large tegument protein UL36; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053  311 APGVHHETKSSLATQGSSADSQNTLVSITTPVSsqPPRSTGSSSPVSVSKTVDPTNTAAAVVPAHTAVSKSALPvsslSA 390
Cdd:PHA03247 2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAP--PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP----RR 2782

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053  391 TPLEGGWTLSCSLPSSSVSASELKNINSLTRISSAGNTQTTWTTLHLAGNTIQPLSQPPSSA-STPALNECGTsptpsnh 469
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGpPPPSLPLGGS------- 2855

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053  470 khMATGITFNNSPPTDGQPveqivvTLPSCPPLPMQPLIAQPQVKSQPPKNILPLNSAMQVIQMAQPvgsgvtAAPANQN 549
Cdd:PHA03247 2856 --VAPGGDVRRRPPSRSPA------AKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAP------PPPQPQP 2921

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053  550 VIILQPPSTTPCPAMMRAEVSNQAVGQQIVIIQAANQNPLPLLSAPHPGPVRLPVNGASAiigSHNSVQnVPAPQTFGGK 629
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ---PAPSRE-APASSTPPLT 2997

                         330
                  ....*....|....*
gi 392352053  630 HlvHILPRPSSLSTS 644
Cdd:PHA03247 2998 G--HSLSRVSSWASS 3010

Helix-loop-helix DNA-binding domain;

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 392352053    20 RETHNAVERHRKKKINAGINRIGELIPCSPAL-KQSKNMILDQAFKYITELK 70
Cdd:pfam00010    2 REAHNERERRRRDRINDAFDELRELLPTLPPDkKLSKAEILRLAIEYIKHLQ 53

large tegument protein UL36; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053  311 APGVHHETKSSLATQGSSADSQNTLVSITTPVSsqPPRSTGSSSPVSVSKTVDPTNTAAAVVPAHTAVSKSALPvsslSA 390
Cdd:PHA03247 2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAP--PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP----RR 2782

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053  391 TPLEGGWTLSCSLPSSSVSASELKNINSLTRISSAGNTQTTWTTLHLAGNTIQPLSQPPSSA-STPALNECGTsptpsnh 469
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGpPPPSLPLGGS------- 2855

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053  470 khMATGITFNNSPPTDGQPveqivvTLPSCPPLPMQPLIAQPQVKSQPPKNILPLNSAMQVIQMAQPvgsgvtAAPANQN 549
Cdd:PHA03247 2856 --VAPGGDVRRRPPSRSPA------AKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAP------PPPQPQP 2921

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053  550 VIILQPPSTTPCPAMMRAEVSNQAVGQQIVIIQAANQNPLPLLSAPHPGPVRLPVNGASAiigSHNSVQnVPAPQTFGGK 629
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ---PAPSRE-APASSTPPLT 2997

                         330
                  ....*....|....*
gi 392352053  630 HlvHILPRPSSLSTS 644
Cdd:PHA03247 2998 G--HSLSRVSSWASS 3010

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053   12 KKQHRKKNRETHNAVE-----RHRKKKINAGINRigelipcspaLKQSKNMI---LDQAFKYITELKRQNDELLLNGGSS 83
Cdd:COG1340    42 AEKRDELNAQVKELREeaqelREKRDELNEKVKE----------LKEERDELnekLNELREELDELRKELAELNKAGGSI 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 392352053   84 EQA-------------------------EEIKKLRKQLEEIQKEN 103
Cdd:COG1340   112 DKLrkeierlewrqqtevlspeeekelvEKIKELEKELEKAKKAL 156

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 392352053   22 THNAVERHRKKKINAGINRIGELIPCSP----ALKQSKNMILDQAFKYITELKRQNDE 75
Cdd:cd11387     1 SHNAVERRRRDNINEKIQELGSLVPPSRletkDLKPNKGSILSKAVEYIRELQNQNQE 58

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factors, USF1, USF2 and similar proteins; Upstream stimulatory factor 1 and 2 (USF-1 and USF-2) are members of bHLHzip transcription factor family. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 392352053   22 THNAVERHRKKKINAGINRIGELIP-CSPA---LKQSKNMILDQAFKYITELKRQNDE 75
Cdd:cd11396     1 THNEVERRRRDKINNWIVKLAKIVPdCEKDnskQGQSKGGILSKACDYIQELRSQNER 58

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392352053   16 RKKNRETHNAVERHRKKKINAGINRIGELIPCSPALKQSKNMILDQAFKYITELKRQNDEL 76
Cdd:cd11419     1 RRIRREIANSNERRRMQSINAGFQSLRTLLPHCDGEKLSKAAILQQTAEYIFSLEQEKTRL 61

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins; USF1, also termed Class B basic helix-loop-helix protein 11 (bHLHb11), or major late transcription factor 1, is a bHLHzip transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. It is ubiquitously expressed and involved in the transcription activation of various functional genes implicated in lipid and glucose metabolism, stress response, immune response, cell cycle control and tumour suppression. USF-1 recruits chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. Genetic polymorphisms of USF1 are associated with some metabolic and cardiovascular diseases, like diabetes, atherosclerosis, coronary artery calcifications and familial combined hyperlipidaemia (FCHL).

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392352053   17 KKNRETHNAVERHRKKKINAGINRIGELIP-CS---PALKQSKNMILDQAFKYITELKRQN 73
Cdd:cd18924     3 EKRRAQHNEVERRRRDKINNWIVQLSKIIPdCSmesTKSGQSKGGILSKACDYIQELRQSN 63

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins; TFE3, also termed Class E basic helix-loop-helix protein 33 (bHLHe33), is a bHLHzip transcription factor that is involved in B cell function. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053   13 KQHRKKnrETHNAVERHRKKKINAGINRIGELIPCS--PALKQSKNMILDQAFKYITELKRQNdelllnggssEQAEEIK 90
Cdd:cd18928     7 KERQKK--DNHNLIERRRRFNINDRIKELGTLIPKStdPEMRWNKGTILKASVDYIRKLQKEQ----------QRSKEIE 74

                  ....*...
gi 392352053   91 KLRKQLEE 98
Cdd:cd18928    75 MRQRKLEQ 82

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins; MITF, also termed Class E basic helix-loop-helix protein 32 (bHLHe32), is a bHLHzip transcription factor that is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. It regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. It binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053    6 EHETPTKKQHRKKnRETHNAVERHRKKKINAGINRIGELIPCS--PALKQSKNMILDQAFKYITELKRQNdelllnggss 83
Cdd:cd18926     1 ESEARALAKERQK-KDNHNLIERRRRFNINDRIKELGTLIPKSndPDMRWNKGTILKASVDYIRKLQREQ---------- 69

                          90
                  ....*....|....*...
gi 392352053   84 EQAEEIKKLRKQLEEIQK 101
Cdd:cd18926    70 QRAKELENRQKKLEHANR 87

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 392352053   23 HNAVERHRKKKINAGINRIGELIPcsPALKQSKNMILDQAFKYITELKRQNDEL 76
Cdd:cd11393     1 HSIAERKRREKINERIRALRSLVP--NGGKTDKASILDEAIEYIKFLQEQVKVL 52

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins; USF2, also termed Class B basic helix-loop-helix protein 12 (bHLHb12), or major late transcription factor 2, or FOS-interacting protein (FIP), or upstream transcription factor 2, is a bHLHzip transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053   17 KKNRETHNAVERHRKKKINAGINRIGELIP-C---SPALKQSKNMILDQAFKYITELKRQNDELllnggsSEQAEEIKKL 92
Cdd:cd18923     6 ERRRAQHNEVERRRRDKINNWIVQLSKIIPdCntdNSKTGASKGGILSKACDYIRELRQTNQRM------QETYKEAERL 79

                  .
gi 392352053   93 R 93
Cdd:cd18923    80 Q 80

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053   23 HNAVERHRKKKINAGINRIGELIP--CSPAL--------------KQSKNMILDQAFKYITELKRQNDELllnggsseqA 86
Cdd:cd11395     7 HNAIEKRYRSNLNTKIERLRDAIPslRSPEGksddgglgglapttKLSKATILTKAIEYIRHLEQENERL---------E 77

                          90
                  ....*....|
gi 392352053   87 EEIKKLRKQL 96
Cdd:cd11395    78 EENEELRQQV 87

large tegument protein UL36; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053  311 APGVHHETKSSLATQGSSADSQNTLVSITTPVSsqPPRSTGSSSPVSVSKTVDPTNTAAAVVPAHTAVSKSALPvsslSA 390
Cdd:PHA03247 2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAP--PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP----RR 2782

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053  391 TPLEGGWTLSCSLPSSSVSASELKNINSLTRISSAGNTQTTWTTLHLAGNTIQPLSQPPSSA-STPALNECGTsptpsnh 469
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGpPPPSLPLGGS------- 2855

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053  470 khMATGITFNNSPPTDGQPveqivvTLPSCPPLPMQPLIAQPQVKSQPPKNILPLNSAMQVIQMAQPvgsgvtAAPANQN 549
Cdd:PHA03247 2856 --VAPGGDVRRRPPSRSPA------AKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAP------PPPQPQP 2921

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053  550 VIILQPPSTTPCPAMMRAEVSNQAVGQQIVIIQAANQNPLPLLSAPHPGPVRLPVNGASAiigSHNSVQnVPAPQTFGGK 629
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ---PAPSRE-APASSTPPLT 2997

                         330
                  ....*....|....*
gi 392352053  630 HlvHILPRPSSLSTS 644
Cdd:PHA03247 2998 G--HSLSRVSSWASS 3010

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053   20 RETHNAVERHRKKKINagiNRIGELIPCSPALKQ----SKNMILDQAFKYITELkrQNDELLLNGGSSEQAEEIKKLRKQ 95
Cdd:cd11400     2 RRLHNVLERQRRNDLK---NSFEKLRDLVPELADnekaSKVVILKKATEYIKQL--QQEEKKLEKEKDKLKARNEQLRKK 76

                  ....
gi 392352053   96 LEEI 99
Cdd:cd11400    77 LERL 80

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053   19 NRETHNAVERHRKKKINAGINRIGELIPCS---PALKQSKNMILDQAFKYITELKRQNDELLlnggsseqaEEIKKLRKQ 95
Cdd:cd11405     3 RRLSHISAEQKRRFNIKSGFDTLQSLIPSLgqnPNQKVSKAAMLQKAAEYIKSLKRERQQMQ---------EEAEQLRQE 73

basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins; E47 is a class I bHLH transcriptional regulator that forms heterodimers with class II bHLH proteins to regulate distinct differentiation pathways. Its homodimers regulate B lymphocytes development.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392352053   12 KKQHRKKNRETHNAVERHRKKKINAGINRIGELipCSPALK----QSKNMILDQAFKYITELKRQNDELLLN 79
Cdd:cd18943     3 KDLRDRERRMANNARERVRVRDINEAFKELGRM--CQMHLKsdkaQTKLIILQQAVQVILGLEQQVRERNLN 72

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae phosphate system positive regulatory protein PHO4 and similar proteins; PHO4 is a transcriptional activator that regulates the expression of repressible phosphatase under phosphate starvation conditions in Saccharomyces cerevisiae. The PHO4 protein has four functional domains with the bHLH domain at its carboxyl-terminal region. It regulates transcription by binding to promoter of the genes as a homodimer.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392352053   20 RETHNAVERHRKKKINAGINRIGELIPCSPALK----------------------QSKNMILDQAFKYITELKRQNDE 75
Cdd:cd11392     3 RTAHKVAERGRRDRLNAALKELASLMPAEFVEGkmgadgsasdsndkekaaasaaGSKAATVEMAIDYIKHLQKEVEE 80

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins; TFEB, also termed Class E basic helix-loop-helix protein 35 (bHLHe35), is a bHLHzip transcription factor that is required for vascularization of the mouse placenta. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392352053   13 KQHRKKnrETHNAVERHRKKKINAGINRIGELIPCSPAL--KQSKNMILDQAFKYItelKRQNDELllnggssEQAEEIK 90
Cdd:cd18927     7 KERQKK--DNHNLIERRRRFNINDRIKELGTLIPKTNDLdvRWNKGTILKASVDYI---KRMQKDL-------QRSRELE 74

                          90
                  ....*....|..
gi 392352053   91 KLRKQLEEIQKE 102
Cdd:cd18927    75 NHSRRLEMTNKQ 86

tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain family includes transcription regulators whose expression are restricted to certain tissues. They are involved in cell-fate determination and process in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis and include proteins from myogenic regulatory factor (MRF) family, twist-related protein (TWIST) family, scleraxis-like family, heart- and neural crest derivatives-expressed protein (HAND) family, helix-loop-helix protein (HEN) family, musculin-like family, germline alpha (FIGLA) family, T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family, ovary, uterus and testis protein (OUT) family, mesoderm posterior protein (Mesp) family, muscle, intestine and stomach expression 1 (MIST-1) family, protein atonal homologs (ATOH) family, neurogenin (NGN) family, neurogenic differentiation factor (NeuroD) family, achaete-scute complex-like (ASCL) family, Fer3-like protein (FERD3L)-like family, and Oligodendrocyte lineage genes (OLIG) family of transcription factors.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 392352053   20 RETHNAVERHRKKKINAGINRIGELIPCSPALKQ-SKNMILDQAFKYITELKR 71
Cdd:cd11390     1 RNAANARERRRMHDLNDAFEALRKVLPTVPPDKKlSKIETLRLAINYIAALSD 53

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar proteins; Protein taxi, also termed protein delilah (Dei), is a bHLH transcription factor that is involved in regulation of cell adhesion and attachment that is expressed in specialized cells that provide anchoring sites to either muscles (tendon cells), or proprioceptors (chordotonal attachment cells) during embryonic development. It probably plays an important role in the differentiation of epidermal cells into the tendon cells that form the attachment sites for all muscles.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 392352053   20 RETHNAVERHRKKKINAGINRIGELIPCSPA----LKQSKNMILDQAFKYITEL 69
Cdd:cd11431     2 RKTANARERDRMREINDAFEALRRAVPEYPVagkdGKLTKITTLRLAMNYIKAL 55

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins; INO2 is a positive regulatory factor required for depression of the co-regulated phospholipid biosynthetic enzymes in Saccharomyces cerevisiae. It is also involved in the expression of ITR1.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392352053   20 RETHNAVERHRKKKINAGINRIGELIP---CSPALKQSKNMILDQAFKYITELKRQNDELLLN 79
Cdd:cd11388     4 KWKHVEAEKKRRNQIKKGFEDLINLINyprNNNEKRISKSELLNKAVDDIRGLLKANEQLQEE 66

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as FAMA, MUTE and SPEECHLESS, which work together to regulate the sequential cell fate specification during stomatal development and differentiation. FAMA, also termed AtbHLH97, or EN 14, is a transcription activator required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. It mediates the formation of stomata. MUTE, also termed AtbHLH45, or EN 20, is required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. It promotes the conversion of the leaf epidermis into stomata. SPEECHLESS, also termed AtbHLH98, or EN 19, is required for the initiation and the formation of stomata, by promoting the first asymmetric cell divisions. FAMA, MUTE and SPEECHLESS form heterodimers with SCREAM/ICE1 and SCRM2 to regulate transcription of genes during stomatal development.

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gi 392352053   22 THNAVERHRKKKINAGINRIGELIPCSPALKQSKNMILDQAFKYITELkrqndELLLnggsseQAEEIKKLRKQLEEI 99
Cdd:cd11448     2 THIAVERNRRKQMNEHLNVLRSLMPGSYIQRGDQASIVGGAIEFVKEL-----EQLL------QSLEAQKRRRTLNES 68

basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The achaete-scute complex-like (ASCL, also known as achaete-scute complex homolog or ASH) family of bHLH transcription factors, ASCL1-5, have been implicated in cell fate specification and differentiation. They are critical for proper development of the nervous system. The deregulation of ASCL plays a key role in psychiatric and neurological disorders. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete-scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete-scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. The family also includes Drosophila melanogaster achaete-scute complex (AS-C) proteins, which consists of lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.

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gi 392352053   24 NAVERHRKKKINAGINRIGELIPCSPALKQ-SKNMILDQAFKYITELKRQ 72
Cdd:cd11418     6 NERERRRVQAVNDAFDRLRQHVPYLKRRKKlSKVKTLRRAIEYIRHLQKL 55

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins; ARNT, also termed Class E basic helix-loop-helix protein 2 (bHLHe2), or Dioxin receptor, nuclear translocator, or hypoxia-inducible factor 1-beta (HIF1b), or HIF-1-beta, or HIF1-beta, is a member of bHLH-PAS transcription regulators that acts as the heterodimeric partner for bHLH-PAS proteins such as aryl hydrocarbon receptor (AhR), hypoxia-inducible factor (HIF), and single-minded (SIM). These bHLH-PAS transcription complexes are involved in transcriptional responses to xenobiotic, hypoxia, and developmental pathways. Heterodimerization of bHLH-PAS proteins with ARNT is mediated by contacts between both the bHLH and the tandem PAS domains. ARNT use bHLH and/or PAS domains to interact with several transcriptional coactivators. It is required for activity of the aryl hydrocarbon (dioxin) receptor.

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gi 392352053   20 RETHNAVERHRKKKINAGINRIGELIP-CSP-ALKQSKNMILDQAFKYITELK 70
Cdd:cd18947     6 RENHSEIERRRRNKMTAYITELSDMVPtCSAlARKPDKLTILRMAVSHMKSLR 58