KHA, dimerization domain of potassium ion channel, similar to doublecortin-like domain, found in potassium channel tetramerization domain containing 9 (KCTD9) and similar proteins; This family corresponds to KHA, the tetramerization domain of eukaryotic voltage-dependent potassium ion-channel proteins, mainly found in vertebrates KCTD9 and plants AKT proteins. In plants the domain lies at the C-terminus whereas in many chordates it lies at the N-terminus. KHA shows high sequence similarity with doublecortin-like domain, which has a stable ubiquitin-like tertiary fold. KCTD9, also termed BTB/POZ domain-containing protein 9, belongs to the KCTD protein family, which corresponds to potassium channel tetramerization domain proteins, a class of BTB-domain-containing proteins. It is involved in potassium channel formation. Moreover, KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus (HBV)-induced acute-on-chronic liver failure. AKT proteins play crucial roles in K+ uptake and translocation in plant cells.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217372360   2 RRVTLFLNGSPKNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFVCE 66
Cdd:cd17073     1 KRVTVFVNGSSSGGKVIALPSTLSELLKIASEKLGIPAKRLYTGSGGEIDDIALIRDDDVLYVSE 65

KHA, dimerization domain of potassium ion channel, similar to doublecortin-like domain, found in potassium channel tetramerization domain containing 9 (KCTD9) and similar proteins; This family corresponds to KHA, the tetramerization domain of eukaryotic voltage-dependent potassium ion-channel proteins, mainly found in vertebrates KCTD9 and plants AKT proteins. In plants the domain lies at the C-terminus whereas in many chordates it lies at the N-terminus. KHA shows high sequence similarity with doublecortin-like domain, which has a stable ubiquitin-like tertiary fold. KCTD9, also termed BTB/POZ domain-containing protein 9, belongs to the KCTD protein family, which corresponds to potassium channel tetramerization domain proteins, a class of BTB-domain-containing proteins. It is involved in potassium channel formation. Moreover, KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus (HBV)-induced acute-on-chronic liver failure. AKT proteins play crucial roles in K+ uptake and translocation in plant cells.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217372360   2 RRVTLFLNGSPKNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFVCE 66
Cdd:cd17073     1 KRVTVFVNGSSSGGKVIALPSTLSELLKIASEKLGIPAKRLYTGSGGEIDDIALIRDDDVLYVSE 65

KHA, dimerization domain of potassium ion channel; KHA is the tetramerization domain of eukaryotic voltage-dependent potassium ion-channel proteins. In plants the domain lies at the C-terminus whereas in many chordates it lies at the N-terminus.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217372360   2 RRVTLFLNGSPK--NGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFV 64
Cdd:pfam11834   1 KRVTIFPNHDGKrrNGKLIWLPDSLEELLKIASEKFGISATKILTEDGAEIDDIDVIRDGDHLYL 65

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217372360 224 NFSGADLSRLDLRYINFKMANLSRCNLAHANLCCANLERADLSGSVLDCANLQGVKMLCSNAEGASLKLCNFED 297
Cdd:COG1357    93 NLSGANLSGANLRGANLSGANLSGADLSGADLSGANLSGADLSGANLSGANLSGADLSGADLSGANLSGANLSG 166

Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217372360 243 ANLSRCNLAHANLCCANLERADLSGSVLDCANLQGVKM 280
Cdd:pfam00805   1 ANLSGANLSGANLSGANLSGANLTGANLSGADLSGANL 38

KHA, dimerization domain of potassium ion channel, similar to doublecortin-like domain, found in potassium channel tetramerization domain containing 9 (KCTD9) and similar proteins; This family corresponds to KHA, the tetramerization domain of eukaryotic voltage-dependent potassium ion-channel proteins, mainly found in vertebrates KCTD9 and plants AKT proteins. In plants the domain lies at the C-terminus whereas in many chordates it lies at the N-terminus. KHA shows high sequence similarity with doublecortin-like domain, which has a stable ubiquitin-like tertiary fold. KCTD9, also termed BTB/POZ domain-containing protein 9, belongs to the KCTD protein family, which corresponds to potassium channel tetramerization domain proteins, a class of BTB-domain-containing proteins. It is involved in potassium channel formation. Moreover, KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus (HBV)-induced acute-on-chronic liver failure. AKT proteins play crucial roles in K+ uptake and translocation in plant cells.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217372360   2 RRVTLFLNGSPKNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFVCE 66
Cdd:cd17073     1 KRVTVFVNGSSSGGKVIALPSTLSELLKIASEKLGIPAKRLYTGSGGEIDDIALIRDDDVLYVSE 65

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  90 WLTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVL 169
Cdd:cd18389     2 WVRLNVGGTYFVSTKQTLC-RDPKSFLYRLCQEDPDLDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIINKELAEEGVL 80

                          90       100
                  ....*....|....*....|...
gi 2217372360 170 EEARFFGIDSLIEHLEVAIKNSQ 192
Cdd:cd18389    81 EEAEFYNIASLVRLVKERIRDNE 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  90 WLTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVL 169
Cdd:cd18390     6 WVRLNVGGTYFLTTRQTLC-RDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVL 84

                          90       100
                  ....*....|....*....|
gi 2217372360 170 EEARFFGIDSLIEHLEVAIK 189
Cdd:cd18390    85 EEAEFYNITSLIKLVKDKIR 104

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  91 LTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKDKGvwGNKQDHRGAFLIDRSPEYFEPILNYLRH-GQLIVNDGINLLGVL 169
Cdd:pfam02214   1 VKLNVGGTRFETLKSTL-TRFPDTRLGRLLELEC--DDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDEFL 77

                          90
                  ....*....|..
gi 2217372360 170 EEARFFGIDSLI 181
Cdd:pfam02214  78 EEAEFYGLDELA 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  91 LTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDgiNLLGVLE 170
Cdd:cd18366     6 VPLNVGGMHFTTRLSTLR-KYEDSMLAAMFS--GRHHIPKDSEGRYFIDRDGSYFGYILNFLRDGDLPPRE--RARAVYK 80

                          90
                  ....*....|..
gi 2217372360 171 EARFFGIDSLIE 182
Cdd:cd18366    81 EAQYYGIGPLIE 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  91 LTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKdKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLE 170
Cdd:cd18187     1 VVLNVSGTRFVTNRQTLT-RHPDTLLGRMFK-PGREFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISIPDLRE 78

                  ....*
gi 2217372360 171 EARFF 175
Cdd:cd18187    79 ECDFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  89 DWLTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGV 168
Cdd:cd18395     1 DPITLNVGGKLYTTSLATLT-RYPDSMLGAMFS--GKFPTKKDSQGNCFIDRDGKIFRYILNFLRTSHLDLPEDFQEMGL 77

                          90
                  ....*....|....*...
gi 2217372360 169 LE-EARFFGIDSLIEHLE 185
Cdd:cd18395    78 LKrEADFYQIQPLIEALQ 95

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360   90 WLTLNVGGRYFTTTRSTLvNKEPDSMLAhMFKDKGVwgnKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGiNLLGVL 169
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVL-AAHSPYFKA-LFSSDFK---ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-NVEELL 74

                           90       100
                   ....*....|....*....|..
gi 2217372360  170 EEARFFGIDSLIEHLEVAIKNS 191
Cdd:smart00225  75 ELADYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  89 DWLTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNdGINLLGV 168
Cdd:cd18393     2 EVIHLNVGGKRFSTSRQTL-TWIPDSFFSSLLS--GRISTLKDETGAIFIDRDPTVFAPILNFLRTKELDPR-GIHVSLL 77

                          90
                  ....*....|....*...
gi 2217372360 169 LEEARFFGIDSLIEHLEV 186
Cdd:cd18393    78 LHEAQFYGITPLVRRLQL 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  91 LTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKDKGVwgNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLE 170
Cdd:cd18364     2 VTLNVGGYLYITQRQTLT-KYPDSFLEGMVNGKIQ--CTVDADGNYFIDRDGLLFRHVLNFLRNGELLLPEGFQENQLLA 78

                  ....*...
gi 2217372360 171 -EARFFGI 177
Cdd:cd18364    79 lEADFYQL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  93 LNVGGRYFTTTRSTLvNKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNdgiNLLGVLEEA 172
Cdd:cd18371     6 LNVGGHIYTTTLSTL-RKFPGSKLAELFN--GQPKLRTDSEGRYFIDRDGTYFRYILEYLRTNQVPTQ---HIQEVYKEA 79

                          90
                  ....*....|...
gi 2217372360 173 RFFGIDSLIEHLE 185
Cdd:cd18371    80 LFYDIEPLVKLLE 92

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360 216 SELRCQGLNFSGADLSRLDLRYINFKMANLSRCNLAHANLCCANLERADLSGSVLDCANLQGVKMlcSNAEGASLKLCNF 295
Cdd:COG1357   100 SGANLRGANLSGANLSGADLSGADLSGANLSGADLSGANLSGANLSGADLSGADLSGANLSGANL--SGANLANLEGADL 177

                  .
gi 2217372360 296 E 296
Cdd:COG1357   178 K 178

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18); KCTD18 is a BTB/POZ domain-containing protein with with unknown biological function. A duplication of the KCTD18 gene has been found in a patient with epilepsy, developmental delay, and autistic behavior, which may contribute to the phenotype. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  89 DWLTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLrHGQL-IVNDGINLLG 167
Cdd:cd18372     1 DVLRLNVGGCIYTARRESLC-RFKDSMLSSMFS--GRFPLKLDESGACVIDRDGRLFKYLLDYL-HGELqIPEDEQTRLA 76

                          90       100
                  ....*....|....*....|
gi 2217372360 168 VLEEARFFGID---SLIEHL 184
Cdd:cd18372    77 LQEEADYFGIPypySLTDHL 96

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360 216 SELRCQGLNFSGADLSRL---DLRYINFKMANLSRCNLAHANLCCANLERADLSGSVLDCANLQGVKMLCSNAEGASLKL 292
Cdd:COG1357    72 SGANLTGADLSGANLANLsgaNLSGANLSGANLRGANLSGANLSGADLSGADLSGANLSGADLSGANLSGANLSGADLSG 151

                          90
                  ....*....|....*
gi 2217372360 293 CNFEDPSGLKANLEE 307
Cdd:COG1357   152 ADLSGANLSGANLSG 166

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360 224 NFSGADLSRLDLRYINFKMANLSRCNLAHANLCCANLERADLSGSVLDCANLQGVKMLCSNAEGASLKLCNFEDPSGLKA 303
Cdd:COG1357    88 NLSGANLSGANLSGANLRGANLSGANLSGADLSGADLSGANLSGADLSGANLSGANLSGADLSGADLSGANLSGANLSGA 167

                  ..
gi 2217372360 304 NL 305
Cdd:COG1357   168 NL 169

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  89 DWLTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKdkgvwGNKQDHR---GAFLIDRSPEYFEPILNYLRHGQLIVNDGI-N 164
Cdd:cd18375     1 ELVTLNVGGKKFTTRPSTL-RRFPDSRLARMLD-----GKDQDFKvvnGQFFVDRDGSLFSYILDYLRTGQLTLPTEFsD 74

                          90       100
                  ....*....|....*....|.
gi 2217372360 165 LLGVLEEARFFGIDSLIEHLE 185
Cdd:cd18375    75 YNRLAREAEFYGLYSLADLLS 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  93 LNVGGRYFTTTRSTLVnKEPDSMLAHMFKdkgvwGN--------KQdHrgaFLIDRSPEYFEPILNYLRHGQLIVNDGIN 164
Cdd:cd18361     3 IDVGGHIYTSSLETLT-KYPESRLGKLFN-----GSipivldslKQ-H---YFIDRDGKMFRHILNFLRTSKLLLPDDFT 72

                          90       100
                  ....*....|....*....|..
gi 2217372360 165 LL-GVLEEARFFGIDSLIEHLE 185
Cdd:cd18361    73 EFdLLYEEARYYELQPMVKQLE 94

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360 225 FSGADLSRLDLRYINFKMANLSRCNLAHANLCCANLERADLSGSVLDCANLQGVKMLcsNAEGASLKLCNFEDPSGLKAN 304
Cdd:COG1357    31 LSGANLSGANLSGANLTGANLSGADLSGADLSGANLSGADLSGANLTGADLSGANLA--NLSGANLSGANLSGANLRGAN 108

                  ....
gi 2217372360 305 LEEC 308
Cdd:COG1357   109 LSGA 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  93 LNVGGRYFTTTRSTLVNKepDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLG-VLEE 171
Cdd:cd18369     3 LNVGGSLHYTTIGTLTKQ--DTMLRAMFS--GRMEVLTDSEGWILIDRCGKHFGTILNYLRDGSVPLPESRRELAeLLAE 78

                          90
                  ....*....|.
gi 2217372360 172 ARFFGIDSLIE 182
Cdd:cd18369    79 AKYYLVQGLVE 89

type III secretion system effector PipB;

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217372360 224 NFSGADLSRLDLRYINFKMANLSRCNLAHANLCCANLERADLSGSVLDCANLQGVKMLCSNAEGASL 290
Cdd:PRK15197  165 DFQGEDLSDIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNL 231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  93 LNVGGRYFTTTRSTLVNKePDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGI-NLLGVLEE 171
Cdd:cd18396     8 LNVGGQVYVTKHSTLLSV-PDSTLASMFSRRAARELPRDNRGRFFIDRDGFLFRYVLDYLRDKQLALPDHFpEKERLLRE 86

                          90
                  ....*....|...
gi 2217372360 172 ARFFGIDSLIEHL 184
Cdd:cd18396    87 AEYFQLGDLVKLL 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  93 LNVGGRYFTTTRSTLVNKePDSMLAHMFKDKGVWGNK--QDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLE 170
Cdd:cd18398     7 LNVGGQVYFTRHATLVSI-PHSLLWKMFSPKRDTANDlaKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKGRLK 85

                          90
                  ....*....|....*
gi 2217372360 171 -EARFFGIDSLIEHL 184
Cdd:cd18398    86 rEAEYFQLPDLVKLL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 10 (KCTD10); KCTD10, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (BACURD3), is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. Furthermore, KCTD10 may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD10 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  88 TDWLTLNVGGRYFTTTRSTLVNKepDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQL-IVNDGINLL 166
Cdd:cd18399     6 SKYVKLNVGGALYYTTMQTLTKQ--DTMLKAMFS--GRMEVLTDSEGWILIDRCGKHFGTILNYLRDGAVpLPESRREIE 81

                          90       100
                  ....*....|....*....|....*....
gi 2217372360 167 GVLEEARFFGIDSLIEHLEVAIKNSQPPE 195
Cdd:cd18399    82 ELLAEAKYYLVQGLVEECQAALQNKDTYE 110

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217372360   2 RRVTLFLNGSPKNGKVVAV-----YGTLSDLLSVASSKLGI---KATSVYNGKGGLIDDIALIRDDDVLFVC 65
Cdd:cd01617     1 KRITVFRNGDKNFKGVKVLvkprrFRTFDQLLDELTEKLGLptgGVRKLYTPSGKLVKSLSDLEDGESYVVC 72

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  91 LTLNVGGRYFTTTRSTLvNKEPDSMLA----HMFKDkgvwgnkqDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLL 166
Cdd:cd18420    38 LIINVSGRRFETWRNTL-EKYPDTLLGsnerEFFYD--------EETKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLT 108

                          90
                  ....*....|.
gi 2217372360 167 GVLEEARFFGI 177
Cdd:cd18420   109 AYDEELAFFGI 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372360  93 LNVGGRYFTTTRSTLVnKEPDSMLAHMFK--DKGVWGNKQDHrgaFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVL- 169
Cdd:cd18388     6 IDVGGHMYTSSLATLT-KYPDSRISRLFNgtEPIVLDSLKQH---YFIDRDGEIFRYILSFLRTSKLLLPEDFKDFNLLy 81