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Conserved domains on  [gi|2124533856|ref|XP_044632159|]
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natural cytotoxicity triggering receptor 3 isoform X2 [Equus asinus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 8-119 9.02e-84

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


:

Pssm-ID: 409520  Cd Length: 112  Bit Score: 243.73  E-value: 9.02e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856   8 ALWVAQPPEIRTQEGTTAFLPCSFNASQGRPAIGSVTWYRDKVAPGKEVKNGTPDFRGRLASLASSRFLCDHQAELHIWD 87
Cdd:cd20926     1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSRFLRDHQAELHIWD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2124533856  88 IRGRDAGVYVCRVEVLGLGVGTGNGTLLVVEK 119
Cdd:cd20926    81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
 
Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 8-119 9.02e-84

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 243.73  E-value: 9.02e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856   8 ALWVAQPPEIRTQEGTTAFLPCSFNASQGRPAIGSVTWYRDKVAPGKEVKNGTPDFRGRLASLASSRFLCDHQAELHIWD 87
Cdd:cd20926     1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSRFLRDHQAELHIWD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2124533856  88 IRGRDAGVYVCRVEVLGLGVGTGNGTLLVVEK 119
Cdd:cd20926    81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 13-117 1.78e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.53  E-value: 1.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856  13 QPPEIRTQEGTTAFLPCSFNASQGrPAIGSVTWYRDKVAPGKEV-------KNGTPDFRGRLASLASSRFlcdHQAELHI 85
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMS-EASTSVYWYRQPPGKGPTFliayysnGSEEGVKKGRFSGRGDPSN---GDGSLTI 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2124533856  86 WDIRGRDAGVYVCRVeVLGLGVGTGNGTLLVV 117
Cdd:pfam07686  78 QNLTLSDSGTYTCAV-IPSGEGVFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 14-116 3.50e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.34  E-value: 3.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856   14 PPEIRTQEGTTAFLPCSFNasqGRPAIgSVTWYRDKVAPGKEVKNGTPDFRGrlaslassrflcdHQAELHIWDIRGRDA 93
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS---GSPPP-EVTWYKQGGKLLAESGRFSVSRSG-------------STSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|...
gi 2124533856   94 GVYVCRVEVlGLGVGTGNGTLLV 116
Cdd:smart00410  64 GTYTCAATN-SSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 8-119 9.02e-84

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 243.73  E-value: 9.02e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856   8 ALWVAQPPEIRTQEGTTAFLPCSFNASQGRPAIGSVTWYRDKVAPGKEVKNGTPDFRGRLASLASSRFLCDHQAELHIWD 87
Cdd:cd20926     1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSRFLRDHQAELHIWD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2124533856  88 IRGRDAGVYVCRVEVLGLGVGTGNGTLLVVEK 119
Cdd:cd20926    81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 13-117 1.78e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.53  E-value: 1.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856  13 QPPEIRTQEGTTAFLPCSFNASQGrPAIGSVTWYRDKVAPGKEV-------KNGTPDFRGRLASLASSRFlcdHQAELHI 85
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMS-EASTSVYWYRQPPGKGPTFliayysnGSEEGVKKGRFSGRGDPSN---GDGSLTI 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2124533856  86 WDIRGRDAGVYVCRVeVLGLGVGTGNGTLLVV 117
Cdd:pfam07686  78 QNLTLSDSGTYTCAV-IPSGEGVFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 14-116 3.50e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.34  E-value: 3.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856   14 PPEIRTQEGTTAFLPCSFNasqGRPAIgSVTWYRDKVAPGKEVKNGTPDFRGrlaslassrflcdHQAELHIWDIRGRDA 93
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS---GSPPP-EVTWYKQGGKLLAESGRFSVSRSG-------------STSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|...
gi 2124533856   94 GVYVCRVEVlGLGVGTGNGTLLV 116
Cdd:smart00410  64 GTYTCAATN-SSGSASSGTTLTV 85
I-set pfam07679
Immunoglobulin I-set domain;
13-101 1.67e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 41.86  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856  13 QPPEIRTQEGTTAFLPCSFnasQGRPAIgSVTWYRDkvapGKEVKngtPDFRGRLASLASSrflcdhqAELHIWDIRGRD 92
Cdd:pfam07679   6 KPKDVEVQEGESARFTCTV---TGTPDP-EVSWFKD----GQPLR---SSDRFKVTYEGGT-------YTLTISNVQPDD 67


                  ....*....
gi 2124533856  93 AGVYVCRVE 101
Cdd:pfam07679  68 SGKYTCVAT 76
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 25-101 3.39e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 40.78  E-value: 3.39e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2124533856  25 AFLPCSFnasQGRPAIgSVTWYRDkvapGKEVKNGTPDFRGRLaslassrflcDHQAELHIWDIRGRDAGVYVCRVE 101
Cdd:cd00096     1 VTLTCSA---SGNPPP-TITWYKN----GKPLPPSSRDSRRSE----------LGNGTLTISNVTLEDSGTYTCVAS 59
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 14-116 1.16e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 40.12  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856  14 PPEIRTQEGTTAFLPCSFnASQGRPAIGSVTWYRDKVAPGKEVKNGTPDF--------RGRLASLASSRFLCDhqAELHI 85
Cdd:cd05718     6 PTEVTGFLGGSVTLPCSL-TSPGTTKITQVTWMKIGAGSSQNVAVFHPQYgpsvpnpyAERVEFLAARLGLRN--ATLRI 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2124533856  86 WDIRGRDAGVYVCRVEVLGLGVGTGNGTLLV 116
Cdd:cd05718    83 RNLRVEDEGNYICEFATFPQGNRQGTTWLRV 113
IgV_CTLA-4 cd05721
Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); ...
 11-117 1.60e-04

Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); The members here are composed of the variable(v)-type immunoglobulin (Ig) domain found in cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). CTLA-4 is involved in the regulation of T cell response, acting as an inhibitor of intracellular signaling. CTLA-4 is similar to CD28, a T cell co-receptor protein that recognizes the B7 proteins (CD80 and CD86). CD28 binding of the B7 proteins occurs after the presentation of antigen to the T cell receptor (TCR) via the peptide-MHC complex on the surface of an antigen presenting cell (APC). CTLA-4 also binds the B7 molecules with a higher affinity than does CD28. The B7/CTLA-4 interaction generates inhibitory signals down-regulating the response, and may prevent T cell activation by weak TCR signals. CD28 and CTLA-4 then elicit opposing signals in the regulation of T cell responsiveness and homeostasis. T cell activation leads to increased CTLA-4 gene expression and trafficking of CTLA-4 protein to the cell surface. CTLA-4 is not detected on the T-cell surface until 24 hours after activation. Covalent dimerization of CTLA-4 has been shown to be required for its high binding avidity, although each CTLA-4 monomer contains a binding site for CD80 and CD86.


Pssm-ID: 409386  Cd Length: 115  Bit Score: 39.98  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856  11 VAQPPEIRTQEGTTAFLPCSFnASQGRPAIGSVTWYRDKVAPGKEVKNGTPDFRGRLASLASSrfLC-----DHQAELHI 85
Cdd:cd05721     2 VAQPAVVLASSRGVASFVCEY-ASSGNATEVRVTVLRQADSQMTEVCAATYTMGNELTFLDDS--ICtgtssGNQVNLTI 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2124533856  86 WDIRGRDAGVYVCRVEVL---GLGVGTGNGTLLVV 117
Cdd:cd05721    79 QGLRAMDTGLYICKVELMyppPYYVGMGNGTQIYV 113
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 11-101 1.64e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.09  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856  11 VAQPPEIRTQEGTTAFLPCSfnaSQGRPAIgSVTWYrdkvapgkevKNGTPDFRGRLASLASSrflcDHQAELHIWDIRG 90
Cdd:pfam13927   5 TVSPSSVTVREGETVTLTCE---ATGSPPP-TITWY----------KNGEPISSGSTRSRSLS----GSNSTLTISNVTR 66

                          90
                  ....*....|.
gi 2124533856  91 RDAGVYVCRVE 101
Cdd:pfam13927  67 SDAGTYTCVAS 77
IGv smart00406
Immunoglobulin V-Type;
27-98 1.64e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 38.90  E-value: 1.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856   27 LPCSFnaSQGRPAIGSVTWYRdkVAPGKEVKN-----------GTPDFRGRLASLASSRflcDHQAELHIWDIRGRDAGV 95
Cdd:smart00406   4 LSCKF--SGSTFSSYYVSWVR--QPPGKGLEWlgyigsngssyYQESYKGRFTISKDTS---KNDVSLTISNLRVEDTGT 76


                   ...
gi 2124533856   96 YVC 98
Cdd:smart00406  77 YYC 79
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 11-118 2.76e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 39.18  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856  11 VAQPP-EIRTQEGTTAFLPCSFNASqgrpAIGSVTWYRDKvaPGKE-------VKNGTPDFRGRL-ASLASSRflcdHQA 81
Cdd:cd04983     1 VTQSPqSLSVQEGENVTLNCNYSTS----TFYYLFWYRQY--PGQGpqfliyiSSDSGNKKKGRFsATLDKSR----KSS 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2124533856  82 ELHIWDIRGRDAGVYVCRV-EVLGLGVGT-GNGTLLVVE 118
Cdd:cd04983    71 SLHISAAQLSDSAVYFCALsESGGTGKLTfGKGTRLTVE 109
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 14-100 2.81e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 38.72  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856  14 PPEIRTQEGTTAFLPCSfnASQGRPAIgSVTWYRDkvapGKEVKNGTPDFRGRLASlassrflcdHQAELHIWDIRGRDA 93
Cdd:pfam00047   3 PPTVTVLEGDSATLTCS--ASTGSPGP-DVTWSKE----GGTLIESLKVKHDNGRT---------TQSSLLISNVTKEDA 66


                  ....*..
gi 2124533856  94 GVYVCRV 100
Cdd:pfam00047  67 GTYTCVV 73
IgI_4_MYLK-like cd20976
Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a ...
 14-101 3.86e-04

Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain from smooth muscle myosin light chain kinase (MYLK) and similar domains. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of this group shows that the fourth Ig-like domain from myosin light chain kinase lacks this strand and thus belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409568 [Multi-domain]  Cd Length: 90  Bit Score: 38.39  E-value: 3.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856  14 PPEIRTQEGTTAFLPCSfnaSQGRPaIGSVTWYRDkvapgkevkngtpdfrGRLASLASSRFLCDHQ-AELHIWDIRGRD 92
Cdd:cd20976     8 PKDLEAVEGQDFVAQCS---ARGKP-VPRITWIRN----------------AQPLQYAADRSTCEAGvGELHIQDVLPED 67


                  ....*....
gi 2124533856  93 AGVYVCRVE 101
Cdd:cd20976    68 HGTYTCLAK 76
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 10-101 9.47e-04

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 37.75  E-value: 9.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856  10 WVAQPPEIRTQEGTTAFLPCSFNASQG----RPAIGsvTWYRDK--------VA---PGKEVKngtPDFRGRlaslasSR 74
Cdd:cd05712     2 GLQMPKSVTVQEGLCVLIPCSFSYPADywvsNPVHG--YWYRGGpypkyrppVAtnnRTREVH---ESTQGR------FR 70

                          90       100       110
                  ....*....|....*....|....*....|
gi 2124533856  75 FLCDHQAE---LHIWDIRGRDAGVYVCRVE 101
Cdd:cd05712    71 LLGDPGKKncsLSISDARPEDSGKYFFRVE 100
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 14-101 1.40e-03

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 37.17  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856  14 PPE-IRTQEGTTAFLPCSFNasqgrPAIGS----VTWYRDKVAP-------GKEVKNG-TPDFRGRlaslasSRFLCDHQ 80
Cdd:cd05713     6 PTEpILALVGEDAELPCHLS-----PKMSAehmeVRWFRSQFSPvvhlyrdGQDQEEEqMPEYRGR------TELLKDAI 74

                          90       100
                  ....*....|....*....|....*
gi 2124533856  81 AE----LHIWDIRGRDAGVYVCRVE 101
Cdd:cd05713    75 AEgsvaLRIHNVRPSDEGQYTCFFR 99
IgV_EVA1 cd05880
Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are ...
 11-101 1.89e-03

Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are composed of the immunoglobulin (Ig) domain of epithelial V-like antigen 1 (EVA 1). EVA is also known as myelin protein zero-like 2. EVA is an adhesion molecule and may play a role in the structural organization of the thymus and early lymphocyte development.


Pssm-ID: 409464  Cd Length: 116  Bit Score: 36.73  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124533856  11 VAQPPEIRTQEGTTAFLPCSFNASQGRPAIGSVTWYRDKVAPGKE------VKNGTPDFRGRLASLAS-SRFLCDHQAEL 83
Cdd:cd05880     3 VYTSKEVEAVNGTDVRLKCTFSSSAPIGDTLVITWNFRPLDGGREesvfyyHKRPYPPPDGRFKGRVVwDGNIMRRDASI 82

                          90
                  ....*....|....*...
gi 2124533856  84 HIWDIRGRDAGVYVCRVE 101
Cdd:cd05880    83 LIWQLQPTDNGTYTCQVK 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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