BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  47 KPSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFM 126
Cdd:cd18192     1 RPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFM 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958783100 127 YLGKILTAPSSFEQFKVAMNYLQLYNVPDCLEDI 160
Cdd:cd18192    81 YLGKIMTAPSDFEQLKVAMNYLQLYYIPECLEDI 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  47 KPSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFM 126
Cdd:cd18192     1 RPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFM 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958783100 127 YLGKILTAPSSFEQFKVAMNYLQLYNVPDCLEDI 160
Cdd:cd18192    81 YLGKIMTAPSDFEQLKVAMNYLQLYYIPECLEDI 114

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100   69 DCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKILTAPSSFEQFKVAMNYL 148
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|..
gi 1958783100  149 QLYNVPDCLEDI 160
Cdd:smart00225  81 QIPGLVELCEEF 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  47 KPSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFM 126
Cdd:cd18192     1 RPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFM 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958783100 127 YLGKILTAPSSFEQFKVAMNYLQLYNVPDCLEDI 160
Cdd:cd18192    81 YLGKIMTAPSDFEQLKVAMNYLQLYYIPECLEDI 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  45 MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQ 124
Cdd:cd18194     1 MEFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLNSDIVTAPAFGLLLD 80

                          90       100
                  ....*....|....*....|....*....
gi 1958783100 125 FMYLGKILTAPSSFEQFKVAMNYLQLYNV 153
Cdd:cd18194    81 FMYEGRLALRDLPVEDVLAAASYLHMYDI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  45 MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQ 124
Cdd:cd18324     1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLE 80

                          90       100
                  ....*....|....*....|....*....
gi 1958783100 125 FMYLGKILTAPSSFEQFKVAMNYLQLYNV 153
Cdd:cd18324    81 FMYEGKLQFKDLPIEDVLAAASYLHMYDI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  45 MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQ 124
Cdd:cd18323     1 MEFPDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCINNEIVTAPAFSLLLE 80

                          90       100
                  ....*....|....*....|....*....
gi 1958783100 125 FMYLGKILTAPSSFEQFKVAMNYLQLYNV 153
Cdd:cd18323    81 FMYEGRLSFNDTPVEDVLAAASYLHMNDI 109

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  58 LNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNH--QHSTAQLNLSNmkISAECFDLILQFMYLGKILTAP 135
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQesESSVSEITLDD--VSPEDFEALLEFMYTGKLISEE 78

                          90
                  ....*....|....*...
gi 1958783100 136 SSFEQFKVAmNYLQLYNV 153
Cdd:pfam00651  79 NVDDLLAAA-DKLQIPSL 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  50 HSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSnmKISAECFDLILQFMYLG 129
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLDQS--QVSADGFQKLLEFIYTG 78

                          90       100
                  ....*....|....*....|....
gi 1958783100 130 KILTAPSSFEQFKVAMNYLQLYNV 153
Cdd:cd18217    79 NLNLDSWNVAEIHQAASYLGMEEV 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  45 MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNH-QHSTAQLNLSNMKISAECFDLIL 123
Cdd:cd18956     1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRpAGGRDTVRLNGDIVTAPAFGRLL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958783100 124 QFMYLGKILTAPSSFEQFKVAMNYLQLYNV 153
Cdd:cd18956    81 DFMYEGRLDLRSLPVEDVLAAASYLHMYDI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  48 PSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKI-SAECFDLILQFM 126
Cdd:cd18230     2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIvTAQGFKAIIDFM 81

                          90       100
                  ....*....|....*....|....*..
gi 1958783100 127 YLGKILTAPSSFEQFKVAMNYLQLYNV 153
Cdd:cd18230    82 YSAHLALTSKNVIEVMSAASYLQMTDI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  48 PSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQhstaQLNLSNMKISAECFDLILQFMY 127
Cdd:cd18333     2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDN----LINLDHEMVSPGIFRLILDYIY 77

                          90       100
                  ....*....|....*....|....*..
gi 1958783100 128 LGKILTAPSSFEQ----FKVAMNYLQL 150
Cdd:cd18333    78 TGRLSEGDPGSEQnlgaVLAAASYLQI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  52 SYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFM-----NHQHSTAQLNLsnmkISAECFDLILQFM 126
Cdd:cd18330     3 TKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIhyiqdSGRHSTASLDI----VTSEAFSIILDFL 78

                          90       100
                  ....*....|....*....|....*..
gi 1958783100 127 YLGKILTAPSSFEQFKVAMNYLQLYNV 153
Cdd:cd18330    79 YSGKLDLCSENVIEVMSAASYLQMTDV 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  49 SHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMN-HQHSTAQLNLSNMkiSAECFDLILQFMY 127
Cdd:cd18212     5 THKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADeGEVGQSIYMLEGM--VAETFGALLEFIY 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958783100 128 LGKILTAPSSFEQFKVAMNYLQLYNVPDCLEDIQ 161
Cdd:cd18212    83 TGCLQVGEKSLEQILATAQFLKVNDLVKAYSDYQ 116

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100   69 DCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKILTAPSSFEQFKVAMNYL 148
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|..
gi 1958783100  149 QLYNVPDCLEDI 160
Cdd:smart00225  81 QIPGLVELCEEF 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  48 PSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSnmkISAECFDLILQFMY 127
Cdd:cd18289    10 PNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPAT---VPPACFQQILSFCY 86

                          90       100
                  ....*....|....*....|....*...
gi 1958783100 128 LGKILTAPSsfEQFKV--AMNYLQLYNV 153
Cdd:cd18289    87 TGKLTMAAS--EQLVVmyTAGFLQIQHI 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  50 HSSYVLQQLNNQRE-WGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNM-KISAECFDLILQFMY 127
Cdd:cd18207     9 HSADMLHNLNQQRKsGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMhTISSKVFGDILDFAY 88

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958783100 128 LGKILTAPSSFEQFKVAMNYLQLYNVPD-CLEDIQ 161
Cdd:cd18207    89 TSRIVVRLESFPELMTAAKFLLMRSVIDiCQEVIK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  49 SHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFF-MNHQHSTAQLNLSNMKISA-ECFDLILQFM 126
Cdd:cd18201     3 SYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYcFTNKESCDQTTVTHLDVVAvQGFSVILDFM 82

                          90       100
                  ....*....|....*....|....*...
gi 1958783100 127 YLGK-ILTAPSSFEQFKVAmNYLQLYNV 153
Cdd:cd18201    83 YSGNlVLTSQNAIEVMSVA-SYLQMTEV 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  50 HSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLG 129
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTS 80

                          90       100
                  ....*....|....*....|....
gi 1958783100 130 KILTAPSSFEQFKVAMNYLQLYNV 153
Cdd:cd18255    81 ELTLDLDCIQDVLGAAVHLQMLPV 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  55 LQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKILTA 134
Cdd:cd18240     5 CNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPIT 84

                          90
                  ....*....|
gi 1958783100 135 PSSFEQFKVA 144
Cdd:cd18240    85 AENVEELLPA 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  44 EMAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSnmkISAECFDLIL 123
Cdd:cd18290     4 QMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAA---VQPQSFQQIL 80

                  ....*...
gi 1958783100 124 QFMYLGKI 131
Cdd:cd18290    81 SFCYTGRL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  50 HSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNH-QHSTAQLNLSNmKISAECFDLILQFMYL 128
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQlKNNVSVINLDP-EIEPEGFRILLDFMYT 80

                          90       100
                  ....*....|....*....|....*..
gi 1958783100 129 GKILTAPSSFEQFKVAMNYLQLYNVPD 155
Cdd:cd18215    81 SRLNLREGNIMAVMATAMYLQMEHVVD 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  50 HSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFmnhQHSTAQLN----LSNMKISAecFDLILQF 125
Cdd:cd18233     1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLF---QNSSSQKNdvfhLDIKNVGG--IGQILDF 75

                  ..
gi 1958783100 126 MY 127
Cdd:cd18233    76 MY 77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  50 HSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNH-QHSTAQLNLSNmKISAECFDLILQFMYL 128
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRvGEGVSVLTLPS-GLEARGFQLLLDFMYT 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958783100 129 GKILTAPSSFEQFKVAMNYLQLYNVPD-CLEDIQ 161
Cdd:cd18332    81 SRLPLTPRTVPAVLAAATYLQMEHVVEtCRRFIQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  50 HSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLG 129
Cdd:cd18253     1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTG 80

                          90       100
                  ....*....|....*....|.
gi 1958783100 130 KILTAPSSFEQFKVAMNYLQL 150
Cdd:cd18253    81 KVKITTENVQYLFETSSLFQI 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  50 HSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLG 129
Cdd:cd18257     1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG 80

                          90       100
                  ....*....|....*....|....
gi 1958783100 130 KILTAPSSFEQFKVAMNYLQLYNV 153
Cdd:cd18257    81 TVFISQATVESLLPAANLLQIKLV 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  48 PSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQhSTAQLNLSNMK-ISAECFDLILQFM 126
Cdd:cd18198     6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGA-VVDQQNVYEIDfVSPEALTALLEFA 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958783100 127 YLGKILTAPSSFEQFKVAMNYLQLYNVPD-CLEDIQ 161
Cdd:cd18198    85 YTATLTVSTANVGDILSAARLLEIPCVSHvCAEILD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  48 PSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRmffmnhQHST----AQLNLSNMKiSAECFDLIL 123
Cdd:cd18220     6 PEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFR------DHSAlstmSGLSISVIK-NPNVFEQLL 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958783100 124 QFMYLGKILTAPSSFEQFKVAMNYLQLYNVPD 155
Cdd:cd18220    79 SFCYTGRMSLQLKDVVSFLTAASFLQMQCVID 110

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  67 LCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMN---HQHSTAQL---NLSNMKisaecfdLILQFMYLGKILTAPSSFEQ 140
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtppDEHPVIILpdvPYSELK-------ALLDFIYTGEVNVSQEQLES 73

                  ....*....
gi 1958783100 141 FKVAMNYLQ 149
Cdd:cd18315    74 LLKLAELLQ 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783100  48 PSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTaqLNLSNMKiSAECFDLILQFMY 127
Cdd:cd18222     6 PDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMST--VSISVIK-NPTVFEQLLSFCY 82

                          90       100
                  ....*....|....*....|....*...
gi 1958783100 128 LGKILTAPSSFEQFKVAMNYLQLYNVPD 155
Cdd:cd18222    83 TGRICLQLADIISYLTAASFLQMQHIID 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958783100  50 HSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFR 94
Cdd:cd18195     1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFR 45