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Conserved domains on  [gi|2118853849|ref|XP_044512463|]
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cyclin-D1-1-like [Mangifera indica]

Protein Classification

cyclin-D( domain architecture ID 15334368)

cyclin-D such the G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 76-173 2.02e-44

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410246  Cd Length: 99  Bit Score: 146.31  E-value: 2.02e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  76 ARLDAVKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLP-GKEWHWRLLSAACLSLAAKMEETNVPLLLDLQIIEPRFL 154
Cdd:cd20543     1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPkDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                          90
                  ....*....|....*....
gi 2118853849 155 FKPKTVQQMELLVGGSLKW 173
Cdd:cd20543    81 FEAKTIQRMELLVLSTLEW 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 178-268 6.53e-14

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410247  Cd Length: 90  Bit Score: 66.18  E-value: 6.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849 178 TTPFDFLHYFISKVSyflspqHSNGLSCVFSAASDIIISTSRVIDLFDYPPSAIAAAVVLWVTNQ--PVDDGKLEC---L 252
Cdd:cd20544     1 VTPFSFLDYFISKIG------LSDSREELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDElpPDDADDASSrlsL 74

                          90
                  ....*....|....*.
gi 2118853849 253 HKRLNKDMVKRCYSLV 268
Cdd:cd20544    75 LLSPNKEKVKKCYELM 90
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 76-173 2.02e-44

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 146.31  E-value: 2.02e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  76 ARLDAVKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLP-GKEWHWRLLSAACLSLAAKMEETNVPLLLDLQIIEPRFL 154
Cdd:cd20543     1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPkDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                          90
                  ....*....|....*....
gi 2118853849 155 FKPKTVQQMELLVGGSLKW 173
Cdd:cd20543    81 FEAKTIQRMELLVLSTLEW 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 77-176 7.34e-27

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 101.82  E-value: 7.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  77 RLDAVKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKEWHwrLLSAACLSLAAKMEETNVPLLLDLQIIEPRfLFK 156
Cdd:pfam00134  31 RAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQ--LVGVTCLFIAAKYEEIYPPTVEDLVYITDN-AYT 107

                          90       100
                  ....*....|....*....|
gi 2118853849 157 PKTVQQMELLVGGSLKWRLR 176
Cdd:pfam00134 108 REEILRMERLILETLNFDLS 127
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 82-167 6.61e-15

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 68.39  E-value: 6.61e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849   82 KWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPgkEWHWRLLSAACLSLAAKMEETNVPLLLDLQIIeprFLFKPKTVQ 161
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFL--KYSPSLIAAAALYLASKTEETPPWTKELVHYT---GYFTEEEIL 75


                   ....*.
gi 2118853849  162 QMELLV 167
Cdd:smart00385  76 RMERLL 81
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 178-268 6.53e-14

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 66.18  E-value: 6.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849 178 TTPFDFLHYFISKVSyflspqHSNGLSCVFSAASDIIISTSRVIDLFDYPPSAIAAAVVLWVTNQ--PVDDGKLEC---L 252
Cdd:cd20544     1 VTPFSFLDYFISKIG------LSDSREELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDElpPDDADDASSrlsL 74

                          90
                  ....*....|....*.
gi 2118853849 253 HKRLNKDMVKRCYSLV 268
Cdd:cd20544    75 LLSPNKEKVKKCYELM 90
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
81-236 2.65e-08

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 54.40  E-value: 2.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  81 VKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKewHWRLLSAACLSLAAKMEETNVPLLLDLQIIEPRfLFKPKTV 160
Cdd:COG5024   217 VDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLE--KYQLVGISALFIASKYEEVNCPSIKDLVYATDG-AFTRDDI 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849 161 QQMELLVGGSLKWRLRTTTPFDFLHYfISKVSyflspqhsnglscVFSAASDIIISTSRVIDLFDY-----PPSAIAAAV 235
Cdd:COG5024   294 IRAERYMLEVLDFNISWPSPMSFLRR-ISKAS-------------DYDIFSRTPAKFSSEISPVDYkfiqiSPSWCAAAA 359


                  .
gi 2118853849 236 V 236
Cdd:COG5024   360 M 360
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 104-237 6.31e-05

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 43.67  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849 104 YLDRFILSHNLpgKEWHWRLLSAACLSLAAKMEETNVPLLLDLQIIEPRFLFKPKTVQQMELLVGGSLKWRLRTTTPFDF 183
Cdd:TIGR00569  85 YFKRFYLNNSV--MEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLKETPLKALEQVLEYELLLIQQLNFHLIVHNPYRP 162

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2118853849 184 LHYF---ISKVSYFLspQHSNGLSCVfsaASDIIISTSRVIDLFDYPPSAIAAAVVL 237
Cdd:TIGR00569 163 LEGFlidIKTRLPGL--ENPEYLRKH---ADKFLNRTLLTDAYLLYTPSQIALAAIL 214
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 76-173 2.02e-44

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 146.31  E-value: 2.02e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  76 ARLDAVKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLP-GKEWHWRLLSAACLSLAAKMEETNVPLLLDLQIIEPRFL 154
Cdd:cd20543     1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPkDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                          90
                  ....*....|....*....
gi 2118853849 155 FKPKTVQQMELLVGGSLKW 173
Cdd:cd20543    81 FEAKTIQRMELLVLSTLEW 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 77-176 7.34e-27

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 101.82  E-value: 7.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  77 RLDAVKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKEWHwrLLSAACLSLAAKMEETNVPLLLDLQIIEPRfLFK 156
Cdd:pfam00134  31 RAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQ--LVGVTCLFIAAKYEEIYPPTVEDLVYITDN-AYT 107

                          90       100
                  ....*....|....*....|
gi 2118853849 157 PKTVQQMELLVGGSLKWRLR 176
Cdd:pfam00134 108 REEILRMERLILETLNFDLS 127
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 82-167 6.61e-15

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 68.39  E-value: 6.61e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849   82 KWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPgkEWHWRLLSAACLSLAAKMEETNVPLLLDLQIIeprFLFKPKTVQ 161
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFL--KYSPSLIAAAALYLASKTEETPPWTKELVHYT---GYFTEEEIL 75


                   ....*.
gi 2118853849  162 QMELLV 167
Cdd:smart00385  76 RMERLL 81
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 178-268 6.53e-14

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 66.18  E-value: 6.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849 178 TTPFDFLHYFISKVSyflspqHSNGLSCVFSAASDIIISTSRVIDLFDYPPSAIAAAVVLWVTNQ--PVDDGKLEC---L 252
Cdd:cd20544     1 VTPFSFLDYFISKIG------LSDSREELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDElpPDDADDASSrlsL 74

                          90
                  ....*....|....*.
gi 2118853849 253 HKRLNKDMVKRCYSLV 268
Cdd:cd20544    75 LLSPNKEKVKKCYELM 90
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 83-173 1.64e-13

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 66.94  E-value: 1.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  83 WMLKVHSHHRFQPETAYLSVNYLDRFILShnLPGKEWHWRLLSAACLSLAAKMEETnVPLLLDLQIIEPRFLFKPKTVQQ 162
Cdd:cd20574    62 WMLEVCEEQKCEEEVFPLAMNYLDRFLAV--VPTRKCHLQLLGAVCMFLASKLKET-IPLTAEKLCIYTDNSIKPQELLE 138

                          90
                  ....*....|.
gi 2118853849 163 MELLVGGSLKW 173
Cdd:cd20574   139 WELVVLGKLKW 149
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 83-173 2.65e-13

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 66.16  E-value: 2.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  83 WMLKVHSHHRFQPETAYLSVNYLDRFILSHnlPGKEWHWRLLSAACLSLAAKMEETnVPLLLDLQIIEPRFLFKPKTVQQ 162
Cdd:cd20573    61 WMLEVCEEQKCEEEVFPLAMNYLDRFLSVE--PTKKSRLQLLGATCMFLASKMKET-IPLTAEKLCIYTDNSIRPEELLQ 137

                          90
                  ....*....|.
gi 2118853849 163 MELLVGGSLKW 173
Cdd:cd20573   138 MELLVLNKLKW 148
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 81-173 8.39e-13

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 63.39  E-value: 8.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  81 VKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPgkEWHWRLLSAACLSLAAKMEE--TNVPLLLDLQIIEPRFLFKPK 158
Cdd:cd20528    11 VDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDIS--EDQLHLVALTCLLLAAKFEEldDNIPKISDLNRYLCNSVYSKQ 88

                          90
                  ....*....|....*
gi 2118853849 159 TVQQMELLVGGSLKW 173
Cdd:cd20528    89 EYLQMELLILEFFQW 103
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 83-173 2.21e-12

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 63.47  E-value: 2.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  83 WMLKVHSHHRFQPETAYLSVNYLDRFILSHNLpgKEWHWRLLSAACLSLAAKMEETnVPLLLDLQIIEPRFLFKPKTVQQ 162
Cdd:cd20515    62 WMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPI--RKSQLQLLGAVCLFLASKLKET-IPLTAEKLCIYTDNSITLQELLD 138

                          90
                  ....*....|.
gi 2118853849 163 MELLVGGSLKW 173
Cdd:cd20515   139 WELLVLTKLKW 149
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 83-173 1.00e-11

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 61.93  E-value: 1.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  83 WMLKVHSHHRFQPETAYLSVNYLDRFILShnLPGKEWHWRLLSAACLSLAAKMEETnVPLLLDLQIIEPRFLFKPKTVQQ 162
Cdd:cd20575    62 WMLEVCEEQKCEEEVFPLAMNYVDRYLSC--VPTRKAQLQLLGAVCMLLASKLRET-TPLTIEKLCIYTDNSISPRQLLD 138

                          90
                  ....*....|.
gi 2118853849 163 MELLVGGSLKW 173
Cdd:cd20575   139 WEILVLGKLKW 149
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 77-175 1.76e-10

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 56.94  E-value: 1.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  77 RLDAVKWMLKVHSHHRFQPETAYLSVNYLDRFILShnLPGKEWHWRLLSAACLSLAAKM--EETNVPLLLDLqIIEPRFL 154
Cdd:cd20526     2 RDEAVRWLAELNSQFKFYPETFALAVSILDRFLAS--VKARPKYLRCIAISCLFLAAKTneEDEVIPSTKDL-VRVSKCG 78

                          90       100
                  ....*....|....*....|.
gi 2118853849 155 FKPKTVQQMELLVGGSLKWRL 175
Cdd:cd20526    79 CSVAEVLRMERIILDKLHWDL 99
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 81-175 3.67e-10

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 55.79  E-value: 3.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  81 VKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKEwhWRLLSAACLSLAAKMEETNVPllldlqiiEPRFL------ 154
Cdd:cd20542     5 VDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSL--LQLLGITCLFIACKFEERFPP--------EVATLcyltdd 74

                          90       100
                  ....*....|....*....|..
gi 2118853849 155 -FKPKTVQQMELLVGGSLKWRL 175
Cdd:cd20542    75 sYSKKQVLRMERRVLRRLRFDL 96
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 81-141 2.66e-09

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 54.18  E-value: 2.66e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2118853849  81 VKWMLKVHSHHRFQPETAYLSVNYLDRFiLSHN--LPGKewhWRLLSAACLSLAAKMEETNVP 141
Cdd:cd20504    39 VDWLVEVAEEYKLVPETLYLAVNYIDRF-LSQMsvLRSK---LQLVGTACMFIAAKYEEIYPP 97
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 79-166 3.63e-09

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 52.80  E-value: 3.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  79 DAVKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKewHWRLLSAACLSLAAKMEETNVPllldLQIIEPRFLFKPK 158
Cdd:cd00043     1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGR--SPELIAAACLYLACKLEELPRT----LKEIAKVSGVSEK 74


                  ....*...
gi 2118853849 159 TVQQMELL 166
Cdd:cd00043    75 ELRKAEKE 82
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 81-141 6.57e-09

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 53.57  E-value: 6.57e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2118853849  81 VKWMLKVHSHHRFQPETAYLSVNYLDRFiLSHNLPGKEWhWRLLSAACLSLAAKMEETNVP 141
Cdd:cd20562    46 VDWLVEVAEEYKLVPDTLYLTVSYIDRF-LSGNYVNRQR-LQLLGVSCMLIASKYEEICAP 104
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 69-167 8.36e-09

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 53.14  E-value: 8.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  69 KIPGII-TARLDAVKWMLKVHSHHRFQPETAYLSVNYLDRFILSHN-LPGKewhWRLLSAACLSLAAKMEETNVPLLLDL 146
Cdd:cd20561    28 KQPDITnSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSvLRGK---LQLVGTAAMLLASKFEEIYPPEVAEF 104

                          90       100
                  ....*....|....*....|.
gi 2118853849 147 QIIEPRfLFKPKTVQQMELLV 167
Cdd:cd20561   105 VYITDD-TYTKKQVLRMEHLV 124
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 81-173 8.76e-09

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 53.50  E-value: 8.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  81 VKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKEwhWRLLSAACLSLAAKMEETNVPLLLDLQIIEPRfLFKPKTV 160
Cdd:cd20567    58 IDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKE--LQLVGVTAMLIASKYEEIWAPEVNDFVYISDN-AYTRKQI 134

                          90
                  ....*....|...
gi 2118853849 161 QQMELLVGGSLKW 173
Cdd:cd20567   135 LVMEKTMLNTLEF 147
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 81-141 9.26e-09

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 53.07  E-value: 9.26e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2118853849  81 VKWMLKVHSHHRFQPETAYLSVNYLDRFiLSHNLP--GKewhWRLLSAACLSLAAKMEETNVP 141
Cdd:cd20568    45 VDWLVEVHEKFRLLPETLFLAVNIIDRF-LSKRVVslNK---LQLVGISALFIASKYEEVNSP 103
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 74-146 1.20e-08

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 52.53  E-value: 1.20e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2118853849  74 ITARLDA--VKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKEWHwrLLSAACLSLAAKMEETNVPLLLDL 146
Cdd:cd20507    32 ITERMRAilVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQ--LVGVTALLIASKYEEIYPPEIKDF 104
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 81-149 2.53e-08

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 50.79  E-value: 2.53e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2118853849  81 VKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKEwhWRLLSAACLSLAAKMEETNVPLLLDLQII 149
Cdd:cd20536     6 ISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDC--FQLLGVTSLLIACKQEEIYPPEVKDLLAL 72
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
81-236 2.65e-08

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 54.40  E-value: 2.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  81 VKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKewHWRLLSAACLSLAAKMEETNVPLLLDLQIIEPRfLFKPKTV 160
Cdd:COG5024   217 VDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLE--KYQLVGISALFIASKYEEVNCPSIKDLVYATDG-AFTRDDI 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849 161 QQMELLVGGSLKWRLRTTTPFDFLHYfISKVSyflspqhsnglscVFSAASDIIISTSRVIDLFDY-----PPSAIAAAV 235
Cdd:COG5024   294 IRAERYMLEVLDFNISWPSPMSFLRR-ISKAS-------------DYDIFSRTPAKFSSEISPVDYkfiqiSPSWCAAAA 359


                  .
gi 2118853849 236 V 236
Cdd:COG5024   360 M 360
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 74-167 1.82e-07

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 49.48  E-value: 1.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  74 ITARLDA--VKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKEwhWRLLSAACLSLAAKMEETNVPLLLDLQIIEP 151
Cdd:cd20566    35 INERMRAilVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKK--LQLVGVTALLLASKYEEMYSPEIGDFVYITD 112

                          90
                  ....*....|....*.
gi 2118853849 152 RfLFKPKTVQQMELLV 167
Cdd:cd20566   113 N-AYTKAQIREMEMLI 127
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 83-173 2.42e-07

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 48.85  E-value: 2.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  83 WMLKVHSHHRFQPETAYLSVNYLDRFI-LSHNLPgKEwHWRLLSAACLSLAAKMEETNVPLLLD-----------LQIIE 150
Cdd:cd20519    43 WLMEVCEVYRLHRETFYLAVDFVDRYLsTQTNVP-KT-QLQLIGITCLFIAAKLEEIYPPKLSEfayvtdgacteDEILT 120

                          90       100
                  ....*....|....*....|...
gi 2118853849 151 prflfkpktvqqMELLVGGSLKW 173
Cdd:cd20519   121 ------------MELIILKALNW 131
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 69-141 1.89e-06

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 47.14  E-value: 1.89e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2118853849  69 KIPGIITA-RLDAVKWMLKVHSHHRFQPETAYLSVNYLDRFILSHN-LPGKewhWRLLSAACLSLAAKMEETNVP 141
Cdd:cd20560    60 KQPDITTGmRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSvLRGK---LQLVGTAAILLASKYEEIYPP 131
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 81-174 2.52e-06

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 45.07  E-value: 2.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  81 VKWMLKVHSHHRFQPETAYLSVNYLDRFilSHNLPGKEWHWRLLSAACLSLAAKMEETN--VPLLLDLQII------EPR 152
Cdd:cd20559     3 LDFLFELHVELRLSPQTFFLSVNLIDRY--CSKRIVLKKHYQLVGCTCLWIASKFWESKarVPLLSELSKMccnsygEEL 80

                          90       100
                  ....*....|....*....|..
gi 2118853849 153 FLfkpktvqQMELLVGGSLKWR 174
Cdd:cd20559    81 FI-------QMEMHILNTLNWD 95
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 82-238 3.11e-06

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 47.80  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  82 KWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLpgKEWHWRLLSAACLSLAAKMEETNVPLLLDLQIIEPRFLFKPKT-- 159
Cdd:COG5333    50 KLIMDLCTRLNLPQTVLATAILFFSRFYLKNSV--EEISLYSVVTTCVYLACKVEDTPRDISIESFEARDLWSEEPKSsr 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849 160 --VQQMELLVGGSLKWRLRTTTPFDFLHYFISKvsyflspQHSNGLSCVFSAASDIIISTSRVIDLFDYPPSAIAAAVVL 237
Cdd:COG5333   128 erILEYEFELLEALDFDLHVHHPYKYLEGFLKD-------LQEKDKYKLLQIAWKIINDALRTDLCLLYPPHIIALAALL 200


                  .
gi 2118853849 238 W 238
Cdd:COG5333   201 I 201
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 74-173 5.85e-06

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 44.87  E-value: 5.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  74 ITARLDAV--KWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKEwhWRLLSAACLSLAAKMEETNVPLLLDLQIIEP 151
Cdd:cd20565    31 VTGNMRAIliDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKM--LQLVGVTAMFIASKYEEMYPPEIGDFAFVTD 108

                          90       100
                  ....*....|....*....|..
gi 2118853849 152 RfLFKPKTVQQMELLVGGSLKW 173
Cdd:cd20565   109 N-TYTKHQIRQMEMKILRALDF 129
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 104-237 6.31e-05

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 43.67  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849 104 YLDRFILSHNLpgKEWHWRLLSAACLSLAAKMEETNVPLLLDLQIIEPRFLFKPKTVQQMELLVGGSLKWRLRTTTPFDF 183
Cdd:TIGR00569  85 YFKRFYLNNSV--MEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLKETPLKALEQVLEYELLLIQQLNFHLIVHNPYRP 162

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2118853849 184 LHYF---ISKVSYFLspQHSNGLSCVfsaASDIIISTSRVIDLFDYPPSAIAAAVVL 237
Cdd:TIGR00569 163 LEGFlidIKTRLPGL--ENPEYLRKH---ADKFLNRTLLTDAYLLYTPSQIALAAIL 214
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 84-175 3.66e-04

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 40.27  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  84 MLKVHSHHRFQPETAYLSVNYLDRFILSHNLpgKEWHWRLLSAACLSLAAKMEETNVPLLLDLQIIEPRFLFkPKTVQQM 163
Cdd:cd20524    62 LLEFCRAFKLPDSVLATALTYFKRFYLKNSV--MEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESEKT-AEIILEY 138

                          90
                  ....*....|..
gi 2118853849 164 ELLVGGSLKWRL 175
Cdd:cd20524   139 ELLLLQGLNFHL 150
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 58-173 4.40e-04

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 39.86  E-value: 4.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  58 MQGHELLAkhgkiPGIITARLDavkWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKEwHWRLLSAACLSLAAKMEE 137
Cdd:cd20579    32 LQKHPLLQ-----PKMRAILLD---WLMEVCEVYKLHRETFYLAQDFFDRFMATQENVVKT-RLQLIGISSLFIAAKLEE 102

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2118853849 138 TNVPLLLDLQIIEPRFLFKPKtVQQMELLVGGSLKW 173
Cdd:cd20579   103 IYPPKLHQFAYVTDGACTEDE-ILSMELIIMKALKW 137
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 77-146 5.77e-04

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 38.49  E-value: 5.77e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2118853849  77 RLDAVKWMLKVHSHHRFQPETAYLSVNYLDRFIlsHNLPGKEWHWRLLSAACLSLAAKM--EETNVPLLLDL 146
Cdd:cd20523     1 RDAAVDRLRCLHRFYGFSPETFALAVNLLDRFL--SKVKVKPKHLACITVSCFHIAIKSveEDQNIPSAEDL 70
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 81-174 9.47e-04

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 37.88  E-value: 9.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  81 VKWMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKewHWRLLSAACLSLAAKM--EETNVPLLLDLQIIEpRFLFKPK 158
Cdd:cd20583     6 VKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPK--HLGCVGLSCFYLAVKAieEERNVPLATDLIRIS-QYRFTVS 82

                          90
                  ....*....|....*.
gi 2118853849 159 TVQQMELLVGGSLKWR 174
Cdd:cd20583    83 DMMRMEKIILEKLCWK 98
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 83-173 1.42e-03

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 38.29  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  83 WMLKVHSHHRFQPETAYLSVNYLDRFILSHNLPGKEwHWRLLSAACLSLAAKMEETNVPLLLDLQIIEPRFLFKPKTVqQ 162
Cdd:cd20580    49 WLLEVCEVYTLHRETFYLAQDFFDRFMLTQKNINKS-MLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDIL-D 126

                          90
                  ....*....|.
gi 2118853849 163 MELLVGGSLKW 173
Cdd:cd20580   127 MELIILKALKW 137
CYCLIN_ScCTK2-like_rpt1 cd20547
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ...
 77-138 3.30e-03

first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410250 [Multi-domain]  Cd Length: 110  Bit Score: 36.55  E-value: 3.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2118853849  77 RLDAVKWMLKVHSHHRFQPETAYLSVNYLDRFILSHnlPGKEWHWRLLSAACLSLAAKMEET 138
Cdd:cd20547     2 RLAAFQFISQLCKKLKFPRRTLGTAMLLYQRFHLFN--PFTDSSNYEVALACLFLASKIEDT 61
CYCLIN_CABLES cd20556
cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes ...
 84-179 4.67e-03

cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes CABLES1 and CABLES2. CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. Both, CABLES1 and CABLES2, contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410259  Cd Length: 119  Bit Score: 36.39  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2118853849  84 MLKV-HSHHRFQPETAYLSVNYLDRFILShNLPGKEwHWRLLSAACLSLAAKMEE----TNVPLLLDLqiIEPRFLFKPK 158
Cdd:cd20556    13 MLKIaLKLCGLDVSTVALAYVYFEKLVLK-GLVNKS-NRKLIAGACLLLAAKFNDdvkkEDLKSLLEE--IEDVFRLTRK 88

                          90       100
                  ....*....|....*....|.
gi 2118853849 159 TVQQMELLVGGSLKWRLRTTT 179
Cdd:cd20556    89 ELIAFEFPVLVALEFSLHVPD 109
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 81-146 5.46e-03

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 36.46  E-value: 5.46e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2118853849  81 VKWMLKVHSHHRFQPETAYLSVNYLDRFiLSHNLPGKEwHWRLLSAACLSLAAKMEETNVPLLLDL 146
Cdd:cd20508    52 VDWLVEVQENFELNHETLYLAVKLVDLY-LSKKVVKKE-KLQLLGATAILIASKFDERCPPCVDDF 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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