|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
90-606 |
1.16e-77 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 251.23 E-value: 1.16e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 90 VGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELinaeeeqlvag 169
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 170 nssteeaelmgvdvsnrqtsvelifvnedtsaadftslmqnkqnlngvpmvtksiktanqqqqkkqhqsqekpgvptpss 249
Cdd:COG0471 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 250 knQELNKKKYRShhdqmvckCLSLSISYAATIGGLTTIIGTSTSLIFLEHFNNQYpaAEVVNFGTWFLFSFPISLIMLVV 329
Cdd:COG0471 70 --GSEKRSKFGS--------ALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT--GIPISFFEWMLVGLPVALVGLLL 137
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 330 SWFWMHWLFlgcnfketcslskKKKTRREELSERRIREEYEKLGDISYPEMVTAFFFILMTVLWFTREPGFVPgwdsffe 409
Cdd:COG0471 138 LWLVLYRLL-------------PPEIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIP------- 197
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 410 kkgyrtDATVSVFLGFLLFLIPakkpcfgkksdgagqeasrgiepIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLS 489
Cdd:COG0471 198 ------IAVVALLGAVLLLLTG-----------------------VLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLA 248
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 490 TWIGHQMLS-LSSLPPWAITLLACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFAVMLPVGNP 568
Cdd:COG0471 249 AWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTP 328
|
490 500 510
....*....|....*....|....*....|....*...
gi 1958771237 569 PNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTW 606
Cdd:COG0471 329 PNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
31-611 |
1.99e-55 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 195.28 E-value: 1.99e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 31 PTSEAACAYVLLVTAVYWVSEAVPLGAAALVP----AFLYPFFGVLRSSEVAAEYFKNTTLLLVGVICVAAAVEKWNLHK 106
Cdd:pfam00939 27 PSKAWHLFAIFIATIVGWILEPLPMAVIALFAislsAILIGTLLAKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 107 RIALRMVLMAGAKPgmLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELInaeeeqlvagnssteeaelmgvdvsnr 186
Cdd:pfam00939 107 RIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLP--------------------------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 187 qtsvelifvnedtsaadftslmqnkqnlngvpmvtksiktanqqqqkkqhqsqekpgvptpssknqELNKKKYRSHHDQM 266
Cdd:pfam00939 158 ------------------------------------------------------------------PAFGSDPEKGSERR 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 267 VCKCLSLSISYAATIGGLTTIIGTSTSLIFLEHFNNQypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLGcnfkET 346
Cdd:pfam00939 172 IGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI--LGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPP----EI 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 347 CSLSKKKKTRREELSErrireeyekLGDISYPEMVTAFFFILMTVLWFTREPgfvPGWDsffekkgyrtDATVSVFLGFL 426
Cdd:pfam00939 246 KSVPDAKAIAKTELKE---------LGPMTFREKALLGLFVLLLLLWIFGGS---LNID----------ATTVAIIGLAL 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 427 LFLIPakkpcfgkksdgagqeasrgiepIITWKD-FQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPW 505
Cdd:pfam00939 304 MLLLR-----------------------ILDWKDiVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSP 360
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 506 AITLLACVLVSIVT--EFVSNPATITIFLPILCTLSETLH-INPLYTLVPVTMSISFA-VMLPVGNPPNAIVFSYGHCQI 581
Cdd:pfam00939 361 AMAFIIILSLFYLShyLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKV 440
|
570 580 590
....*....|....*....|....*....|
gi 1958771237 582 KDMVKAGLGVNVIGLVIVMVAINTWGVSLF 611
Cdd:pfam00939 441 KDWWRIGAILTIIGLLILLLLGNWWWKPLG 470
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
38-607 |
2.15e-55 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 192.80 E-value: 2.15e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 38 AYVLLVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSSEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAG 117
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 118 AKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELinaeeeqlvagnssteeaelmgvdvsnrqtsvelifvne 197
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKL--------------------------------------- 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 198 dtsaadftslmqnkqnlngvpmvtksiktanqqqqkkqhqsqekpgvptpssknqelnkkkyrshhdQMVCKCLSLSISY 277
Cdd:cd01115 122 -------------------------------------------------------------------DISPSRLLMPLAF 134
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 278 AATIGGLTTIIGTSTSLIFLEHFNnqYPAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslskkkktrr 357
Cdd:cd01115 135 AASIGGMLTLIGTPPNLVASGYLE--SLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLAV------------------- 193
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 358 eelserrireeyeklgdisypemvtaFFFILMTVLWFTREPGFVPgwdsffekkgyrtdATVSVFLGFLLFLIPAKkpcf 437
Cdd:cd01115 194 --------------------------LIITIVLLAALAAITGLLP--------------VSVAIAIGAIVLVFGGV---- 229
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 438 gkksdgagqeasrgiepiITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLS-LSSLPPWAITLLACVLVS 516
Cdd:cd01115 230 ------------------LLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTL 291
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 517 IVTEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGL 596
Cdd:cd01115 292 VLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSL 371
|
570
....*....|.
gi 1958771237 597 VIVMVAINTWG 607
Cdd:cd01115 372 VVSVTMIPLIW 382
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
40-606 |
2.18e-43 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 161.36 E-value: 2.18e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 40 VLLVTAVYWVSEAVPLGAAALVP-AFLYPFFGVLRSSEVAAE--YFKNTTLLLV-GVICVAAAVEKWNLHKRIALRMV-L 114
Cdd:TIGR00785 16 IFVAAIVGWILEPLPLPVTALLAiPIIAVLLGVLSAFKFKNAlsGFADPTIWLFfGAFILATALVKTGLGKRIAYKLVgK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 115 MAGAKPGMLLLCFMCCTTMLSMWLSNTS-TTAMVMPIVeavlqelinaeeeqlvagnssteeaelmgvdvsnrqtsveli 193
Cdd:TIGR00785 96 MGGTTLGLGYFLVFLETLLAPMWPSNTArAGGILLPII------------------------------------------ 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 194 fvnedtsaadftslmqnkqnlNGVPMVTKSiktanqqqqkkqhqsqekpgvptpsskNQELNKKKYRshhdqmvcKCLSL 273
Cdd:TIGR00785 134 ---------------------KSLLPLLGS---------------------------KPEKSPRKIG--------KYLML 157
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 274 SISYAATIGGLTTIIGTSTSLIFLEHFNNQypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslskKK 353
Cdd:TIGR00785 158 GIAYSASIGSSGFLTGSAPNALAAGILSKI--LGIQISWGDWFLAGLPLGIILLLLVPLLLYVLF-------------PP 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 354 KTRREELSERRIREEYEKLGDISYPEMVTAFFFILMTVLWFtrepgfvpgwdsfFEKKGYRTDATVSVFLGFLLFLipak 433
Cdd:TIGR00785 223 ELKLKDEVDLWAKEELEEMGPMSFREKALLGIFLLALLLWI-------------FGGSLGINASVVALLAVVLMLF---- 285
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 434 kpcFGkksdgagqeasrgiepIITWKDFQK-TMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLAC 512
Cdd:TIGR00785 286 ---LG----------------IVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVL 346
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 513 VLVSIV--TEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFA-VMLPVGNPPNAIVFSYGHCQIKDMVKAGL 589
Cdd:TIGR00785 347 VVLFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGA 426
|
570
....*....|....*..
gi 1958771237 590 GVNVIGLVIVMVAINTW 606
Cdd:TIGR00785 427 IIGIVGLIVLLLVGTLW 443
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
2-156 |
4.73e-04 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 42.68 E-value: 4.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 2 GLLQGLLQARKLLLVICVPLLLLPLPTIYPTSEAACAYVLLVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSSEVAAEY 81
Cdd:pfam03600 173 GLLPLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAV 252
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958771237 82 FKNTTLLLVGVICVAAAVEKWNLHKRIALrmVLMAGAKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQ 156
Cdd:pfam03600 253 DWSTLLFFAGLFILVGALEKTGLADALAD--ALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAP 325
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
90-606 |
1.16e-77 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 251.23 E-value: 1.16e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 90 VGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELinaeeeqlvag 169
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 170 nssteeaelmgvdvsnrqtsvelifvnedtsaadftslmqnkqnlngvpmvtksiktanqqqqkkqhqsqekpgvptpss 249
Cdd:COG0471 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 250 knQELNKKKYRShhdqmvckCLSLSISYAATIGGLTTIIGTSTSLIFLEHFNNQYpaAEVVNFGTWFLFSFPISLIMLVV 329
Cdd:COG0471 70 --GSEKRSKFGS--------ALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT--GIPISFFEWMLVGLPVALVGLLL 137
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 330 SWFWMHWLFlgcnfketcslskKKKTRREELSERRIREEYEKLGDISYPEMVTAFFFILMTVLWFTREPGFVPgwdsffe 409
Cdd:COG0471 138 LWLVLYRLL-------------PPEIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIP------- 197
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 410 kkgyrtDATVSVFLGFLLFLIPakkpcfgkksdgagqeasrgiepIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLS 489
Cdd:COG0471 198 ------IAVVALLGAVLLLLTG-----------------------VLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLA 248
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 490 TWIGHQMLS-LSSLPPWAITLLACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFAVMLPVGNP 568
Cdd:COG0471 249 AWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTP 328
|
490 500 510
....*....|....*....|....*....|....*...
gi 1958771237 569 PNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTW 606
Cdd:COG0471 329 PNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
31-611 |
1.99e-55 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 195.28 E-value: 1.99e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 31 PTSEAACAYVLLVTAVYWVSEAVPLGAAALVP----AFLYPFFGVLRSSEVAAEYFKNTTLLLVGVICVAAAVEKWNLHK 106
Cdd:pfam00939 27 PSKAWHLFAIFIATIVGWILEPLPMAVIALFAislsAILIGTLLAKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 107 RIALRMVLMAGAKPgmLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELInaeeeqlvagnssteeaelmgvdvsnr 186
Cdd:pfam00939 107 RIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLP--------------------------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 187 qtsvelifvnedtsaadftslmqnkqnlngvpmvtksiktanqqqqkkqhqsqekpgvptpssknqELNKKKYRSHHDQM 266
Cdd:pfam00939 158 ------------------------------------------------------------------PAFGSDPEKGSERR 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 267 VCKCLSLSISYAATIGGLTTIIGTSTSLIFLEHFNNQypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLGcnfkET 346
Cdd:pfam00939 172 IGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI--LGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPP----EI 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 347 CSLSKKKKTRREELSErrireeyekLGDISYPEMVTAFFFILMTVLWFTREPgfvPGWDsffekkgyrtDATVSVFLGFL 426
Cdd:pfam00939 246 KSVPDAKAIAKTELKE---------LGPMTFREKALLGLFVLLLLLWIFGGS---LNID----------ATTVAIIGLAL 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 427 LFLIPakkpcfgkksdgagqeasrgiepIITWKD-FQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPW 505
Cdd:pfam00939 304 MLLLR-----------------------ILDWKDiVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSP 360
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 506 AITLLACVLVSIVT--EFVSNPATITIFLPILCTLSETLH-INPLYTLVPVTMSISFA-VMLPVGNPPNAIVFSYGHCQI 581
Cdd:pfam00939 361 AMAFIIILSLFYLShyLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKV 440
|
570 580 590
....*....|....*....|....*....|
gi 1958771237 582 KDMVKAGLGVNVIGLVIVMVAINTWGVSLF 611
Cdd:pfam00939 441 KDWWRIGAILTIIGLLILLLLGNWWWKPLG 470
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
38-607 |
2.15e-55 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 192.80 E-value: 2.15e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 38 AYVLLVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSSEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAG 117
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 118 AKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELinaeeeqlvagnssteeaelmgvdvsnrqtsvelifvne 197
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKL--------------------------------------- 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 198 dtsaadftslmqnkqnlngvpmvtksiktanqqqqkkqhqsqekpgvptpssknqelnkkkyrshhdQMVCKCLSLSISY 277
Cdd:cd01115 122 -------------------------------------------------------------------DISPSRLLMPLAF 134
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 278 AATIGGLTTIIGTSTSLIFLEHFNnqYPAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslskkkktrr 357
Cdd:cd01115 135 AASIGGMLTLIGTPPNLVASGYLE--SLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLAV------------------- 193
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 358 eelserrireeyeklgdisypemvtaFFFILMTVLWFTREPGFVPgwdsffekkgyrtdATVSVFLGFLLFLIPAKkpcf 437
Cdd:cd01115 194 --------------------------LIITIVLLAALAAITGLLP--------------VSVAIAIGAIVLVFGGV---- 229
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 438 gkksdgagqeasrgiepiITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLS-LSSLPPWAITLLACVLVS 516
Cdd:cd01115 230 ------------------LLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTL 291
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 517 IVTEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGL 596
Cdd:cd01115 292 VLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSL 371
|
570
....*....|.
gi 1958771237 597 VIVMVAINTWG 607
Cdd:cd01115 372 VVSVTMIPLIW 382
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
40-606 |
2.18e-43 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 161.36 E-value: 2.18e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 40 VLLVTAVYWVSEAVPLGAAALVP-AFLYPFFGVLRSSEVAAE--YFKNTTLLLV-GVICVAAAVEKWNLHKRIALRMV-L 114
Cdd:TIGR00785 16 IFVAAIVGWILEPLPLPVTALLAiPIIAVLLGVLSAFKFKNAlsGFADPTIWLFfGAFILATALVKTGLGKRIAYKLVgK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 115 MAGAKPGMLLLCFMCCTTMLSMWLSNTS-TTAMVMPIVeavlqelinaeeeqlvagnssteeaelmgvdvsnrqtsveli 193
Cdd:TIGR00785 96 MGGTTLGLGYFLVFLETLLAPMWPSNTArAGGILLPII------------------------------------------ 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 194 fvnedtsaadftslmqnkqnlNGVPMVTKSiktanqqqqkkqhqsqekpgvptpsskNQELNKKKYRshhdqmvcKCLSL 273
Cdd:TIGR00785 134 ---------------------KSLLPLLGS---------------------------KPEKSPRKIG--------KYLML 157
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 274 SISYAATIGGLTTIIGTSTSLIFLEHFNNQypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslskKK 353
Cdd:TIGR00785 158 GIAYSASIGSSGFLTGSAPNALAAGILSKI--LGIQISWGDWFLAGLPLGIILLLLVPLLLYVLF-------------PP 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 354 KTRREELSERRIREEYEKLGDISYPEMVTAFFFILMTVLWFtrepgfvpgwdsfFEKKGYRTDATVSVFLGFLLFLipak 433
Cdd:TIGR00785 223 ELKLKDEVDLWAKEELEEMGPMSFREKALLGIFLLALLLWI-------------FGGSLGINASVVALLAVVLMLF---- 285
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 434 kpcFGkksdgagqeasrgiepIITWKDFQK-TMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLAC 512
Cdd:TIGR00785 286 ---LG----------------IVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVL 346
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 513 VLVSIV--TEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFA-VMLPVGNPPNAIVFSYGHCQIKDMVKAGL 589
Cdd:TIGR00785 347 VVLFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGA 426
|
570
....*....|....*..
gi 1958771237 590 GVNVIGLVIVMVAINTW 606
Cdd:TIGR00785 427 IIGIVGLIVLLLVGTLW 443
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
45-603 |
7.53e-34 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 133.53 E-value: 7.53e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 45 AVYWVSEAVPLGAAALVPAFLYPFFGVLRSSEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLL 124
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 125 LcFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELinaeeeqlvagnssteeaelmgvdvsnrqtsvelifvnedtsaadf 204
Cdd:cd00625 81 L-LMLLTAALSAFFSNDATAVLLTPIVLALLRKL---------------------------------------------- 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 205 tslmqnkQNLNGVPMVtksiktanqqqqkkqhqsqekpgvptpssknqelnkkkyrshhdqmvckclsLSISYAATIGGL 284
Cdd:cd00625 114 -------GLSPPVPLL----------------------------------------------------LALAFAANIGGA 134
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 285 TTIIGTSTSLIFLehfnnqypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslsKKKKTRREELSERR 364
Cdd:cd00625 135 ATPIGNPPNLIIA--------SLSGLGFLDFLAFMAPPALGLLLLLLGLLYLLF------------RKKLLLPDEDKLTV 194
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 365 IREEYEKLGDISYPEMVTAFFFILMTVLWFTREPGFVPgwdsffekkgyrtdATVSVFLGFLLFLIpakkpcfgkksdga 444
Cdd:cd00625 195 LAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLI--------------ALLGALLLLLLLVR-------------- 246
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 445 gqeasrgiepIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACVLVSIVTEFVSN 524
Cdd:cd00625 247 ----------GLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISN 316
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 525 PATITIFLPILCTLSET-----LHINPLYTLVPVTMSISFAVMLPVGNPPNAIVfsygHCQIKDMVKAGLGVNVIGLVIV 599
Cdd:cd00625 317 VPTVALLLPIAASLAPPepawlALALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVGLPLTLLSLVVS 392
|
....
gi 1958771237 600 MVAI 603
Cdd:cd00625 393 LLYL 396
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
45-551 |
1.67e-20 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 93.15 E-value: 1.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 45 AVYWVSEAVPLGAAALVPAFLYPFFGVLRSSEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLL 124
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 125 LCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELinaeeeqlvagnssteeaelmgvdvsnrqtsvelifvnedtsaadf 204
Cdd:pfam03600 81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRL---------------------------------------------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 205 tslmqnkqNLNGVPMVtksiktanqqqqkkqhqsqekpgvptpssknqelnkkkyrshhdqmvckclsLSISYAATIGGL 284
Cdd:pfam03600 115 --------GLPPSPLL----------------------------------------------------IALAFAANIGGT 134
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 285 TTIIGTSTSLIFLEHFnnqypaaeVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLgcnfketcslskkkktRREELSERR 364
Cdd:pfam03600 135 ATPIGDPPNIIIASAL--------GLSFGDFGFFMFPPVGVALLLVGLLPLLLIF----------------RKLLPVRKE 190
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 365 IREEYEKLGDISYPEMVTAFFFILMTVLWFtrepgfvpgwdsffekkgyrtdatVSVFLGFLLFLIPAkkpcfgkksdga 444
Cdd:pfam03600 191 EEAELEELRKRAIKDKLLLAISALVLALVI------------------------LGFLLLSVLALAGA------------ 234
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 445 gqeASRGIEPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSslPPWAITLLACVLVSIVTEFVSN 524
Cdd:pfam03600 235 ---LLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS--GLLVALALILWLSALLSAFISN 309
|
490 500
....*....|....*....|....*..
gi 1958771237 525 PATITIFLPILCTLSETLHINPLYTLV 551
Cdd:pfam03600 310 VPTAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
454-603 |
9.35e-12 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 66.95 E-value: 9.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 454 PIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACVLVSIVTEFVSNPATITIFLP 533
Cdd:pfam03600 26 GVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIP 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958771237 534 ILCTLSETLHINPLYTLVPVTMSISFA-VMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAI 603
Cdd:pfam03600 106 IVLALARRLGLPPSPLLIALAFAANIGgTATPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLP 176
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
455-578 |
3.44e-09 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 59.37 E-value: 3.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 455 IITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACVLVSIVTEFVSNPATITIFLPI 534
Cdd:COG1055 41 VVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPV 120
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1958771237 535 LCTLSETLHINPlytlVPVTMSISFA-----VMLPVGNPPNAIVFSYGH 578
Cdd:COG1055 121 VLAIARRLGLNP----VPFLIAIVFAaniggAATPIGNPTNIMIASAGG 165
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
36-551 |
2.36e-08 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 56.68 E-value: 2.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 36 ACAYVLLVTAVYWVSEAVP--LGAAALVpaflypFFGVLRSSEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMV 113
Cdd:COG1055 10 VLTYLLIILEPRGLNRAVAalLGAALLL------LLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 114 LMAGAKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELinaeeeqlvagnssteeaelmgvdvsnrqtsveli 193
Cdd:COG1055 84 RRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRL----------------------------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 194 fvnedtsaadftslmqnkqNLNGVPMVtksiktanqqqqkkqhqsqekpgvptpssknqelnkkkyrshhdqmvckclsL 273
Cdd:COG1055 129 -------------------GLNPVPFL----------------------------------------------------I 137
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 274 SISYAATIGGLTTIIGTSTSLIFLEHFNnqypaaevVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslsKKK 353
Cdd:COG1055 138 AIVFAANIGGAATPIGNPTNIMIASAGG--------LSFLDFLANLFPPSLVSLLVTLLVLYLLF------------RKE 197
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 354 KTRREELSErrirEEYEKLGDISYPEMVTAFFFILMTVLWFTREPGFVPGWdsffekkgyrtdatVSVFLGFLLFLIpak 433
Cdd:COG1055 198 LPAAPDLED----DPKEAIKDRRLLRISLLVLALLLVGFVLHSFLGLPPAL--------------IALLGAAVLLLL--- 256
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 434 kpcfgkksdgagqeASRGIEPIItwkdfqKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACV 513
Cdd:COG1055 257 --------------ARVDVREVL------KKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILW 316
|
490 500 510
....*....|....*....|....*....|....*...
gi 1958771237 514 LVSIVTEFVSNPATITIFLPILCTLSETLHINPLYTLV 551
Cdd:COG1055 317 LSAILSAVVDNVPLVAALLPLIPDLGATGNPEPLWLAL 354
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
40-158 |
9.24e-07 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 51.31 E-value: 9.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 40 VLLVTAVYWVSEA---VPLGAAALVPAFLYPFFGVLRSSEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMV-LM 115
Cdd:COG0471 180 IFALTVLLWITGSlhgIPIAVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLpLL 259
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1958771237 116 AGAKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQEL 158
Cdd:COG0471 260 GGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
449-601 |
1.85e-06 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 50.71 E-value: 1.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 449 SRGIEPIITWKDfqktmpWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACVLVSIVTEFVSNPATI 528
Cdd:cd01116 35 SPDLETIVSWVD------WETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTV 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958771237 529 TIFLPILCTLSETLHINPlytlVPVTMSISFA-----VMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMV 601
Cdd:cd01116 109 LLMVPVTIRLCEVLGLNP----VPVLISEVIAaniggAATLIGDPPNIMIGSAAGLTFNDFLLHMLPSVVLALVVTFI 182
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
28-158 |
1.48e-05 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 47.58 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 28 TIYPTSEAACAYVLLVTAVYWVSEAVPLGAAALVPAFLYpFFGVLRSSEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKR 107
Cdd:cd01115 187 FIFRLAVLIITIVLLAALAAITGLLPVSVAIAIGAIVLV-FGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAAL 265
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1958771237 108 IALRMVLMA-GAKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQEL 158
Cdd:cd01115 266 IAEALISLLgGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSL 317
|
|
| DctM |
pfam06808 |
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a ... |
468-602 |
3.50e-04 |
|
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers. Note that many family members are hypothetical proteins.
Pssm-ID: 284275 [Multi-domain] Cd Length: 413 Bit Score: 43.40 E-value: 3.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 468 EIVILVGGGYALASGSKSSGLSTWIGHQMLSLSsLPPWAITLLACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPl 547
Cdd:pfam06808 274 AVLFILAAAGIFAGLLTITGVPFKLSDWLLSLG-GGNLLFLILVNLLCLVLGMFLDPTAAIIILVPILAPAAAQLGIDP- 351
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1958771237 548 ytlVPVTMSISFAVMLPVGNPPNAIVFsYGHCQIKDMVKAGLGVNVIGLVIVMVA 602
Cdd:pfam06808 352 ---IHFGVVIVYNGSIGLITPPVGLAL-FVAAGIAKVSFEEVVKGVVPFLFVLVP 402
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
2-156 |
4.73e-04 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 42.68 E-value: 4.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771237 2 GLLQGLLQARKLLLVICVPLLLLPLPTIYPTSEAACAYVLLVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSSEVAAEY 81
Cdd:pfam03600 173 GLLPLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAV 252
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958771237 82 FKNTTLLLVGVICVAAAVEKWNLHKRIALrmVLMAGAKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQ 156
Cdd:pfam03600 253 DWSTLLFFAGLFILVGALEKTGLADALAD--ALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAP 325
|
|
| |
