|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
12-731 |
0e+00 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 1185.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 12 PSYTPpARSSAPQILAG---SLQAPLWLRAYFQGLLFSLGCRIQKHCGKVLFLGLVALGALALGLRVAVIETDLEQLWVE 88
Cdd:TIGR00918 13 PSYCD-AAFALEQIDKGkatGRRAPLWLRAKFQRLLFTLGCYIQKHCGKVLFVGLLVFSAFAVGLRAANIETNVEQLWVE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 89 VGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGANILTPEALGFHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLI 168
Cdd:TIGR00918 92 VGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPST 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 169 ENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPQQLLEELGPFAS-LEGFRELLDKAQVGQAY 247
Cdd:TIGR00918 172 EGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSqVESWEEMLKKAAVGQGY 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 248 VGRPCLDPDDPHCPPSAPNRHSRQAPNVAQELSGGCHGFSHKFMHWQEELLLGGTARDLQGQLLRAEAFQSTFLLMSPRQ 327
Cdd:TIGR00918 252 MERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPKQ 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 328 LYEHFRGDYQTHDIGWSEEQASMVLQAWQRRFVQLAQEALPANASQQIHAFSSTTLDDILQAFSEVSATRVVGGYLLMLA 407
Cdd:TIGR00918 332 MYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLA 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 408 YACITMLRWDCAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDIFLLAHAFTKAPPNTPL 487
Cdd:TIGR00918 412 YACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNIPF 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 488 PERMGECLRRTGTSVALTSINNMVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAVMLVFPAVLSLDLRRRHRQRLDVLCC 567
Cdd:TIGR00918 492 EERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCC 571
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 568 FSSPCSAQVIQMLPQELGDR-AVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLLSPTSDPLGSELYSPGGSTRDLL 646
Cdd:TIGR00918 572 FFSPCSARVIQIEPQAYADGsAPPVYSSHMQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQPSDPLSCQSPDIAGSTRDLL 651
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 647 GQEEGTrpKASCRSLLCAHWTLAHFARYQFAPLLLQTQAKALVLLFFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAF 726
Cdd:TIGR00918 652 SQFEDS--KAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDF 729
|
....*
gi 1958777723 727 LSAQL 731
Cdd:TIGR00918 730 LDAQF 734
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
418-570 |
4.65e-56 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 189.33 E-value: 4.65e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 418 CAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDIFLLAHAFTKAPPNTPLPERMGECLRR 497
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958777723 498 TGTSVALTSINNMVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAVMLVFPAVLSLDLRRRHRQRLDVLCCFSS 570
Cdd:pfam12349 81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
384-561 |
5.84e-18 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 88.76 E-value: 5.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 384 DDILQAFSEVSATRVVGGYLLMLAYACITMLRWdcaqsqgAVGLAGVLLVALAVASGLGLCALLGITFNAATTqVLPFLA 463
Cdd:COG1033 210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL-------RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 464 LGIGVDD-IFLLAHAFTKAPPNTPLPERMGECLRRTGTSVALTSINNMVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAV 542
Cdd:COG1033 282 LAIGIDYgIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS 361
|
170
....*....|....*....
gi 1958777723 543 MLVFPAVLSLDLRRRHRQR 561
Cdd:COG1033 362 LTLLPALLSLLPRPKPKTR 380
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
12-731 |
0e+00 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 1185.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 12 PSYTPpARSSAPQILAG---SLQAPLWLRAYFQGLLFSLGCRIQKHCGKVLFLGLVALGALALGLRVAVIETDLEQLWVE 88
Cdd:TIGR00918 13 PSYCD-AAFALEQIDKGkatGRRAPLWLRAKFQRLLFTLGCYIQKHCGKVLFVGLLVFSAFAVGLRAANIETNVEQLWVE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 89 VGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGANILTPEALGFHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLI 168
Cdd:TIGR00918 92 VGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPST 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 169 ENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPQQLLEELGPFAS-LEGFRELLDKAQVGQAY 247
Cdd:TIGR00918 172 EGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSqVESWEEMLKKAAVGQGY 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 248 VGRPCLDPDDPHCPPSAPNRHSRQAPNVAQELSGGCHGFSHKFMHWQEELLLGGTARDLQGQLLRAEAFQSTFLLMSPRQ 327
Cdd:TIGR00918 252 MERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPKQ 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 328 LYEHFRGDYQTHDIGWSEEQASMVLQAWQRRFVQLAQEALPANASQQIHAFSSTTLDDILQAFSEVSATRVVGGYLLMLA 407
Cdd:TIGR00918 332 MYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLA 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 408 YACITMLRWDCAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDIFLLAHAFTKAPPNTPL 487
Cdd:TIGR00918 412 YACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNIPF 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 488 PERMGECLRRTGTSVALTSINNMVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAVMLVFPAVLSLDLRRRHRQRLDVLCC 567
Cdd:TIGR00918 492 EERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCC 571
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 568 FSSPCSAQVIQMLPQELGDR-AVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLLSPTSDPLGSELYSPGGSTRDLL 646
Cdd:TIGR00918 572 FFSPCSARVIQIEPQAYADGsAPPVYSSHMQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQPSDPLSCQSPDIAGSTRDLL 651
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 647 GQEEGTrpKASCRSLLCAHWTLAHFARYQFAPLLLQTQAKALVLLFFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAF 726
Cdd:TIGR00918 652 SQFEDS--KAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDF 729
|
....*
gi 1958777723 727 LSAQL 731
Cdd:TIGR00918 730 LDAQF 734
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
418-570 |
4.65e-56 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 189.33 E-value: 4.65e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 418 CAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDIFLLAHAFTKAPPNTPLPERMGECLRR 497
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958777723 498 TGTSVALTSINNMVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAVMLVFPAVLSLDLRRRHRQRLDVLCCFSS 570
Cdd:pfam12349 81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
21-567 |
4.74e-32 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 134.65 E-value: 4.74e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 21 SAPQILAGSLQAPlwlRAYFQGLLFSLGCRIQKHCGKVLFLGLVALGALALGLRVAVIETDLEQLWVEVGSRVSQELHYT 100
Cdd:TIGR00917 293 NTPQRNWGQLSTV---QGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYF 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 101 KEKLGeeAAYTSQMLIQTARQEGANILTPEALG-------FHLQAALtaSKVQVSLYGKSWDLNKICYKSGVPLieNGMI 173
Cdd:TIGR00917 370 DTHFG--PFYRIEQLIIATVQTSSHEKAPEILTddnlkllFDIQKKV--SQLFANYEGELITLDSPCFKPNHPY--NCFI 443
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 174 ERMIEKLFPcviltpldcfwegaklqggsaylpgrpdiQWTNLDPQQLlEELGPFASLEGFRELLDKAQvgqayvgrPCL 253
Cdd:TIGR00917 444 YSTCKKLQN-----------------------------MYSKLKPENY-DDYGGVDYVKYCFEHFTSPE--------SCL 485
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 254 DpddphcppsapnrhSRQAPnvaqelsggchgfshkfmhWQEELLLGGTARDLQGQllrAEAFQSTFLLmsprqlyehfr 333
Cdd:TIGR00917 486 S--------------AFGGP-------------------VDPTTVLGGFSGNNFSE---ASAFVVTFPV----------- 518
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 334 gdyqthDIGWSEEQASMVLQAWQRRFVQLAQEALPANASQQIHAFSSTTLDDILQAFSEVSATRVVGGYLLMLAYACITM 413
Cdd:TIGR00917 519 ------NNFVNKTNKTEKAVAWEKAFIQLAKDELLPMVQATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTL 592
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 414 -----LRWDCAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDIFLLAHAF---------- 478
Cdd:TIGR00917 593 gdsprLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqv 672
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 479 -TKAPPNTPLPERMGECLRRTGTSVALTSINNMVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAVMLVFPAVLSLDLRRR 557
Cdd:TIGR00917 673 gVDNEQELTLERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRT 752
|
570
....*....|
gi 1958777723 558 HRQRLDVLCC 567
Cdd:TIGR00917 753 EDKRVDCFPC 762
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
374-570 |
2.55e-28 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 122.08 E-value: 2.55e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 374 QIHAFSSTTLDDILQAFSEVSATRVVGGYLLMLAYACIT-----MLRWDCAQSQGAVGLAGVLLVALAVASGLGLCALLG 448
Cdd:pfam02460 195 QFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVsvtlsSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMG 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 449 ITFNAATTqVLPFLALGIGVDDIFLLAHAFTKAPPNTPLPERMGECLRRTGTSVALTSINNMVAFFMAVLVPIPALRAFS 528
Cdd:pfam02460 275 FPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFC 353
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1958777723 529 LQAAIVVGCNFAAVMLVFPAVLSLDLRRRHRQRLDVLCCFSS 570
Cdd:pfam02460 354 AYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVWATS 395
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
384-561 |
5.84e-18 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 88.76 E-value: 5.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 384 DDILQAFSEVSATRVVGGYLLMLAYACITMLRWdcaqsqgAVGLAGVLLVALAVASGLGLCALLGITFNAATTqVLPFLA 463
Cdd:COG1033 210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL-------RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 464 LGIGVDD-IFLLAHAFTKAPPNTPLPERMGECLRRTGTSVALTSINNMVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAV 542
Cdd:COG1033 282 LAIGIDYgIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS 361
|
170
....*....|....*....
gi 1958777723 543 MLVFPAVLSLDLRRRHRQR 561
Cdd:COG1033 362 LTLLPALLSLLPRPKPKTR 380
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
425-561 |
5.03e-14 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 76.05 E-value: 5.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 425 VGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPfLALGIGVDDIFLLAHAFTKA-PPNTPLPERMGECLRRTGTSVA 503
Cdd:COG1033 631 LGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYTIHFLSRYREErRKGGDLEEAIRRALRTTGKAIL 709
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1958777723 504 LTSINNMVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAVMLVFPAVLSLdLRRRHRQR 561
Cdd:COG1033 710 FTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLL-LDPRIAKK 766
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
426-566 |
5.67e-07 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 53.30 E-value: 5.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 426 GLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLaLGIGVD-DIFLLAHAFTKAPPNTPLPERMGECLRRTGTSVAL 504
Cdd:TIGR00921 220 PLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPML-IGVGIDyGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLI 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958777723 505 TSINNmVAFFMAVLVPI-PALRAFSLQAAIVVGCNFAAVMLVFPAVL-SLDLRRRHRQRLDVLC 566
Cdd:TIGR00921 299 ALLTT-SAGFAALALSEfPMVSEFGLGLVAGLITAYLLTLLVLPALLqSIDIGREKVKKEIIAI 361
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
423-563 |
9.93e-07 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 52.46 E-value: 9.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 423 GAVGLAGV--LLVALAVASGLGLCALLG--ITFNAATTQVLPFLALGIGVD-DIFL-------LAHAFTKAppntplpER 490
Cdd:COG2409 191 RSLVAALLplLTAGLAVGVALGLLALLAafTDVSSFAPNLLTMLGLGVGIDyALFLvsryreeLRAGEDRE-------EA 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 491 MGECLRRTGTSV---ALTSInnmVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAVMLVFPAVLSL------DLRRRHRQR 561
Cdd:COG2409 264 VARAVATAGRAVlfsGLTVA---IALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPALLALlgrrvfWPRRPRRRR 340
|
..
gi 1958777723 562 LD 563
Cdd:COG2409 341 AA 342
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
425-552 |
1.78e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 48.29 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 425 VGLAGVLLVALAVasgLGLCALLGITFNAaTTQVLPFLALGIGVDDIFLLAHAFTKAPPNTPLPERMGECLRRTGTSVAL 504
Cdd:TIGR00921 596 FPLIAIGSGILWA---IGLMGLRGIPSFL-AMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILF 671
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1958777723 505 TSINNMVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAVMLVFPAVLSL 552
Cdd:TIGR00921 672 SGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
357-550 |
2.23e-05 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 48.07 E-value: 2.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 357 RRFVQLAQEALPANASQQIHAFSSTtlDDILQAFSEVSATRVVGGYLLMLayacITMLRWDCAqsqgAVGLAGVLLVALA 436
Cdd:TIGR03480 683 RRFVRAVRKVAPDATGAPVSILESG--DTVVGAFLQAFIYALVAITVLLL----LTLRRVRDV----LLVLAPLLLAGLL 752
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 437 VasgLGLCALLGITFNAATTQVLPFLaLGIGVDDIFLLAHAFTKAPPNTPLPErmgeclRRTGTSVALTSINNMVAFFMA 516
Cdd:TIGR03480 753 T---VAAMVLLGIPFNFANIIALPLL-LGLGVDFGIYMVHRWRNGVDSGNLLQ------SSTARAVFFSALTTATAFGSL 822
|
170 180 190
....*....|....*....|....*....|....
gi 1958777723 517 VLVPIPALRAFSLQAAIVVGCNFAAVMLVFPAVL 550
Cdd:TIGR03480 823 AVSSHPGTASMGILLSLGLGLTLLCTLIFLPALL 856
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
385-539 |
7.60e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 46.38 E-value: 7.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777723 385 DILQAFSEV-SATRVVGGYLLMLAYACITMLRWdcAQSQGAVGLAGVLLV-ALAVASGLGLCALLGITFNAATTQVLpFL 462
Cdd:COG4258 625 DRKAESSSLfGRYRNDALWLLLLALLLILLLLL--LRLRSLRRALRVLLPpLLAVLLTLAILGLLGIPLNLFHLIAL-LL 701
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958777723 463 ALGIGVD-DIFLLAHAFTKAPpntplpermgecLRRTGTSVALTSINNMVAFFMAVLVPIPALRAFSLQAAIVVGCNF 539
Cdd:COG4258 702 VLGIGIDyALFFTEGLLDKGE------------LARTLLSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLAL 767
|
|
| |
