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Conserved domains on  [gi|1958770103|ref|XP_038963728|]
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gamma-glutamylcyclotransferase isoform X1 [Rattus norvegicus]

Protein Classification

gamma-glutamylcyclotransferase family protein( domain architecture ID 10159924)

gamma-glutamylcyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl

CATH:  3.10.490.10
EC:  2.3.2.-
Gene Ontology:  GO:0016746
PubMed:  18515354|20110353
SCOP:  4002485

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GGCT_like cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 19-96 8.10e-20

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


:

Pssm-ID: 119400  Cd Length: 99  Bit Score: 76.61  E-value: 8.10e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958770103 19 YFAYGSNLLTERIHLRNPSAVFCCVARLQDFKLDFGnfqgkmserWHGGIATIFQSPGDEVWGVVWKMNKSNLSSLDE 96
Cdd:cd06661    1 LFVYGTLMDGEVLHARLGRALFLGPATLKGYRLVFG---------GGSGYPGLVPGPGARVWGELYEVDPEDLARLDA 69
 
Name Accession Description Interval E-value
GGCT_like cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 19-96 8.10e-20

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


Pssm-ID: 119400  Cd Length: 99  Bit Score: 76.61  E-value: 8.10e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958770103 19 YFAYGSNLLTERIHLRNPSAVFCCVARLQDFKLDFGnfqgkmserWHGGIATIFQSPGDEVWGVVWKMNKSNLSSLDE 96
Cdd:cd06661    1 LFVYGTLMDGEVLHARLGRALFLGPATLKGYRLVFG---------GGSGYPGLVPGPGARVWGELYEVDPEDLARLDA 69
YtfP COG2105
Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family [Amino acid ...
 18-96 7.05e-04

Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family [Amino acid transport and metabolism];


Pssm-ID: 441708 [Multi-domain]  Cd Length: 114  Bit Score: 35.63  E-value: 7.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770103  18 LYFAYGSNLLTERIHLRNPSAVFCCVARLQdFKL-DFGNFqgkmserwhggiATIFQSPGDEVWGVVWKMNKSNLSSLDE 96
Cdd:COG2105     2 LLFVYGTLRRGESNHHLLRGARFLGPATLE-GRLyDLGAY------------PALVPDGGGRVYGELYEVDDALLAALDE 68
GGACT pfam06094
Gamma-glutamyl cyclotransferase, AIG2-like; GGACT, gamma-glutamylamine cyclotransferase, is a ...
 19-96 8.42e-04

Gamma-glutamyl cyclotransferase, AIG2-like; GGACT, gamma-glutamylamine cyclotransferase, is a ubiquitous enzyme found in bacteria, plants, and metazoans from Dictyostelium through to humans. It converts gamma-glutamylamines to free amines and 5-oxoproline.


Pssm-ID: 428763 [Multi-domain]  Cd Length: 118  Bit Score: 35.83  E-value: 8.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770103  19 YFAYGSNLLTERIH---LRNPSAVFCCVARLQDFKLdfgnfqgkmseRWHGGIATIFQSPGDEVWGVVWKMNKSNLSSLD 95
Cdd:pfam06094   1 VFVYGTLRRGEPNHhalLLGARFPGLGPATLPGYRL-----------YDLGGYPALVPGEGERVVGELYEVDDALLARLD 69


                  .
gi 1958770103  96 E 96
Cdd:pfam06094  70 E 70
 
Name Accession Description Interval E-value
GGCT_like cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 19-96 8.10e-20

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


Pssm-ID: 119400  Cd Length: 99  Bit Score: 76.61  E-value: 8.10e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958770103 19 YFAYGSNLLTERIHLRNPSAVFCCVARLQDFKLDFGnfqgkmserWHGGIATIFQSPGDEVWGVVWKMNKSNLSSLDE 96
Cdd:cd06661    1 LFVYGTLMDGEVLHARLGRALFLGPATLKGYRLVFG---------GGSGYPGLVPGPGARVWGELYEVDPEDLARLDA 69
YtfP COG2105
Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family [Amino acid ...
 18-96 7.05e-04

Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family [Amino acid transport and metabolism];


Pssm-ID: 441708 [Multi-domain]  Cd Length: 114  Bit Score: 35.63  E-value: 7.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770103  18 LYFAYGSNLLTERIHLRNPSAVFCCVARLQdFKL-DFGNFqgkmserwhggiATIFQSPGDEVWGVVWKMNKSNLSSLDE 96
Cdd:COG2105     2 LLFVYGTLRRGESNHHLLRGARFLGPATLE-GRLyDLGAY------------PALVPDGGGRVYGELYEVDDALLAALDE 68
GGACT pfam06094
Gamma-glutamyl cyclotransferase, AIG2-like; GGACT, gamma-glutamylamine cyclotransferase, is a ...
 19-96 8.42e-04

Gamma-glutamyl cyclotransferase, AIG2-like; GGACT, gamma-glutamylamine cyclotransferase, is a ubiquitous enzyme found in bacteria, plants, and metazoans from Dictyostelium through to humans. It converts gamma-glutamylamines to free amines and 5-oxoproline.


Pssm-ID: 428763 [Multi-domain]  Cd Length: 118  Bit Score: 35.83  E-value: 8.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770103  19 YFAYGSNLLTERIH---LRNPSAVFCCVARLQDFKLdfgnfqgkmseRWHGGIATIFQSPGDEVWGVVWKMNKSNLSSLD 95
Cdd:pfam06094   1 VFVYGTLRRGEPNHhalLLGARFPGLGPATLPGYRL-----------YDLGGYPALVPGEGERVVGELYEVDDALLARLD 69


                  .
gi 1958770103  96 E 96
Cdd:pfam06094  70 E 70
AIG2_2 pfam13772
AIG2-like family; This family is found in bacteria and metazoa.
 78-96 1.21e-03

AIG2-like family; This family is found in bacteria and metazoa.


Pssm-ID: 433465  Cd Length: 83  Bit Score: 34.54  E-value: 1.21e-03
                         10
                 ....*....|....*....
gi 1958770103 78 EVWGVVWKMNKSNLSSLDE 96
Cdd:pfam13772  1 HVFGVLWEIPMENLKDLDK 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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