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Conserved domains on  [gi|1958770041|ref|XP_038963704|]
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nuclear pore complex protein Nup205 isoform X1 [Rattus norvegicus]

Protein Classification

nuclear pore complex Nup192/Nup205 family protein( domain architecture ID 10571003)

nuclear pore complex Nup192/Nup205 family protein; similar to Homo sapiens Nup205 and Saccharomyces cerevisiae Nup192, which are components (nucleoporins, NUPs) of the nuclear pore complex (NPC) that can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
 206-1725 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


:

Pssm-ID: 463387  Cd Length: 1484  Bit Score: 1088.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  206 ELVSMTTRFTDELME-QGLTYKVLTLVSQIDVNNEFEKLqrdRGLGSEKHRKevsDLIKECRQSLAESLFAWACQSPLAK 284
Cdd:pfam11894    3 SATTLVTNILDSFKEiHGLLQRLLDLVNKADILGEIQDN---RFLGTIKFRR---DSLFKEHELLAQILFGLVAQRGLPK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  285 DDTLLLIGHLERVtveanGSLDAVNLALLMALLYCF----DTSFIEQSTEERDDMIHHLpllterqyiatihsrlqdSQP 360
Cdd:pfam11894   77 DDFLKLIDHAKKA-----DKYDFLTLHYLPALLAAFgsleDLSVLQDVRELHSKITKSL------------------DSE 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  361 WKLP--GLQATVRLAWALALRG-ISQLPD-VTALAEFTEADEAIAELAIADNVFLFL----------------------- 413
Cdd:pfam11894  134 WPLYtdGLKAAIIFVFLAEFIGwCKQEPEeRAKQFDFKEDIEKPMDEALEDGAFEFLlsiaadtsnkdwedplrydfrsl 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  414 -------SESVVLAENFYQEEFYIRRIHNLITDFLAFMPMKVKQLKNRADEDARMIHMSIQMGneppislRRDLEHLMLL 486
Cdd:pfam11894  214 lqrhiprLTPEKLLLSDYFEEFLLRQLHTFITDFISNMADVLTKLRDREEDSLLSQESLLQEG-------RADLERFLLI 286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  487 IGELYKKNPfhlELALEYWcpseplqtptvmgsylgvahqrpPQRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQ 566
Cdd:pfam11894  287 IAYLYEGRP---DLALEFW-----------------------SDRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEE 340

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  567 CAHYCFSLLKVNGSSHVENiqgaGGSPVSWEHFFHSLLLYHEHLRKDLPSA----DSVQYRHLPSRGITQKEQDGLIAFL 642
Cdd:pfam11894  341 NARAAFNFLKDNNNSGKKR----RSSSVSWDHIFDSLNYYIDKLRQKPENFesdgDRQQRQEAIPIELEPESIIFLSSYL 416

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  643 QLTSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPALKAELLKTLAAFG-KSPEIAASLWQSLE-----YTQILQT 716
Cdd:pfam11894  417 RLISSVAKNSEEARLALLEHPSWRFLDVLFGLLSCKVPTPLKAAILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPT 496

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  717 VRVPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVES-----------SFPSNLGAGLRPPGFDPYLQFLRDSVF 785
Cdd:pfam11894  497 VPRTSSYKPRGSYSELEAFESRLEGYPEVRAFLQLLKALLSPpedssslfgklPFPENLGAGYRKPGIWPYLDFVLDEVF 576

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  786 LRfRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQLEDFVDQFVE-----LQGEEIIAY-KPPGFSLMYHLLNESPMLEL 859
Cdd:pfam11894  577 LK-STRDYKDPAEKWELQLSCLEFIETCLRSFDPSLILFSNPSGInldslVSTSDFATYvKLHPFHAVLNYLFNEKVLKA 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  860 ALSLLEEGVKQLDTYApfpGKKHLEKAVQHCLALLNLTLQKENLFMDLLR----ESQLALIVSPL---------EQLLQG 926
Cdd:pfam11894  656 LFSIIDEGVDELDNYL---GKSPLELLVLLALEIIDKVLDLQETYLDELLpilkKSQNIYRPKNVgnhglssfyDALLFN 732

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  927 INprtkkadNVVNIARYLYHGnsNPELAFESAKILCCISCNSNI----------QIKMVGDFTHDQNvSQKLMAGFVECL 996
Cdd:pfam11894  733 LS-------LVLNLGLYVGYG--HPELALASLKILEKISSSPKFsassagrllhRNKLLTIFESVDE-SERIKRGFIEQL 802

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  997 DSEDTEEfvrveegselEKKLAAIRHETRIHILNLLITSLERSP--PNLALYLLGFELKKPISTTNLQDPgVLGCPRTCL 1074
Cdd:pfam11894  803 EAPIDEE----------EQGAESIGLQIKEAILDFLNSNLSASPkrPTIAHFLLGFDVRNDLSLGPDQST-FIASPRSLL 871

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1075 HAILNILEKGTDGRSGPVAV-QACPQLAELCYQVIYQLCACSDTSGPTMRYLRtSQDFLFSQLQHLPFSNKEYE------ 1147
Cdd:pfam11894  872 HSLLLLLLSSLDLISEGDYIdYAPARLAELILEILYKLCRNPLTSSITLRYLR-ENCFLFRHLLSLPPKIDPNTlwngqs 950

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1148 ---------------ISMLNQMSWLMKTASIELRVTSLNRQRSHTQRLLHLLlddlpvkpysdgeggmedenrsVSGFLH 1212
Cdd:pfam11894  951 fdgvffisspsagalLSFLNQRSLLLQYLSLELHSTSQSGSPSKKKRYVDLL----------------------LGNNIL 1008

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1213 FDTATKVRRKILSILDSIDFS-QEIPEPLQLDFFDRAQIEQVIANCEHKNLQ-GQTVCNVKLLHRVLVAEV---NALQGM 1287
Cdd:pfam11894 1009 DGGEPIGSPTIFDFLDFLNFEfINFEPQPQLEFFDIKNLSLDLDKCELDDADsGNKLYDISKLHELLRLELkqlLLVQGE 1088

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1288 AAIGQRPLLMEEISTILQYVVGRNKLLQCLHAKRHALESWRQLVEIILTACpqeLIQAEDRQLIIRDILQDVHDKV---- 1363
Cdd:pfam11894 1089 SKAGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQLVQVLVSDG---DLSSTVRSNFILEVLQAILPKIndyv 1165

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1364 -LDDEAAQELMPVVAGAVFTLTAHLSQAVRTEQKQplvsgpaeahyafmldssftsapaaesqpvgFASIGDSSLHIILK 1442
Cdd:pfam11894 1166 eLDIAFAEELASLASVLLFDLYAKLRQCINLDEEQ-------------------------------KGNLSSDRLHQLFK 1214

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1443 KLLDFILKTgGGFQRVRTHLYGSLLYYLQIAQRPDepdtleaakktmwerltapeDVFSKLQRENMAIIESYGAALMEVV 1522
Cdd:pfam11894 1215 TCIDGILSS-GSTQKLRSDLYVILNNYLQIVFKNR--------------------SSEESLRKETLQIIKSYGEKLIEVI 1273

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1523 CRDACDGHEIGRMLALALLDRIVSVDKQQQ--WLLYLSNSGYLKVLVDSLLEDDRTLQSLLTPQPPLLKALY--TYESKM 1598
Cdd:pfam11894 1274 CNDAIGGEGTCRITALLLLDSLVHLDSNKSnfILETLSKNNYLLLLVRSLKRTDEELRECLAPDPESLDPLYetAFESKL 1353

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1599 AFLTRVAKLQQGSLELLRSGVIVRLAQCQVYDMRPEVdshsmfGM-RDPPIFIPTPVDRYRQILLPALQLCQVILTSSMS 1677
Cdd:pfam11894 1354 ALLIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPDL------GLsLDNPLSLPDALERYFELLVPVLQLITAILLSLGS 1427

                         1610      1620      1630      1640      1650
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958770041 1678 QHLQAAGQVLQFLVSHSDTIQAILR---------CQDVSAGSLQELALLTGIISKAA 1725
Cdd:pfam11894 1428 SNKSAIEQVRKFLKHHRDLVVGVLKrdalpesgiGYAELEEGLQELAKLFVLLATLT 1484
 
Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
 206-1725 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


Pssm-ID: 463387  Cd Length: 1484  Bit Score: 1088.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  206 ELVSMTTRFTDELME-QGLTYKVLTLVSQIDVNNEFEKLqrdRGLGSEKHRKevsDLIKECRQSLAESLFAWACQSPLAK 284
Cdd:pfam11894    3 SATTLVTNILDSFKEiHGLLQRLLDLVNKADILGEIQDN---RFLGTIKFRR---DSLFKEHELLAQILFGLVAQRGLPK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  285 DDTLLLIGHLERVtveanGSLDAVNLALLMALLYCF----DTSFIEQSTEERDDMIHHLpllterqyiatihsrlqdSQP 360
Cdd:pfam11894   77 DDFLKLIDHAKKA-----DKYDFLTLHYLPALLAAFgsleDLSVLQDVRELHSKITKSL------------------DSE 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  361 WKLP--GLQATVRLAWALALRG-ISQLPD-VTALAEFTEADEAIAELAIADNVFLFL----------------------- 413
Cdd:pfam11894  134 WPLYtdGLKAAIIFVFLAEFIGwCKQEPEeRAKQFDFKEDIEKPMDEALEDGAFEFLlsiaadtsnkdwedplrydfrsl 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  414 -------SESVVLAENFYQEEFYIRRIHNLITDFLAFMPMKVKQLKNRADEDARMIHMSIQMGneppislRRDLEHLMLL 486
Cdd:pfam11894  214 lqrhiprLTPEKLLLSDYFEEFLLRQLHTFITDFISNMADVLTKLRDREEDSLLSQESLLQEG-------RADLERFLLI 286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  487 IGELYKKNPfhlELALEYWcpseplqtptvmgsylgvahqrpPQRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQ 566
Cdd:pfam11894  287 IAYLYEGRP---DLALEFW-----------------------SDRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEE 340

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  567 CAHYCFSLLKVNGSSHVENiqgaGGSPVSWEHFFHSLLLYHEHLRKDLPSA----DSVQYRHLPSRGITQKEQDGLIAFL 642
Cdd:pfam11894  341 NARAAFNFLKDNNNSGKKR----RSSSVSWDHIFDSLNYYIDKLRQKPENFesdgDRQQRQEAIPIELEPESIIFLSSYL 416

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  643 QLTSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPALKAELLKTLAAFG-KSPEIAASLWQSLE-----YTQILQT 716
Cdd:pfam11894  417 RLISSVAKNSEEARLALLEHPSWRFLDVLFGLLSCKVPTPLKAAILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPT 496

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  717 VRVPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVES-----------SFPSNLGAGLRPPGFDPYLQFLRDSVF 785
Cdd:pfam11894  497 VPRTSSYKPRGSYSELEAFESRLEGYPEVRAFLQLLKALLSPpedssslfgklPFPENLGAGYRKPGIWPYLDFVLDEVF 576

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  786 LRfRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQLEDFVDQFVE-----LQGEEIIAY-KPPGFSLMYHLLNESPMLEL 859
Cdd:pfam11894  577 LK-STRDYKDPAEKWELQLSCLEFIETCLRSFDPSLILFSNPSGInldslVSTSDFATYvKLHPFHAVLNYLFNEKVLKA 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  860 ALSLLEEGVKQLDTYApfpGKKHLEKAVQHCLALLNLTLQKENLFMDLLR----ESQLALIVSPL---------EQLLQG 926
Cdd:pfam11894  656 LFSIIDEGVDELDNYL---GKSPLELLVLLALEIIDKVLDLQETYLDELLpilkKSQNIYRPKNVgnhglssfyDALLFN 732

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  927 INprtkkadNVVNIARYLYHGnsNPELAFESAKILCCISCNSNI----------QIKMVGDFTHDQNvSQKLMAGFVECL 996
Cdd:pfam11894  733 LS-------LVLNLGLYVGYG--HPELALASLKILEKISSSPKFsassagrllhRNKLLTIFESVDE-SERIKRGFIEQL 802

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  997 DSEDTEEfvrveegselEKKLAAIRHETRIHILNLLITSLERSP--PNLALYLLGFELKKPISTTNLQDPgVLGCPRTCL 1074
Cdd:pfam11894  803 EAPIDEE----------EQGAESIGLQIKEAILDFLNSNLSASPkrPTIAHFLLGFDVRNDLSLGPDQST-FIASPRSLL 871

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1075 HAILNILEKGTDGRSGPVAV-QACPQLAELCYQVIYQLCACSDTSGPTMRYLRtSQDFLFSQLQHLPFSNKEYE------ 1147
Cdd:pfam11894  872 HSLLLLLLSSLDLISEGDYIdYAPARLAELILEILYKLCRNPLTSSITLRYLR-ENCFLFRHLLSLPPKIDPNTlwngqs 950

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1148 ---------------ISMLNQMSWLMKTASIELRVTSLNRQRSHTQRLLHLLlddlpvkpysdgeggmedenrsVSGFLH 1212
Cdd:pfam11894  951 fdgvffisspsagalLSFLNQRSLLLQYLSLELHSTSQSGSPSKKKRYVDLL----------------------LGNNIL 1008

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1213 FDTATKVRRKILSILDSIDFS-QEIPEPLQLDFFDRAQIEQVIANCEHKNLQ-GQTVCNVKLLHRVLVAEV---NALQGM 1287
Cdd:pfam11894 1009 DGGEPIGSPTIFDFLDFLNFEfINFEPQPQLEFFDIKNLSLDLDKCELDDADsGNKLYDISKLHELLRLELkqlLLVQGE 1088

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1288 AAIGQRPLLMEEISTILQYVVGRNKLLQCLHAKRHALESWRQLVEIILTACpqeLIQAEDRQLIIRDILQDVHDKV---- 1363
Cdd:pfam11894 1089 SKAGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQLVQVLVSDG---DLSSTVRSNFILEVLQAILPKIndyv 1165

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1364 -LDDEAAQELMPVVAGAVFTLTAHLSQAVRTEQKQplvsgpaeahyafmldssftsapaaesqpvgFASIGDSSLHIILK 1442
Cdd:pfam11894 1166 eLDIAFAEELASLASVLLFDLYAKLRQCINLDEEQ-------------------------------KGNLSSDRLHQLFK 1214

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1443 KLLDFILKTgGGFQRVRTHLYGSLLYYLQIAQRPDepdtleaakktmwerltapeDVFSKLQRENMAIIESYGAALMEVV 1522
Cdd:pfam11894 1215 TCIDGILSS-GSTQKLRSDLYVILNNYLQIVFKNR--------------------SSEESLRKETLQIIKSYGEKLIEVI 1273

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1523 CRDACDGHEIGRMLALALLDRIVSVDKQQQ--WLLYLSNSGYLKVLVDSLLEDDRTLQSLLTPQPPLLKALY--TYESKM 1598
Cdd:pfam11894 1274 CNDAIGGEGTCRITALLLLDSLVHLDSNKSnfILETLSKNNYLLLLVRSLKRTDEELRECLAPDPESLDPLYetAFESKL 1353

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1599 AFLTRVAKLQQGSLELLRSGVIVRLAQCQVYDMRPEVdshsmfGM-RDPPIFIPTPVDRYRQILLPALQLCQVILTSSMS 1677
Cdd:pfam11894 1354 ALLIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPDL------GLsLDNPLSLPDALERYFELLVPVLQLITAILLSLGS 1427

                         1610      1620      1630      1640      1650
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958770041 1678 QHLQAAGQVLQFLVSHSDTIQAILR---------CQDVSAGSLQELALLTGIISKAA 1725
Cdd:pfam11894 1428 SNKSAIEQVRKFLKHHRDLVVGVLKrdalpesgiGYAELEEGLQELAKLFVLLATLT 1484
 
Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
 206-1725 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


Pssm-ID: 463387  Cd Length: 1484  Bit Score: 1088.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  206 ELVSMTTRFTDELME-QGLTYKVLTLVSQIDVNNEFEKLqrdRGLGSEKHRKevsDLIKECRQSLAESLFAWACQSPLAK 284
Cdd:pfam11894    3 SATTLVTNILDSFKEiHGLLQRLLDLVNKADILGEIQDN---RFLGTIKFRR---DSLFKEHELLAQILFGLVAQRGLPK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  285 DDTLLLIGHLERVtveanGSLDAVNLALLMALLYCF----DTSFIEQSTEERDDMIHHLpllterqyiatihsrlqdSQP 360
Cdd:pfam11894   77 DDFLKLIDHAKKA-----DKYDFLTLHYLPALLAAFgsleDLSVLQDVRELHSKITKSL------------------DSE 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  361 WKLP--GLQATVRLAWALALRG-ISQLPD-VTALAEFTEADEAIAELAIADNVFLFL----------------------- 413
Cdd:pfam11894  134 WPLYtdGLKAAIIFVFLAEFIGwCKQEPEeRAKQFDFKEDIEKPMDEALEDGAFEFLlsiaadtsnkdwedplrydfrsl 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  414 -------SESVVLAENFYQEEFYIRRIHNLITDFLAFMPMKVKQLKNRADEDARMIHMSIQMGneppislRRDLEHLMLL 486
Cdd:pfam11894  214 lqrhiprLTPEKLLLSDYFEEFLLRQLHTFITDFISNMADVLTKLRDREEDSLLSQESLLQEG-------RADLERFLLI 286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  487 IGELYKKNPfhlELALEYWcpseplqtptvmgsylgvahqrpPQRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQ 566
Cdd:pfam11894  287 IAYLYEGRP---DLALEFW-----------------------SDRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEE 340

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  567 CAHYCFSLLKVNGSSHVENiqgaGGSPVSWEHFFHSLLLYHEHLRKDLPSA----DSVQYRHLPSRGITQKEQDGLIAFL 642
Cdd:pfam11894  341 NARAAFNFLKDNNNSGKKR----RSSSVSWDHIFDSLNYYIDKLRQKPENFesdgDRQQRQEAIPIELEPESIIFLSSYL 416

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  643 QLTSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPALKAELLKTLAAFG-KSPEIAASLWQSLE-----YTQILQT 716
Cdd:pfam11894  417 RLISSVAKNSEEARLALLEHPSWRFLDVLFGLLSCKVPTPLKAAILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPT 496

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  717 VRVPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVES-----------SFPSNLGAGLRPPGFDPYLQFLRDSVF 785
Cdd:pfam11894  497 VPRTSSYKPRGSYSELEAFESRLEGYPEVRAFLQLLKALLSPpedssslfgklPFPENLGAGYRKPGIWPYLDFVLDEVF 576

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  786 LRfRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQLEDFVDQFVE-----LQGEEIIAY-KPPGFSLMYHLLNESPMLEL 859
Cdd:pfam11894  577 LK-STRDYKDPAEKWELQLSCLEFIETCLRSFDPSLILFSNPSGInldslVSTSDFATYvKLHPFHAVLNYLFNEKVLKA 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  860 ALSLLEEGVKQLDTYApfpGKKHLEKAVQHCLALLNLTLQKENLFMDLLR----ESQLALIVSPL---------EQLLQG 926
Cdd:pfam11894  656 LFSIIDEGVDELDNYL---GKSPLELLVLLALEIIDKVLDLQETYLDELLpilkKSQNIYRPKNVgnhglssfyDALLFN 732

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  927 INprtkkadNVVNIARYLYHGnsNPELAFESAKILCCISCNSNI----------QIKMVGDFTHDQNvSQKLMAGFVECL 996
Cdd:pfam11894  733 LS-------LVLNLGLYVGYG--HPELALASLKILEKISSSPKFsassagrllhRNKLLTIFESVDE-SERIKRGFIEQL 802

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041  997 DSEDTEEfvrveegselEKKLAAIRHETRIHILNLLITSLERSP--PNLALYLLGFELKKPISTTNLQDPgVLGCPRTCL 1074
Cdd:pfam11894  803 EAPIDEE----------EQGAESIGLQIKEAILDFLNSNLSASPkrPTIAHFLLGFDVRNDLSLGPDQST-FIASPRSLL 871

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1075 HAILNILEKGTDGRSGPVAV-QACPQLAELCYQVIYQLCACSDTSGPTMRYLRtSQDFLFSQLQHLPFSNKEYE------ 1147
Cdd:pfam11894  872 HSLLLLLLSSLDLISEGDYIdYAPARLAELILEILYKLCRNPLTSSITLRYLR-ENCFLFRHLLSLPPKIDPNTlwngqs 950

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1148 ---------------ISMLNQMSWLMKTASIELRVTSLNRQRSHTQRLLHLLlddlpvkpysdgeggmedenrsVSGFLH 1212
Cdd:pfam11894  951 fdgvffisspsagalLSFLNQRSLLLQYLSLELHSTSQSGSPSKKKRYVDLL----------------------LGNNIL 1008

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1213 FDTATKVRRKILSILDSIDFS-QEIPEPLQLDFFDRAQIEQVIANCEHKNLQ-GQTVCNVKLLHRVLVAEV---NALQGM 1287
Cdd:pfam11894 1009 DGGEPIGSPTIFDFLDFLNFEfINFEPQPQLEFFDIKNLSLDLDKCELDDADsGNKLYDISKLHELLRLELkqlLLVQGE 1088

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1288 AAIGQRPLLMEEISTILQYVVGRNKLLQCLHAKRHALESWRQLVEIILTACpqeLIQAEDRQLIIRDILQDVHDKV---- 1363
Cdd:pfam11894 1089 SKAGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQLVQVLVSDG---DLSSTVRSNFILEVLQAILPKIndyv 1165

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1364 -LDDEAAQELMPVVAGAVFTLTAHLSQAVRTEQKQplvsgpaeahyafmldssftsapaaesqpvgFASIGDSSLHIILK 1442
Cdd:pfam11894 1166 eLDIAFAEELASLASVLLFDLYAKLRQCINLDEEQ-------------------------------KGNLSSDRLHQLFK 1214

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1443 KLLDFILKTgGGFQRVRTHLYGSLLYYLQIAQRPDepdtleaakktmwerltapeDVFSKLQRENMAIIESYGAALMEVV 1522
Cdd:pfam11894 1215 TCIDGILSS-GSTQKLRSDLYVILNNYLQIVFKNR--------------------SSEESLRKETLQIIKSYGEKLIEVI 1273

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1523 CRDACDGHEIGRMLALALLDRIVSVDKQQQ--WLLYLSNSGYLKVLVDSLLEDDRTLQSLLTPQPPLLKALY--TYESKM 1598
Cdd:pfam11894 1274 CNDAIGGEGTCRITALLLLDSLVHLDSNKSnfILETLSKNNYLLLLVRSLKRTDEELRECLAPDPESLDPLYetAFESKL 1353

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770041 1599 AFLTRVAKLQQGSLELLRSGVIVRLAQCQVYDMRPEVdshsmfGM-RDPPIFIPTPVDRYRQILLPALQLCQVILTSSMS 1677
Cdd:pfam11894 1354 ALLIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPDL------GLsLDNPLSLPDALERYFELLVPVLQLITAILLSLGS 1427

                         1610      1620      1630      1640      1650
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958770041 1678 QHLQAAGQVLQFLVSHSDTIQAILR---------CQDVSAGSLQELALLTGIISKAA 1725
Cdd:pfam11894 1428 SNKSAIEQVRKFLKHHRDLVVGVLKrdalpesgiGYAELEEGLQELAKLFVLLATLT 1484
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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