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Conserved domains on  [gi|2130914321|ref|XP_044905679|]
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F-box/WD repeat-containing protein 12 isoform X4 [Felis catus]

Protein Classification

F-box/WD repeat-containing protein( domain architecture ID 18134528)

F-box/WD repeat-containing protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50|2.130.10.10
Gene Ontology:  GO:0019005|GO:0005515|GO:0016567|GO:0006511
PubMed:  31898225|11178263|30069656|29026209
SCOP:  4001927|4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
98-259 4.17e-05

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130914321  98 TVSSKHVLYAWDVQEGTMIWSSPVQQSSITHLATLPQMHLAFTVDLEGTVKVWNCQDQDALATF-----PVSQACFSlev 172
Cdd:COG2319   179 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLtghsgSVRSVAFS--- 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130914321 173 cltKDGPFLMVGNSEGDIYTLTVPELRGVSKVHAFKYTVDLLHCSPDKKWVfASGTHQNILpRVFFTEC--LLKPSEGKS 250
Cdd:COG2319   256 ---PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL-ASGSDDGTV-RLWDLATgkLLRTLTGHT 330


                  ....*....
gi 2130914321 251 PLSLSIPFS 259
Cdd:COG2319   331 GAVRSVAFS 339
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 5-23 1.60e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22137:

Pssm-ID: 459239  Cd Length: 44  Bit Score: 38.90  E-value: 1.60e-04
                          10
                  ....*....|....*....
gi 2130914321   5 VFQEWNRVAENDHLWRNLC 23
Cdd:cd22137    26 VNKQWNKVADSDYLWRNLC 44
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
98-259 4.17e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130914321  98 TVSSKHVLYAWDVQEGTMIWSSPVQQSSITHLATLPQMHLAFTVDLEGTVKVWNCQDQDALATF-----PVSQACFSlev 172
Cdd:COG2319   179 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLtghsgSVRSVAFS--- 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130914321 173 cltKDGPFLMVGNSEGDIYTLTVPELRGVSKVHAFKYTVDLLHCSPDKKWVfASGTHQNILpRVFFTEC--LLKPSEGKS 250
Cdd:COG2319   256 ---PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL-ASGSDDGTV-RLWDLATgkLLRTLTGHT 330


                  ....*....
gi 2130914321 251 PLSLSIPFS 259
Cdd:COG2319   331 GAVRSVAFS 339
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
 5-23 1.60e-04

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 38.90  E-value: 1.60e-04
                          10
                  ....*....|....*....
gi 2130914321   5 VFQEWNRVAENDHLWRNLC 23
Cdd:cd22137    26 VNKQWNKVADSDYLWRNLC 44
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
98-259 4.17e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130914321  98 TVSSKHVLYAWDVQEGTMIWSSPVQQSSITHLATLPQMHLAFTVDLEGTVKVWNCQDQDALATF-----PVSQACFSlev 172
Cdd:COG2319   179 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLtghsgSVRSVAFS--- 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130914321 173 cltKDGPFLMVGNSEGDIYTLTVPELRGVSKVHAFKYTVDLLHCSPDKKWVfASGTHQNILpRVFFTEC--LLKPSEGKS 250
Cdd:COG2319   256 ---PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL-ASGSDDGTV-RLWDLATgkLLRTLTGHT 330


                  ....*....
gi 2130914321 251 PLSLSIPFS 259
Cdd:COG2319   331 GAVRSVAFS 339
WD40 COG2319
WD40 repeat [General function prediction only];
98-227 1.53e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130914321  98 TVSSKHVLYAWDVQEGTMIWSSPVQQSSITHLATLPQMHLAFTVDLEGTVKVWNCQDQDALATF-----PVSQACFSlev 172
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtghtgAVRSVAFS--- 339

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2130914321 173 cltKDGPFLMVGNSEGDI--YTLTVPELRGVSKVHAfkYTVDLLHCSPDKKWVfASG 227
Cdd:COG2319   340 ---PDGKTLASGSDDGTVrlWDLATGELLRTLTGHT--GAVTSVAFSPDGRTL-ASG 390
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
 5-23 1.60e-04

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 38.90  E-value: 1.60e-04
                          10
                  ....*....|....*....
gi 2130914321   5 VFQEWNRVAENDHLWRNLC 23
Cdd:cd22137    26 VNKQWNKVADSDYLWRNLC 44
WD40 COG2319
WD40 repeat [General function prediction only];
98-227 4.38e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 4.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130914321  98 TVSSKHVLYAWDVQEGTMIWSSPVQQSSITHLATLPQMHLAFTVDLEGTVKVWNCQDQDALATF-----PVSQACFSlev 172
Cdd:COG2319    95 SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLtghsgAVTSVAFS--- 171

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2130914321 173 cltKDGPFLMVGNSEGDI--YTLTVPELRGVSKVHafKYTVDLLHCSPDKKWVfASG 227
Cdd:COG2319   172 ---PDGKLLASGSDDGTVrlWDLATGKLLRTLTGH--TGAVRSVAFSPDGKLL-ASG 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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