTLLLAFGLAFELPLVLVLLARLGIVTPETLRKKRRYAIVGIFVVAAILTPPDPFSQLLLA 208
PRK10921 PRK10921
Sec-independent protein translocase subunit TatC;
7-244 1.72e-10

Sec-independent protein translocase subunit TatC;


Pssm-ID: 182840  Cd Length: 258  Bit Score: 59.38  E-value: 1.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033   7 HLFELKLRGFYLILSAITTFFICWNYQLEIVYILGRPFI-QLHQ--TFIFLELTEAFYTLVKISLILTLFLLLPLVLYHF 83
Cdd:PRK10921  12 HLIELRKRLLNCIIAVLVIFLALVYFANDIYHLVSAPLIkQLPQgaTMIATDVASPFFTPIKLTFMVSLILSAPVILYQV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033  84 WCFLIPSFYQMERSGVNFLYGIFLLLVLSEFLFTYFFLLPKIFHFllsfemssaslesfteLSKQPLVSVEFNARIACYV 163
Cdd:PRK10921  92 WAFIAPALYKHERRLVVPLLVSSSLLFYIGMAFAYFVVFPLAFGF----------------LAKTAPEGVQVSTDIASYL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033 164 KLVVKIITTVLVLFQIPFGISLLYSKKMLKVSSFYFNRKYLAGTSLLVSAFIVPPDFSSQLGLAFLFYMLFEFLIFIGLF 243
Cdd:PRK10921 156 SFVMALFMAFGVSFEVPVAIVLLCWMGVTTPEDLRKKRPYVLVGAFVVGMLLTPPDVFSQTLLAIPMYCLFEIGVFFSRF 235

                 .
gi 671743033 244 F 244
Cdd:PRK10921 236 Y 236
 
Name Accession Description Interval E-value
TatC COG0805
Twin-arginine protein secretion pathway component TatC [Intracellular trafficking, secretion, ...
7-245 4.58e-19

Twin-arginine protein secretion pathway component TatC [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440568  Cd Length: 249  Bit Score: 83.24  E-value: 4.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033   7 HLFELKLRGFYLILSAITTFFICWNYQLEIVYILGRPFIQL---HQTFIFLELTEAFYTLVKISLILTLFLLLPLVLYHF 83
Cdd:COG0805   14 HLEELRKRLIRSLIAFLVGFIVGFFFADPIYDFLAAPLKAAlpeGVKLIATGPTEPFFTYLKVALLAGLILALPVILYQL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033  84 WCFLIPSFYQMERSGVNFLYGIFLLLVLSEFLFTYFFLLPKIFHFLLSFEMSsaslesftelskqplvSVEFNARIACYV 163
Cdd:COG0805   94 WAFIAPGLYRHERRLALPFVLASVLLFLAGAAFAYFVVLPLAFKFLLSFAPE----------------GVEPLLDISEYL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033 164 KLVVKIITTVLVLFQIPFGISLLYSKKMLKVSSFYFNRKYLAGTSLLVSAFIVPPDFSSQLGLAFLFYMLFEFLIFIGLF 243
Cdd:COG0805  158 SFVLKLLLAFGLAFELPVVLVLLNRLGIVTPETLRKKRRYAIVGIFVLAAILTPPDVISQLLLAIPLILLYELSILIARL 237

                 ..
gi 671743033 244 FE 245
Cdd:COG0805  238 VE 239
tatC TIGR00945
Twin arginine targeting (Tat) protein translocase TatC; This model represents the TatC ...
7-234 1.07e-16

Twin arginine targeting (Tat) protein translocase TatC; This model represents the TatC translocase component of the Sec-independent protein translocation system. This system is responsible for translocation of folded proteins, often with bound cofactors across the periplasmic membrane. A related model (TIGR01912) represents the archaeal clade of this family. TatC is often found in a gene cluster with the two other components of the system, TatA/E (TIGR01411) and TatB (TIGR01410). A model also exists for the Twin-arginine signal sequence (TIGR01409). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273355  Cd Length: 215  Bit Score: 76.10  E-value: 1.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033    7 HLFELKLRGFYLILSAITTFFICWNYQLEIVYILGRPFIQLHQTFIFLELTEAFYTLVKISLILTLFLLLPLVLYHFWCF 86
Cdd:TIGR00945   4 HLEELRKRLLISLIAFLVAFFICFYFSKPIIELLQAPLLALGVTFIATSPTEPFFTYIKISLIVGIILASPVILYQIWAF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033   87 LIPSFYQMERSGVNFLYGIFLLLVLSEFLFTYFFLLPKIFHFLLsfemssasleSFTELSKQPLVSvefnarIACYVKLV 166
Cdd:TIGR00945  84 ILPGLYEHERRLLLPLLLGSILLFLAGLAFAYYVLFPAALNFLL----------TLGADVVEPLLS------IDQYFEFV 147
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 671743033  167 VKIITTVLVLFQIPFGISLLYSKKMLKVSSFYFNRKYLAGTSLLVSAFIVPPDFSSQLGLAFLFYMLF 234
Cdd:TIGR00945 148 LKLLFSFGVAFQVPVLQVLLGKLGIVTPEQLRSKRRYVIVGAFVIGAILTPPDPLSQILLAIPLLLLY 215
TatC pfam00902
Sec-independent protein translocase protein (TatC); The bacterial Tat system has a remarkable ...
7-227 1.21e-15

Sec-independent protein translocase protein (TatC); The bacterial Tat system has a remarkable ability to transport folded proteins even enzyme complexes across the cytoplasmic membrane. It is structurally and mechanistically similar to the Delta pH-driven thylakoidal protein import pathway. A functional Tat system or Delta pH-dependent pathway requires three integral membrane proteins: TatA/Tha4, TatB/Hcf106 and TatC/cpTatC. The TatC protein is essential for the function of both pathways. It might be involved in twin-arginine signal peptide recognition, protein translocation and proton translocation. Sequence analysis predicts that TatC contains six transmembrane helices (TMHs), and experimental data confirmed that N- and C-termini of TatC or cpTatC are exposed to the cytoplasmic or stromal face of the membrane. The cytoplasmic N-terminus and the first cytoplasmic loop region of the Escherichia coli TatC protein are essential for protein export. At least two TatC molecules co-exist within each Tat translocon.


Pssm-ID: 459989  Cd Length: 210  Bit Score: 73.23  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033    7 HLFELKLRGFYLILSAITTFFICWNYQLEIVYILGRPFIQLHQ-TFIFLELTEAFYTLVKISLILTLFLLLPLVLYHFWC 85
Cdd:pfam00902   2 HLEELRKRLIRSLIAIVVGFIVAFFFAEPIFDFLLAPLKAPEGvKLIATGPTEAFFTYLKVSLLAGLILALPVILYQLWA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033   86 FLIPSFYQMERSGVNFLYGIFLLLVLSEFLFTYFFLLPKIFHFLLSFEMSSAslesftelskqplvsVEFNARIACYVKL 165
Cdd:pfam00902  82 FIAPGLYKHERRYVLPFVFASVLLFLLGAAFAYFVVFPLALRFLLGFGVSAG---------------VVPMLSISEYLSF 146
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 671743033  166 VVKIITTVLVLFQIPFGISLLYSKKMLKVSSFYFNRKYLAGTSLLVSAFIVPPDFSSQLGLA 227
Cdd:pfam00902 147 VLTLLLAFGLAFELPLVLVLLARLGIVTPETLRKKRRYAIVGIFVVAAILTPPDPFSQLLLA 208
PRK10921 PRK10921
Sec-independent protein translocase subunit TatC;
7-244 1.72e-10

Sec-independent protein translocase subunit TatC;


Pssm-ID: 182840  Cd Length: 258  Bit Score: 59.38  E-value: 1.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033   7 HLFELKLRGFYLILSAITTFFICWNYQLEIVYILGRPFI-QLHQ--TFIFLELTEAFYTLVKISLILTLFLLLPLVLYHF 83
Cdd:PRK10921  12 HLIELRKRLLNCIIAVLVIFLALVYFANDIYHLVSAPLIkQLPQgaTMIATDVASPFFTPIKLTFMVSLILSAPVILYQV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033  84 WCFLIPSFYQMERSGVNFLYGIFLLLVLSEFLFTYFFLLPKIFHFllsfemssaslesfteLSKQPLVSVEFNARIACYV 163
Cdd:PRK10921  92 WAFIAPALYKHERRLVVPLLVSSSLLFYIGMAFAYFVVFPLAFGF----------------LAKTAPEGVQVSTDIASYL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671743033 164 KLVVKIITTVLVLFQIPFGISLLYSKKMLKVSSFYFNRKYLAGTSLLVSAFIVPPDFSSQLGLAFLFYMLFEFLIFIGLF 243
Cdd:PRK10921 156 SFVMALFMAFGVSFEVPVAIVLLCWMGVTTPEDLRKKRPYVLVGAFVVGMLLTPPDVFSQTLLAIPMYCLFEIGVFFSRF 235

                 .
gi 671743033 244 F 244
Cdd:PRK10921 236 Y 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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