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Conserved domains on  [gi|1958782177|ref|XP_038967824|]
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zinc transporter 6 isoform X1 [Rattus norvegicus]

Protein Classification

cation transporter( domain architecture ID 10479921)

cation transporter of the cation diffusion facilitator (CDF) family that facilitates the active efflux of one or more from a variety of metal cations including Zn, Cd, Ni, Co, Mn, and Cu; similar to zinc transporter 6 (ZnT6) which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
6-206 8.13e-26

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


:

Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 103.12  E-value: 8.13e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177   6 TNSIALTAYTYLTIFDLFSLITCLISYWVMMRRPSAAYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLE-QPEIH 84
Cdd:pfam01545  13 TGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYESIQRLLSpGEEID 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177  85 TGRLLVGTFVALSFNLFTMLSIRNKPFAYvseaastswlqehvadlsrslcgiipglSSIFLPRMNPFVLIDLAGALALC 164
Cdd:pfam01545  93 PGLALILALVSLLVNLFLLLYLRRAARRI----------------------------RSPALKADALHALSDVLASLGVL 144
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958782177 165 ITYMLIEINNYFA---VDTASAIAIALMTFGTMYPMSVYSGKVLL 206
Cdd:pfam01545 145 ISALLIYLGPITGgllADPLASLLIGLLILYTALRLLKESLSILL 189
 
Name Accession Description Interval E-value
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
6-206 8.13e-26

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 103.12  E-value: 8.13e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177   6 TNSIALTAYTYLTIFDLFSLITCLISYWVMMRRPSAAYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLE-QPEIH 84
Cdd:pfam01545  13 TGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYESIQRLLSpGEEID 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177  85 TGRLLVGTFVALSFNLFTMLSIRNKPFAYvseaastswlqehvadlsrslcgiipglSSIFLPRMNPFVLIDLAGALALC 164
Cdd:pfam01545  93 PGLALILALVSLLVNLFLLLYLRRAARRI----------------------------RSPALKADALHALSDVLASLGVL 144
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958782177 165 ITYMLIEINNYFA---VDTASAIAIALMTFGTMYPMSVYSGKVLL 206
Cdd:pfam01545 145 ISALLIYLGPITGgllADPLASLLIGLLILYTALRLLKESLSILL 189
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
6-271 2.48e-25

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 104.43  E-value: 2.48e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177   6 TNSIALTAYTYLTIFDLFSLITCLISYWVMMRRPSAAYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHT 85
Cdd:COG1230    41 SGSLALLADAGHMLSDALALGLALFAYRLARRPADARFTFGYKRAEILAALANALLLLVVAGYILYEAIQRLFNPPPVAG 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177  86 GRLLVGTFVALSFNLFTMLSIRnkpfayvseaastswlQEHVADLSrslcgiipgLSSIFLprmnpFVLIDLAGALALCI 165
Cdd:COG1230   121 GGMLVVAVIGLVVNLVSAWLLH----------------RGSKHDLN---------LRGAYL-----HVLADALGSVAVIV 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177 166 TYMLIEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVigQLDKLIREVSTLDGVLEVRNEHFWTLGFGS 245
Cdd:COG1230   171 AALVILFTGWTWLDPLLSLLIALLILRSAWGLLRESLRILLEGVPDGI--DLEEVRAALEALPGVADVHDLHVWSLSSGE 248
                         250       260
                  ....*....|....*....|....*.
gi 1958782177 246 LAGSVHVRIRRDANEQMVLAHVTNRL 271
Cdd:COG1230   249 NALTAHVVVDDGADADAILDEIRELL 274
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
6-259 1.48e-23

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 98.83  E-value: 1.48e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177   6 TNSIALTAYTYLTIFDLFSLITCLISYWVMMRRPSAAYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLE-QPEIH 84
Cdd:TIGR01297  13 SGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEAIERLINpEPEID 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177  85 TGRLLVGTFVALSFNLFtMLSIRNKPFAYVSEAASTSWLQEHVADLSRSLCGIIPGLSSIFlprmnpfvlidlagalalc 164
Cdd:TIGR01297  93 GGTMLIVAIVGLIVNLI-LALYLHRVGHRLGSLALRAAALHVLSDALSSVGVLIGALLIYF------------------- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177 165 itymlieinNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVigQLDKLIREVSTLDGVLEVRNEHFWTLGFG 244
Cdd:TIGR01297 153 ---------GWHWADPIAALLISLLILYTAFRLLKESINVLLDAAPDEE--DLEEIKKAILSIPGVKGVHDLHIWRIGPG 221
                         250
                  ....*....|....*
gi 1958782177 245 SLAGSVHVRIRRDAN 259
Cdd:TIGR01297 222 KLFLDVHVVVDPDLD 236
PRK03557 PRK03557
CDF family zinc transporter ZitB;
8-242 5.22e-03

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 38.57  E-value: 5.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177   8 SIALTAYTYLTIFDLFSLITCLISYWVMMRRPSAAYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGR 87
Cdd:PRK03557   44 SLALLADAGHMLTDAAALLFALLAVQFSRRPPTIRHTFGWLRLTTLAAFVNAIALVVITILIVWEAIERFRTPRPVAGGM 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177  88 LLVGTFVALSFNLFTMlsirnkpfayvseaastsWLQEHVADlSRSLCGIIPGLSsiflprmnpfVLIDLAGALALCITY 167
Cdd:PRK03557  124 MMAIAVAGLLANILSF------------------WLLHHGSE-EKNLNVRAAALH----------VLGDLLGSVGAIIAA 174
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958782177 168 MLIEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVigQLDKLIREVSTldGVLEVRN---EHFWTLG 242
Cdd:PRK03557  175 LIIIWTGWTPADPILSILVSVLVLRSAWRLLKESVNELLEGAPVSL--DIAELKRRLCR--EIPEVRNvhhVHVWMVG 248
 
Name Accession Description Interval E-value
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
6-206 8.13e-26

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 103.12  E-value: 8.13e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177   6 TNSIALTAYTYLTIFDLFSLITCLISYWVMMRRPSAAYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLE-QPEIH 84
Cdd:pfam01545  13 TGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYESIQRLLSpGEEID 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177  85 TGRLLVGTFVALSFNLFTMLSIRNKPFAYvseaastswlqehvadlsrslcgiipglSSIFLPRMNPFVLIDLAGALALC 164
Cdd:pfam01545  93 PGLALILALVSLLVNLFLLLYLRRAARRI----------------------------RSPALKADALHALSDVLASLGVL 144
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958782177 165 ITYMLIEINNYFA---VDTASAIAIALMTFGTMYPMSVYSGKVLL 206
Cdd:pfam01545 145 ISALLIYLGPITGgllADPLASLLIGLLILYTALRLLKESLSILL 189
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
6-271 2.48e-25

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 104.43  E-value: 2.48e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177   6 TNSIALTAYTYLTIFDLFSLITCLISYWVMMRRPSAAYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHT 85
Cdd:COG1230    41 SGSLALLADAGHMLSDALALGLALFAYRLARRPADARFTFGYKRAEILAALANALLLLVVAGYILYEAIQRLFNPPPVAG 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177  86 GRLLVGTFVALSFNLFTMLSIRnkpfayvseaastswlQEHVADLSrslcgiipgLSSIFLprmnpFVLIDLAGALALCI 165
Cdd:COG1230   121 GGMLVVAVIGLVVNLVSAWLLH----------------RGSKHDLN---------LRGAYL-----HVLADALGSVAVIV 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177 166 TYMLIEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVigQLDKLIREVSTLDGVLEVRNEHFWTLGFGS 245
Cdd:COG1230   171 AALVILFTGWTWLDPLLSLLIALLILRSAWGLLRESLRILLEGVPDGI--DLEEVRAALEALPGVADVHDLHVWSLSSGE 248
                         250       260
                  ....*....|....*....|....*.
gi 1958782177 246 LAGSVHVRIRRDANEQMVLAHVTNRL 271
Cdd:COG1230   249 NALTAHVVVDDGADADAILDEIRELL 274
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
6-259 1.48e-23

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 98.83  E-value: 1.48e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177   6 TNSIALTAYTYLTIFDLFSLITCLISYWVMMRRPSAAYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLE-QPEIH 84
Cdd:TIGR01297  13 SGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEAIERLINpEPEID 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177  85 TGRLLVGTFVALSFNLFtMLSIRNKPFAYVSEAASTSWLQEHVADLSRSLCGIIPGLSSIFlprmnpfvlidlagalalc 164
Cdd:TIGR01297  93 GGTMLIVAIVGLIVNLI-LALYLHRVGHRLGSLALRAAALHVLSDALSSVGVLIGALLIYF------------------- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177 165 itymlieinNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVigQLDKLIREVSTLDGVLEVRNEHFWTLGFG 244
Cdd:TIGR01297 153 ---------GWHWADPIAALLISLLILYTAFRLLKESINVLLDAAPDEE--DLEEIKKAILSIPGVKGVHDLHIWRIGPG 221
                         250
                  ....*....|....*
gi 1958782177 245 SLAGSVHVRIRRDAN 259
Cdd:TIGR01297 222 KLFLDVHVVVDPDLD 236
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
6-268 2.40e-08

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 54.73  E-value: 2.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177   6 TNSIALTAYTYLTIFDLFSLITCLISYWVMMRRPSAAYSFGFERLEVLA-VFASTVLAqLGALFILKESAERFLE-QPEI 83
Cdd:COG0053    26 TGSVALLADALHSLSDLVASLLVLLGLRLAAKPADEEHPYGHGKAEYLAsLIVAVLIL-LAGLFILYEAIERLLHpEPVE 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177  84 HTGRLLVGTFVALSFNLFTMLSIRNKPFAYVSEAASTSWLqEHVADLsrslcgiipgLSSIflprmnpFVLIDLAGALAL 163
Cdd:COG0053   105 PSGLGLAVLLISIVVNEALARYLRRVGKKTGSPALKADAL-HDRSDA----------LTSL-------GVLIGLLLALLT 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177 164 citymlieinNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLL-QTTPPHVIGQLDKLIREVstlDGVLEVrneHfwtlg 242
Cdd:COG0053   167 ----------GWPWLDPIAAILIGLLILKVAYKLARESLSLLMdEALDEELVERIRAIILSV---PGVIGV---H----- 225
                         250       260
                  ....*....|....*....|....*.
gi 1958782177 243 fgslagsvHVRIRRDANEQMVLAHVT 268
Cdd:COG0053   226 --------DLRTRKSGPRIFVDLHIE 243
PRK03557 PRK03557
CDF family zinc transporter ZitB;
8-242 5.22e-03

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 38.57  E-value: 5.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177   8 SIALTAYTYLTIFDLFSLITCLISYWVMMRRPSAAYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGR 87
Cdd:PRK03557   44 SLALLADAGHMLTDAAALLFALLAVQFSRRPPTIRHTFGWLRLTTLAAFVNAIALVVITILIVWEAIERFRTPRPVAGGM 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782177  88 LLVGTFVALSFNLFTMlsirnkpfayvseaastsWLQEHVADlSRSLCGIIPGLSsiflprmnpfVLIDLAGALALCITY 167
Cdd:PRK03557  124 MMAIAVAGLLANILSF------------------WLLHHGSE-EKNLNVRAAALH----------VLGDLLGSVGAIIAA 174
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958782177 168 MLIEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVigQLDKLIREVSTldGVLEVRN---EHFWTLG 242
Cdd:PRK03557  175 LIIIWTGWTPADPILSILVSVLVLRSAWRLLKESVNELLEGAPVSL--DIAELKRRLCR--EIPEVRNvhhVHVWMVG 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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