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Conserved domains on  [gi|2217323840|ref|XP_047295633|]
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zinc finger protein 845 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 5.71e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 5.71e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217323840   7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
381-813 5.07e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 5.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 381 KPYKCNECSRTFSRKSSLTRHRRLHTGEKPYKCND--CGKTFSQMSSLVYHRRLHTGEKPYKCE-ECDEAFSFKSNLERH 457
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 458 RRIHTGEKPYKCNDCGKTFSQTSSLVYHRRLHTgeKPYKCEECDEAFSFKSNLERHRIIHTGEKlykcNECGKTFSRKSS 537
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPA----NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 538 LTRHCRLHTGEKPYQCNECGKAFRGQSALIYHQAIHGIGKLYKCNDCHQVFSnaTTIANHWRIHNEErSYKCNRCGKFFR 617
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP--KSLLSQSPSSLSS-SDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 618 H-----RSYLAVHWRTHSGE-----KPYKCEECDEAFSFKSNLQRHRR--IHTGE--KPYRCNE--CGKTFSRKSYLTCH 681
Cdd:COG5048   263 SslptaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 682 RRLHTGEKPYKC--NECGKTFGRNSaliihkaihtgekpykcNECGKAFSQKSSLTCHLRLHTGEKPykceECDKVFSRK 759
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLL-----------------NNEPPQSLQQYKDLKNDKKSETLSN----SCIRNFKRD 401

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217323840 760 SSLEKHRRIHTGEKP--YKCKVCDKAFGRDSHLAQHTRIHTGEKPYKCNECGKNFR 813
Cdd:COG5048   402 SNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-564 1.83e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 169 NSASLVSTSQRISCRPKTHISKNYGNNFLNSSLLTQKQEV-----------HMREKSFQCNESGKAFNYSSVL---RKHQ 234
Cdd:COG5048     5 SSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSrlehltrhirsHTGEKPSQCSYSGCDKSFSRPLelsRHLR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 235 IIHLGAKQYKCDVCGKVFNQKRYLACHRRCHTGKKPYKCNDCGKTFSQELTLTCHHRLHTGEKHYKCSEC---------- 304
Cdd:COG5048    85 THHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqs 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 305 ------------GKTFSRNSALVIHKAIHTGEKSYKCNECGKTFSQTSYLVYHRRLHTGEKPYKCEECDKAFSFKSNLER 372
Cdd:COG5048   165 nslhpplpanslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQS 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 373 HRKIHTGEKPYKCNECSRTFSRKSSLTRHRRLHTGE-------KPYKCNDCGKTFSQMSSLVYHRR--LHTGE--KPYKC 441
Cdd:COG5048   245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSC 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 442 EE--CDEAFSFKSNLERHRRIHTGEKPYKCNDCGKTFSQTSSLVY----HRRLHTGEKPYKCEECDEAFSFK-----SNL 510
Cdd:COG5048   325 PYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLSNSCIRnfkrdSNL 404

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217323840 511 ERHRIIHT--GEKLYKCNECGKTFSRKSSLTRHCRLHTGEKPYQCNECGKAFRGQS 564
Cdd:COG5048   405 SLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
873-898 4.24e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.24e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217323840 873 NLSRHHRLHTGEKPYKCNKCGKVFNQ 898
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
845-870 7.27e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 7.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217323840 845 ALEIHKAIHTGEKPYKCSECGKVFNR 870
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 5.71e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 5.71e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217323840   7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
8-48 1.91e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.89  E-value: 1.91e-24
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2217323840    8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 1.08e-21

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 88.38  E-value: 1.08e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2217323840   8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSL 47
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
381-813 5.07e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 5.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 381 KPYKCNECSRTFSRKSSLTRHRRLHTGEKPYKCND--CGKTFSQMSSLVYHRRLHTGEKPYKCE-ECDEAFSFKSNLERH 457
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 458 RRIHTGEKPYKCNDCGKTFSQTSSLVYHRRLHTgeKPYKCEECDEAFSFKSNLERHRIIHTGEKlykcNECGKTFSRKSS 537
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPA----NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 538 LTRHCRLHTGEKPYQCNECGKAFRGQSALIYHQAIHGIGKLYKCNDCHQVFSnaTTIANHWRIHNEErSYKCNRCGKFFR 617
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP--KSLLSQSPSSLSS-SDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 618 H-----RSYLAVHWRTHSGE-----KPYKCEECDEAFSFKSNLQRHRR--IHTGE--KPYRCNE--CGKTFSRKSYLTCH 681
Cdd:COG5048   263 SslptaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 682 RRLHTGEKPYKC--NECGKTFGRNSaliihkaihtgekpykcNECGKAFSQKSSLTCHLRLHTGEKPykceECDKVFSRK 759
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLL-----------------NNEPPQSLQQYKDLKNDKKSETLSN----SCIRNFKRD 401

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217323840 760 SSLEKHRRIHTGEKP--YKCKVCDKAFGRDSHLAQHTRIHTGEKPYKCNECGKNFR 813
Cdd:COG5048   402 SNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-564 1.83e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 169 NSASLVSTSQRISCRPKTHISKNYGNNFLNSSLLTQKQEV-----------HMREKSFQCNESGKAFNYSSVL---RKHQ 234
Cdd:COG5048     5 SSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSrlehltrhirsHTGEKPSQCSYSGCDKSFSRPLelsRHLR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 235 IIHLGAKQYKCDVCGKVFNQKRYLACHRRCHTGKKPYKCNDCGKTFSQELTLTCHHRLHTGEKHYKCSEC---------- 304
Cdd:COG5048    85 THHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqs 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 305 ------------GKTFSRNSALVIHKAIHTGEKSYKCNECGKTFSQTSYLVYHRRLHTGEKPYKCEECDKAFSFKSNLER 372
Cdd:COG5048   165 nslhpplpanslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQS 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 373 HRKIHTGEKPYKCNECSRTFSRKSSLTRHRRLHTGE-------KPYKCNDCGKTFSQMSSLVYHRR--LHTGE--KPYKC 441
Cdd:COG5048   245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSC 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 442 EE--CDEAFSFKSNLERHRRIHTGEKPYKCNDCGKTFSQTSSLVY----HRRLHTGEKPYKCEECDEAFSFK-----SNL 510
Cdd:COG5048   325 PYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLSNSCIRnfkrdSNL 404

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217323840 511 ERHRIIHT--GEKLYKCNECGKTFSRKSSLTRHCRLHTGEKPYQCNECGKAFRGQS 564
Cdd:COG5048   405 SLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
649-674 2.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.79e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217323840 649 NLQRHRRIHTGEKPYRCNECGKTFSR 674
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 269-317 4.61e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.85  E-value: 4.61e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2217323840 269 KPYkCNDCGKTFSQELTLTCHHRlhtgEKHYKCSECGKTFSRNSALVIH 317
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
873-898 4.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.24e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217323840 873 NLSRHHRLHTGEKPYKCNKCGKVFNQ 898
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
845-870 7.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 7.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217323840 845 ALEIHKAIHTGEKPYKCSECGKVFNR 870
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 5.71e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 5.71e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217323840   7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
8-48 1.91e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.89  E-value: 1.91e-24
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2217323840    8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 1.08e-21

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 88.38  E-value: 1.08e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2217323840   8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSL 47
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
381-813 5.07e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 5.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 381 KPYKCNECSRTFSRKSSLTRHRRLHTGEKPYKCND--CGKTFSQMSSLVYHRRLHTGEKPYKCE-ECDEAFSFKSNLERH 457
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 458 RRIHTGEKPYKCNDCGKTFSQTSSLVYHRRLHTgeKPYKCEECDEAFSFKSNLERHRIIHTGEKlykcNECGKTFSRKSS 537
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPA----NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 538 LTRHCRLHTGEKPYQCNECGKAFRGQSALIYHQAIHGIGKLYKCNDCHQVFSnaTTIANHWRIHNEErSYKCNRCGKFFR 617
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP--KSLLSQSPSSLSS-SDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 618 H-----RSYLAVHWRTHSGE-----KPYKCEECDEAFSFKSNLQRHRR--IHTGE--KPYRCNE--CGKTFSRKSYLTCH 681
Cdd:COG5048   263 SslptaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 682 RRLHTGEKPYKC--NECGKTFGRNSaliihkaihtgekpykcNECGKAFSQKSSLTCHLRLHTGEKPykceECDKVFSRK 759
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLL-----------------NNEPPQSLQQYKDLKNDKKSETLSN----SCIRNFKRD 401

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217323840 760 SSLEKHRRIHTGEKP--YKCKVCDKAFGRDSHLAQHTRIHTGEKPYKCNECGKNFR 813
Cdd:COG5048   402 SNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
493-907 2.95e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 2.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 493 KPYKCEECDEAFSFKSNLERHRIIHTGEKLYKCN--ECGKTFSRKSSLTRHCRLHTGEKPYQCNecGKAFRGQSALIYHQ 570
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 571 AIHGIGKLYKCNDCHQV-----FSNATTIANHWRIHNEERSYK-CNRCGKFFRHRSYLAV-HWRTHSGEKPYKCeecdea 643
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHslppsSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHPpLPANSLSKDPSSN------ 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 644 fsfkSNLQRHRRIHTGEKPYRCNECGKTFSRKSYLTCHRRLHTGEKPYKCNECGKTFGRNSALIIHKAIHTGEKPYKCNE 723
Cdd:COG5048   184 ----LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 724 C-----GKAFSQKSSLTCHLRL-HTG-EKPYKCEECDKVFSRKSSLEKHRR--IHTGE--KPYKCKV--CDKAFGRDSHL 790
Cdd:COG5048   260 SprsslPTASSQSSSPNESDSSsEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 791 AQHTRIHTGEKPYKCNECGKNFRHNSALVIHKA----IHSGEKPYKCNEC-------GKTFRHNSALEIHKAIHTGEKPY 859
Cdd:COG5048   340 KRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPqslqQYKDLKNDKKSETlsnscirNFKRDSNLSLHIITHLSFRPYNC 419

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 2217323840 860 KCSECGKVFNRKANLSRHHRLHTGEKPYKCNKCGKvFNQQAHLACHHR 907
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
521-963 1.06e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 521 KLYKCNECGKTFSRKSSLTRHCRLHTGEKPYQCNECGKA---FRGQSALIYHQAIHGIGKLYKCNDCHQVFSNATTIANH 597
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 598 WRIHNEERSYKCNRCGKFFRHRSYLA--VHWRTHSGEKPYKceecDEAFSFKSNLQRHRRIHtgekPYRCNECGKTFSRK 675
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLP----GNNSSSVNTPQSNSLHP----PLPANSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 676 SYLTCHRRLHTGEKPYKCNECGKTFGRNSALIIHKAIHTGEKPYKCNECGKAF------SQKSSLTCHLRLHTGEKPYKC 749
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 750 EECDKVFSRKSSLEKHRRIHTG-EKPYKCKVCDKAFGRDSHLAQHTR--IHTGE--KPYKCNE--CGKNFRHNSALVIHK 822
Cdd:COG5048   264 SLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 823 AIHSGEKPYKCNECGKTFRHNSALEIhkaihtgekpykcsecgkvfNRKANLSRHHRLHTGEKPYKC-NKCGKVFNQQAH 901
Cdd:COG5048   344 LLHTSISPAKEKLLNSSSKFSPLLNN--------------------EPPQSLQQYKDLKNDKKSETLsNSCIRNFKRDSN 403

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217323840 902 LACHHRIHTGEKPY--KCNECGKTFRHNSVLVIHKTIHTgEKPYKCNECGKVFNRKAKLARHHR 963
Cdd:COG5048   404 LSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
241-677 1.30e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 1.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 241 KQYKCDVCGKVFNQKRYLACHRRCHTGKKPYKCND--CGKTFSQELTLTCHHRLHTGEKHYKCS-ECGKTFSRNSALVIH 317
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 318 KAIHTGEKSYKCNECGKTFSQTSYLVYHRRLHTgeKPYKCEECDKAFSFKSNLERHRKIHTGEKpykcNECSRTFSRKSS 397
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPA----NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 398 LTRHRRLHTGEKPYKCNDCGKTFSQMSSLVYHRRLHTGEKPYKCEECDEAFSFKSNLERHRRIHTGEKPYKCNDCGKTFS 477
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 478 QTSSLVYHRRLHTGE-------KPYKCEECDEAFSFKSNLERHR--IIHTGEKL--YKCNE--CGKTFSRKSSLTRHCRL 544
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLkpFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 545 HTGEKPYQCNECGKAFRGQSALIyhqaihgigklykcNDCHQVFSNATTIANhwrIHNEERSYkcNRCGKFFRHRSYLAV 624
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFSPLLN--------------NEPPQSLQQYKDLKN---DKKSETLS--NSCIRNFKRDSNLSL 406

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217323840 625 HWRTHSGEKP--YKCEECDEAFSFKSNLQRHRRIHTGEKPYRCNECGKTFSRKSY 677
Cdd:COG5048   407 HIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-564 1.83e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 169 NSASLVSTSQRISCRPKTHISKNYGNNFLNSSLLTQKQEV-----------HMREKSFQCNESGKAFNYSSVL---RKHQ 234
Cdd:COG5048     5 SSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSrlehltrhirsHTGEKPSQCSYSGCDKSFSRPLelsRHLR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 235 IIHLGAKQYKCDVCGKVFNQKRYLACHRRCHTGKKPYKCNDCGKTFSQELTLTCHHRLHTGEKHYKCSEC---------- 304
Cdd:COG5048    85 THHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqs 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 305 ------------GKTFSRNSALVIHKAIHTGEKSYKCNECGKTFSQTSYLVYHRRLHTGEKPYKCEECDKAFSFKSNLER 372
Cdd:COG5048   165 nslhpplpanslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQS 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 373 HRKIHTGEKPYKCNECSRTFSRKSSLTRHRRLHTGE-------KPYKCNDCGKTFSQMSSLVYHRR--LHTGE--KPYKC 441
Cdd:COG5048   245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSC 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 442 EE--CDEAFSFKSNLERHRRIHTGEKPYKCNDCGKTFSQTSSLVY----HRRLHTGEKPYKCEECDEAFSFK-----SNL 510
Cdd:COG5048   325 PYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLSNSCIRnfkrdSNL 404

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217323840 511 ERHRIIHT--GEKLYKCNECGKTFSRKSSLTRHCRLHTGEKPYQCNECGKAFRGQS 564
Cdd:COG5048   405 SLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
633-966 7.60e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 7.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 633 KPYKCEECDEAFSFKSNLQRHRRIHTGEKPYRCN--ECGKTFSRKSYLTCHRRLHTGEKPYKCN-ECGKTFGRNSALIIH 709
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 710 KAIHTGEKPYKCNECGKAFSQKSSLTCHLRLHTGEKPYKCEEC----------------------DKVFSRKSSLEKHRR 767
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 768 IHTGEKPYKCKVCDKAFGRDSHLAQHTRIHTGEKPYKCNECGKNFRHNSALVIHKAIHSGEKPYKCNECGKTFRHNSALE 847
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 848 IHKAIHTGE-------KPYKCSECGKVFNRKANLSRH--HRLHTGE--KPYKC--NKCGKVFNQQAHLACHHRIHTGEKP 914
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 915 YKC--NECGKTFRHNSV------LVIHKTIHT-------------------------------GEKPYKCNECGKVFNRK 955
Cdd:COG5048   352 AKEklLNSSSKFSPLLNneppqsLQQYKDLKNdkksetlsnscirnfkrdsnlslhiithlsfRPYNCKNPPCSKSFNRH 431

                         410
                  ....*....|.
gi 2217323840 956 AKLARHHRIHT 966
Cdd:COG5048   432 YNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
142-401 8.94e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 8.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 142 SSFHSHLPELHMFQTEGKIGNQVEKSINSASLVSTSQRiSCRPKTHISKNYGNNFLNSSLLTQKQEVHMREKSFQcNESG 221
Cdd:COG5048   195 SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN-SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA-SSQS 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 222 KAFNYSSVLrKHQIIHLgakQYKCDVCGKVFNQKRYLACHRRC--HTGK--KPYKC--NDCGKTFSQELTLTCHHRLHTG 295
Cdd:COG5048   273 SSPNESDSS-SEKGFSL---PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 296 EKHYKCSECGKTFSRNSAL-----------VIHKAIHTGEKSYkcNECGKTFSQTSYLVYHRRLHTGEKPY--KCEECDK 362
Cdd:COG5048   349 ISPAKEKLLNSSSKFSPLLnneppqslqqyKDLKNDKKSETLS--NSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSK 426

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2217323840 363 AFSFKSNLERHRKIHTgEKPYKCNECSRTFSRKSSLTRH 401
Cdd:COG5048   427 SFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 402-486 2.45e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.87  E-value: 2.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 402 RRLHT-GEKPYKCN--DCGKTFSQMSSLVYHRrLHTGEKPYKCEECDEafsfksnlERHRRIHTGEKPYKCNDCGKTFSQ 478
Cdd:COG5189   340 RMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKN 410


                  ....*...
gi 2217323840 479 TSSLVYHR 486
Cdd:COG5189   411 LNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 346-430 5.31e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.10  E-value: 5.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 346 RRLHT-GEKPYKCE--ECDKAFSFKSNLERHRKiHtgekpykcNECSRTFSRKSSLTRHRRLHTGEKPYKCNDCGKTFSQ 422
Cdd:COG5189   340 RMLKVkDGKPYKCPveGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKN 410


                  ....*...
gi 2217323840 423 MSSLVYHR 430
Cdd:COG5189   411 LNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 766-850 1.58e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 766 RRIHT-GEKPYKCKV--CDKAFGRDSHLAQHtRIHtgekpykcNECGKNFRHNSALVIHKAIHSGEKPYKCNECGKTFRH 842
Cdd:COG5189   340 RMLKVkDGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKN 410


                  ....*...
gi 2217323840 843 NSALEIHK 850
Cdd:COG5189   411 LNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
649-674 2.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.79e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217323840 649 NLQRHRRIHTGEKPYRCNECGKTFSR 674
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 3.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.94e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217323840 453 NLERHRRIHTGEKPYKCNDCGKTFSQ 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 269-317 4.61e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.85  E-value: 4.61e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2217323840 269 KPYkCNDCGKTFSQELTLTCHHRlhtgEKHYKCSECGKTFSRNSALVIH 317
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 715-793 8.03e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 8.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 715 GEKPYKCN--ECGKAFSQKSSLTCHlRLHTgekpykceECDKVFSRKSSLEKHRRIHTGEKPYKCKVCDKAFGRDSHLAQ 792
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 2217323840 793 H 793
Cdd:COG5189   417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 430-514 9.38e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 9.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 430 RRLHT-GEKPYKCE--ECDEAFSFKSNLERHRrihtgekpyKCNDCGKTFSQTSSLVYHRRLHTGEKPYKCEECDEAFSF 506
Cdd:COG5189   340 RMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKN 410


                  ....*...
gi 2217323840 507 KSNLERHR 514
Cdd:COG5189   411 LNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 486-569 9.54e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 9.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217323840 486 RRLHT-GEKPYKCE--ECDEAFSFKSNLERHRiihtgeklyKCNECGKTFSRKSSLTRHCRLHTGEKPYQCNECGKAFRG 562
Cdd:COG5189   340 RMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKN 410


                  ....*..
gi 2217323840 563 QSALIYH 569
Cdd:COG5189   411 LNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 1.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.50e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217323840 369 NLERHRKIHTGEKPYKCNECSRTFSR 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
761-784 1.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|....
gi 2217323840 761 SLEKHRRIHTGEKPYKCKVCDKAF 784
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
873-898 4.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.24e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217323840 873 NLSRHHRLHTGEKPYKCNKCGKVFNQ 898
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
789-814 4.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217323840 789 HLAQHTRIHTGEKPYKCNECGKNFRH 814
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
537-560 5.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 5.06e-03
                          10        20
                  ....*....|....*....|....
gi 2217323840 537 SLTRHCRLHTGEKPYQCNECGKAF 560
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
397-422 5.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 5.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217323840 397 SLTRHRRLHTGEKPYKCNDCGKTFSQ 422
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
845-870 7.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 7.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217323840 845 ALEIHKAIHTGEKPYKCSECGKVFNR 870
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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