NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958782532|ref|XP_038967956|]
View 

ubiquinone biosynthesis monooxygenase COQ6, mitochondrial isoform X3 [Rattus norvegicus]

Protein Classification

Rossmann-fold NAD(P)-binding domain-containing protein( domain architecture ID 229380)

Rossmann-fold NAD(P)-binding domain-containing protein may function as an oxidoreductase

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NADB_Rossmann super family cl21454
Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a ...
 57-269 6.63e-109

Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.


The actual alignment was detected with superfamily member TIGR01989:

Pssm-ID: 473865 [Multi-domain]  Cd Length: 437  Bit Score: 322.09  E-value: 6.63e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  57 AMACALGHDIHFHDKKILLLEAG--PKK---TLEKLSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDS 131
Cdd:TIGR01989  14 ALAAALGNNPLTKDLKVLLLDAVdnPKLksrNYEKPDGPYSNRVSSITPASISFFKKIGAWDHIQSDRIQPFGRMQVWDG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 132 CSEALIMFDKDN-LDDMGYIVENDVIMHAITKQLEAV-ADRVKVLYESKAVGYAWPGPfSLADSSPWVHITLGDGSTLQT 209
Cdd:TIGR01989  94 CSLALIRFDRDNgKEDMACIIENDNIQNSLYNRLQEYnGDNVKILNPARLISVTIPSK-YPNDNSNWVHITLSDGQVLYT 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 210 KLLIGADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLP 269
Cdd:TIGR01989 173 KLLIGADGSNSNVRKAANIDTTGWNYNQHAVVATLKLEEATENDVAWQRFLPTGPIALLP 232
 
Name Accession Description Interval E-value
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 57-269 6.63e-109

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 322.09  E-value: 6.63e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  57 AMACALGHDIHFHDKKILLLEAG--PKK---TLEKLSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDS 131
Cdd:TIGR01989  14 ALAAALGNNPLTKDLKVLLLDAVdnPKLksrNYEKPDGPYSNRVSSITPASISFFKKIGAWDHIQSDRIQPFGRMQVWDG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 132 CSEALIMFDKDN-LDDMGYIVENDVIMHAITKQLEAV-ADRVKVLYESKAVGYAWPGPfSLADSSPWVHITLGDGSTLQT 209
Cdd:TIGR01989  94 CSLALIRFDRDNgKEDMACIIENDNIQNSLYNRLQEYnGDNVKILNPARLISVTIPSK-YPNDNSNWVHITLSDGQVLYT 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 210 KLLIGADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLP 269
Cdd:TIGR01989 173 KLLIGADGSNSNVRKAANIDTTGWNYNQHAVVATLKLEEATENDVAWQRFLPTGPIALLP 232
ubiF PRK08020
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed
 94-269 3.61e-35

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed


Pssm-ID: 181199 [Multi-domain]  Cd Length: 391  Bit Score: 130.10  E-value: 3.61e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  94 RVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSeALIMFDKD--NLDDMGYIVENDVIMHAITKQLEAvADRV 171
Cdd:PRK08020   51 RISAISAASVALLKGLGVWDAVQAMRSHPYRRLETWEWET-AHVVFDAAelKLPELGYMVENRVLQLALWQALEA-HPNV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 172 KVLYeskavgyawpgPFSLADSSP----WvHITLGDGSTLQTKLLIGADGHNSGVRQAAGIQNVGWNYDQSAVVATLHlS 247
Cdd:PRK08020  129 TLRC-----------PASLQALQRdddgW-ELTLADGEEIQAKLVIGADGANSQVRQMAGIGVHGWQYRQSCMLISVK-C 195

                         170       180
                  ....*....|....*....|..
gi 1958782532 248 EATENNVAWQRFLPSGPIALLP 269
Cdd:PRK08020  196 ENPPGDSTWQQFTPSGPRAFLP 217
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 57-246 1.34e-18

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 83.83  E-value: 1.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  57 AMACALGHdiHFHDkkILLLEAGPkktleklSETYSNRVSSISLGSTTLLSSFGAWDHICnMRCKAFRRMQVWDSCS-EA 135
Cdd:COG0654    17 ALALALAR--AGIR--VTVVERAP-------PPRPDGRGIALSPRSLELLRRLGLWDRLL-ARGAPIRGIRVRDGSDgRV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 136 LIMFD-KDNLDDMGYIVENDVIMHAITKQLEAvaDRVKVLYESKAVGYAWpgpfsLADSspwVHITLGDGSTLQTKLLIG 214
Cdd:COG0654    85 LARFDaAETGLPAGLVVPRADLERALLEAARA--LGVELRFGTEVTGLEQ-----DADG---VTVTLADGRTLRADLVVG 154

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1958782532 215 ADGHNSGVRQAAGIQNVGWNYDQSAVVATLHL 246
Cdd:COG0654   155 ADGARSAVRRLLGIGFTGRDYPQRALWAGVRT 186
 
Name Accession Description Interval E-value
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 57-269 6.63e-109

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 322.09  E-value: 6.63e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  57 AMACALGHDIHFHDKKILLLEAG--PKK---TLEKLSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDS 131
Cdd:TIGR01989  14 ALAAALGNNPLTKDLKVLLLDAVdnPKLksrNYEKPDGPYSNRVSSITPASISFFKKIGAWDHIQSDRIQPFGRMQVWDG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 132 CSEALIMFDKDN-LDDMGYIVENDVIMHAITKQLEAV-ADRVKVLYESKAVGYAWPGPfSLADSSPWVHITLGDGSTLQT 209
Cdd:TIGR01989  94 CSLALIRFDRDNgKEDMACIIENDNIQNSLYNRLQEYnGDNVKILNPARLISVTIPSK-YPNDNSNWVHITLSDGQVLYT 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 210 KLLIGADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLP 269
Cdd:TIGR01989 173 KLLIGADGSNSNVRKAANIDTTGWNYNQHAVVATLKLEEATENDVAWQRFLPTGPIALLP 232
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 57-269 2.29e-69

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 219.00  E-value: 2.29e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  57 AMACALGHDIhfhdKKILLLEAGPkkTLEKLSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEAL 136
Cdd:TIGR01988  13 ALALALARSG----LKVALIEATP--LPAPADPGFDNRVSALSAASIRLLEKLGVWDKIEPARAQPIRDIHVSDGGSFGA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 137 IMFDKD--NLDDMGYIVENDVIMHAITKQLEAvADRVKVLYESKAVgyawpgpfSLADSSPWVHITLGDGSTLQTKLLIG 214
Cdd:TIGR01988  87 LRFDADeiGLEALGYVVENRVLQQALWERLQE-LPNVTLLCPARVV--------ELPRHSDHVELTLDDGQQLRARLLVG 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958782532 215 ADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLSEATeNNVAWQRFLPSGPIALLP 269
Cdd:TIGR01988 158 ADGANSKVRQLAGIPTTGWDYGQSAVVANVKHERPH-QGTAWERFTPTGPLALLP 211
ubiF PRK08020
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed
 94-269 3.61e-35

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed


Pssm-ID: 181199 [Multi-domain]  Cd Length: 391  Bit Score: 130.10  E-value: 3.61e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  94 RVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSeALIMFDKD--NLDDMGYIVENDVIMHAITKQLEAvADRV 171
Cdd:PRK08020   51 RISAISAASVALLKGLGVWDAVQAMRSHPYRRLETWEWET-AHVVFDAAelKLPELGYMVENRVLQLALWQALEA-HPNV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 172 KVLYeskavgyawpgPFSLADSSP----WvHITLGDGSTLQTKLLIGADGHNSGVRQAAGIQNVGWNYDQSAVVATLHlS 247
Cdd:PRK08020  129 TLRC-----------PASLQALQRdddgW-ELTLADGEEIQAKLVIGADGANSQVRQMAGIGVHGWQYRQSCMLISVK-C 195

                         170       180
                  ....*....|....*....|..
gi 1958782532 248 EATENNVAWQRFLPSGPIALLP 269
Cdd:PRK08020  196 ENPPGDSTWQQFTPSGPRAFLP 217
PRK08850 PRK08850
2-octaprenyl-6-methoxyphenol hydroxylase; Validated
 85-269 8.76e-32

2-octaprenyl-6-methoxyphenol hydroxylase; Validated


Pssm-ID: 236341 [Multi-domain]  Cd Length: 405  Bit Score: 121.03  E-value: 8.76e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  85 EKLSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDKDNL--DDMGYIVENDVIMHAITK 162
Cdd:PRK08850   40 EALNELPDVRVSALSRSSEHILRNLGAWQGIEARRAAPYIAMEVWEQDSFARIEFDAESMaqPDLGHIVENRVIQLALLE 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 163 QLEAvADRVKVLYESKAVGYAwpgpfsLADSSPWvhITLGDGSTLQTKLLIGADGHNSGVRQAAGIQNVGWNYDQSAVVA 242
Cdd:PRK08850  120 QVQK-QDNVTLLMPARCQSIA------VGESEAW--LTLDNGQALTAKLVVGADGANSWLRRQMDIPLTHWDYGHSALVA 190

                         170       180
                  ....*....|....*....|....*..
gi 1958782532 243 TLHLSEaTENNVAWQRFLPSGPIALLP 269
Cdd:PRK08850  191 NVRTVD-PHNSVARQIFTPQGPLAFLP 216
PRK08849 PRK08849
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 71-271 1.01e-31

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 181564 [Multi-domain]  Cd Length: 384  Bit Score: 120.65  E-value: 1.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  71 KKILLLEAGPKKTLEKlSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDScSEALIMFDKD--NLDDMG 148
Cdd:PRK08849   27 RSVAVIEGGEPKAFEP-SQPMDIRVSAISQTSVDLLESLGAWSSIVAMRVCPYKRLETWEH-PECRTRFHSDelNLDQLG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 149 YIVENDVIMHAITKQLEAVaDRVKVLYeskavgyawpgPFSLAD---SSPWVHITLGDGSTLQTKLLIGADGHNSGVRQA 225
Cdd:PRK08849  105 YIVENRLIQLGLWQQFAQY-PNLTLMC-----------PEKLADlefSAEGNRVTLESGAEIEAKWVIGADGANSQVRQL 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958782532 226 AGIQNVGWNYDQSAVVATLHlSEATENNVAWQRFLPSGPIALLPAC 271
Cdd:PRK08849  173 AGIGITAWDYRQHCMLINVE-TEQPQQDITWQQFTPSGPRSFLPLC 217
PRK08773 PRK08773
UbiH/UbiF family hydroxylase;
94-269 1.98e-28

UbiH/UbiF family hydroxylase;


Pssm-ID: 181552 [Multi-domain]  Cd Length: 392  Bit Score: 111.88  E-value: 1.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  94 RVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDKDNL--DDMGYIVENDVIMHAITKQLEAVAdrV 171
Cdd:PRK08773   51 RVYAFAADNAALLDRLGVWPAVRAARAQPYRRMRVWDAGGGGELGFDADTLgrEQLGWIVENDLLVDRLWAALHAAG--V 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 172 KVLYESKAVgyawpgpfSLADSSPWVHITLGDGSTLQTKLLIGADGHNSGVRQAAGIQNVGWNYDQSAVVA---TLHLSE 248
Cdd:PRK08773  129 QLHCPARVV--------ALEQDADRVRLRLDDGRRLEAALAIAADGAASTLRELAGLPVSRHDYAQRGVVAfvdTEHPHQ 200

                         170       180
                  ....*....|....*....|.
gi 1958782532 249 ATennvAWQRFLPSGPIALLP 269
Cdd:PRK08773  201 AT----AWQRFLPTGPLALLP 217
PRK08013 PRK08013
oxidoreductase; Provisional
 57-269 2.23e-28

oxidoreductase; Provisional


Pssm-ID: 236139 [Multi-domain]  Cd Length: 400  Bit Score: 111.68  E-value: 2.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  57 AMACAL-GHDIhfhdkKILLLEAGPKKTLEkLSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEA 135
Cdd:PRK08013   17 AVACGLqGSGL-----RVAVLEQRVPEPLA-ADAPPALRVSAINAASEKLLTRLGVWQDILARRASCYHGMEVWDKDSFG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 136 LIMFDKDN--LDDMGYIVENDVIMHAITKQLEAVADrVKVLYESKAVGYAWpgpfsladSSPWVHITLGDGSTLQTKLLI 213
Cdd:PRK08013   91 RIAFDDQSmgYSHLGHIIENSVIHYALWQKAQQSSD-ITLLAPAELQQVAW--------GENEAFLTLKDGSMLTARLVV 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958782532 214 GADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLSEAtENNVAWQRFLPSGPIALLP 269
Cdd:PRK08013  162 GADGANSWLRNKADIPLTFWDYQHHALVATIRTEEP-HDAVARQVFHGDGILAFLP 216
PRK05714 PRK05714
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 57-269 1.87e-26

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 168201 [Multi-domain]  Cd Length: 405  Bit Score: 106.84  E-value: 1.87e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  57 AMACALGHDihfhDKKILLLEAGPKKTLE-KLSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEA 135
Cdd:PRK05714   16 ALALALQGS----GLEVLLLDGGPLSVKPfDPQAPFEPRVSALSAASQRILERLGAWDGIAARRASPYSEMQVWDGSGTG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 136 LIMFDKDNL--DDMGYIVENDVIMHAItkqLEAVAD-RVKVLYESKAVGYAWPGpfsladsSPWVhITLGDGSTLQTKLL 212
Cdd:PRK05714   92 QIHFSAASVhaEVLGHIVENRVVQDAL---LERLHDsDIGLLANARLEQMRRSG-------DDWL-LTLADGRQLRAPLV 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958782532 213 IGADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLSEAtENNVAWQRFLPSGPIALLP 269
Cdd:PRK05714  161 VAADGANSAVRRLAGCATREWDYLHHAIVTSVRCSEP-HRATAWQRFTDDGPLAFLP 216
PRK07333 PRK07333
ubiquinone biosynthesis hydroxylase;
70-269 2.77e-26

ubiquinone biosynthesis hydroxylase;


Pssm-ID: 180935 [Multi-domain]  Cd Length: 403  Bit Score: 106.22  E-value: 2.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  70 DKKILLLEAGPKKTLEKlsetySNRVSSISLGSTTLLSSFGAWDHICNmRCKAFRRMQVWDSCSE-----ALIMFDKDNL 144
Cdd:PRK07333   26 HLPVTVVDAAPAGAWSR-----DPRASAIAAAARRMLEALGVWDEIAP-EAQPITDMVITDSRTSdpvrpVFLTFEGEVE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 145 DD--MGYIVENDVIMHAITKQLEAVAdrVKVLYESKAVGyawpgpFSLADSSpwVHITLGDGSTLQTKLLIGADGHNSGV 222
Cdd:PRK07333  100 PGepFAHMVENRVLINALRKRAEALG--IDLREATSVTD------FETRDEG--VTVTLSDGSVLEARLLVAADGARSKL 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958782532 223 RQAAGIQNVGWNYDQSAVVATL-HlsEATENNVAWQRFLPSGPIALLP 269
Cdd:PRK07333  170 RELAGIKTVGWDYGQSGIVCTVeH--ERPHGGRAEEHFLPAGPFAILP 215
PRK07364 PRK07364
FAD-dependent hydroxylase;
58-269 1.93e-25

FAD-dependent hydroxylase;


Pssm-ID: 236001 [Multi-domain]  Cd Length: 415  Bit Score: 103.95  E-value: 1.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  58 MACALGHDihfhDKKILLLEAGPKKTLEKLSETYSnrvssISLGSTTLLSSFGAWDHICNmRCKAFRRMQVWDSCSEALI 137
Cdd:PRK07364   33 LAAALKDS----GLRIALIEAQPAEAAAAKGQAYA-----LSLLSARIFEGIGVWEKILP-QIGKFRQIRLSDADYPGVV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 138 MFDKDNL--DDMGYIVENDVIMHAITKQLEAvADRVKVLYESKAVgyawpgpfSLADSSPWVHITL---GDGSTLQTKLL 212
Cdd:PRK07364  103 KFQPTDLgtEALGYVGEHQVLLEALQEFLQS-CPNITWLCPAEVV--------SVEYQQDAATVTLeieGKQQTLQSKLV 173

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958782532 213 IGADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLsEATENNVAWQRFLPSGPIALLP 269
Cdd:PRK07364  174 VAADGARSPIRQAAGIKTKGWKYWQSCVTATVKH-EAPHNDIAYERFWPSGPFAILP 229
PRK07608 PRK07608
UbiH/UbiF family hydroxylase;
57-269 2.22e-21

UbiH/UbiF family hydroxylase;


Pssm-ID: 181057 [Multi-domain]  Cd Length: 388  Bit Score: 92.32  E-value: 2.22e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  57 AMACALGHDihfhDKKILLLEAGPkkTLEKLSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDScSEAL 136
Cdd:PRK07608   19 SLALALAQS----GLRVALLAPRA--PPRPADDAWDSRVYAISPSSQAFLERLGVWQALDAARLAPVYDMRVFGD-AHAR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 137 IMFD--KDNLDDMGYIVENDVIMHAITKQLeAVADRVKVLyESKAVGYAWPgpfslADSspwVHITLGDGSTLQTKLLIG 214
Cdd:PRK07608   92 LHFSayQAGVPQLAWIVESSLIERALWAAL-RFQPNLTWF-PARAQGLEVD-----PDA---ATLTLADGQVLRADLVVG 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958782532 215 ADGHNSGVRQAAGIQNVGWNYDQSAVVATLhLSEATENNVAWQRFLPSGPIALLP 269
Cdd:PRK07608  162 ADGAHSWVRSQAGIKAERRPYRQTGVVANF-KAERPHRGTAYQWFRDDGILALLP 215
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 57-246 1.34e-18

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 83.83  E-value: 1.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  57 AMACALGHdiHFHDkkILLLEAGPkktleklSETYSNRVSSISLGSTTLLSSFGAWDHICnMRCKAFRRMQVWDSCS-EA 135
Cdd:COG0654    17 ALALALAR--AGIR--VTVVERAP-------PPRPDGRGIALSPRSLELLRRLGLWDRLL-ARGAPIRGIRVRDGSDgRV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 136 LIMFD-KDNLDDMGYIVENDVIMHAITKQLEAvaDRVKVLYESKAVGYAWpgpfsLADSspwVHITLGDGSTLQTKLLIG 214
Cdd:COG0654    85 LARFDaAETGLPAGLVVPRADLERALLEAARA--LGVELRFGTEVTGLEQ-----DADG---VTVTLADGRTLRADLVVG 154

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1958782532 215 ADGHNSGVRQAAGIQNVGWNYDQSAVVATLHL 246
Cdd:COG0654   155 ADGARSAVRRLLGIGFTGRDYPQRALWAGVRT 186
PRK05732 PRK05732
2-octaprenyl-6-methoxyphenyl hydroxylase; Validated
 59-269 1.09e-17

2-octaprenyl-6-methoxyphenyl hydroxylase; Validated


Pssm-ID: 235584 [Multi-domain]  Cd Length: 395  Bit Score: 81.82  E-value: 1.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  59 ACALGHDIHfHDKKILLLEAgpKKTLEKLSETYSNRVSSISLGSTTLLSSFGAWDHIcNMRCKAFRRMQVWDSCSEALIM 138
Cdd:PRK05732   19 ALALSRLSH-GGLPVALIEA--FAPESDAHPGFDARAIALAAGTCQQLARLGVWQAL-ADCATPITHIHVSDRGHAGFVR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 139 FDKD--NLDDMGYIVENdvimHAITKQLEAVADrvkvlyesKAVGYAWPGPFSLADSSP---WVHITLGDGSTLQTKLLI 213
Cdd:PRK05732   95 LDAEdyGVPALGYVVEL----HDVGQRLFALLD--------KAPGVTLHCPARVANVERtqgSVRVTLDDGETLTGRLLV 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958782532 214 GADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLSEAtENNVAWQRFLPSGPIALLP 269
Cdd:PRK05732  163 AADGSHSALREALGIDWQQHPYEQVAVIANVTTSEA-HQGRAFERFTEHGPLALLP 217
PRK09126 PRK09126
FAD-dependent hydroxylase;
72-269 2.97e-15

FAD-dependent hydroxylase;


Pssm-ID: 236385 [Multi-domain]  Cd Length: 392  Bit Score: 74.98  E-value: 2.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  72 KILLLEAGPKKTLEklSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDKDN--LDDMGY 149
Cdd:PRK09126   28 KVTLIERQPLAALA--DPAFDGREIALTHASREILQRLGAWDRIPEDEISPLRDAKVLNGRSPFALTFDARGrgADALGY 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 150 IVENdvimHAITKQL-EAVADRVKV-LYESKAVGYAWPGPfsladssPWVHITLGDGSTLQTKLLIGADGHNSGVRQAAG 227
Cdd:PRK09126  106 LVPN----HLIRRAAyEAVSQQDGIeLLTGTRVTAVRTDD-------DGAQVTLANGRRLTARLLVAADSRFSATRRQLG 174

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1958782532 228 IQNVGWNYDQSAVVATLHlSEATENNVAWQRFLPSGPIALLP 269
Cdd:PRK09126  175 IGADMHDFGRTMLVCRMR-HELPHHHTAWEWFGYGQTLALLP 215
PRK07494 PRK07494
UbiH/UbiF family hydroxylase;
197-269 1.89e-13

UbiH/UbiF family hydroxylase;


Pssm-ID: 181001 [Multi-domain]  Cd Length: 388  Bit Score: 69.55  E-value: 1.89e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958782532 197 VHITLGDGSTLQTKLLIGADGHNSGVRQAAGIQNVGWNYDQSAVV-ATLHlsEATENNVAWQRFLPSGPIALLP 269
Cdd:PRK07494  144 VTVTLADGTTLSARLVVGADGRNSPVREAAGIGVRTWSYPQKALVlNFTH--SRPHQNVSTEFHTEGGPFTQVP 215
PRK06996 PRK06996
UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase;
36-269 3.21e-09

UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase;


Pssm-ID: 235905 [Multi-domain]  Cd Length: 398  Bit Score: 57.00  E-value: 3.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  36 TSSSTDSVYDVVVSGGGMVGSAMACALGHDIHFHDKKILLLEAGpkktlEKLSETYSNRVSSISLGSTTLLSSFGAWDhi 115
Cdd:PRK06996    4 AASMAAPDFDIAIVGAGPVGLALAGWLARRSATRALSIALIDAR-----EPAASANDPRAIALSHGSRVLLETLGAWP-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 116 cnMRCKAFRRMQVwdscSE------ALIMFDKDNLDDMGYIVENDVIMHAITKQLEAVADRVkvlyeskavgyawpgPFS 189
Cdd:PRK06996   77 --ADATPIEHIHV----SQrghfgrTLIDRDDHDVPALGYVVRYGSLVAALARAVRGTPVRW---------------LTS 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 190 LADSSP-----WVHITLGDGS---TLQTKLLIGADGH-NSGVRQAAGIQNVGWNYDQSAVVATLHLSeATENNVAWQRFL 260
Cdd:PRK06996  136 TTAHAPaqdadGVTLALGTPQgarTLRARIAVQAEGGlFHDQKADAGDSARRRDYGQTAIVGTVTVS-APRPGWAWERFT 214


                  ....*....
gi 1958782532 261 PSGPIALLP 269
Cdd:PRK06996  215 HEGPLALLP 223
PRK06834 PRK06834
hypothetical protein; Provisional
 197-268 7.99e-07

hypothetical protein; Provisional


Pssm-ID: 235870 [Multi-domain]  Cd Length: 488  Bit Score: 49.63  E-value: 7.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 197 VHITLGDGSTLQTKLLIGADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLSEATENNV--------AWQRFLPSGPIALL 268
Cdd:PRK06834  133 VDVELSDGRTLRAQYLVGCDGGRSLVRKAAGIDFPGWDPTTSYLIAEVEMTEEPEWGVhrdalgihAFGRLEDEGPVRVM 212
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
69-228 3.16e-04

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 41.49  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  69 HDKKILLLEAGPkktleklSETYSNRVSSISLGSTTLLSSFGAWDHICNmrckAFRRMQVWdSCSEALIMFDKDNldDMG 148
Cdd:COG0644    15 AGLSVLLLEKGS-------FPGDKICGGGLLPRALEELEPLGLDEPLER----PVRGARFY-SPGGKSVELPPGR--GGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 149 YIVENDVIMHAITKQleAVADRVKVLYESKAVGyawpgpfsLADSSPWVHITLGDGSTLQTKLLIGADGHNSGVRQAAGI 228
Cdd:COG0644    81 YVVDRARFDRWLAEQ--AEEAGAEVRTGTRVTD--------VLRDDGRVVVRTGDGEEIRADYVVDADGARSLLARKLGL 150
PRK06617 PRK06617
2-octaprenyl-6-methoxyphenyl hydroxylase; Validated
 94-269 9.09e-04

2-octaprenyl-6-methoxyphenyl hydroxylase; Validated


Pssm-ID: 168629 [Multi-domain]  Cd Length: 374  Bit Score: 40.29  E-value: 9.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532  94 RVSSISLGSTTLLSSFGAWDHICNMRCKaFRRMQVWDSCSEALIMFDKDNLDDMGYIVENdvimhaitkqleavADRVKV 173
Cdd:PRK06617   45 RTTALTPHSKNFLFSIDIWEELEKFVAE-MQDIYVVDNKASEILDLRNDADAVLGYVVKN--------------SDFKKI 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782532 174 LYeSKAVGYAWpgpFSLADSSPW--------VHITLGDGSTLQTKLLIGADGHNSGVRQAAGIQNVGWNYDQSAVVATLH 245
Cdd:PRK06617  110 LL-SKITNNPL---ITLIDNNQYqevishndYSIIKFDDKQIKCNLLIICDGANSKVRSHYFANEIEKPYQTALTFNIKH 185

                         170       180
                  ....*....|....*....|....
gi 1958782532 246 lsEATENNVAWQRFLPSGPIALLP 269
Cdd:PRK06617  186 --EKPHENCAMEHFLPLGPFALLP 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH