NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958782485|ref|XP_038967940|]
View 

protein phosphatase 1 regulatory subunit 36 isoform X1 [Rattus norvegicus]

Protein Classification

PPPI_inhib domain-containing protein( domain architecture ID 10632860)

PPPI_inhib domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PPPI_inhib super family cl20785
Protein phosphatase 1 inhibitor; This family of proteins interacts with and inhibits the ...
83-433 9.19e-106

Protein phosphatase 1 inhibitor; This family of proteins interacts with and inhibits the phosphatase activity of protein phosphatase 1 (PP1) complexes.


The actual alignment was detected with superfamily member pfam14895:

Pssm-ID: 464358  Cd Length: 346  Bit Score: 317.38  E-value: 9.19e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782485  83 FTPAVELKEKGKKGKAVHFAEMDGTASERLTDKRFVpRDEKSAKTlekrgqqGNVTLDDVKFVALLSLQDTEMQRvcSFT 162
Cdd:pfam14895   1 HTDLEDAKERYIKTNGYKFLRTINQEEELIFRQVFV-RDDKSYDA-------DTVVLDDVRDLVLFLMPKEFLQR--KFV 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782485 163 TFMRNKSLDSFLMALLYYLSYYLErlsmekkpqsyMV--GLVEKKEIELVMSKLEDAQ---------KYL-------AQK 224
Cdd:pfam14895  71 EFMHNPAVHRLLHALIIYFEYFLR-----------MVefVLIRRDELSGKMAQIQSEQtnemkrifsKYLsqyrmlvARN 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782485 225 YCKLVLGVG-MADKHHMNcGKDKISDTQKDWKFFESFYTFCTCIAWIVFRRQYLKEIEEEVGRLFRTNMFNIPRRKRED- 302
Cdd:pfam14895 140 YCVIVKGEGdMPKFYHMK-EIVNISATIKDKKFHEQFLAVATQIVWITMHRRAYTVIEMEMNRLFRSEHFNMPRPEYLDf 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782485 303 ---EESGGEKKRMTLVQFRRMMAkrPAIKKAMDMRSPVLSTLLpslrekaqhIAEKKYV-AGIKLQPRVEKDITNLESVV 378
Cdd:pfam14895 219 tpaERSLLYGRNMKIVNYRRQMS--PLIQELINVRSEDMPILW---------IGERKYRgTDIRIAELELEYIVPGSQLR 287
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958782485 379 MPVV--GILGEPRNLFNphTLLPLESEengktSGRNSS---------IVERNNTSIQNTLNLVMSK 433
Cdd:pfam14895 288 LIDVshGILGHPKCLYN--TLLPLDWP-----AVRFSNfseqydpyhIIRQPNLRIPNIDELAMRK 346
 
Name Accession Description Interval E-value
PPPI_inhib pfam14895
Protein phosphatase 1 inhibitor; This family of proteins interacts with and inhibits the ...
83-433 9.19e-106

Protein phosphatase 1 inhibitor; This family of proteins interacts with and inhibits the phosphatase activity of protein phosphatase 1 (PP1) complexes.


Pssm-ID: 464358  Cd Length: 346  Bit Score: 317.38  E-value: 9.19e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782485  83 FTPAVELKEKGKKGKAVHFAEMDGTASERLTDKRFVpRDEKSAKTlekrgqqGNVTLDDVKFVALLSLQDTEMQRvcSFT 162
Cdd:pfam14895   1 HTDLEDAKERYIKTNGYKFLRTINQEEELIFRQVFV-RDDKSYDA-------DTVVLDDVRDLVLFLMPKEFLQR--KFV 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782485 163 TFMRNKSLDSFLMALLYYLSYYLErlsmekkpqsyMV--GLVEKKEIELVMSKLEDAQ---------KYL-------AQK 224
Cdd:pfam14895  71 EFMHNPAVHRLLHALIIYFEYFLR-----------MVefVLIRRDELSGKMAQIQSEQtnemkrifsKYLsqyrmlvARN 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782485 225 YCKLVLGVG-MADKHHMNcGKDKISDTQKDWKFFESFYTFCTCIAWIVFRRQYLKEIEEEVGRLFRTNMFNIPRRKRED- 302
Cdd:pfam14895 140 YCVIVKGEGdMPKFYHMK-EIVNISATIKDKKFHEQFLAVATQIVWITMHRRAYTVIEMEMNRLFRSEHFNMPRPEYLDf 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782485 303 ---EESGGEKKRMTLVQFRRMMAkrPAIKKAMDMRSPVLSTLLpslrekaqhIAEKKYV-AGIKLQPRVEKDITNLESVV 378
Cdd:pfam14895 219 tpaERSLLYGRNMKIVNYRRQMS--PLIQELINVRSEDMPILW---------IGERKYRgTDIRIAELELEYIVPGSQLR 287
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958782485 379 MPVV--GILGEPRNLFNphTLLPLESEengktSGRNSS---------IVERNNTSIQNTLNLVMSK 433
Cdd:pfam14895 288 LIDVshGILGHPKCLYN--TLLPLDWP-----AVRFSNfseqydpyhIIRQPNLRIPNIDELAMRK 346
 
Name Accession Description Interval E-value
PPPI_inhib pfam14895
Protein phosphatase 1 inhibitor; This family of proteins interacts with and inhibits the ...
83-433 9.19e-106

Protein phosphatase 1 inhibitor; This family of proteins interacts with and inhibits the phosphatase activity of protein phosphatase 1 (PP1) complexes.


Pssm-ID: 464358  Cd Length: 346  Bit Score: 317.38  E-value: 9.19e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782485  83 FTPAVELKEKGKKGKAVHFAEMDGTASERLTDKRFVpRDEKSAKTlekrgqqGNVTLDDVKFVALLSLQDTEMQRvcSFT 162
Cdd:pfam14895   1 HTDLEDAKERYIKTNGYKFLRTINQEEELIFRQVFV-RDDKSYDA-------DTVVLDDVRDLVLFLMPKEFLQR--KFV 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782485 163 TFMRNKSLDSFLMALLYYLSYYLErlsmekkpqsyMV--GLVEKKEIELVMSKLEDAQ---------KYL-------AQK 224
Cdd:pfam14895  71 EFMHNPAVHRLLHALIIYFEYFLR-----------MVefVLIRRDELSGKMAQIQSEQtnemkrifsKYLsqyrmlvARN 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782485 225 YCKLVLGVG-MADKHHMNcGKDKISDTQKDWKFFESFYTFCTCIAWIVFRRQYLKEIEEEVGRLFRTNMFNIPRRKRED- 302
Cdd:pfam14895 140 YCVIVKGEGdMPKFYHMK-EIVNISATIKDKKFHEQFLAVATQIVWITMHRRAYTVIEMEMNRLFRSEHFNMPRPEYLDf 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782485 303 ---EESGGEKKRMTLVQFRRMMAkrPAIKKAMDMRSPVLSTLLpslrekaqhIAEKKYV-AGIKLQPRVEKDITNLESVV 378
Cdd:pfam14895 219 tpaERSLLYGRNMKIVNYRRQMS--PLIQELINVRSEDMPILW---------IGERKYRgTDIRIAELELEYIVPGSQLR 287
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958782485 379 MPVV--GILGEPRNLFNphTLLPLESEengktSGRNSS---------IVERNNTSIQNTLNLVMSK 433
Cdd:pfam14895 288 LIDVshGILGHPKCLYN--TLLPLDWP-----AVRFSNfseqydpyhIIRQPNLRIPNIDELAMRK 346
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH