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Conserved domains on  [gi|2052811266|ref|XP_041935327|]
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transcription factor EC isoform X4 [Alosa sapidissima]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bHLHzip_TFEC cd18925
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and ...
 207-291 5.03e-54

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and similar proteins; TFEC, also termed Class E basic helix-loop-helix protein 34 (bHLHe34), or transcription factor EC-like (TFEC-L), is a bHLHzip transcriptional regulator that acts as a repressor or an activator and regulates gene expression in macrophages. It plays an important role in the niche to expand hematopoietic progenitors through the modulation of several cytokines.


:

Pssm-ID: 381495  Cd Length: 85  Bit Score: 175.27  E-value: 5.03e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 207 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQHARELESRQKKLEQANRR 286
Cdd:cd18925     1 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRR 80


                  ....*
gi 2052811266 287 LLLRI 291
Cdd:cd18925    81 LLLRI 85
DUF3371 pfam11851
Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain ...
 296-447 3.87e-23

Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.


:

Pssm-ID: 463372  Cd Length: 128  Bit Score: 94.40  E-value: 3.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 296 IQARAHGLPSMATS-LGPVELSNHLLKQQqhqpqgpqqpplypdelnggaeylprtPIMGAQPGGAAAVATSGGATSGMP 374
Cdd:pfam11851   1 MQARAHGLPVASSSgLCTAELAARVIKQE---------------------------PALPPCPPDLYDMSQPQPPTQAAV 53

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2052811266 375 SVPSSGatggagEPGDGSTTFSdplshFTDF---FSATLKEEHRLEEILMDDPLSPFG-TDPLLSAASPDASKGSSH 447
Cdd:pfam11851  54 SSSSTL------DLNDGLITFS-----FGDLsasFSDALKPGSKLDDILMDDTLSPLGpSDPLLSAMSPDASKDSSR 119
MITF_TFEB_C_3_N super family cl24504
MITF/TFEB/TFEC/TFE3 N-terminus; This domain is found at the N-terminus of several ...
 53-184 5.19e-07

MITF/TFEB/TFEC/TFE3 N-terminus; This domain is found at the N-terminus of several transcription factors including microphthalmia-associated transcription factor, transcription factor EB, transcription factor EC and transcription factor E3.


The actual alignment was detected with superfamily member pfam15951:

Pssm-ID: 464952  Cd Length: 151  Bit Score: 48.97  E-value: 5.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266  53 QLKQEPEDQNQNYQTHQNQSEWGHTGHPWFQAAHTGTYG---HNQLPATWPTS-WQVQSHIENP-KYHLHQAQAQ----Y 123
Cdd:pfam15951   6 QQLMREQAQQEEQREQQQQQQNHQYMQPAPPPSSTPAISvpqSPPSPAQVPVEvLKVQTHLENPtKYHIQQAQRQqvkqY 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2052811266 124 L--TLSSKLAGQAHPGPHPHAGQP-LGTVPVMRNGHMPPQgdGSTPGSPIHLLTLAtSSHDSEV 184
Cdd:pfam15951  86 LstTYGAKQALIPSASPPPPAQSPpPRTSPLMRGNQLPPG--NSAPNSPMAMLSIG-SSEEKEI 146
 
Name Accession Description Interval E-value
bHLHzip_TFEC cd18925
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and ...
 207-291 5.03e-54

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and similar proteins; TFEC, also termed Class E basic helix-loop-helix protein 34 (bHLHe34), or transcription factor EC-like (TFEC-L), is a bHLHzip transcriptional regulator that acts as a repressor or an activator and regulates gene expression in macrophages. It plays an important role in the niche to expand hematopoietic progenitors through the modulation of several cytokines.


Pssm-ID: 381495  Cd Length: 85  Bit Score: 175.27  E-value: 5.03e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 207 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQHARELESRQKKLEQANRR 286
Cdd:cd18925     1 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRR 80


                  ....*
gi 2052811266 287 LLLRI 291
Cdd:cd18925    81 LLLRI 85
DUF3371 pfam11851
Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain ...
 296-447 3.87e-23

Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.


Pssm-ID: 463372  Cd Length: 128  Bit Score: 94.40  E-value: 3.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 296 IQARAHGLPSMATS-LGPVELSNHLLKQQqhqpqgpqqpplypdelnggaeylprtPIMGAQPGGAAAVATSGGATSGMP 374
Cdd:pfam11851   1 MQARAHGLPVASSSgLCTAELAARVIKQE---------------------------PALPPCPPDLYDMSQPQPPTQAAV 53

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2052811266 375 SVPSSGatggagEPGDGSTTFSdplshFTDF---FSATLKEEHRLEEILMDDPLSPFG-TDPLLSAASPDASKGSSH 447
Cdd:pfam11851  54 SSSSTL------DLNDGLITFS-----FGDLsasFSDALKPGSKLDDILMDDTLSPLGpSDPLLSAMSPDASKDSSR 119
MITF_TFEB_C_3_N pfam15951
MITF/TFEB/TFEC/TFE3 N-terminus; This domain is found at the N-terminus of several ...
 53-184 5.19e-07

MITF/TFEB/TFEC/TFE3 N-terminus; This domain is found at the N-terminus of several transcription factors including microphthalmia-associated transcription factor, transcription factor EB, transcription factor EC and transcription factor E3.


Pssm-ID: 464952  Cd Length: 151  Bit Score: 48.97  E-value: 5.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266  53 QLKQEPEDQNQNYQTHQNQSEWGHTGHPWFQAAHTGTYG---HNQLPATWPTS-WQVQSHIENP-KYHLHQAQAQ----Y 123
Cdd:pfam15951   6 QQLMREQAQQEEQREQQQQQQNHQYMQPAPPPSSTPAISvpqSPPSPAQVPVEvLKVQTHLENPtKYHIQQAQRQqvkqY 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2052811266 124 L--TLSSKLAGQAHPGPHPHAGQP-LGTVPVMRNGHMPPQgdGSTPGSPIHLLTLAtSSHDSEV 184
Cdd:pfam15951  86 LstTYGAKQALIPSASPPPPAQSPpPRTSPLMRGNQLPPG--NSAPNSPMAMLSIG-SSEEKEI 146
HLH smart00353
helix loop helix domain;
216-268 2.56e-03

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 36.04  E-value: 2.56e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2052811266  216 NLIERRRRYNINYRIKELGTLIPkSNDPDMRWNKGTILKASVEYIKWLQKEQQ 268
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLP-TLPKNKKLSKAEILRLAIEYIKSLQEELQ 52
 
Name Accession Description Interval E-value
bHLHzip_TFEC cd18925
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and ...
 207-291 5.03e-54

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and similar proteins; TFEC, also termed Class E basic helix-loop-helix protein 34 (bHLHe34), or transcription factor EC-like (TFEC-L), is a bHLHzip transcriptional regulator that acts as a repressor or an activator and regulates gene expression in macrophages. It plays an important role in the niche to expand hematopoietic progenitors through the modulation of several cytokines.


Pssm-ID: 381495  Cd Length: 85  Bit Score: 175.27  E-value: 5.03e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 207 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQHARELESRQKKLEQANRR 286
Cdd:cd18925     1 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRR 80


                  ....*
gi 2052811266 287 LLLRI 291
Cdd:cd18925    81 LLLRI 85
bHLHzip_MITF cd18926
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated ...
 199-302 4.55e-50

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins; MITF, also termed Class E basic helix-loop-helix protein 32 (bHLHe32), is a bHLHzip transcription factor that is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. It regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. It binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR).


Pssm-ID: 381496  Cd Length: 104  Bit Score: 165.64  E-value: 4.55e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 199 EHDTRVMAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQHARELESRQK 278
Cdd:cd18926     1 ESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQK 80

                          90       100
                  ....*....|....*....|....
gi 2052811266 279 KLEQANRRLLLRIQELEIQARAHG 302
Cdd:cd18926    81 KLEHANRHLLLRIQELEMQARAHG 104
bHLHzip_TFE3 cd18928
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and ...
 201-291 4.59e-42

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins; TFE3, also termed Class E basic helix-loop-helix protein 33 (bHLHe33), is a bHLHzip transcription factor that is involved in B cell function. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF.


Pssm-ID: 381498 [Multi-domain]  Cd Length: 91  Bit Score: 144.04  E-value: 4.59e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 201 DTRVMAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQHARELESRQKKL 280
Cdd:cd18928     1 EAKAFLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSTDPEMRWNKGTILKASVDYIRKLQKEQQRSKEIEMRQRKL 80

                          90
                  ....*....|.
gi 2052811266 281 EQANRRLLLRI 291
Cdd:cd18928    81 EQANRSLQLRI 91
bHLHzip_TFEB cd18927
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and ...
 201-291 3.19e-38

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins; TFEB, also termed Class E basic helix-loop-helix protein 35 (bHLHe35), is a bHLHzip transcription factor that is required for vascularization of the mouse placenta. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF.


Pssm-ID: 381497  Cd Length: 91  Bit Score: 133.95  E-value: 3.19e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 201 DTRVMAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQHARELESRQKKL 280
Cdd:cd18927     1 EARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKTNDLDVRWNKGTILKASVDYIKRMQKDLQRSRELENHSRRL 80

                          90
                  ....*....|.
gi 2052811266 281 EQANRRLLLRI 291
Cdd:cd18927    81 EMTNKQLWLRI 91
bHLHzip_MITF_like cd11397
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated ...
 207-274 3.51e-34

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated transcription factor family (MITF) family; The MITF (also known as microphthalmia-TFE, or MiT) family is a small family that contain a basic helix loop helix domain associated with a leucine zipper (bHLHZip). The MITF family comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF family can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381403  Cd Length: 69  Bit Score: 122.40  E-value: 3.51e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2052811266 207 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQHARELE 274
Cdd:cd11397     1 KDRQKKDNHNMIERRRRFNINDRIKELGTLLPKSNDPDMRWNKGTILKASVDYIRKLQKEQERLRQLE 68
DUF3371 pfam11851
Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain ...
 296-447 3.87e-23

Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.


Pssm-ID: 463372  Cd Length: 128  Bit Score: 94.40  E-value: 3.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 296 IQARAHGLPSMATS-LGPVELSNHLLKQQqhqpqgpqqpplypdelnggaeylprtPIMGAQPGGAAAVATSGGATSGMP 374
Cdd:pfam11851   1 MQARAHGLPVASSSgLCTAELAARVIKQE---------------------------PALPPCPPDLYDMSQPQPPTQAAV 53

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2052811266 375 SVPSSGatggagEPGDGSTTFSdplshFTDF---FSATLKEEHRLEEILMDDPLSPFG-TDPLLSAASPDASKGSSH 447
Cdd:pfam11851  54 SSSSTL------DLNDGLITFS-----FGDLsasFSDALKPGSKLDDILMDDTLSPLGpSDPLLSAMSPDASKDSSR 119
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
 214-268 1.38e-10

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 56.49  E-value: 1.38e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2052811266 214 NHNLIERRRRYNINYRIKELGTLIPKSND--PDMRWNKGTILKASVEYIKWLQKEQQ 268
Cdd:cd11387     1 SHNAVERRRRDNINEKIQELGSLVPPSRLetKDLKPNKGSILSKAVEYIRELQNQNQ 57
bHLHzip_scCBP1 cd11398
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae ...
 207-292 4.34e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins; CBP-1, also termed centromere promoter factor 1 (CPF1), or centromere-binding factor 1 (CBF1), is a bHLHzip protein that is required for chromosome stability and methionine prototrophy. It binds as a homodimer to the centromere DNA elements I (CDEI, GTCACATG) region of the centromere that is required for optimal centromere function.


Pssm-ID: 381404 [Multi-domain]  Cd Length: 89  Bit Score: 50.42  E-value: 4.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 207 KERQKKDNHNLIERRRRYNINYRIKELGTLIPkSNDPDMrwNKGTILKASVEYIKWLQKEQqharelesrQKKLEQANRR 286
Cdd:cd11398     3 WHRQRRDNHKEVERRRRENINEGINELAALVP-GNAREK--NKGAILARAVEYIQELQETE---------AKNIEKWTLE 70


                  ....*.
gi 2052811266 287 LLLRIQ 292
Cdd:cd11398    71 KLLTDQ 76
MITF_TFEB_C_3_N pfam15951
MITF/TFEB/TFEC/TFE3 N-terminus; This domain is found at the N-terminus of several ...
 53-184 5.19e-07

MITF/TFEB/TFEC/TFE3 N-terminus; This domain is found at the N-terminus of several transcription factors including microphthalmia-associated transcription factor, transcription factor EB, transcription factor EC and transcription factor E3.


Pssm-ID: 464952  Cd Length: 151  Bit Score: 48.97  E-value: 5.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266  53 QLKQEPEDQNQNYQTHQNQSEWGHTGHPWFQAAHTGTYG---HNQLPATWPTS-WQVQSHIENP-KYHLHQAQAQ----Y 123
Cdd:pfam15951   6 QQLMREQAQQEEQREQQQQQQNHQYMQPAPPPSSTPAISvpqSPPSPAQVPVEvLKVQTHLENPtKYHIQQAQRQqvkqY 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2052811266 124 L--TLSSKLAGQAHPGPHPHAGQP-LGTVPVMRNGHMPPQgdGSTPGSPIHLLTLAtSSHDSEV 184
Cdd:pfam15951  86 LstTYGAKQALIPSASPPPPAQSPpPRTSPLMRGNQLPPG--NSAPNSPMAMLSIG-SSEEKEI 146
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
 249-294 8.68e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 40.99  E-value: 8.68e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2052811266 249 KGTILKASVEYIKWLQKEQqhaRELESRQKKLEQANRRLLLRIQEL 294
Cdd:cd11400    38 KVVILKKATEYIKQLQQEE---KKLEKEKDKLKARNEQLRKKLERL 80
bHLHzip_SREBP cd11394
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 207-287 3.46e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box.


Pssm-ID: 381400 [Multi-domain]  Cd Length: 73  Bit Score: 38.79  E-value: 3.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 207 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKsndPDMRWNKGTILKASVEYIKWLQKEQQharelesrqkKLEQANRR 286
Cdd:cd11394     2 PKVEKRSAHNAIEKRYRSSINDRIIELKDLVVG---PDAKMNKSAVLRKAIDYIRYLQKVNQ----------KLKQENMA 68


                  .
gi 2052811266 287 L 287
Cdd:cd11394    69 L 69
bHLHzip_SREBP2 cd18922
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 207-272 1.37e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 2 (SREBP2) and similar proteins; SREBP2, also termed Class D basic helix-loop-helix protein 2 (bHLHd2), or sterol regulatory element-binding transcription factor 2 (SREBF2), is a member of a family of bHLHzip transcription factors that recognize sterol regulatory element 1 (SRE-1). It acts as a transcription activator of cholesterol biosynthesis.


Pssm-ID: 381492 [Multi-domain]  Cd Length: 77  Bit Score: 37.63  E-value: 1.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2052811266 207 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSndpDMRWNKGTILKASVEYIKWLQKEQQHARE 272
Cdd:cd18922     2 KEGERRTTHNIIEKRYRSSINDKIIELKDLVMGT---DAKMHKSGVLRKAIDYIKYLQQVNHKLRQ 64
bHLHzip_SREBP1 cd18921
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 210-293 1.41e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins; SREBP1, also termed Class D basic helix-loop-helix protein 1 (bHLHd1), or sterol regulatory element-binding transcription factor 1 (SREBF1), is a member of a family of bHLHzip transcription factors that recognize sterol regulatory element 1 (SRE-1). It acts as a transcriptional activator required for lipid homeostasis. It may control transcription of the low-density lipoprotein receptor gene as well as the fatty acid. SREBP1 has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').


Pssm-ID: 381491  Cd Length: 75  Bit Score: 37.18  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 210 QKKDNHNLIERRRRYNINYRIKELGTLIPksnDPDMRWNKGTILKASVEYIKWLQKEQQharelesrqkKLEQANRRLLL 289
Cdd:cd18921     5 EKRTAHNAIEKRYRSSINDKIIELKDLVV---GTEAKLNKSAVLRKAIDYIRFLQQSNQ----------KLKQENMALKM 71


                  ....
gi 2052811266 290 RIQE 293
Cdd:cd18921    72 AVQK 75
UDM1_RNF168_RNF169-like cd22249
UDM1 (ubiquitin-dependent DSB recruitment module 1) found in RING finger proteins RNF168, ...
 254-287 2.47e-03

UDM1 (ubiquitin-dependent DSB recruitment module 1) found in RING finger proteins RNF168, RNF169 and similar proteins; This model represents the UDM1 (ubiquitin-dependent double-strand break [DSB] recruitment module 1) found in RING finger proteins, RNF168 and RNF169. RNF168 is an E3 ubiquitin-protein ligase that promotes non-canonical K27 ubiquitination to signal DNA damage. It functions, together with RNF8, as a DNA damage response (DDR) factor that promotes a series of ubiquitylation events on substrates such as H2A and H2AX. With H2AK13/15 ubiquitylation, it facilitates recruitment of repair factors p53-binding protein 1 (53BP1) or the RAP80-BRCA1 complex to sites of double-strand breaks (DSBs), and inhibits homologous recombination (HR) in cells deficient in the tumor suppressor BRCA1. RNF168 also promotes H2A neddylation, which antagonizes ubiquitylation of H2A and regulates DNA damage repair. In addition, RNF168 forms a functional complex with RAD6A or RAD6B during the DNA damage response. RNF169 is an uncharacterized E3 ubiquitin-protein ligase paralogous to RNF168. It functions as a negative regulator of the DNA damage signaling cascade. RNF169 recognizes polyubiquitin structures but does not itself contribute to double-strand break (DSB)-induced chromatin ubiquitylation. It contributes to the regulation of DSB repair pathway utilization via functionally competing with recruiting repair factors, 53BP1 and RAP80-BRCA1, for association with RNF168-modified chromatin, independent of its catalytic activity, limiting the magnitude of the RNF8/RNF168-dependent signaling response to DSBs. The UDM1 domain comprises LRM1 (LR motif 1), UMI (ubiquitin-interacting motif [UIM]- and MIU-related UBD) and MIU1 (motif interacting with ubiquitin 1). Mutations of Ub-interacting residues in UDM1 have little effect on the accumulation of RNF168 to DSB sites, suggesting that it may not be the main site of binding ubiquitylated and polyubiquitylated targets.


Pssm-ID: 409016 [Multi-domain]  Cd Length: 66  Bit Score: 36.48  E-value: 2.47e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2052811266 254 KASVEYIKWLQKEQQHA--RELESRQKKLEQANRRL 287
Cdd:cd22249    31 KASEELIRKLQEEEERQrkREREEQLKQDEELAKQL 66
HLH smart00353
helix loop helix domain;
216-268 2.56e-03

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 36.04  E-value: 2.56e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2052811266  216 NLIERRRRYNINYRIKELGTLIPkSNDPDMRWNKGTILKASVEYIKWLQKEQQ 268
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLP-TLPKNKKLSKAEILRLAIEYIKSLQEELQ 52
bHLHzip_scHMS1_like cd11399
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription ...
 209-281 6.21e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription factor HMS1 and similar proteins; HMS1, also termed high-copy MEP suppressor protein 1, is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation.


Pssm-ID: 381405 [Multi-domain]  Cd Length: 96  Bit Score: 35.91  E-value: 6.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052811266 209 RQKKDNHNLIER------------------------RRRYNINYRIKELGTLIPKSndpdmRWNKGTILKASVEYIKWLQ 264
Cdd:cd11399     1 PSKKTAHNMIEKryrsnindriaelrdsvpalreayKSARGEDEDEEDLGGLTPAT-----KLNKATILSKATEYIRHLE 75

                          90
                  ....*....|....*...
gi 2052811266 265 -KEQQHARELESRQKKLE 281
Cdd:cd11399    76 kKNKRLSRENASLRERLA 93
bZIP_u3 cd14812
Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and ...
 264-299 6.39e-03

Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain; uncharacterized subfamily; Basic leucine zipper (bZIP) factors comprise one of the most important classes of enhancer-type transcription factors. They act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes including cell survival, learning and memory, lipid metabolism, and cancer progression, among others. They also play important roles in responses to stimuli or stress signals such as cytokines, genotoxic agents, or physiological stresses. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269874 [Multi-domain]  Cd Length: 52  Bit Score: 34.88  E-value: 6.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2052811266 264 QKEQQHARELESRQKKLEQANRRLLLRIQELEIQAR 299
Cdd:cd14812    17 QRKKEEVEELEARVKELEAENRRLRQLLAQPEAEAS 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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