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Conserved domains on  [gi|1992479501|ref|XP_039550668|]
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muellerian-inhibiting factor [Pimephales promelas]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMH_N super family cl04695
Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling ...
 77-437 4.82e-89

Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism. This family represents the N terminal part of the protein, which is not thought to be essential for activity. AMH contains a TGF-beta domain (pfam00019), at the C terminus.


The actual alignment was detected with superfamily member pfam04709:

Pssm-ID: 461402  Cd Length: 389  Bit Score: 279.39  E-value: 4.82e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501  77 FLSALNGESEQGRINFQNFGICSPGAPGFQLSDL----LQNAQQTQKGLKGVHaikdVWDAEQEGGITLTLTFPRHARPT 152
Cdd:pfam04709   7 FLEALGRDGEWGPQDLATFGICSPSDSSSALPLLqrlvAWLGEPGGQGLLVLH----LEEVTWEPTITLTFQLPLLGGAS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 153 NPASVMLLFNVDPIKGGGL-RVTFNSHSIqPNTQMVCISEATRFLILAGGH---THAHVHLKLSVTVEAWKDESGSKPSV 228
Cdd:pfam04709  83 PPELALLLLYPGPGTGGSLpEVTVTGAGL-PNTQSLCISEDTRYLLLAVDRptgAWSEGQLRWGISLELRPRGNGSPLST 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 229 SELQEVLMRKMDGSNTTMRPVLLFLSDRDKQST---------------------PRLKYHGIPLDERPPSRTFLFLCELQ 287
Cdd:pfam04709 162 AELQALLFGGDSGCFTRMTPVLLLLSGEEGTDTrlsgpsplpahgqldtvpfpqPRPSPEPEEGSSSAPPQTDPFLCELT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 288 KFLSDVL-QQKEGPTPQDDGKAFFLDTLHSLPPLSLGVSSTESlLSGLVNSSMPTIFVFPQRQQGLQTHRVEVALDSPLL 366
Cdd:pfam04709 242 RFLRALLgPPARAPQQKSPRLALDLDALASLPPLLLNLSDPAA-LERLINSEEPTLLLFTGWPAGLQGHSGEWALSPALL 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1992479501 367 SVLRMRLDEAMALVRQ-QEAGQTVIDRLQKLSELSAVSPDGEDDEAvnkdhkeAQYRSVLLLKALQTVLSTW 437
Cdd:pfam04709 321 RRLAQRLQAAAAELRDlPGLPPAATPLLARLLALCAGQPDEPGADP-------SPLRALLLLKALQTVRAEW 385
TGF_beta_AMH cd13757
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) ...
 458-551 6.28e-47

transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.


:

Pssm-ID: 381635  Cd Length: 99  Bit Score: 159.07  E-value: 6.28e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 458 QCRLQSLTVSLR--KFFLEPSQANINNCEGVCGFPL---NNANNHAVLLNSHIQSGHPVNRSLCCVPVDYDDLCVIELES 532
Cdd:cd13757     1 YCRLRELSVSLRseKFILSPKRYNINNCQGPCRFPLsdrPRYNNHAVLLLKMQERGLPLQRAPCCVPVAYEELLVVELSD 80

                          90
                  ....*....|....*....
gi 1992479501 533 EGTNVSFKTNVVATKCECR 551
Cdd:cd13757    81 EGTEISLKPNMVATECGCR 99
 
Name Accession Description Interval E-value
AMH_N pfam04709
Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling ...
 77-437 4.82e-89

Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism. This family represents the N terminal part of the protein, which is not thought to be essential for activity. AMH contains a TGF-beta domain (pfam00019), at the C terminus.


Pssm-ID: 461402  Cd Length: 389  Bit Score: 279.39  E-value: 4.82e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501  77 FLSALNGESEQGRINFQNFGICSPGAPGFQLSDL----LQNAQQTQKGLKGVHaikdVWDAEQEGGITLTLTFPRHARPT 152
Cdd:pfam04709   7 FLEALGRDGEWGPQDLATFGICSPSDSSSALPLLqrlvAWLGEPGGQGLLVLH----LEEVTWEPTITLTFQLPLLGGAS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 153 NPASVMLLFNVDPIKGGGL-RVTFNSHSIqPNTQMVCISEATRFLILAGGH---THAHVHLKLSVTVEAWKDESGSKPSV 228
Cdd:pfam04709  83 PPELALLLLYPGPGTGGSLpEVTVTGAGL-PNTQSLCISEDTRYLLLAVDRptgAWSEGQLRWGISLELRPRGNGSPLST 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 229 SELQEVLMRKMDGSNTTMRPVLLFLSDRDKQST---------------------PRLKYHGIPLDERPPSRTFLFLCELQ 287
Cdd:pfam04709 162 AELQALLFGGDSGCFTRMTPVLLLLSGEEGTDTrlsgpsplpahgqldtvpfpqPRPSPEPEEGSSSAPPQTDPFLCELT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 288 KFLSDVL-QQKEGPTPQDDGKAFFLDTLHSLPPLSLGVSSTESlLSGLVNSSMPTIFVFPQRQQGLQTHRVEVALDSPLL 366
Cdd:pfam04709 242 RFLRALLgPPARAPQQKSPRLALDLDALASLPPLLLNLSDPAA-LERLINSEEPTLLLFTGWPAGLQGHSGEWALSPALL 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1992479501 367 SVLRMRLDEAMALVRQ-QEAGQTVIDRLQKLSELSAVSPDGEDDEAvnkdhkeAQYRSVLLLKALQTVLSTW 437
Cdd:pfam04709 321 RRLAQRLQAAAAELRDlPGLPPAATPLLARLLALCAGQPDEPGADP-------SPLRALLLLKALQTVRAEW 385
TGF_beta_AMH cd13757
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) ...
 458-551 6.28e-47

transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.


Pssm-ID: 381635  Cd Length: 99  Bit Score: 159.07  E-value: 6.28e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 458 QCRLQSLTVSLR--KFFLEPSQANINNCEGVCGFPL---NNANNHAVLLNSHIQSGHPVNRSLCCVPVDYDDLCVIELES 532
Cdd:cd13757     1 YCRLRELSVSLRseKFILSPKRYNINNCQGPCRFPLsdrPRYNNHAVLLLKMQERGLPLQRAPCCVPVAYEELLVVELSD 80

                          90
                  ....*....|....*....
gi 1992479501 533 EGTNVSFKTNVVATKCECR 551
Cdd:cd13757    81 EGTEISLKPNMVATECGCR 99
TGF_beta pfam00019
Transforming growth factor beta like domain;
458-550 3.85e-17

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 76.98  E-value: 3.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 458 QCRLQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLN---NANNHAVLLNSHIQSGHPVNRSLCCVPVDYDDLCVIE 529
Cdd:pfam00019   1 ECRRHSLYVDFEDlgwddWIIAPKGYNAYYCSGSCPSHLNpqlSATNHAILQSLLHSLKPANVPKPCCVPTKLSPLSVLY 80

                          90       100
                  ....*....|....*....|...
gi 1992479501 530 LESEGtNVSFKT--NVVATKCEC 550
Cdd:pfam00019  81 YDDEG-NVVLKTypDMVVESCGC 102
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 459-551 1.08e-15

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 72.69  E-value: 1.08e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501  459 CRLQSLTVSLRKF-----FLEPSQANINNCEGVCGFPL---NNANNHAVLLNS-HIQSGHPVNRSlCCVPVDYDDLCVIE 529
Cdd:smart00204   1 CRRRQLYVDFKDLgwddwIIAPKGYNAYYCEGECPFPLstsLNATNHAIVQTLvHLLGPNPVPKP-CCVPTKLSPLSMLY 79

                           90       100
                   ....*....|....*....|....
gi 1992479501  530 LESEGtNVSFKT--NVVATKCECR 551
Cdd:smart00204  80 YDDDG-NVVLRNypNMVVEECGCR 102
 
Name Accession Description Interval E-value
AMH_N pfam04709
Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling ...
 77-437 4.82e-89

Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism. This family represents the N terminal part of the protein, which is not thought to be essential for activity. AMH contains a TGF-beta domain (pfam00019), at the C terminus.


Pssm-ID: 461402  Cd Length: 389  Bit Score: 279.39  E-value: 4.82e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501  77 FLSALNGESEQGRINFQNFGICSPGAPGFQLSDL----LQNAQQTQKGLKGVHaikdVWDAEQEGGITLTLTFPRHARPT 152
Cdd:pfam04709   7 FLEALGRDGEWGPQDLATFGICSPSDSSSALPLLqrlvAWLGEPGGQGLLVLH----LEEVTWEPTITLTFQLPLLGGAS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 153 NPASVMLLFNVDPIKGGGL-RVTFNSHSIqPNTQMVCISEATRFLILAGGH---THAHVHLKLSVTVEAWKDESGSKPSV 228
Cdd:pfam04709  83 PPELALLLLYPGPGTGGSLpEVTVTGAGL-PNTQSLCISEDTRYLLLAVDRptgAWSEGQLRWGISLELRPRGNGSPLST 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 229 SELQEVLMRKMDGSNTTMRPVLLFLSDRDKQST---------------------PRLKYHGIPLDERPPSRTFLFLCELQ 287
Cdd:pfam04709 162 AELQALLFGGDSGCFTRMTPVLLLLSGEEGTDTrlsgpsplpahgqldtvpfpqPRPSPEPEEGSSSAPPQTDPFLCELT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 288 KFLSDVL-QQKEGPTPQDDGKAFFLDTLHSLPPLSLGVSSTESlLSGLVNSSMPTIFVFPQRQQGLQTHRVEVALDSPLL 366
Cdd:pfam04709 242 RFLRALLgPPARAPQQKSPRLALDLDALASLPPLLLNLSDPAA-LERLINSEEPTLLLFTGWPAGLQGHSGEWALSPALL 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1992479501 367 SVLRMRLDEAMALVRQ-QEAGQTVIDRLQKLSELSAVSPDGEDDEAvnkdhkeAQYRSVLLLKALQTVLSTW 437
Cdd:pfam04709 321 RRLAQRLQAAAAELRDlPGLPPAATPLLARLLALCAGQPDEPGADP-------SPLRALLLLKALQTVRAEW 385
TGF_beta_AMH cd13757
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) ...
 458-551 6.28e-47

transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.


Pssm-ID: 381635  Cd Length: 99  Bit Score: 159.07  E-value: 6.28e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 458 QCRLQSLTVSLR--KFFLEPSQANINNCEGVCGFPL---NNANNHAVLLNSHIQSGHPVNRSLCCVPVDYDDLCVIELES 532
Cdd:cd13757     1 YCRLRELSVSLRseKFILSPKRYNINNCQGPCRFPLsdrPRYNNHAVLLLKMQERGLPLQRAPCCVPVAYEELLVVELSD 80

                          90
                  ....*....|....*....
gi 1992479501 533 EGTNVSFKTNVVATKCECR 551
Cdd:cd13757    81 EGTEISLKPNMVATECGCR 99
TGF_beta_BMPs_GDFs cd13756
transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP ...
 459-550 1.87e-18

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.


Pssm-ID: 381634  Cd Length: 102  Bit Score: 80.82  E-value: 1.87e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLN---NANNHAVLLNS-HIQSGHPVNRSLCCVPVDYDDLCVIE 529
Cdd:cd13756     1 CRRRPLYVDFSDlgwddWIIAPKGYNANYCAGSCPFPLSshaNATNHAILQALlHSLNPKKSVPKPCCVPTKYSPLSVLY 80

                          90       100
                  ....*....|....*....|...
gi 1992479501 530 LESEGtNVSFKT--NVVATKCEC 550
Cdd:cd13756    81 YDEDG-NVVLKTypDMVVEECGC 102
TGF_beta pfam00019
Transforming growth factor beta like domain;
458-550 3.85e-17

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 76.98  E-value: 3.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 458 QCRLQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLN---NANNHAVLLNSHIQSGHPVNRSLCCVPVDYDDLCVIE 529
Cdd:pfam00019   1 ECRRHSLYVDFEDlgwddWIIAPKGYNAYYCSGSCPSHLNpqlSATNHAILQSLLHSLKPANVPKPCCVPTKLSPLSVLY 80

                          90       100
                  ....*....|....*....|...
gi 1992479501 530 LESEGtNVSFKT--NVVATKCEC 550
Cdd:pfam00019  81 YDDEG-NVVLKTypDMVVESCGC 102
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 459-551 1.08e-15

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 72.69  E-value: 1.08e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501  459 CRLQSLTVSLRKF-----FLEPSQANINNCEGVCGFPL---NNANNHAVLLNS-HIQSGHPVNRSlCCVPVDYDDLCVIE 529
Cdd:smart00204   1 CRRRQLYVDFKDLgwddwIIAPKGYNAYYCEGECPFPLstsLNATNHAIVQTLvHLLGPNPVPKP-CCVPTKLSPLSMLY 79

                           90       100
                   ....*....|....*....|....
gi 1992479501  530 LESEGtNVSFKT--NVVATKCECR 551
Cdd:smart00204  80 YDDDG-NVVLRNypNMVVEECGCR 102
TGF_beta_BMP5_like cd13761
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins ...
 458-551 8.50e-14

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins BMP-5, BMP-6, BMP-7, BMP-8A/B and similar proteins; The family includes BMP-5, BMP-6, BMP-7 and BMP-8A/B, which may induce cartilage and bone formation.


Pssm-ID: 381639  Cd Length: 103  Bit Score: 67.60  E-value: 8.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 458 QCRLQSLTVSLRKFFLE-----PSQANINNCEGVCGFPLN---NANNHAVllnshIQS-GHPVNRSL----CCVPVDYDD 524
Cdd:cd13761     1 SCRRHNLYVDFRDLGWQdwiiaPDGYNAYYCSGECSFPLNshmNATNHAI-----VQTlVHLMNPNRvpkpCCAPTKLSP 75

                          90       100
                  ....*....|....*....|....*....
gi 1992479501 525 LCVIELESEGtNVSFKT--NVVATKCECR 551
Cdd:cd13761    76 ISVLYYDDNS-NVVLKKykNMVVESCGCH 103
TGF_beta_SF cd08698
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 459-550 4.46e-13

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


Pssm-ID: 381627  Cd Length: 100  Bit Score: 65.19  E-value: 4.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLRKFF-----LEPSQANINNCEGVCGFPLNNANNHAVLLNSHIQSGHPVNRSL--CCVPVDYDDLCVIELE 531
Cdd:cd08698     1 CCKQPLYVNFKDLGglnwiIAPSGFTANYCRGSCNSESSATTNHTKLLQWSRTRRHTPREELkpCCVPTSYEPLSILYYD 80

                          90       100
                  ....*....|....*....|
gi 1992479501 532 SEGT-NVSFKTNVVATKCEC 550
Cdd:cd08698    81 NNGTvVETLLPNLIVTECGC 100
TGF_beta_TGFbeta1_2_3 cd13753
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 459-550 1.10e-09

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381631  Cd Length: 97  Bit Score: 55.39  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLR-----KFFLEPSQANINNCEGVCGFPLNNANNHAVLLnSHIQSGHPVNRSL-CCVPVDYDDLCVIELES 532
Cdd:cd13753     1 CCLRPLYINFRrdlgwKWIHEPKGFNANYCAGACPYLWSADTQHSTVL-QLYNRLNPVASAApCCSPRELEPLTILYYDG 79

                          90
                  ....*....|....*...
gi 1992479501 533 EGTNVSFKTNVVATKCEC 550
Cdd:cd13753    80 RNPKIETLSNMIVTSCKC 97
TGF_beta_BMP6 cd19396
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 ...
 459-550 2.53e-07

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 (BMP-6) and similar proteins; BMP-6, also termed VG-1-related protein, or VG-1-R, or VGR-1, induces cartilage and bone formation.


Pssm-ID: 381666  Cd Length: 103  Bit Score: 48.88  E-value: 2.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLN---NANNHAVLLN-SHIQSGHPVNRSlCCVPVDYDDLCVIE 529
Cdd:cd19396     2 CRKHELYVSFQDlgwqdWIIAPKGYAANYCDGECSFPLNahmNATNHAIVQTlVHLMNPEYVPKP-CCAPTKLNAISVLY 80

                          90       100
                  ....*....|....*....|...
gi 1992479501 530 LEsEGTNVSFKT--NVVATKCEC 550
Cdd:cd19396    81 FD-DNSNVILKKyrNMVVRACGC 102
TGF_beta_GDF5_6_7 cd13766
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 459-551 5.71e-07

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5), factor 6 (GDF6), factor 7 (GDF7) and similar proteins; The family includes GDF5, GDF6 and GDF7. GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation. GDF6, also termed bone morphogenetic protein 13 (BMP-13), or growth/differentiation factor 16, is a growth factor that controls proliferation and cellular differentiation in the retina and bone formation. GDF7, also termed bone morphogenetic protein 12 (BMP-12), may play an active role in the motor area of the primate neocortex.


Pssm-ID: 381644  Cd Length: 102  Bit Score: 47.81  E-value: 5.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLNN---ANNHAV---LLNSHIQSGHPvnrSLCCVPVDYDDLCV 527
Cdd:cd13766     1 CSRKPLHVNFKDlgwddWIIAPLDYEAYHCEGVCDFPLRShlePTNHAIiqtLMNSMDPESTP---PSCCVPTKLSPISI 77

                          90       100
                  ....*....|....*....|....*.
gi 1992479501 528 IELESeGTNVSFKT--NVVATKCECR 551
Cdd:cd13766    78 LYIDS-ANNVVYKQyeDMVVESCGCR 102
TGF_beta_BMP2 cd19390
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ...
 457-551 1.12e-06

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins; BMP-2, also termed BMP-2A, induces cartilage and bone formation. It stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway.


Pssm-ID: 381660  Cd Length: 103  Bit Score: 47.29  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 457 SQCRLQSLTVSLR-----KFFLEPSQANINNCEGVCGFPLN---NANNHAV---LLNShIQSGHPvnrSLCCVPVDYDDL 525
Cdd:cd19390     1 SSCKRHPLYVDFSdvgwnDWIVAPPGYHAFYCHGECPFPLAdhlNSTNHAIvqtLVNS-VNSKIP---KACCVPTELSAI 76

                          90       100
                  ....*....|....*....|....*...
gi 1992479501 526 CVIELEsEGTNVSFK--TNVVATKCECR 551
Cdd:cd19390    77 SMLYLD-ENEKVVLKnyQDMVVEGCGCR 103
TGF_beta_BMP9_like cd13767
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, ...
 459-551 1.56e-06

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, BMP-9, BMP-10 and similar proteins; The family includes BMP9 (also known as GDF2) and BMP10. BMP-9 is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs). BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.


Pssm-ID: 381645  Cd Length: 105  Bit Score: 46.97  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLR-----KFFLEPSQANINNCEGVCGFPLNN---ANNHAVL-LNSHIQSGHPVNRSlCCVPVDYDDLCVIE 529
Cdd:cd13767     3 CRRKPLYVNFAdigwdSWIIAPKGYEAYECSGKCFFPLADhlsPTKHAIIqTLVHSKSPEKVSRA-CCVPTKLEPISLLY 81

                          90       100
                  ....*....|....*....|....*
gi 1992479501 530 LESEGTnVSFK---TNVVATKCECR 551
Cdd:cd13767    82 IDENGV-LTYKykyEGMVVAECGCR 105
TGF_beta_GDF5 cd19399
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 458-551 7.22e-06

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins; GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation.


Pssm-ID: 381669  Cd Length: 103  Bit Score: 45.00  E-value: 7.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 458 QCRLQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLNN---ANNHAV---LLNSHIQSGHPVNrslCCVPVDYDDLC 526
Cdd:cd19399     1 RCSRKALHVNFKDmgwddWIIAPLEYEAFHCEGLCEFPLRShlePTNHAViqtLMNSMDPESTPPT---CCVPTRLSPIS 77

                          90       100
                  ....*....|....*....|....*..
gi 1992479501 527 VIELESeGTNVSFKT--NVVATKCECR 551
Cdd:cd19399    78 ILFIDS-ANNVVYKQyeDMVVESCGCR 103
TGF_beta_maverick cd13755
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 459-550 7.38e-06

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster maverick and similar proteins; Maverick, also termed MAV, is a novel member of the TGF-beta superfamily in Drosophila. It's a bone morphogenetic protein (BMP)/TGF-beta related ligand.


Pssm-ID: 381633  Cd Length: 102  Bit Score: 44.61  E-value: 7.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRlQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLNNANNHAvLLNSHIQSGHPVNRSLCCVPVDYDDLCVIELESE 533
Cdd:cd13755     5 CR-HSLKVDFKKlpgfeWIIQPKEFDAGYCKGRCPPRYNYANNHA-LIQSLLRRMKKKVPRPCCAPSKLESLEVLHYDES 82

                          90       100
                  ....*....|....*....|
gi 1992479501 534 GTN---VSFKTNVVATKCEC 550
Cdd:cd13755    83 DSSklkVTKWKGMIVSECAC 102
TGF_beta_BMP7 cd19397
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 ...
 459-550 9.16e-06

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins; BMP-7, also termed osteogenic protein 1 (OP-1), or eptotermin alfa, induces cartilage and bone formation. It may act as the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis and play a role in calcium regulation and bone homeostasis.


Pssm-ID: 381667  Cd Length: 107  Bit Score: 44.65  E-value: 9.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLN---NANNHAVLLN-SHIQSGHPVNRSlCCVPVDYDDLCVIE 529
Cdd:cd19397     6 CKKHELYVSFRDlgwqdWIIAPEGYAAYYCEGECAFPLNsymNATNHAIVQTlVHFINPETVPKP-CCAPTQLNAISVLY 84

                          90       100
                  ....*....|....*....|...
gi 1992479501 530 LEsEGTNVSFKT--NVVATKCEC 550
Cdd:cd19397    85 FD-DSSNVILKKyrNMVVRACGC 106
TGF_beta_BMP8 cd19398
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A ...
 459-550 5.14e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A (BMP-8A), 8B (BMP-8B) and similar proteins; BMP-8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. BMP-8B, also termed BMP-8, or osteogenic protein 2 (OP-2), may act as secreted factor in cancer progression. It also plays an essential role in bone metabolism and can regulate thermogenesis and energy balance. Like BMP-8A, BMP-8B plays a role in spermatogenesis and placental development. Mutation in either of the genes encoding BMP-8A or BMP-8B causes postnatal depletion of spermatogonia in mice.


Pssm-ID: 381668  Cd Length: 105  Bit Score: 42.60  E-value: 5.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLN---NANNHAVL-LNSHIQSGHPVNRSlCCVPVDYDDLCVIE 529
Cdd:cd19398     4 CKRHELYVSFQDlgwldWVIAPQGYSAYYCEGECSFPLDscmNATNHAILqSLVHLMKPEAVPKA-CCAPTKLSATSVLY 82

                          90       100
                  ....*....|....*....|...
gi 1992479501 530 LESEgTNVSFKT--NVVATKCEC 550
Cdd:cd19398    83 YDSN-NNVILKKhrNMVVKSCGC 104
TGF_beta_BMP10 cd19401
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 ...
 457-551 1.19e-04

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 (BMP-10) and similar proteins; BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.


Pssm-ID: 381671  Cd Length: 105  Bit Score: 41.38  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 457 SQCRLQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLNN---ANNHAVLLN-SHIQSGHPVNRSlCCVPVDYDDLCV 527
Cdd:cd19401     1 NYCKRSPLYVDFKEigwdsWIIAPTGYEAYECRGVCYYPLTEhvtPTKHAIVQTlVHLKNPQKASKA-CCVPTKLDPISI 79

                          90       100
                  ....*....|....*....|....*..
gi 1992479501 528 IELESEGTnVSFK---TNVVATKCECR 551
Cdd:cd19401    80 LYLDDAGV-VTYKfkyEGMVVAECGCR 105
TGF_beta_univin cd19387
transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus ...
 459-551 1.41e-04

transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus univin and similar proteins; Univin may have a critical role in early developmental decisions in the sea urchin embryo.


Pssm-ID: 381657  Cd Length: 104  Bit Score: 41.33  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLR-----KFFLEPSQANINNCEGVCGFPLN---NANNHAVLLNShIQSGHPVNRSL-CCVPVDYDDLCVIE 529
Cdd:cd19387     3 CQRHSLYVDFKdvgwsDWIIAPRGYQAYRCAGECPFPLNehlNGTNHAIIQTL-VNSIDPSNVPKaCCAPTKLSSISMLY 81

                          90       100
                  ....*....|....*....|....
gi 1992479501 530 LESEGtNVSFKT--NVVATKCECR 551
Cdd:cd19387    82 FDNND-NVVLRQyeDMVVEACGCR 104
TGF_beta_BMP9 cd19400
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 ...
 457-551 1.85e-04

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 (BMP-9) and similar proteins; BMP-9, also termed growth/differentiation factor 2 (GDF-2), is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs).


Pssm-ID: 381670  Cd Length: 105  Bit Score: 41.02  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 457 SQCRLQSLTVSLR-----KFFLEPSQANINNCEGVCGFPLNN---ANNHAVLLN-SHIQSGHPVNRSlCCVPVDYDDLCV 527
Cdd:cd19400     1 NHCRKTSLRVNFKdigwdSWIIAPKEYDAYECKGGCYFPLTDdvtPTKHAIIQTlVHLKNPKKAGKA-CCVPTKLDPISV 79

                          90       100
                  ....*....|....*....|....*.
gi 1992479501 528 IELESEGT-NVSFK-TNVVATKCECR 551
Cdd:cd19400    80 LYKDDMGVpTLKYHyEGMKVAECGCR 105
TGF_beta_TGFB2 cd19385
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 459-550 2.10e-04

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins; TGF-beta-2, also termed BSC-1 cell growth inhibitor, or cetermin, or glioblastoma-derived T-cell suppressor factor (G-TSF), or polyergin, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth.


Pssm-ID: 381655  Cd Length: 97  Bit Score: 40.40  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLR-----KFFLEPSQANINNCEGVCGFPLNNANNHAVLLNSHIQSGHPVNRSLCCVPVDYDDLCVIELESE 533
Cdd:cd19385     1 CCLRPLYIDFKrdlgwKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGK 80

                          90
                  ....*....|....*..
gi 1992479501 534 GTNVSFKTNVVATKCEC 550
Cdd:cd19385    81 TPKIEQLSNMIVKSCKC 97
TGF_beta_GDF1_3_like cd13764
transforming growth factor beta (TGF-beta) like domain found in embryonic growth ...
 459-551 2.48e-04

transforming growth factor beta (TGF-beta) like domain found in embryonic growth/differentiation factor 1 (GDF1), factor 3 (GDF3) and similar proteins; The family includes GDF-1 and GDF-3. GDF1 may mediate cell differentiation events during embryonic development. GDF3 is a growth factor involved in early embryonic development and adipose-tissue homeostasis. The family also contains protein DVR-1, also termed vegetal hemisphere VG1 protein (VG-1), which serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.


Pssm-ID: 381642  Cd Length: 102  Bit Score: 40.53  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLR-----KFFLEPSQANINNCEGVCGFPLN---NANNHAVlLNSHIQSGHPVNRSL-CCVPVDYDDLCVIE 529
Cdd:cd13764     1 CKKRRLYISFRdvgwqNWIIAPQGYMANYCHGECPFPLTeslNGTNHAI-LQTLVHSVDPEGTPQpCCVPTRLSPISMLY 79

                          90       100
                  ....*....|....*....|....
gi 1992479501 530 LESEgTNVSFK--TNVVATKCECR 551
Cdd:cd13764    80 YDNN-DNVVLRhyEDMVVDECGCR 102
TGF_beta_TGFB1 cd19384
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 458-551 2.56e-04

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins; TGF-beta-1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis.


Pssm-ID: 381654  Cd Length: 99  Bit Score: 40.24  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 458 QCRLQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLNNANNHAVLLNSHIQSGHPVNRSLCCVPVDYDDLCVIELES 532
Cdd:cd19384     1 NCCVRQLYIDFRKdlgwkWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVG 80

                          90
                  ....*....|....*....
gi 1992479501 533 EGTNVSFKTNVVATKCECR 551
Cdd:cd19384    81 RKPKVEQLSNMIVRSCKCS 99
TGF_beta_BMP5 cd19395
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 ...
 459-550 4.37e-04

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 (BMP-5) and similar proteins; BMP-5 induces cartilage and bone formation.


Pssm-ID: 381665  Cd Length: 113  Bit Score: 40.07  E-value: 4.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLN---NANNHAVLLN-SHIQSGHPVNRSlCCVPVDYDDLCVIE 529
Cdd:cd19395    12 CKKHELYVSFRDlgwqdWIIAPEGYAAFYCDGECSFPLNahmNATNHAIVQTlVHLMFPDNVPKP-CCAPTKLNAISVLY 90

                          90       100
                  ....*....|....*....|...
gi 1992479501 530 LEsEGTNVSFKT--NVVATKCEC 550
Cdd:cd19395    91 FD-DSSNVILKKyrNMVVRSCGC 112
TGF_beta_BMP2_like cd13760
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ...
 483-551 4.59e-04

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2), 4 (BMP-4) and similar proteins; The family includes BMP2 and BMP4 (also known as BMP2B), both of which induce cartilage and bone formation. BMP-2 stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP-4 acts in mesoderm induction, tooth development, limb formation and fracture repair.


Pssm-ID: 381638  Cd Length: 102  Bit Score: 39.78  E-value: 4.59e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1992479501 483 CEGVCGFPLN---NANNHAV---LLNSHIQSGHPvnrSLCCVPVDYDDLCVIELEsEGTNVSFKT--NVVATKCECR 551
Cdd:cd13760    30 CHGECPFPLAdhlNSTNHAIvqtLVNSVNPGAVP---KACCVPTELSPISMLYLD-EYDKVVLKNyqDMVVEGCGCR 102
TGF_beta_DPP cd19392
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 459-551 9.45e-04

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster protein decapentaplegic (Dpp) and similar proteins; decapentaplegic (Dpp) and similar proteins Dpp, also termed as protein DPP-C, is required later in embryogenesis for dorsal closure and patterning of the hindgut. It also functions postembryonically as a long-range morphogen during imaginal disk development and is responsible for the progression of the morphogenetic furrow during eye development.


Pssm-ID: 381662  Cd Length: 109  Bit Score: 39.05  E-value: 9.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLRK-----FFLEPSQANINNCEGVCGFPLN---NANNHAV---LLNSHIQSGHPvnrSLCCVPVDYDDLCV 527
Cdd:cd19392     8 CRRHPLYVDFSDvgwddWIVAPLGYDAYYCNGECPFPLAdylNATNHAVvqtLVNSVDPQAVP---KACCVPTELSSIAM 84

                          90       100
                  ....*....|....*....|....*.
gi 1992479501 528 IELEsEGTNVSFKT--NVVATKCECR 551
Cdd:cd19392    85 LYVD-EHDKVVLKNyqDMVVEGCGCR 109
TGF_beta_GDF9 cd19403
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 458-551 9.53e-04

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins; GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.


Pssm-ID: 381673  Cd Length: 106  Bit Score: 39.07  E-value: 9.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 458 QCRLQSLTVSLR-----KFFLEPSQANINNCEGVCgfPLNNANNHAVLLNSHIQS------GHPVNRSlCCVPVDYDDLC 526
Cdd:cd19403     4 ECELHDFRLSFSqlkwdHWIIAPHRYNPRYCKGSC--PRAVGHRYGSPVHTMVQNiiyeklDSSIPRP-SCVPSEYNPLS 80

                          90       100
                  ....*....|....*....|....*..
gi 1992479501 527 VIELESEGTnVSFK--TNVVATKCECR 551
Cdd:cd19403    81 VLTIEPDGS-IAYKeyEDMIATKCTCR 106
TGF_beta_TGFB3 cd19386
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 459-550 1.17e-03

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins; TGF-beta-3 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381656  Cd Length: 101  Bit Score: 38.46  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 459 CRLQSLTVSLR-----KFFLEPSQANINNCEGVCGFPLNNANNHAVLLNSHIQSGHPVNRSLCCVPVDYDDLCVIELESE 533
Cdd:cd19386     4 CCVRPLYIDFRqdlgwKWVHEPKGYFANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGR 83

                          90
                  ....*....|....*..
gi 1992479501 534 GTNVSFKTNVVATKCEC 550
Cdd:cd19386    84 TPKVEQLSNMVVKSCKC 100
TGF_beta_ADMP cd13765
transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic ...
 475-551 4.25e-03

transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic protein (ADMP) and similar proteins; ADMP is a bone morphogenetic protein (BMP)-like transforming growth factor beta ligand, functions in the trunk organizer to antagonize head formation, thereby regulating organizer patterning. It negatively affects the formation of the organizer, although it is robustly expressed within the organizer itself. The organizer-promoting signal of ADMP is mediated by the activin A type I receptor, ACVR1 (also known as activin receptor-like kinase-2, ALK2).


Pssm-ID: 381643  Cd Length: 105  Bit Score: 36.95  E-value: 4.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992479501 475 PSQANINNCEGVCGFPLNNA---NNHAVllnshIQS-------GHPVNRSlCCVPVDYDDLCVIELESEGtNVSFKT--N 542
Cdd:cd13765    24 PKGYNAYHCKGSCPFPLGQNqkpTNHAT-----VQSivhalklAKGVEMP-CCVPDKLYSISLLYFDDDE-NVVLKQydD 96


                  ....*....
gi 1992479501 543 VVATKCECR 551
Cdd:cd13765    97 MVAASCGCH 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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