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Conserved domains on  [gi|125745132|ref|YP_001034018|]
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transcriptional regulator ICP4 [Gallid alphaherpesvirus 2]

Protein Classification

protein kinase family protein; Mps1 family protein kinase( domain architecture ID 11476204)

protein kinase family protein, may catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine and/or tyrosine residues on protein substrates| Mps1 family protein kinase may be a dual-specificity kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 956-2276 0e+00

transcriptional regulator ICP4; Provisional


:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1068.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  956 DDGQPMFPPLPVPDWNNPSTDWRPSPPR---SGPKKDFCGDLPAPLTSGPRLTTPSSGRMSELPHTTSSPRSSPRPRGPE 1032
Cdd:PHA03307  218 SSPAPAPGRSAADDAGASSSDSSSSESSgcgWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPS 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1033 TSPSNehiiispPRNPPSNTTHRNVGHVSRSPSSSSSSSSSSSPSSSSLIVPSSPSSSRSPSPSPPRPRADCSSRPRRGR 1112
Cdd:PHA03307  298 PSPSS-------PGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPR 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1113 GSNRGGRSgPQSKGRKTSPRTRKLEDEDYLPQETANRRGGGRPRGRPPKSGravqrndiqVTSSSGLADTSPYDLCGSVW 1192
Cdd:PHA03307  371 PSRAPSSP-AASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAG---------AASGAFYARYPLLTPSGEPW 440

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1193 WEVPLPPPGRCWFGGLGGHRQALTDSPEIVEAIHRFNTSHGPVPVYVEEMKDYAKQYDALVNSLFHKSMKVNPlnWMHHG 1272
Cdd:PHA03307  441 PGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMG--WLQNP 518

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1273 KLSPADAALNHIYVQKFQSsYDSPGAAVTGTVNRCIPHIAGAMKERKLLWAFPHIAASIAMTRRYCKDQKTFLFRSLKKA 1352
Cdd:PHA03307  519 KLTGPDQALDQFCQKKFQA-PRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRA 597

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1353 YASMAFPDNSSETEkgisskpstspsvlittstqttapphapkidvtaihgrvyqsvvdlsrcladgslDDPEFSFAGCT 1432
Cdd:PHA03307  598 YAPMAYPENAADTG-------------------------------------------------------AGAAAPAPAAP 622

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1433 RPDCLVEEFDAARPLEELADACVLACDSVVAALLCGPDGPHRVaKMLSFYDSRITPHvpdlqQWEKCRILLVSWYHELSD 1512
Cdd:PHA03307  623 RPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSAV-PGLAFPRPACPPR-----ALEACPARLESWLRELRD 696

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1513 LRAAVYGAYGNT--PTSQHLDERALAARVVSLIAETIGPLVRQDPDRAWVRMGSRDITSLLLRDWRGTNdgdPGLVKAKH 1590
Cdd:PHA03307  697 LRDAVYLARLRGdlPVAGGREERVAAVRAVSLVARTVAPLVRYSPRRARARASAWDITDALFSNPSLVP---AKLAEALA 773

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1591 LRRTAELLNDGRSSkgtygvfaPPRRPDQLFRGPGRPRRSTSSSQSASDKSPIKSTHRHTSDPIPISTprperdpagtph 1670
Cdd:PHA03307  774 LLEPAEPQRGAGSS--------PPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESS------------ 833

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1671 entmsgpvqpaanghscsstptpakkgnktssdtislkdptktrikasakaqtDETLPETSTAHPSAMDQSSSLERKNLY 1750
Cdd:PHA03307  834 -----------------------------------------------------GPARPPGAAARPPPARSSESSKSKPAA 860

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1751 TGPAVSSKERRRSAQSSTPSDIGGVSRKRKSAPEQYKQGLQTPLPMPEPSVGqtlldptttthdilSSSLPnrscsssps 1830
Cdd:PHA03307  861 AGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVK--------------LGPMP--------- 917

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1831 pskrpyhpscysptdimtgalvgPRGRQDRAAFRQFPVGTVIGQTPPQSVLNAYCPNGAFVELVEFARIPEPWQEVLRYS 1910
Cdd:PHA03307  918 -----------------------PGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALAFD 974

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1911 PEAMADIARVANALPGKYNSNEiitsaaseAFHTATSKLRARTAWMRyQQESPDDVSIVVLYSPLPGEHLFCVPAPDTPP 1990
Cdd:PHA03307  975 PEALAEIAARCGGPPPRSGSAF--------GPLRASGPLRRRAAWMR-QIPDPEDVRVVVLYSPLPGEHLFGVPAPDASP 1045

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1991 GGLKFDNKRGGLSFLLAAFSNRLCLPKSSAWAGRWKAAPDISPLTRMGVLFLSTEDLGYQGAVEYLQRQCMKRKKKLIIM 2070
Cdd:PHA03307 1046 GGPAWSPERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVL 1125

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 2071 DTVEDRYRLPNGPCiIEEATRYMKCIISPRSQCCVRWPGLLDFGTTIITSRDVVGPLTLMDLEQyYYCEIGIEDSTINLC 2150
Cdd:PHA03307 1126 DTVDPEDWPADGPA-VSQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEA-AFARLYPDAPPLRLC 1203

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 2151 CTGNVRYTVETRLEDVSCVPTTPLFYFAAV-----------------KHVRPDFLCGETYSNRAARKWGLCAPLRPIYVI 2213
Cdd:PHA03307 1204 RGANVRYTVRTRLGPRTRVPLPPREYRQAVlpaldgckdmaaqaeglGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLA 1283

                        1290      1300      1310      1320      1330      1340
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 125745132 2214 ESKMNAIVSPSFLHPTARNLCRSVILPPDPEARPVVVHIpegtcSALAEDMvaSIRSSCITWG 2276
Cdd:PHA03307 1284 EGRRAAIAGPDELPAVVRAFCRAALLEPDPEAPPLVLPP-----SAAAEAA--HARAPRVTWA 1339
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 220-449 8.68e-10

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 64.42  E-value: 8.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  220 ISPTTSEDIDELLVLLSPQSVNRASERQLADTAASALRAPSPVF--WSAFDSRYPHLAPANQSNSDPLCPETSTASAQIL 297
Cdd:PHA03307   22 PRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFepPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  298 HTNSPTPPTSTSPAPIPSPTQPPACLPSPAPISSPVQPPAllplifspitpvefiqpQSPPSPPQAPSPPAHSSSSCSPS 377
Cdd:PHA03307  102 REGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPV-----------------GSPGPPPAASPPAAGASPAAVAS 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 125745132  378 HLAPSPLSSSPLSSPPQLSPAPVSPPSSPPPLSPGELAPSPDPPRHSISSQPQSCPVPSLGRSADFRREVAA 449
Cdd:PHA03307  165 DAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASS 236
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 620-670 2.63e-04

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 2.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 125745132  620 DDALHSESHENVLGSRGCGWGPRSECPVPPPGMVTLPSCVWEAAARLPTPA 670
Cdd:PHA03307  230 DDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSS 280
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 956-2276 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1068.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  956 DDGQPMFPPLPVPDWNNPSTDWRPSPPR---SGPKKDFCGDLPAPLTSGPRLTTPSSGRMSELPHTTSSPRSSPRPRGPE 1032
Cdd:PHA03307  218 SSPAPAPGRSAADDAGASSSDSSSSESSgcgWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPS 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1033 TSPSNehiiispPRNPPSNTTHRNVGHVSRSPSSSSSSSSSSSPSSSSLIVPSSPSSSRSPSPSPPRPRADCSSRPRRGR 1112
Cdd:PHA03307  298 PSPSS-------PGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPR 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1113 GSNRGGRSgPQSKGRKTSPRTRKLEDEDYLPQETANRRGGGRPRGRPPKSGravqrndiqVTSSSGLADTSPYDLCGSVW 1192
Cdd:PHA03307  371 PSRAPSSP-AASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAG---------AASGAFYARYPLLTPSGEPW 440

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1193 WEVPLPPPGRCWFGGLGGHRQALTDSPEIVEAIHRFNTSHGPVPVYVEEMKDYAKQYDALVNSLFHKSMKVNPlnWMHHG 1272
Cdd:PHA03307  441 PGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMG--WLQNP 518

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1273 KLSPADAALNHIYVQKFQSsYDSPGAAVTGTVNRCIPHIAGAMKERKLLWAFPHIAASIAMTRRYCKDQKTFLFRSLKKA 1352
Cdd:PHA03307  519 KLTGPDQALDQFCQKKFQA-PRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRA 597

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1353 YASMAFPDNSSETEkgisskpstspsvlittstqttapphapkidvtaihgrvyqsvvdlsrcladgslDDPEFSFAGCT 1432
Cdd:PHA03307  598 YAPMAYPENAADTG-------------------------------------------------------AGAAAPAPAAP 622

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1433 RPDCLVEEFDAARPLEELADACVLACDSVVAALLCGPDGPHRVaKMLSFYDSRITPHvpdlqQWEKCRILLVSWYHELSD 1512
Cdd:PHA03307  623 RPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSAV-PGLAFPRPACPPR-----ALEACPARLESWLRELRD 696

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1513 LRAAVYGAYGNT--PTSQHLDERALAARVVSLIAETIGPLVRQDPDRAWVRMGSRDITSLLLRDWRGTNdgdPGLVKAKH 1590
Cdd:PHA03307  697 LRDAVYLARLRGdlPVAGGREERVAAVRAVSLVARTVAPLVRYSPRRARARASAWDITDALFSNPSLVP---AKLAEALA 773

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1591 LRRTAELLNDGRSSkgtygvfaPPRRPDQLFRGPGRPRRSTSSSQSASDKSPIKSTHRHTSDPIPISTprperdpagtph 1670
Cdd:PHA03307  774 LLEPAEPQRGAGSS--------PPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESS------------ 833

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1671 entmsgpvqpaanghscsstptpakkgnktssdtislkdptktrikasakaqtDETLPETSTAHPSAMDQSSSLERKNLY 1750
Cdd:PHA03307  834 -----------------------------------------------------GPARPPGAAARPPPARSSESSKSKPAA 860

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1751 TGPAVSSKERRRSAQSSTPSDIGGVSRKRKSAPEQYKQGLQTPLPMPEPSVGqtlldptttthdilSSSLPnrscsssps 1830
Cdd:PHA03307  861 AGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVK--------------LGPMP--------- 917

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1831 pskrpyhpscysptdimtgalvgPRGRQDRAAFRQFPVGTVIGQTPPQSVLNAYCPNGAFVELVEFARIPEPWQEVLRYS 1910
Cdd:PHA03307  918 -----------------------PGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALAFD 974

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1911 PEAMADIARVANALPGKYNSNEiitsaaseAFHTATSKLRARTAWMRyQQESPDDVSIVVLYSPLPGEHLFCVPAPDTPP 1990
Cdd:PHA03307  975 PEALAEIAARCGGPPPRSGSAF--------GPLRASGPLRRRAAWMR-QIPDPEDVRVVVLYSPLPGEHLFGVPAPDASP 1045

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1991 GGLKFDNKRGGLSFLLAAFSNRLCLPKSSAWAGRWKAAPDISPLTRMGVLFLSTEDLGYQGAVEYLQRQCMKRKKKLIIM 2070
Cdd:PHA03307 1046 GGPAWSPERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVL 1125

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 2071 DTVEDRYRLPNGPCiIEEATRYMKCIISPRSQCCVRWPGLLDFGTTIITSRDVVGPLTLMDLEQyYYCEIGIEDSTINLC 2150
Cdd:PHA03307 1126 DTVDPEDWPADGPA-VSQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEA-AFARLYPDAPPLRLC 1203

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 2151 CTGNVRYTVETRLEDVSCVPTTPLFYFAAV-----------------KHVRPDFLCGETYSNRAARKWGLCAPLRPIYVI 2213
Cdd:PHA03307 1204 RGANVRYTVRTRLGPRTRVPLPPREYRQAVlpaldgckdmaaqaeglGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLA 1283

                        1290      1300      1310      1320      1330      1340
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 125745132 2214 ESKMNAIVSPSFLHPTARNLCRSVILPPDPEARPVVVHIpegtcSALAEDMvaSIRSSCITWG 2276
Cdd:PHA03307 1284 EGRRAAIAGPDELPAVVRAFCRAALLEPDPEAPPLVLPP-----SAAAEAA--HARAPRVTWA 1339
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 1861-2282 0e+00

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 659.76  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  1861 AAFRQFPVGTVIGQTPPQSVLNAYCPNGAFVELVEFARIPEPWQEVLRYSPEAMADI-ARVANALP--GKYNSNEIITSA 1937
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIaARVANALPggGDYNSNEIITSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  1938 ASEAFH--TATSKLRARTAWMRyQQESPDDVSIVVLYSPLPGEHLFCVPAPDTPPgglKFDNKRGGLSFLLAAFSNRLCL 2015
Cdd:pfam03585   81 ASRAFGppTATSKLRRRTAWMR-QIPDPEDVRIVVLYSPLPGEDLFCVPAPDTPP---KWSNKRGGLSFLLAALSNRLCL 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  2016 PKSSAWAGRWKAAPDISPLTRMGVLFLSTEDLGYQGAVEYLQRQCMKRKKKLIIMDTVEDRYRLPNGPCIIEEATrYMKC 2095
Cdd:pfam03585  157 PKTSAWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHT-YMKC 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  2096 IISPRSQCCVRWPGLLDFGTTIITSRDVVGPLTLMDLEQyYYCEIGIEDSTINLCCTGNVRYTVETRLEDVSCVPTTPLF 2175
Cdd:pfam03585  236 IISPRSQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQ-AYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPRE 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  2176 YFAAVKHV-----------------RPDFLCGETYSNRAARKWGLCAPLRPIYVIESKMNAIVSPSFLH-PTARNLCRSV 2237
Cdd:pfam03585  315 YRAAVLPVfdgckdlarqsrglglgAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSFLHvPTARNFCRSA 394

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 125745132  2238 ILPPDPEARPVVVHIPEGTCSALAEDMVASIRSSC--ITWGQ---HEEGG 2282
Cdd:pfam03585  395 LLEPDPEARPLVLHIPEGTCSALAEDMVASALPPCprITWGQgfgHEEGG 444
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 220-449 8.68e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 64.42  E-value: 8.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  220 ISPTTSEDIDELLVLLSPQSVNRASERQLADTAASALRAPSPVF--WSAFDSRYPHLAPANQSNSDPLCPETSTASAQIL 297
Cdd:PHA03307   22 PRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFepPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  298 HTNSPTPPTSTSPAPIPSPTQPPACLPSPAPISSPVQPPAllplifspitpvefiqpQSPPSPPQAPSPPAHSSSSCSPS 377
Cdd:PHA03307  102 REGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPV-----------------GSPGPPPAASPPAAGASPAAVAS 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 125745132  378 HLAPSPLSSSPLSSPPQLSPAPVSPPSSPPPLSPGELAPSPDPPRHSISSQPQSCPVPSLGRSADFRREVAA 449
Cdd:PHA03307  165 DAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASS 236
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 620-670 2.63e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 2.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 125745132  620 DDALHSESHENVLGSRGCGWGPRSECPVPPPGMVTLPSCVWEAAARLPTPA 670
Cdd:PHA03307  230 DDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSS 280
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 956-2276 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1068.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  956 DDGQPMFPPLPVPDWNNPSTDWRPSPPR---SGPKKDFCGDLPAPLTSGPRLTTPSSGRMSELPHTTSSPRSSPRPRGPE 1032
Cdd:PHA03307  218 SSPAPAPGRSAADDAGASSSDSSSSESSgcgWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPS 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1033 TSPSNehiiispPRNPPSNTTHRNVGHVSRSPSSSSSSSSSSSPSSSSLIVPSSPSSSRSPSPSPPRPRADCSSRPRRGR 1112
Cdd:PHA03307  298 PSPSS-------PGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPR 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1113 GSNRGGRSgPQSKGRKTSPRTRKLEDEDYLPQETANRRGGGRPRGRPPKSGravqrndiqVTSSSGLADTSPYDLCGSVW 1192
Cdd:PHA03307  371 PSRAPSSP-AASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAG---------AASGAFYARYPLLTPSGEPW 440

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1193 WEVPLPPPGRCWFGGLGGHRQALTDSPEIVEAIHRFNTSHGPVPVYVEEMKDYAKQYDALVNSLFHKSMKVNPlnWMHHG 1272
Cdd:PHA03307  441 PGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMG--WLQNP 518

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1273 KLSPADAALNHIYVQKFQSsYDSPGAAVTGTVNRCIPHIAGAMKERKLLWAFPHIAASIAMTRRYCKDQKTFLFRSLKKA 1352
Cdd:PHA03307  519 KLTGPDQALDQFCQKKFQA-PRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRA 597

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1353 YASMAFPDNSSETEkgisskpstspsvlittstqttapphapkidvtaihgrvyqsvvdlsrcladgslDDPEFSFAGCT 1432
Cdd:PHA03307  598 YAPMAYPENAADTG-------------------------------------------------------AGAAAPAPAAP 622

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1433 RPDCLVEEFDAARPLEELADACVLACDSVVAALLCGPDGPHRVaKMLSFYDSRITPHvpdlqQWEKCRILLVSWYHELSD 1512
Cdd:PHA03307  623 RPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSAV-PGLAFPRPACPPR-----ALEACPARLESWLRELRD 696

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1513 LRAAVYGAYGNT--PTSQHLDERALAARVVSLIAETIGPLVRQDPDRAWVRMGSRDITSLLLRDWRGTNdgdPGLVKAKH 1590
Cdd:PHA03307  697 LRDAVYLARLRGdlPVAGGREERVAAVRAVSLVARTVAPLVRYSPRRARARASAWDITDALFSNPSLVP---AKLAEALA 773

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1591 LRRTAELLNDGRSSkgtygvfaPPRRPDQLFRGPGRPRRSTSSSQSASDKSPIKSTHRHTSDPIPISTprperdpagtph 1670
Cdd:PHA03307  774 LLEPAEPQRGAGSS--------PPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESS------------ 833

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1671 entmsgpvqpaanghscsstptpakkgnktssdtislkdptktrikasakaqtDETLPETSTAHPSAMDQSSSLERKNLY 1750
Cdd:PHA03307  834 -----------------------------------------------------GPARPPGAAARPPPARSSESSKSKPAA 860

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1751 TGPAVSSKERRRSAQSSTPSDIGGVSRKRKSAPEQYKQGLQTPLPMPEPSVGqtlldptttthdilSSSLPnrscsssps 1830
Cdd:PHA03307  861 AGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVK--------------LGPMP--------- 917

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1831 pskrpyhpscysptdimtgalvgPRGRQDRAAFRQFPVGTVIGQTPPQSVLNAYCPNGAFVELVEFARIPEPWQEVLRYS 1910
Cdd:PHA03307  918 -----------------------PGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALAFD 974

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1911 PEAMADIARVANALPGKYNSNEiitsaaseAFHTATSKLRARTAWMRyQQESPDDVSIVVLYSPLPGEHLFCVPAPDTPP 1990
Cdd:PHA03307  975 PEALAEIAARCGGPPPRSGSAF--------GPLRASGPLRRRAAWMR-QIPDPEDVRVVVLYSPLPGEHLFGVPAPDASP 1045

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1991 GGLKFDNKRGGLSFLLAAFSNRLCLPKSSAWAGRWKAAPDISPLTRMGVLFLSTEDLGYQGAVEYLQRQCMKRKKKLIIM 2070
Cdd:PHA03307 1046 GGPAWSPERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVL 1125

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 2071 DTVEDRYRLPNGPCiIEEATRYMKCIISPRSQCCVRWPGLLDFGTTIITSRDVVGPLTLMDLEQyYYCEIGIEDSTINLC 2150
Cdd:PHA03307 1126 DTVDPEDWPADGPA-VSQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEA-AFARLYPDAPPLRLC 1203

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 2151 CTGNVRYTVETRLEDVSCVPTTPLFYFAAV-----------------KHVRPDFLCGETYSNRAARKWGLCAPLRPIYVI 2213
Cdd:PHA03307 1204 RGANVRYTVRTRLGPRTRVPLPPREYRQAVlpaldgckdmaaqaeglGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLA 1283

                        1290      1300      1310      1320      1330      1340
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 125745132 2214 ESKMNAIVSPSFLHPTARNLCRSVILPPDPEARPVVVHIpegtcSALAEDMvaSIRSSCITWG 2276
Cdd:PHA03307 1284 EGRRAAIAGPDELPAVVRAFCRAALLEPDPEAPPLVLPP-----SAAAEAA--HARAPRVTWA 1339
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 1861-2282 0e+00

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 659.76  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  1861 AAFRQFPVGTVIGQTPPQSVLNAYCPNGAFVELVEFARIPEPWQEVLRYSPEAMADI-ARVANALP--GKYNSNEIITSA 1937
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIaARVANALPggGDYNSNEIITSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  1938 ASEAFH--TATSKLRARTAWMRyQQESPDDVSIVVLYSPLPGEHLFCVPAPDTPPgglKFDNKRGGLSFLLAAFSNRLCL 2015
Cdd:pfam03585   81 ASRAFGppTATSKLRRRTAWMR-QIPDPEDVRIVVLYSPLPGEDLFCVPAPDTPP---KWSNKRGGLSFLLAALSNRLCL 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  2016 PKSSAWAGRWKAAPDISPLTRMGVLFLSTEDLGYQGAVEYLQRQCMKRKKKLIIMDTVEDRYRLPNGPCIIEEATrYMKC 2095
Cdd:pfam03585  157 PKTSAWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHT-YMKC 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  2096 IISPRSQCCVRWPGLLDFGTTIITSRDVVGPLTLMDLEQyYYCEIGIEDSTINLCCTGNVRYTVETRLEDVSCVPTTPLF 2175
Cdd:pfam03585  236 IISPRSQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQ-AYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPRE 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  2176 YFAAVKHV-----------------RPDFLCGETYSNRAARKWGLCAPLRPIYVIESKMNAIVSPSFLH-PTARNLCRSV 2237
Cdd:pfam03585  315 YRAAVLPVfdgckdlarqsrglglgAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSFLHvPTARNFCRSA 394

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 125745132  2238 ILPPDPEARPVVVHIPEGTCSALAEDMVASIRSSC--ITWGQ---HEEGG 2282
Cdd:pfam03585  395 LLEPDPEARPLVLHIPEGTCSALAEDMVASALPPCprITWGQgfgHEEGG 444
Herpes_ICP4_N pfam03584
Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 ...
 1197-1362 1.42e-87

Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerization.


Pssm-ID: 367571 [Multi-domain]  Cd Length: 163  Bit Score: 282.49  E-value: 1.42e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  1197 LPPPGRCWFGGLGGHRQALTDSPEIVEAIHRFNTSHGPVPVYVEEMKDYAKQYDALVNSLFhkSMKVNPLNWMHHGKLSP 1276
Cdd:pfam03584    1 PPPPGRVLYGGLGDSRPGLWGAPEVREARARFEASGAPAPVYVPELGDAAQQYAALVNLLY--TPDAEPLGWLQNPRLNP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  1277 ADAALNHIYvQKFQSSYDSPGAAVTGTVNRCIPHIAGAMKERKLLWAFPHIAASIAMTRRYCKDQKTFLFRSLKKAYASM 1356
Cdd:pfam03584   79 GDVALNQIC-QKISGAARNSGSAVTGSVARAVPHIGYAMAAGRALWALPHAAAAVAMSRRYDRAQKTFLLTSLRRAYAPL 157


                   ....*.
gi 125745132  1357 AFPDNS 1362
Cdd:pfam03584  158 AFPENA 163
PHA03308 PHA03308
transcriptional regulator ICP4; Provisional
 1195-1359 2.06e-15

transcriptional regulator ICP4; Provisional


Pssm-ID: 165563 [Multi-domain]  Cd Length: 1463  Bit Score: 82.93  E-value: 2.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1195 VPLPPP-GRCWFGGlgGHRQALTDSPEIVEAIHRFNTSHGPVPVYVEEMKDYAKQYDALVNSLFhksmkVNPLNWMHHG- 1272
Cdd:PHA03308  355 IPSPPSrGQVYHGS--GYRQSLVDDPQVREAAAEFHANPKSASVYLEEYGMPVEQLERLVEEFM-----VHPLSRVSYGy 427

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1273 ---KLSPADAALNHIYVQKFQSSydSPGAAVTGTVNRCIPHIAGAMKERKLLWAFPHIAASIAMTRRYCKDQKTFLFRSL 1349
Cdd:PHA03308  428 ggpKLSPRDKRLCELCALRGPGS--SEGGLSRSAVPTCLPHVAHAMRDGRVSLALPHLTELVRVCRRYDHPQKTYLLAAL 505

                         170
                  ....*....|
gi 125745132 1350 KKAYASMAFP 1359
Cdd:PHA03308  506 RRAFVPFVFP 515
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 220-449 8.68e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 64.42  E-value: 8.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  220 ISPTTSEDIDELLVLLSPQSVNRASERQLADTAASALRAPSPVF--WSAFDSRYPHLAPANQSNSDPLCPETSTASAQIL 297
Cdd:PHA03307   22 PRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFepPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  298 HTNSPTPPTSTSPAPIPSPTQPPACLPSPAPISSPVQPPAllplifspitpvefiqpQSPPSPPQAPSPPAHSSSSCSPS 377
Cdd:PHA03307  102 REGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPV-----------------GSPGPPPAASPPAAGASPAAVAS 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 125745132  378 HLAPSPLSSSPLSSPPQLSPAPVSPPSSPPPLSPGELAPSPDPPRHSISSQPQSCPVPSLGRSADFRREVAA 449
Cdd:PHA03307  165 DAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASS 236
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 1195-1377 8.63e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 61.41  E-value: 8.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1195 VPLPPPGRCWFGGLGGHRQALTDSPEIVEAIHRFNTSHGPVPVYVEEMKDYAKQYDALVNSLFhksmkVNPLNWMHHG-- 1272
Cdd:PHA03309  629 LPKPPAADYVYYGKTGYRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFM-----LQPLSRVSHSyg 703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132 1273 --KLSPADAALNHIYVQKFQSSYDSPGAAVTG------------TVNRCIPHIAGAMKERKLLWAFPHIAASIAMTRRYC 1338
Cdd:PHA03309  704 gsRLNKTEKNLCKICLPPDGGDDRDGGGKSRGgrgggskdasrtAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYD 783

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 125745132 1339 KDQKTFLFRSLKKAYASMAFPDNSSETEKGISSKPsTSP 1377
Cdd:PHA03309  784 ASQKTYLLSCLRLAFAPLVFPGASPPVGADDSPWP-TSP 821
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1-337 5.44e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 5.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132    1 MDNPPDFDSLLAAFDEDVGIFPHTPATPGDpyqgvslqtpcvpvpslagqsgtyrphssyhgqrslssgpvpAAHSPRSG 80
Cdd:PHA03307    1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGD------------------------------------------AADDLLSG 38

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132   81 RPGQHSTSNGVAAAAPPAATRAVCDTAGPTTD-TSSNRPGGRNSSNGADESGESSSDRSPSYSPCDSYCDPDRVSS---Y 156
Cdd:PHA03307   39 SQGQLVSDSAELAAVTVVAGAAACDRFEPPTGpPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPdppP 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  157 RSSVDGSPE----SGDIESASGSGGTSSPPLLEILAADFGEDTKALDPdyylrADPRFKAYFYGMDEISPTTSEDIDELL 232
Cdd:PHA03307  119 PTPPPASPPpspaPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDA-----ASSRQAALPLSSPEETARAPSSPPAEP 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125745132  233 VLLSPQSVNRASERQLADTAASALRAPSPVFWSAFDSRYPHLAPANQSNSDPLC---PETST----ASAQILHTNSPTPP 305
Cdd:PHA03307  194 PPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCgwgPENECplprPAPITLPTRIWEAS 273

                         330       340       350
                  ....*....|....*....|....*....|..
gi 125745132  306 TSTSPAPIPSPTQPPACLPSPAPISSPVQPPA 337
Cdd:PHA03307  274 GWNGPSSRPGPASSSSSPRERSPSPSPSSPGS 305
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 620-670 2.63e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 2.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 125745132  620 DDALHSESHENVLGSRGCGWGPRSECPVPPPGMVTLPSCVWEAAARLPTPA 670
Cdd:PHA03307  230 DDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSS 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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