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Conserved domains on  [gi|1958769861|ref|XP_038963634|]
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mediator of RNA polymerase II transcription subunit 21 isoform X1 [Rattus norvegicus]

Protein Classification

mediator of RNA polymerase II transcription subunit 21( domain architecture ID 38253)

mediator of RNA polymerase II transcription subunit 21 (Med21) is a component of the mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Gene Symbol:  MED21
Gene Ontology:  GO:0061629|GO:0016592
PubMed:  15175151|16263706

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med21 super family cl12769
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 3-86 2.24e-18

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


The actual alignment was detected with superfamily member pfam11221:

Pssm-ID: 463241  Cd Length: 134  Bit Score: 73.39  E-value: 2.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769861   3 DRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSN---IQTAINKDQPANPTEEYAQL------FAALIARTAKDIDVLI 73
Cdd:pfam11221   1 DRLTQLQDCLDQLAEQFYASVGYLNRHHPPAPLPPndpISPDKAPPQPEPEPDPPEEFeatqreLARDLILKAQQIEYLI 80

                          90
                  ....*....|...
gi 1958769861  74 DSLPSEESTAALQ 86
Cdd:pfam11221  81 DSLPGIGVSEEEQ 93
 
Name Accession Description Interval E-value
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 3-86 2.24e-18

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


Pssm-ID: 463241  Cd Length: 134  Bit Score: 73.39  E-value: 2.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769861   3 DRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSN---IQTAINKDQPANPTEEYAQL------FAALIARTAKDIDVLI 73
Cdd:pfam11221   1 DRLTQLQDCLDQLAEQFYASVGYLNRHHPPAPLPPndpISPDKAPPQPEPEPDPPEEFeatqreLARDLILKAQQIEYLI 80

                          90
                  ....*....|...
gi 1958769861  74 DSLPSEESTAALQ 86
Cdd:pfam11221  81 DSLPGIGVSEEEQ 93
 
Name Accession Description Interval E-value
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 3-86 2.24e-18

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


Pssm-ID: 463241  Cd Length: 134  Bit Score: 73.39  E-value: 2.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769861   3 DRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSN---IQTAINKDQPANPTEEYAQL------FAALIARTAKDIDVLI 73
Cdd:pfam11221   1 DRLTQLQDCLDQLAEQFYASVGYLNRHHPPAPLPPndpISPDKAPPQPEPEPDPPEEFeatqreLARDLILKAQQIEYLI 80

                          90
                  ....*....|...
gi 1958769861  74 DSLPSEESTAALQ 86
Cdd:pfam11221  81 DSLPGIGVSEEEQ 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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