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Conserved domains on  [gi|68404239|ref|XP_686681|]
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zinc finger protein 684 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-87 2.89e-08

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


:

Pssm-ID: 214951  Cd Length: 80  Bit Score: 50.51  E-value: 2.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68404239      4 KCVIGGCPNRSDS---IIHYMLP-EDPRRRSLWMKFIEDSEAAVAVGSAGSswRVCGDHFSEESFFTLNlgfstcRILSV 79
Cdd:smart00980   1 KCCVPGCGNRSKKnpgLSFFRFPkEDPELRKKWLENLGLPDDPNRKPKKRS--RICSRHFEPDDFDNSG------RRLKP 72


                   ....*...
gi 68404239     80 DAVPTVHP 87
Cdd:smart00980  73 GAVPTLFL 80
PHA00733 super family cl26169
hypothetical protein
 257-309 6.69e-03

hypothetical protein


The actual alignment was detected with superfamily member PHA00733:

Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 6.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 68404239  257 PFACHLCPRRFGYKVAFAAHMKHhsSKLTCVCPVCEKSFQYKGSLVQHLKSAH 309
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHVCKKH 123
 
Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-87 2.89e-08

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 50.51  E-value: 2.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68404239      4 KCVIGGCPNRSDS---IIHYMLP-EDPRRRSLWMKFIEDSEAAVAVGSAGSswRVCGDHFSEESFFTLNlgfstcRILSV 79
Cdd:smart00980   1 KCCVPGCGNRSKKnpgLSFFRFPkEDPELRKKWLENLGLPDDPNRKPKKRS--RICSRHFEPDDFDNSG------RRLKP 72


                   ....*...
gi 68404239     80 DAVPTVHP 87
Cdd:smart00980  73 GAVPTLFL 80
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-86 8.97e-08

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 49.07  E-value: 8.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68404239     5 CVIGGCPNRSDSIIH---YMLPEDPRRRSLWMKFIEDSEaavavGSAGSSWRVCGDHFSEESFftlnLGFSTCRILSVDA 81
Cdd:pfam05485   1 CSVPGCTNRKKKNPRtsfHKFPKDPERRKKWLNACKRKD-----LPPPSNSYVCSLHFEENDF----EKSGGKRKLKPGA 71


                  ....*
gi 68404239    82 VPTVH 86
Cdd:pfam05485  72 IPTLF 76
PHA00733 PHA00733
hypothetical protein
 257-309 6.69e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 6.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 68404239  257 PFACHLCPRRFGYKVAFAAHMKHhsSKLTCVCPVCEKSFQYKGSLVQHLKSAH 309
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHVCKKH 123
 
Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-87 2.89e-08

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 50.51  E-value: 2.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68404239      4 KCVIGGCPNRSDS---IIHYMLP-EDPRRRSLWMKFIEDSEAAVAVGSAGSswRVCGDHFSEESFFTLNlgfstcRILSV 79
Cdd:smart00980   1 KCCVPGCGNRSKKnpgLSFFRFPkEDPELRKKWLENLGLPDDPNRKPKKRS--RICSRHFEPDDFDNSG------RRLKP 72


                   ....*...
gi 68404239     80 DAVPTVHP 87
Cdd:smart00980  73 GAVPTLFL 80
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-86 8.97e-08

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 49.07  E-value: 8.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68404239     5 CVIGGCPNRSDSIIH---YMLPEDPRRRSLWMKFIEDSEaavavGSAGSSWRVCGDHFSEESFftlnLGFSTCRILSVDA 81
Cdd:pfam05485   1 CSVPGCTNRKKKNPRtsfHKFPKDPERRKKWLNACKRKD-----LPPPSNSYVCSLHFEENDF----EKSGGKRKLKPGA 71


                  ....*
gi 68404239    82 VPTVH 86
Cdd:pfam05485  72 IPTLF 76
PHA00733 PHA00733
hypothetical protein
 257-309 6.69e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 6.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 68404239  257 PFACHLCPRRFGYKVAFAAHMKHhsSKLTCVCPVCEKSFQYKGSLVQHLKSAH 309
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHVCKKH 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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