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Conserved domains on  [gi|1958782872|ref|XP_038968100|]
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general transcription factor 3C polypeptide 2 isoform X2 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 556-641 1.71e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 556 SLAWMPTrpHHHLAAGYYNGMVVFWNLPTNSPLQRIRL---------------------SDGSLKLY------PFQCFLA 608
Cdd:cd00200   140 SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLTGhtgevnsvafspdgekllsssSDGTIKLWdlstgkCLGTLRG 217

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958782872 609 HDQAVRTIQWCKaNSHFLVSAGSDRKIKFWDLR 641
Cdd:cd00200   218 HENGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 54-295 1.55e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 1.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872   54 PPPLPGFEDSSDKRRLP-PDQESLTRLEQQDLSSEMAKVSNPR-ASKPSGRRGGRTPRGAKRPQQRKPPSAPLVpGLLDQ 131
Cdd:PHA03247  2623 APDPPPPSPSPAANEPDpHPPPTVPPPERPRDDPAPGRVSRPRrARRLGRAAQASSPPQRPRRRAARPTVGSLT-SLADP 2701

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872  132 SNPLSTPMPKKR---SQKSKGDLLLLKLSKGLDQPESPHPKRPPEDFETPSGERPRRRAAQVAllylqelaeelSTALPA 208
Cdd:PHA03247  2702 PPPPPTPEPAPHalvSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTA-----------GPPAPA 2770

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872  209 PLSGPKSPKVSSPTKPKKTRQAASQGEEDGRARDEDFVLQVEGEDEEESEAPSENSSDPEPVAPRSTPRGPAAGKQKPH- 287
Cdd:PHA03247  2771 PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSl 2850

                          250
                   ....*....|
gi 1958782872  288 --CRGMAPNG 295
Cdd:PHA03247  2851 plGGSVAPGG 2860
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 556-641 1.71e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 556 SLAWMPTrpHHHLAAGYYNGMVVFWNLPTNSPLQRIRL---------------------SDGSLKLY------PFQCFLA 608
Cdd:cd00200   140 SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLTGhtgevnsvafspdgekllsssSDGTIKLWdlstgkCLGTLRG 217

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958782872 609 HDQAVRTIQWCKaNSHFLVSAGSDRKIKFWDLR 641
Cdd:cd00200   218 HENGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
552-641 3.38e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 3.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 552 GQCLSLAWMPTRphHHLAAGYYNGMVVFWNLPTNSPLQRirlsdgslklypfqcFLAHDQAVRTIQWcKANSHFLVSAGS 631
Cdd:COG2319   331 GAVRSVAFSPDG--KTLASGSDDGTVRLWDLATGELLRT---------------LTGHTGAVTSVAF-SPDGRTLASGSA 392

                          90
                  ....*....|
gi 1958782872 632 DRKIKFWDLR 641
Cdd:COG2319   393 DGTVRLWDLA 402
PHA03247 PHA03247
large tegument protein UL36; Provisional
 54-295 1.55e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 1.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872   54 PPPLPGFEDSSDKRRLP-PDQESLTRLEQQDLSSEMAKVSNPR-ASKPSGRRGGRTPRGAKRPQQRKPPSAPLVpGLLDQ 131
Cdd:PHA03247  2623 APDPPPPSPSPAANEPDpHPPPTVPPPERPRDDPAPGRVSRPRrARRLGRAAQASSPPQRPRRRAARPTVGSLT-SLADP 2701

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872  132 SNPLSTPMPKKR---SQKSKGDLLLLKLSKGLDQPESPHPKRPPEDFETPSGERPRRRAAQVAllylqelaeelSTALPA 208
Cdd:PHA03247  2702 PPPPPTPEPAPHalvSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTA-----------GPPAPA 2770

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872  209 PLSGPKSPKVSSPTKPKKTRQAASQGEEDGRARDEDFVLQVEGEDEEESEAPSENSSDPEPVAPRSTPRGPAAGKQKPH- 287
Cdd:PHA03247  2771 PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSl 2850

                          250
                   ....*....|
gi 1958782872  288 --CRGMAPNG 295
Cdd:PHA03247  2851 plGGSVAPGG 2860
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 602-639 5.30e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.30e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958782872  602 PFQCFLAHDQAVRTIQWCKaNSHFLVSAGSDRKIKFWD 639
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
602-639 4.36e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.36e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958782872 602 PFQCFLAHDQAVRTIQWCKaNSHFLVSAGSDRKIKFWD 639
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 556-641 1.71e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 556 SLAWMPTrpHHHLAAGYYNGMVVFWNLPTNSPLQRIRL---------------------SDGSLKLY------PFQCFLA 608
Cdd:cd00200   140 SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLTGhtgevnsvafspdgekllsssSDGTIKLWdlstgkCLGTLRG 217

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958782872 609 HDQAVRTIQWCKaNSHFLVSAGSDRKIKFWDLR 641
Cdd:cd00200   218 HENGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 500-641 1.84e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 500 CSDGKVLLFSLPHPEALLAQQPPdamKPAIYKVQCLA------------TLQVGSVQASDPSE-----CGQCLSLAWMPT 562
Cdd:cd00200    28 SGDGTIKVWDLETGELLRTLKGH---TGPVRDVAASAdgtylasgssdkTIRLWDLETGECVRtltghTSYVSSVAFSPD 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 563 RphHHLAAGYYNGMVVFWNLPTNSPLQRIR---------------------LSDGSLKLY---PFQC---FLAHDQAVRT 615
Cdd:cd00200   105 G--RILSSSSRDKTIKVWDVETGKCLTTLRghtdwvnsvafspdgtfvassSQDGTIKLWdlrTGKCvatLTGHTGEVNS 182

                         170       180
                  ....*....|....*....|....*.
gi 1958782872 616 IQWCKANSHFLvSAGSDRKIKFWDLR 641
Cdd:cd00200   183 VAFSPDGEKLL-SSSSDGTIKLWDLS 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 552-641 2.14e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 2.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 552 GQCLSLAWMPtrPHHHLAAGYYNGMVVFWNLPTNSPLQRirlsdgslklypfqcFLAHDQAVRTIQWCkANSHFLVSAGS 631
Cdd:cd00200    10 GGVTCVAFSP--DGKLLATGSGDGTIKVWDLETGELLRT---------------LKGHTGPVRDVAAS-ADGTYLASGSS 71

                          90
                  ....*....|
gi 1958782872 632 DRKIKFWDLR 641
Cdd:cd00200    72 DKTIRLWDLE 81
WD40 COG2319
WD40 repeat [General function prediction only];
552-641 3.38e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 3.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 552 GQCLSLAWMPTRphHHLAAGYYNGMVVFWNLPTNSPLQRirlsdgslklypfqcFLAHDQAVRTIQWcKANSHFLVSAGS 631
Cdd:COG2319   331 GAVRSVAFSPDG--KTLASGSDDGTVRLWDLATGELLRT---------------LTGHTGAVTSVAF-SPDGRTLASGSA 392

                          90
                  ....*....|
gi 1958782872 632 DRKIKFWDLR 641
Cdd:COG2319   393 DGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
556-641 1.35e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 556 SLAWMPTRphHHLAAGYYNGMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQAVRTIQWCkANSHFLVSAGSDRKI 635
Cdd:COG2319   209 SVAFSPDG--KLLASGSADGTVRLWDLATGKLLRTLT---------------GHSGSVRSVAFS-PDGRLLASGSADGTV 270


                  ....*.
gi 1958782872 636 KFWDLR 641
Cdd:COG2319   271 RLWDLA 276
PHA03247 PHA03247
large tegument protein UL36; Provisional
 54-295 1.55e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 1.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872   54 PPPLPGFEDSSDKRRLP-PDQESLTRLEQQDLSSEMAKVSNPR-ASKPSGRRGGRTPRGAKRPQQRKPPSAPLVpGLLDQ 131
Cdd:PHA03247  2623 APDPPPPSPSPAANEPDpHPPPTVPPPERPRDDPAPGRVSRPRrARRLGRAAQASSPPQRPRRRAARPTVGSLT-SLADP 2701

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872  132 SNPLSTPMPKKR---SQKSKGDLLLLKLSKGLDQPESPHPKRPPEDFETPSGERPRRRAAQVAllylqelaeelSTALPA 208
Cdd:PHA03247  2702 PPPPPTPEPAPHalvSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTA-----------GPPAPA 2770

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872  209 PLSGPKSPKVSSPTKPKKTRQAASQGEEDGRARDEDFVLQVEGEDEEESEAPSENSSDPEPVAPRSTPRGPAAGKQKPH- 287
Cdd:PHA03247  2771 PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSl 2850

                          250
                   ....*....|
gi 1958782872  288 --CRGMAPNG 295
Cdd:PHA03247  2851 plGGSVAPGG 2860
WD40 COG2319
WD40 repeat [General function prediction only];
555-641 2.12e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 555 LSLAWMPTRphHHLAAGYYNGMVVFWNLPTNSPLQRI-----------------RL----SDGSLKLY------PFQCFL 607
Cdd:COG2319   250 RSVAFSPDG--RLLASGSADGTVRLWDLATGELLRTLtghsggvnsvafspdgkLLasgsDDGTVRLWdlatgkLLRTLT 327

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958782872 608 AHDQAVRTIQWcKANSHFLVSAGSDRKIKFWDLR 641
Cdd:COG2319   328 GHTGAVRSVAF-SPDGKTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
556-643 2.13e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 556 SLAWMPTRphHHLAAGYYNGMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQAVRTIQWCkANSHFLVSAGSDRKI 635
Cdd:COG2319   167 SVAFSPDG--KLLASGSDDGTVRLWDLATGKLLRTLT---------------GHTGAVRSVAFS-PDGKLLASGSADGTV 228


                  ....*...
gi 1958782872 636 KFWDLRRP 643
Cdd:COG2319   229 RLWDLATG 236
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 602-639 5.30e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.30e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958782872  602 PFQCFLAHDQAVRTIQWCKaNSHFLVSAGSDRKIKFWD 639
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 533-639 5.96e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 5.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 533 QCLATLQvgsvqasdpSECGQCLSLAWMPTRphHHLAAGYYNGMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQA 612
Cdd:cd00200   210 KCLGTLR---------GHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGECVQTLS---------------GHTNS 263

                          90       100
                  ....*....|....*....|....*..
gi 1958782872 613 VRTIQWCkANSHFLVSAGSDRKIKFWD 639
Cdd:cd00200   264 VTSLAWS-PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
566-641 6.48e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 6.48e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958782872 566 HHLAAGYYNGMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQAVRTIQWCkANSHFLVSAGSDRKIKFWDLR 641
Cdd:COG2319   133 KTLASGSADGTVRLWDLATGKLLRTLT---------------GHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLA 192
PHA03247 PHA03247
large tegument protein UL36; Provisional
 54-293 3.29e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 3.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872   54 PPPLPgfedsSDKRRLPPDQESLTRLEQQDLSSEMAKVSNPRASKPSGRRGGRTPRGAKRPQQRKPPSAPLVPGLLDQSN 133
Cdd:PHA03247  2552 PPPLP-----PAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP 2626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872  134 PLSTPMPKKRSQKSKGDLLLLKLSKGLDQPESPH---------PKRPPEDFETPsgERPRRRAAQVALLYLQELAEELST 204
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRvsrprrarrLGRAAQASSPP--QRPRRRAARPTVGSLTSLADPPPP 2704

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872  205 -ALPAPLSGPKSPKVSSPTKPKKTRQAASQGEEDGRARDEDfVLQVEGEDEEESEAPSENSSDPEPVAPRSTPRGPAAGK 283
Cdd:PHA03247  2705 pPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL 2783

                          250
                   ....*....|
gi 1958782872  284 QKPHCRGMAP 293
Cdd:PHA03247  2784 TRPAVASLSE 2793
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 53-286 4.03e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.30  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872  53 LPPPLPGFEDSSDKRRlPPDQESLTRLE----QQDLSSEMAKVSNPR-----------ASKPSGRRGgrtPRGAKRPQQR 117
Cdd:PTZ00449  519 LPPKAPGDKEGEEGEH-EDSKESDEPKEggkpGETKEGEVGKKPGPAkehkpskiptlSKKPEFPKD---PKHPKDPEEP 594

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 118 KPPSAPLVPglldqSNPLSTPMPKKrsqkskgdLLLLKLSKGLDQPESP-HPKRPPEDFETPSGERPRrraaqvallylq 196
Cdd:PTZ00449  595 KKPKRPRSA-----QRPTRPKSPKL--------PELLDIPKSPKRPESPkSPKRPPPPQRPSSPERPE------------ 649

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782872 197 elaeelSTALPAPLSGPKSPKVssPTKPKKTRQ-------AASQGEE--DGRARDEDFVLQVEGEDEEESEAPSENSSDP 267
Cdd:PTZ00449  650 ------GPKIIKSPKPPKSPKP--PFDPKFKEKfyddyldAAAKSKEtkTTVVLDESFESILKETLPETPGTPFTTPRPL 721

                         250
                  ....*....|....*....
gi 1958782872 268 EPVAPRsTPRGPAAGKQKP 286
Cdd:PTZ00449  722 PPKLPR-DEEFPFEPIGDP 739
WD40 pfam00400
WD domain, G-beta repeat;
602-639 4.36e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.36e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958782872 602 PFQCFLAHDQAVRTIQWCKaNSHFLVSAGSDRKIKFWD 639
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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