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Conserved domains on  [gi|1992460274|ref|XP_039540622|]
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glucose-6-phosphate 1-dehydrogenase isoform X3 [Pimephales promelas]

Protein Classification

glucose-6-phosphate 1-dehydrogenase( domain architecture ID 1000188)

glucose-6-phosphate 1-dehydrogenase (G6PD) catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes

EC:  1.1.1.-
Gene Ontology:  GO:0006006|GO:0050661|GO:0016614

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PTZ00309 super family cl29403
glucose-6-phosphate 1-dehydrogenase; Provisional
 28-514 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PTZ00309:

Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 713.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  28 SDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLT--VDTIRAACMPYMKVVDSEAERLAAFFSRNS 105
Cdd:PTZ00309   52 SRALTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSdvERWKKETLARFFKRLDDRECHLEQFLKHIS 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 106 YISGKYVDESSFDNLNTHLLSL-----PGGAGANRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRIIVEKPFGHDLQSSE 180
Cdd:PTZ00309  132 YISGSYDEDEDFKRLNKLIERMeeafqGPEKGGNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSE 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 181 ELSSHLFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQ 260
Cdd:PTZ00309  212 ELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQ 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 261 NHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSDVVLGQYVGDPDGegeAKLGYLDDSTVPKGSTQATFATAV 340
Cdd:PTZ00309  292 NHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADG---SIPGYLEDEGVPKDSTTPTFAAAV 368

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 341 LYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIF-DSQCRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETEL 419
Cdd:PTZ00309  369 LHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPsGDDTQRNELVIRAQPSEAMYLKITAKVPGLSNDLHQTEL 448

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 420 DLTYHSRYrDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPIKYKYGSRGPAEADELVQKVG 499
Cdd:PTZ00309  449 DLTYKTRY-NVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNG 527

                         490
                  ....*....|....*
gi 1992460274 500 FRYEGTYRWVNPHKL 514
Cdd:PTZ00309  528 FKSSKGYQWLQSNDQ 542
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 28-514 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 713.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  28 SDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLT--VDTIRAACMPYMKVVDSEAERLAAFFSRNS 105
Cdd:PTZ00309   52 SRALTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSdvERWKKETLARFFKRLDDRECHLEQFLKHIS 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 106 YISGKYVDESSFDNLNTHLLSL-----PGGAGANRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRIIVEKPFGHDLQSSE 180
Cdd:PTZ00309  132 YISGSYDEDEDFKRLNKLIERMeeafqGPEKGGNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSE 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 181 ELSSHLFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQ 260
Cdd:PTZ00309  212 ELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQ 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 261 NHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSDVVLGQYVGDPDGegeAKLGYLDDSTVPKGSTQATFATAV 340
Cdd:PTZ00309  292 NHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADG---SIPGYLEDEGVPKDSTTPTFAAAV 368

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 341 LYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIF-DSQCRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETEL 419
Cdd:PTZ00309  369 LHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPsGDDTQRNELVIRAQPSEAMYLKITAKVPGLSNDLHQTEL 448

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 420 DLTYHSRYrDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPIKYKYGSRGPAEADELVQKVG 499
Cdd:PTZ00309  449 DLTYKTRY-NVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNG 527

                         490
                  ....*....|....*
gi 1992460274 500 FRYEGTYRWVNPHKL 514
Cdd:PTZ00309  528 FKSSKGYQWLQSNDQ 542
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 31-505 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 690.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  31 HIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLTVDTIRA-ACMPYMKV-VDSEAERLAAFFSRNSYIS 108
Cdd:TIGR00871   3 CILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKvVREAIIKFeTDEIDEQWDEFAQRLSYVS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 109 GKYVDESSFDNLNTHLLSLPGGAG--ANRLFYLALPPSVYHDVTKNIKHQCMSTKG-WNRIIVEKPFGHDLQSSEELSSH 185
Cdd:TIGR00871  83 GDVDDDESYDSLAELLEQLDKTYGteGNRLFYLATPPSLFGTIIKQLKKHGLNEQGkWSRVVVEKPFGHDLASAQELNKA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 186 LFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQ 265
Cdd:TIGR00871 163 LRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLLQ 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 266 MLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSD--VVLGQYVGDPDGeGEAKLGYLDDSTVPKGSTQATFATAVLYV 343
Cdd:TIGR00871 243 LLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDnnTVRGQYGAGEIG-GVSVPGYLEEEGVDKDSNTETFAALKLEI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 344 KNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFDSQCR----RNELVVRVQPNEAIYAKMMSKKPGVYFSPEETEL 419
Cdd:TIGR00871 322 DNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERdanpRNALVIRIQPDEGVYLKFNAKKPGLNFETRPVKL 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 420 DLTYHSRYRDVkLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPIK-YKYGSRGPAEADELVQKV 498
Cdd:TIGR00871 402 DFSYASRFGEL-LPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPSPPnYPAGSWGPKEADELIRKD 480


                  ....*..
gi 1992460274 499 GFRYEGT 505
Cdd:TIGR00871 481 GRSWRKP 487
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 32-511 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 535.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  32 IFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLTVDT----IRAACMPYMKVVDSEAErLAAFFSRNSYI 107
Cdd:COG0364    11 DLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEfreeVREALEEFSRKPFDEEV-WERFLERLHYV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 108 SGKYVDESSFDNLNTHLLSLPG-GAGANRLFYLALPPSVYHDVTKNIKHQCMST-KGWNRIIVEKPFGHDLQSSEELSSH 185
Cdd:COG0364    90 SGDFTDPEGYERLKELLEELDEeRTPGNRVFYLATPPSLFGPICENLGAAGLATeGGWRRVVIEKPFGHDLASARELNDE 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 186 LFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQ 265
Cdd:COG0364   170 LGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHLLQ 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 266 MLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSDV----VLGQYVGdpdGE--GEAKLGYLDDSTVPKGSTQATFATA 339
Cdd:COG0364   250 LLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVaentVRGQYTA---GWigGEPVPGYREEPGVAPDSTTETFVAL 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 340 VLYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFDSQCRR---NELVVRVQPNEAIYAKMMSKKPGVYFSPEE 416
Cdd:COG0364   327 KLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEElppNRLVIRIQPDEGISLRFNAKVPGLGMRLRP 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 417 TELDLTYHSRYrDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPIKYKYGSRGPAEADELVQ 496
Cdd:COG0364   407 VSLDFSYSDAF-GERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADALLA 485

                         490
                  ....*....|....*
gi 1992460274 497 KVGFryegtyRWVNP 511
Cdd:COG0364   486 RDGR------SWREP 494
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
211-502 1.07e-163

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 465.38  E-value: 1.07e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 211 MVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQMLSLVAMEKPASTSSDDVRDEKVKV 290
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 291 LKCIETVSLSDV----VLGQYVGDPDGeGEAKLGYLDDSTVPKGSTQATFATAVLYVKNERWDGVPFILRCGKALNERKA 366
Cdd:pfam02781  81 LRSLRPITPEDVednvVRGQYGAGWIG-GEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 367 EVRLQFTDVPGDIF--DSQCRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETELDLTYHSRYrDVKLPDAYERLILDVF 444
Cdd:pfam02781 160 EIRIQFKDVPHNLFrdPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRF-GERIPEAYERLLLDVM 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1992460274 445 CGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPikYKYGSRGPAEADELVQKVGFRY 502
Cdd:pfam02781 239 RGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPP--YPAGSWGPKAADELLARDGRKW 294
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 28-514 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 713.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  28 SDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLT--VDTIRAACMPYMKVVDSEAERLAAFFSRNS 105
Cdd:PTZ00309   52 SRALTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSdvERWKKETLARFFKRLDDRECHLEQFLKHIS 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 106 YISGKYVDESSFDNLNTHLLSL-----PGGAGANRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRIIVEKPFGHDLQSSE 180
Cdd:PTZ00309  132 YISGSYDEDEDFKRLNKLIERMeeafqGPEKGGNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSE 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 181 ELSSHLFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQ 260
Cdd:PTZ00309  212 ELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQ 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 261 NHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSDVVLGQYVGDPDGegeAKLGYLDDSTVPKGSTQATFATAV 340
Cdd:PTZ00309  292 NHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADG---SIPGYLEDEGVPKDSTTPTFAAAV 368

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 341 LYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIF-DSQCRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETEL 419
Cdd:PTZ00309  369 LHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPsGDDTQRNELVIRAQPSEAMYLKITAKVPGLSNDLHQTEL 448

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 420 DLTYHSRYrDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPIKYKYGSRGPAEADELVQKVG 499
Cdd:PTZ00309  449 DLTYKTRY-NVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNG 527

                         490
                  ....*....|....*
gi 1992460274 500 FRYEGTYRWVNPHKL 514
Cdd:PTZ00309  528 FKSSKGYQWLQSNDQ 542
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 31-505 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 690.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  31 HIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLTVDTIRA-ACMPYMKV-VDSEAERLAAFFSRNSYIS 108
Cdd:TIGR00871   3 CILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKvVREAIIKFeTDEIDEQWDEFAQRLSYVS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 109 GKYVDESSFDNLNTHLLSLPGGAG--ANRLFYLALPPSVYHDVTKNIKHQCMSTKG-WNRIIVEKPFGHDLQSSEELSSH 185
Cdd:TIGR00871  83 GDVDDDESYDSLAELLEQLDKTYGteGNRLFYLATPPSLFGTIIKQLKKHGLNEQGkWSRVVVEKPFGHDLASAQELNKA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 186 LFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQ 265
Cdd:TIGR00871 163 LRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLLQ 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 266 MLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSD--VVLGQYVGDPDGeGEAKLGYLDDSTVPKGSTQATFATAVLYV 343
Cdd:TIGR00871 243 LLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDnnTVRGQYGAGEIG-GVSVPGYLEEEGVDKDSNTETFAALKLEI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 344 KNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFDSQCR----RNELVVRVQPNEAIYAKMMSKKPGVYFSPEETEL 419
Cdd:TIGR00871 322 DNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERdanpRNALVIRIQPDEGVYLKFNAKKPGLNFETRPVKL 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 420 DLTYHSRYRDVkLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPIK-YKYGSRGPAEADELVQKV 498
Cdd:TIGR00871 402 DFSYASRFGEL-LPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPSPPnYPAGSWGPKEADELIRKD 480


                  ....*..
gi 1992460274 499 GFRYEGT 505
Cdd:TIGR00871 481 GRSWRKP 487
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 34-501 0e+00

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 648.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  34 IIMGASGDLAKKKIYPTLWWLFRDGLLPEQTFFV-GFARSDLTVDTIRAACMPYMKVVDSE-AERLAAFFSRNSYISGKY 111
Cdd:PLN02539   21 IVLGASGDLAKKKTFPALFNLYRQGFLPPDEVHIfGYARSKITDEELRDRIRGYLKDEKNApAEAVSKFLQLIKYVSGAY 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 112 VDESSFDNLNT----HLLSLPGGAGAN-RLFYLALPPSVYHDVTKNIKHQCMSTKG-WNRIIVEKPFGHDLQSSEELSSH 185
Cdd:PLN02539  101 DSEEGFRRLDKeiseHEISKNSAEGSSrRLFYLALPPSVYPPVCKMIKKCCMNKSGlWTRIVVEKPFGKDLESAEELSSQ 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 186 LFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQ 265
Cdd:PLN02539  181 IGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQNHLLQ 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 266 MLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSDVVLGQYVgdpdgegeaklGYLDDSTVPKGSTQATFATAVLYVKN 345
Cdd:PLN02539  261 VLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKDEEVVLGQYE-----------GYRDDPTVPDDSNTPTFASVVLRINN 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 346 ERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFDSQCR-RNELVVRVQPNEAIYAKMMSKKPGVYFSPEETELDLTYH 424
Cdd:PLN02539  330 ERWEGVPFILKAGKALDSRKAEIRVQFKDVPGDIFKCQKQgRNEFVIRLQPSEAMYMKLTVKQPGLEMSTVQSELDLSYG 409

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1992460274 425 SRYRDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPIKYKYGSRGPAEADELVQKVGFR 501
Cdd:PLN02539  410 QRYQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHRIDAGKVKPIPYKQGSRGPAEADELLEKAGYV 486
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 32-511 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 535.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  32 IFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLTVD----TIRAACMPYMKVVDSEAErLAAFFSRNSYI 107
Cdd:PRK05722   11 DLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEdfreVVREALKEFARTPFDEEV-WERFLSRLYYV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 108 SGKYVDESSFDNLNTHLLSLPG--GAGANRLFYLALPPSVYHDVTKNIK-HQCMSTKGWNRIIVEKPFGHDLQSSEELSS 184
Cdd:PRK05722   90 SGDVTDPESYERLKELLEELDEerGTGGNRVFYLATPPSLFGTICENLAaAGLNEGGGWRRVVIEKPFGHDLASARELND 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 185 HLFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLL 264
Cdd:PRK05722  170 QVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHLL 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 265 QMLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSDV----VLGQYVGDPDGeGEAKLGYLDDSTVPKGSTQATFATAV 340
Cdd:PRK05722  250 QLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVkentVRGQYTAGWIG-GKPVPGYREEEGVNPDSTTETFVALK 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 341 LYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFDS---QCRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEET 417
Cdd:PRK05722  329 LEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEEsaeELGPNKLVIRIQPDEGISLRFNAKVPGEGMELRPV 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 418 ELDLTYHSRYrDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPIKYKYGSRGPAEADELVQK 497
Cdd:PRK05722  409 KLDFSYSEAF-GEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAADALLAR 487

                         490
                  ....*....|....
gi 1992460274 498 VGFryegtyRWVNP 511
Cdd:PRK05722  488 DGR------SWREP 495
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 32-511 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 535.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  32 IFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLTVDT----IRAACMPYMKVVDSEAErLAAFFSRNSYI 107
Cdd:COG0364    11 DLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEfreeVREALEEFSRKPFDEEV-WERFLERLHYV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 108 SGKYVDESSFDNLNTHLLSLPG-GAGANRLFYLALPPSVYHDVTKNIKHQCMST-KGWNRIIVEKPFGHDLQSSEELSSH 185
Cdd:COG0364    90 SGDFTDPEGYERLKELLEELDEeRTPGNRVFYLATPPSLFGPICENLGAAGLATeGGWRRVVIEKPFGHDLASARELNDE 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 186 LFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQ 265
Cdd:COG0364   170 LGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHLLQ 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 266 MLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSDV----VLGQYVGdpdGE--GEAKLGYLDDSTVPKGSTQATFATA 339
Cdd:COG0364   250 LLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVaentVRGQYTA---GWigGEPVPGYREEPGVAPDSTTETFVAL 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 340 VLYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFDSQCRR---NELVVRVQPNEAIYAKMMSKKPGVYFSPEE 416
Cdd:COG0364   327 KLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEElppNRLVIRIQPDEGISLRFNAKVPGLGMRLRP 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 417 TELDLTYHSRYrDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPIKYKYGSRGPAEADELVQ 496
Cdd:COG0364   407 VSLDFSYSDAF-GERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADALLA 485

                         490
                  ....*....|....*
gi 1992460274 497 KVGFryegtyRWVNP 511
Cdd:COG0364   486 RDGR------SWREP 494
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 21-502 5.67e-178

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 512.64  E-value: 5.67e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  21 DDVEFHQSDVHIFIImGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLTVDTIRAACMPYMKV-VDSEA---ER 96
Cdd:PLN02640   80 EHAEKGESTLSITVV-GASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISSTLTCrIDQREncgDK 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  97 LAAFFSRNSYISGKYVDESSFDNLNTHLLSLPGGAGANRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRIIVEKPFGHDL 176
Cdd:PLN02640  159 MDQFLKRCFYHSGQYDSEEDFAELNKKLKEKEAGKLSNRLFYLSIPPNIFVDVVRCASLRASSENGWTRVIVEKPFGRDS 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 177 QSSEELSSHLFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIR 256
Cdd:PLN02640  239 ESSGELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIR 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 257 DVMQNHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSDVVLGQYVGDPDGeGEAKLGYLDDSTVPKGSTQATF 336
Cdd:PLN02640  319 DIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMKPLQLEDVIVGQYKGHSKG-GKSYPAYTDDPTVPKHSLTPTF 397

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 337 ATAVLYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIF------DSQCRRNELVVRVQPNEAIYAKMMSKKPGV 410
Cdd:PLN02640  398 AAAALFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYkrnfgtDLDKATNELVLRVQPDEAIYLKINNKVPGL 477

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 411 YFSPEETELDLTYHSRY-RDVklPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPIKYKYGSRGPA 489
Cdd:PLN02640  478 GMRLDRSDLNLLYRARYpREI--PDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPELYPYGSRGPV 555

                         490
                  ....*....|...
gi 1992460274 490 EADELVQKVGFRY 502
Cdd:PLN02640  556 GAHYLAAKYNVRW 568
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 14-502 7.32e-174

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 503.35  E-value: 7.32e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  14 QLRKELHDDVEFHQSDVHIFIImGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLTVDTIRAACMPYMKV-VDS 92
Cdd:PLN02333  102 EDKVVAEFDGNKDESTVSITVV-GASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSKTLTCrIDK 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  93 EA---ERLAAFFSRNSYISGKYVDESSFDNLNTHLLSLPGGAGANRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRIIVE 169
Cdd:PLN02333  181 REncgEKMEEFLKRCFYHSGQYDSQEHFAELDKKLKEHEGGRVSNRLFYLSIPPNIFVDAVKCASSSASSVNGWTRVIVE 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 170 KPFGHDLQSSEELSSHLFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYF 249
Cdd:PLN02333  261 KPFGRDSESSAALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYF 340

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 250 DDFGIIRDVMQNHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSDVVLGQYVGDPDGeGEAKLGYLDDSTVPK 329
Cdd:PLN02333  341 DNYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIQLEDVVIGQYKSHTKG-GVTYPAYTDDKTVPK 419

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 330 GSTQATFATAVLYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIF------DSQCRRNELVVRVQPNEAIYAKM 403
Cdd:PLN02333  420 GSLTPTFAAAALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLYnrnfgtDLDQATNELVIRVQPDEAIYLKI 499

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 404 MSKKPGVYFSPEETELDLTYHSRYRDvKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPIKYKY 483
Cdd:PLN02333  500 NNKVPGLGMRLDRSNLNLLYAARYSK-EIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPEYYPY 578

                         490
                  ....*....|....*....
gi 1992460274 484 GSRGPAEADELVQKVGFRY 502
Cdd:PLN02333  579 GSRGPVGAHYLAARYKVRW 597
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
27-512 3.32e-167

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 481.71  E-value: 3.32e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  27 QSDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLTVD----TIRAACMPYMKVVDSEAeRLAAFFS 102
Cdd:PRK12853    5 PAPPCTLVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEqwraRVRESLRAFGADGFDDA-VWDRLAA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 103 RNSYISGKYVDESSFDNLNTHLlslpgGAGANRLFYLALPPSVYHDVTKNIKHQCMsTKGWNRIIVEKPFGHDLQSSEEL 182
Cdd:PRK12853   84 RLSYVQGDVTDPADYARLAEAL-----GPGGNPVFYLAVPPSLFAPVVENLGAAGL-LPEGRRVVLEKPFGHDLASARAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 183 SSHLFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNH 262
Cdd:PRK12853  158 NATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQNH 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 263 LLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSDV--VLGQYVGDPDGeGEAKLGYLDDSTVPKGSTQATFATAV 340
Cdd:PRK12853  238 LLQLLALVAMEPPASFDADAVRDEKAKVLRAIRPLDPDDVhtVRGQYTAGTVG-GEPVPGYREEPGVDPDSRTETFVALK 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 341 LYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFDSQCRR--NELVVRVQPNEAIYAKMMSKKPGVYFSPEETE 418
Cdd:PRK12853  317 LEIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTGVEppNRLVIRLQPDEGISLELNVKRPGPGMRLRPVE 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 419 LDLTYHSRYRDvklPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPIKYKYGSRGPAEADELVQKV 498
Cdd:PRK12853  397 LDADYADDERP---LEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAADPVPPHEYPAGSWGPAAADALLARD 473

                         490
                  ....*....|....
gi 1992460274 499 GfryegtYRWVNPH 512
Cdd:PRK12853  474 G------RGWREPA 481
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
211-502 1.07e-163

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 465.38  E-value: 1.07e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 211 MVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQMLSLVAMEKPASTSSDDVRDEKVKV 290
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 291 LKCIETVSLSDV----VLGQYVGDPDGeGEAKLGYLDDSTVPKGSTQATFATAVLYVKNERWDGVPFILRCGKALNERKA 366
Cdd:pfam02781  81 LRSLRPITPEDVednvVRGQYGAGWIG-GEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 367 EVRLQFTDVPGDIF--DSQCRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETELDLTYHSRYrDVKLPDAYERLILDVF 444
Cdd:pfam02781 160 EIRIQFKDVPHNLFrdPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRF-GERIPEAYERLLLDVM 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1992460274 445 CGSQMHFVRSDELREAWRIFTPLLHQIEKEKTPPikYKYGSRGPAEADELVQKVGFRY 502
Cdd:pfam02781 239 RGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPP--YPAGSWGPKAADELLARDGRKW 294
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 27-508 5.60e-125

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 373.99  E-value: 5.60e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  27 QSDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLTVDT----IRAACMPYMKVVDSEAErLAAFFS 102
Cdd:PRK12854    8 PAPPTVFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAfrehARDALDEFGARKLDDGE-WARFAK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 103 RNSYISGKY-----------VDESSFDnlnthllslpGGAGANRLFYLALPPSVYHDVTKNIKHQCMsTKGwNRIIVEKP 171
Cdd:PRK12854   87 RLRYVPGGFlsagpgalaaaVAAARAE----------LGGDARLVHYLAVPPSAFLDVTRALGEAGL-AEG-SRVVMEKP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 172 FGHDLQSSEELSSHLFSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDD 251
Cdd:PRK12854  155 FGTDLASAEALNAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 252 FGIIRDVMQNHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIETVSLSDVVLGQYVgdpdgegeaklGYLDDSTVPKGS 331
Cdd:PRK12854  235 TGAYRDMVVTHLFQVLAFVAMEPPTALEPDAISEEKNKVFRSMRPLDPAEVVRGQYS-----------GYRDEPGVAPDS 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 332 TQATFATAVLYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFD--SQCRR--NELVVRVQPNEAIYAKMMSKK 407
Cdd:PRK12854  304 TTETFVALKVWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPYSMFPagSVGAQgpDHLTFDLADNSKVSLSFYGKR 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 408 PGVYFSPEETELDLTYHSRYRDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLhqiekEKTPPIK-YKYGSR 486
Cdd:PRK12854  384 PGPGMRLDKLSLQFSLKDTGPKGDVLEAYERLILDALRGDHTLFTTADGIESLWEVSQPLL-----EDPPPVKpYAPGSW 458

                         490       500
                  ....*....|....*....|..
gi 1992460274 487 GPAEADELVQKVGFRYEGTYRW 508
Cdd:PRK12854  459 GPNAIHQLAAPDAWRLPFEREW 480
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
34-209 1.78e-88

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 268.91  E-value: 1.78e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274  34 IIMGASGDLAKKKIYPTLWWLFRDGLLPEQTFFVGFARSDLTVDTIRAACMPYMKVV-DSEAERLAAFFSRNSYISGKYV 112
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKEFkELDEEKWDRFLERLHYVSGDFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992460274 113 DESSFDNLNTHLLSLPGGAGANRLFYLALPPSVYHDVTKNIKHQCMS-TKGWNRIIVEKPFGHDLQSSEELSSHLFSLFT 191
Cdd:pfam00479  81 DPESYEKLKERLEEHEDETRGNRLFYLAVPPSLFGPIAENLGRAGLSeEGGWRRVVIEKPFGHDLESARELNDQLAKVFK 160

                         170
                  ....*....|....*...
gi 1992460274 192 EEQIYRIDHYLGKEMVQN 209
Cdd:pfam00479 161 EEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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