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Conserved domains on  [gi|1985396614|ref|XP_039339004|]
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leucine-rich glioma-inactivated protein 1 isoform X2 [Mauremys reevesii]

Protein Classification

LRR_8 and EPTP domain-containing protein( domain architecture ID 12158096)

LRR_8 and EPTP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
83-141 1.70e-14

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.93  E-value: 1.70e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1985396614  83 PSLQLLFIENNSIKSISRNSFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 141
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 472-512 4.04e-10

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 54.78  E-value: 4.04e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1985396614 472 KFVKFQELNIQAPRSFTHVSIDKRNFLFASSFKGTTLIYKH 512
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 114-189 2.71e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.10  E-value: 2.71e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1985396614  114 LANNNLQTLPKDIFKGLDSLTNVDLRGNTFNCDCKLKWLVEWLGSTNATV---EDIYCESPPEYKKRKINSLSPKEFDC 189
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 240-278 1.20e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.85  E-value: 1.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1985396614 240 FRNYDNITGTSTVVCKPIIIETQLYVIVAQLFGGSHIYK 278
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 334-375 1.73e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 1.73e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1985396614 334 GFYSHQSLHAWyRDTDVEYLEIAGKPHLILSSSSQRPVIYQW 375
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 285-330 1.80e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 1.80e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1985396614 285 KFIKIQDIEIlkiRKPNDIETFRIAEDWYFVVADSSkaGFTTVYKW 330
Cdd:pfam03736   1 KFVPYQTIPT---RGARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 381-422 5.40e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 45.92  E-value: 5.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1985396614 381 EFIKRLEIQDMeDVYAVKHFRVKEDVYICLTRFIGDSKVMKW 422
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 193-233 1.48e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 39.37  E-value: 1.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1985396614 193 EFAVYESLP-YQSLSVDTFSYMNDEHVVIAqPFTGKCIFLEW 233
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
83-141 1.70e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.93  E-value: 1.70e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1985396614  83 PSLQLLFIENNSIKSISRNSFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 141
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 472-512 4.04e-10

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 54.78  E-value: 4.04e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1985396614 472 KFVKFQELNIQAPRSFTHVSIDKRNFLFASSFKGTTLIYKH 512
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 114-189 2.71e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.10  E-value: 2.71e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1985396614  114 LANNNLQTLPKDIFKGLDSLTNVDLRGNTFNCDCKLKWLVEWLGSTNATV---EDIYCESPPEYKKRKINSLSPKEFDC 189
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-141 3.21e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 3.21e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1985396614  63 SLSFVRSAFTKIPEGSFLLTpSLQLLFIENNSIKSISrNSFRGLKSLIHLSLANNNLQTLPKDIfKGLDSLTNVDLRGN 141
Cdd:COG4886   163 SLDLSNNQLTDLPEELGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN 238
LRRCT smart00082
Leucine rich repeat C-terminal domain;
141-189 1.65e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 50.51  E-value: 1.65e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1985396614  141 NTFNCDCKLKWLVEWLGSTNAT--VEDIYCESPPEYKKRKInSLSPKEFDC 189
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRGPLL-ELLHSEFKC 50
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 240-278 1.20e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.85  E-value: 1.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1985396614 240 FRNYDNITGTSTVVCKPIIIETQLYVIVAQLFGGSHIYK 278
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 334-375 1.73e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 1.73e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1985396614 334 GFYSHQSLHAWyRDTDVEYLEIAGKPHLILSSSSQRPVIYQW 375
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 285-330 1.80e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 1.80e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1985396614 285 KFIKIQDIEIlkiRKPNDIETFRIAEDWYFVVADSSkaGFTTVYKW 330
Cdd:pfam03736   1 KFVPYQTIPT---RGARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 81-141 3.70e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 3.70e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1985396614  81 LTPSLQLLFIENNSIKSISrnSFRGLKSLIHLSLANNNLQTLP--KDIFKGLDSLTNVDLRGN 141
Cdd:cd21340   118 LSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 381-422 5.40e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 45.92  E-value: 5.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1985396614 381 EFIKRLEIQDMeDVYAVKHFRVKEDVYICLTRFIGDSKVMKW 422
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
43-126 1.05e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.07  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396614  43 DNALCenarSIPTSVPPDVISLSFVRSAFTKIPEgsfLLTPSLQLLFIENNSIKSISRNSFRGLKsliHLSLANNNLQTL 122
Cdd:PRK15370  334 ENALT----SLPASLPPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNLPENLPAALQ---IMQASRNNLVRL 403


                  ....
gi 1985396614 123 PKDI 126
Cdd:PRK15370  404 PESL 407
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 193-233 1.48e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 39.37  E-value: 1.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1985396614 193 EFAVYESLP-YQSLSVDTFSYMNDEHVVIAqPFTGKCIFLEW 233
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
LRR smart00370
Leucine-rich repeats, outliers;
106-129 7.87e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.95  E-value: 7.87e-04
                           10        20
                   ....*....|....*....|....
gi 1985396614  106 LKSLIHLSLANNNLQTLPKDIFKG 129
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
83-141 1.70e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.93  E-value: 1.70e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1985396614  83 PSLQLLFIENNSIKSISRNSFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 141
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
63-119 3.88e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 3.88e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1985396614  63 SLSFVRSAFTKIPEGSFLLTPSLQLLFIENNSIKSISRNSFRGLKSLIHLSLANNNL 119
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 472-512 4.04e-10

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 54.78  E-value: 4.04e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1985396614 472 KFVKFQELNIQAPRSFTHVSIDKRNFLFASSFKGTTLIYKH 512
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 114-189 2.71e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.10  E-value: 2.71e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1985396614  114 LANNNLQTLPKDIFKGLDSLTNVDLRGNTFNCDCKLKWLVEWLGSTNATV---EDIYCESPPEYKKRKINSLSPKEFDC 189
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-141 3.21e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 3.21e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1985396614  63 SLSFVRSAFTKIPEGSFLLTpSLQLLFIENNSIKSISrNSFRGLKSLIHLSLANNNLQTLPKDIfKGLDSLTNVDLRGN 141
Cdd:COG4886   163 SLDLSNNQLTDLPEELGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN 238
LRRCT smart00082
Leucine rich repeat C-terminal domain;
141-189 1.65e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 50.51  E-value: 1.65e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1985396614  141 NTFNCDCKLKWLVEWLGSTNAT--VEDIYCESPPEYKKRKInSLSPKEFDC 189
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRGPLL-ELLHSEFKC 50
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-141 1.77e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 1.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396614  55 TSVPPDVISLSFVRS------AFTKIPE--GSFlltPSLQLLFIENNSIKSISrNSFRGLKSLIHLSLANNNLQTLPKDI 126
Cdd:COG4886   126 TDLPEELANLTNLKEldlsnnQLTDLPEplGNL---TNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPL 201

                          90
                  ....*....|....*
gi 1985396614 127 fKGLDSLTNVDLRGN 141
Cdd:COG4886   202 -GNLTNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-183 2.75e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 2.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396614  83 PSLQLLFIENNSIKSISrnSFRGLKSLIHLSLANNNLQTLPKdiFKGLDSLTNVDLRGNTFNcDCKLKWLVEWLGSTNAT 162
Cdd:COG4886   228 TNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLL 302

                          90       100
                  ....*....|....*....|.
gi 1985396614 163 VEDIYCESPPEYKKRKINSLS 183
Cdd:COG4886   303 LLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-141 4.39e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 4.39e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1985396614  83 PSLQLLFIENNSIKSISrNSFRGLKSLIHLSLANNNLQTLPKdiFKGLDSLTNVDLRGN 141
Cdd:COG4886   205 TNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 240-278 1.20e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.85  E-value: 1.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1985396614 240 FRNYDNITGTSTVVCKPIIIETQLYVIVAQLFGGSHIYK 278
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 334-375 1.73e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 1.73e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1985396614 334 GFYSHQSLHAWyRDTDVEYLEIAGKPHLILSSSSQRPVIYQW 375
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 285-330 1.80e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 1.80e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1985396614 285 KFIKIQDIEIlkiRKPNDIETFRIAEDWYFVVADSSkaGFTTVYKW 330
Cdd:pfam03736   1 KFVPYQTIPT---RGARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 81-141 3.70e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 3.70e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1985396614  81 LTPSLQLLFIENNSIKSISrnSFRGLKSLIHLSLANNNLQTLP--KDIFKGLDSLTNVDLRGN 141
Cdd:cd21340   118 LSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 381-422 5.40e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 45.92  E-value: 5.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1985396614 381 EFIKRLEIQDMeDVYAVKHFRVKEDVYICLTRFIGDSKVMKW 422
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 83-121 9.75e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 9.75e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1985396614  83 PSLQLLFIENNSIKSISrnSFRGLKSLIHLSLANNNLQT 121
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKIT 37
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
43-126 1.05e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.07  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396614  43 DNALCenarSIPTSVPPDVISLSFVRSAFTKIPEgsfLLTPSLQLLFIENNSIKSISRNSFRGLKsliHLSLANNNLQTL 122
Cdd:PRK15370  334 ENALT----SLPASLPPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNLPENLPAALQ---IMQASRNNLVRL 403


                  ....
gi 1985396614 123 PKDI 126
Cdd:PRK15370  404 PESL 407
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 193-233 1.48e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 39.37  E-value: 1.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1985396614 193 EFAVYESLP-YQSLSVDTFSYMNDEHVVIAqPFTGKCIFLEW 233
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 107-146 4.31e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 4.31e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1985396614 107 KSLIHLSLANNNLQTLPkdIFKGLDSLTNVDLRGNTFNCD 146
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITD 38
LRR smart00370
Leucine-rich repeats, outliers;
106-129 7.87e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.95  E-value: 7.87e-04
                           10        20
                   ....*....|....*....|....
gi 1985396614  106 LKSLIHLSLANNNLQTLPKDIFKG 129
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
106-129 7.87e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.95  E-value: 7.87e-04
                           10        20
                   ....*....|....*....|....
gi 1985396614  106 LKSLIHLSLANNNLQTLPKDIFKG 129
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_8 pfam13855
Leucine rich repeat;
104-144 1.61e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.61e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1985396614 104 RGLKSLIhlsLANNNLQTLPKDIFKGLDSLTNVDLRGNTFN 144
Cdd:pfam13855   1 PNLRSLD---LSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT 38
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-143 2.73e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.73e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1985396614  83 PSLQLLFIENNsiksisrNSFRGLKSLIHLSLANNNLQTLPKDIfKGLDSLTNVDLRGNTF 143
Cdd:COG4886    96 TNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQL 148
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 64-135 4.32e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 4.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1985396614  64 LSFVRSAFTKIPEgsFLLTPSLQLLFIENNSIKSISrnSFRGLKSLIHLSLANNNLQTLPkdifkGLDSLTN 135
Cdd:cd21340     7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIE-----NLENLVN 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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