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Conserved domains on  [gi|1958769855|ref|XP_038963633|]
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ethanolamine kinase 1 isoform X1 [Rattus norvegicus]

Protein Classification

protein kinase family protein( domain architecture ID 229378)

protein kinase family protein may catalyze the transfer of the gamma-phosphoryl group from ATP to substrates such as serine/threonine and/or tyrosine residues on proteins, or may be a pseudokinase

CATH:  1.10.510.10
PubMed:  16244704
SCOP:  4003661

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PKc_like super family cl21453
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ...
 49-234 9.20e-73

Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.


The actual alignment was detected with superfamily member cd05157:

Pssm-ID: 473864 [Multi-domain]  Cd Length: 307  Bit Score: 223.61  E-value: 9.20e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  49 VTLQLFTDGITNKLIACYV-GDTMDDVVLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEAL 127
Cdd:cd05157     1 IKVKRITGGITNALYKVTYpSGDTPKTVLVRIYGPGTELLIDRDRELRILQLLSRAGIGPKLYGRFENGRVEEFLPGRTL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 128 DPQHVCNPAIFRLIARQLAKIHAIHAHNGW--IPKSNLWLKMGKYFSLIPTGFADEDiNKRFLSEIPSPQLLQEEMTWMK 205
Cdd:cd05157    81 TPEDLRDPKISRLIARRLAELHSIVPLGEIegKKKPILWTTIRKWLDLAPEVFEDEK-NKEKKLEKVDLERLRKELEWLE 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958769855 206 EILSSL-GSPVVLCHNDLLCKNIIYNEKQD 234
Cdd:cd05157   160 KWLESLeKSPIVFCHNDLLYGNILYNEDDD 189
 
Name Accession Description Interval E-value
ETNK_euk cd05157
Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group ...
 49-234 9.20e-73

Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate, and displays negligible activity towards N-methylated derivatives of Etn. The Drosophila ETNK is implicated in development and neuronal function. Mammals contain two ETNK proteins, ETNK1 and ETNK2. ETNK1 selectively increases Etn uptake and phosphorylation, as well as PtdEtn synthesis. ETNK2 is found primarily in the liver and reproductive tissues. It plays a critical role in regulating placental hemostasis to support late embryonic development. It may also have a role in testicular maturation. ETNK is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270706 [Multi-domain]  Cd Length: 307  Bit Score: 223.61  E-value: 9.20e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  49 VTLQLFTDGITNKLIACYV-GDTMDDVVLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEAL 127
Cdd:cd05157     1 IKVKRITGGITNALYKVTYpSGDTPKTVLVRIYGPGTELLIDRDRELRILQLLSRAGIGPKLYGRFENGRVEEFLPGRTL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 128 DPQHVCNPAIFRLIARQLAKIHAIHAHNGW--IPKSNLWLKMGKYFSLIPTGFADEDiNKRFLSEIPSPQLLQEEMTWMK 205
Cdd:cd05157    81 TPEDLRDPKISRLIARRLAELHSIVPLGEIegKKKPILWTTIRKWLDLAPEVFEDEK-NKEKKLEKVDLERLRKELEWLE 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958769855 206 EILSSL-GSPVVLCHNDLLCKNIIYNEKQD 234
Cdd:cd05157   160 KWLESLeKSPIVFCHNDLLYGNILYNEDDD 189
Choline_kinase pfam01633
Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of ...
 75-234 2.95e-61

Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway. This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only. However if [add Pfam ID here for Choline_kinase_C] is also present then it is definitely a member of this family.


Pssm-ID: 396278 [Multi-domain]  Cd Length: 211  Bit Score: 190.95  E-value: 2.95e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  75 VLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEALDPQHVCNPAIFRLIARQLAKIHAIHAH 154
Cdd:pfam01633   5 VLLRIYGPGTELLINREDEIVNFALLSERGLGPKLYGFFPNGRIEEFIPSRTLSTEDLRDPEISKLIAKRLAELHSLEMP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 155 ngWIPKSNLWLKMGKYFSLIPTGFADEDINKRFLSEIPSPQLLQEEMTWMKEILSSLGSPVVLCHNDLLCKNIIYNEKQD 234
Cdd:pfam01633  85 --GKKSPSLWKTMRKWLSLLKNLGAPESVNKSEQLKSINLEDLEKEINKLEKWLELLDSPIVFCHNDLQSGNILLLNETK 162
PLN02421 PLN02421
phosphotransferase, alcohol group as acceptor/kinase
 57-234 5.09e-29

phosphotransferase, alcohol group as acceptor/kinase


Pssm-ID: 215231 [Multi-domain]  Cd Length: 330  Bit Score: 110.98  E-value: 5.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  57 GITNKLIACYV-GDTMDDV-VLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEALDPQHVCN 134
Cdd:PLN02421   25 GITNLLLKVSVkEENGNEVsVTVRLFGPNTDYVIDRERELQAIKYLSAAGFGAKLLGVFGNGMIQSFINARTLTPSDMRK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 135 PAIFRLIARQLAKIHAIHahngwIPKSN---LWLKMGKYFSLIPTgFADEDINKRFLSEIPSPQLLQEEMTWMKEILSSL 211
Cdd:PLN02421  105 PKVAAEIAKELRRLHQVE-----IPGSKepqLWNDIFKFYEKAST-VKFEDPEKQKKYETISFEELRDEIVELKEITDSL 178

                         170       180
                  ....*....|....*....|...
gi 1958769855 212 GSPVVLCHNDLLCKNIIYNEKQD 234
Cdd:PLN02421  179 KAPVVFAHNDLLSGNLMLNEDEG 201
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 36-231 7.56e-04

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 39.71  E-value: 7.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  36 LLQHLRPHWDpREVTLQLFTDGITNKLiacYVGDTMDDVVLvRIY--GNKTELLVDRdeEvksFRVLQA-HGCA------ 106
Cdd:COG3173    11 LLAAQLPGLA-GLPEVEPLSGGWSNLT---YRLDTGDRLVL-RRPprGLASAHDVRR--E---ARVLRAlAPRLgvpvpr 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 107 PQLYCTFNNGL-----CYEFIQGEALDPQ-HVCNPAIFRLIARQLAK-IHAIHAhngwIPKSNLWLKMGKyfsliPTGFA 179
Cdd:COG3173    81 PLALGEDGEVIgapfyVMEWVEGETLEDAlPDLSPAERRALARALGEfLAALHA----VDPAAAGLADGR-----PEGLE 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958769855 180 ------DEDINKRFLSEIPSPQLLQEEMTWMKEILSSLGsPVVLCHNDLLCKNIIYNE 231
Cdd:COG3173   152 rqlarwRAQLRRALARTDDLPALRERLAAWLAANLPEWG-PPVLVHGDLRPGNLLVDP 208
 
Name Accession Description Interval E-value
ETNK_euk cd05157
Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group ...
 49-234 9.20e-73

Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate, and displays negligible activity towards N-methylated derivatives of Etn. The Drosophila ETNK is implicated in development and neuronal function. Mammals contain two ETNK proteins, ETNK1 and ETNK2. ETNK1 selectively increases Etn uptake and phosphorylation, as well as PtdEtn synthesis. ETNK2 is found primarily in the liver and reproductive tissues. It plays a critical role in regulating placental hemostasis to support late embryonic development. It may also have a role in testicular maturation. ETNK is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270706 [Multi-domain]  Cd Length: 307  Bit Score: 223.61  E-value: 9.20e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  49 VTLQLFTDGITNKLIACYV-GDTMDDVVLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEAL 127
Cdd:cd05157     1 IKVKRITGGITNALYKVTYpSGDTPKTVLVRIYGPGTELLIDRDRELRILQLLSRAGIGPKLYGRFENGRVEEFLPGRTL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 128 DPQHVCNPAIFRLIARQLAKIHAIHAHNGW--IPKSNLWLKMGKYFSLIPTGFADEDiNKRFLSEIPSPQLLQEEMTWMK 205
Cdd:cd05157    81 TPEDLRDPKISRLIARRLAELHSIVPLGEIegKKKPILWTTIRKWLDLAPEVFEDEK-NKEKKLEKVDLERLRKELEWLE 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958769855 206 EILSSL-GSPVVLCHNDLLCKNIIYNEKQD 234
Cdd:cd05157   160 KWLESLeKSPIVFCHNDLLYGNILYNEDDD 189
Choline_kinase pfam01633
Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of ...
 75-234 2.95e-61

Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway. This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only. However if [add Pfam ID here for Choline_kinase_C] is also present then it is definitely a member of this family.


Pssm-ID: 396278 [Multi-domain]  Cd Length: 211  Bit Score: 190.95  E-value: 2.95e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  75 VLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEALDPQHVCNPAIFRLIARQLAKIHAIHAH 154
Cdd:pfam01633   5 VLLRIYGPGTELLINREDEIVNFALLSERGLGPKLYGFFPNGRIEEFIPSRTLSTEDLRDPEISKLIAKRLAELHSLEMP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 155 ngWIPKSNLWLKMGKYFSLIPTGFADEDINKRFLSEIPSPQLLQEEMTWMKEILSSLGSPVVLCHNDLLCKNIIYNEKQD 234
Cdd:pfam01633  85 --GKKSPSLWKTMRKWLSLLKNLGAPESVNKSEQLKSINLEDLEKEINKLEKWLELLDSPIVFCHNDLQSGNILLLNETK 162
PLN02421 PLN02421
phosphotransferase, alcohol group as acceptor/kinase
 57-234 5.09e-29

phosphotransferase, alcohol group as acceptor/kinase


Pssm-ID: 215231 [Multi-domain]  Cd Length: 330  Bit Score: 110.98  E-value: 5.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  57 GITNKLIACYV-GDTMDDV-VLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEALDPQHVCN 134
Cdd:PLN02421   25 GITNLLLKVSVkEENGNEVsVTVRLFGPNTDYVIDRERELQAIKYLSAAGFGAKLLGVFGNGMIQSFINARTLTPSDMRK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 135 PAIFRLIARQLAKIHAIHahngwIPKSN---LWLKMGKYFSLIPTgFADEDINKRFLSEIPSPQLLQEEMTWMKEILSSL 211
Cdd:PLN02421  105 PKVAAEIAKELRRLHQVE-----IPGSKepqLWNDIFKFYEKAST-VKFEDPEKQKKYETISFEELRDEIVELKEITDSL 178

                         170       180
                  ....*....|....*....|...
gi 1958769855 212 GSPVVLCHNDLLCKNIIYNEKQD 234
Cdd:PLN02421  179 KAPVVFAHNDLLSGNLMLNEDEG 201
ChoK_euk cd05156
Euykaryotic Choline Kinase; ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP ...
 57-228 2.18e-24

Euykaryotic Choline Kinase; ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC) and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. Along with PCho, it is involved in malignant transformation through Ras oncogenes in various human cancers such as breast, lung, colon, prostate, neuroblastoma, and hepatic lymphoma. In mammalian cells, there are three ChoK isoforms (A-1, A-2, and B) which are active in homo- or heterodimeric forms. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270705 [Multi-domain]  Cd Length: 326  Bit Score: 98.47  E-value: 2.18e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  57 GITNKLIACYVGDTMDDV------VLVRIYGN---KTELLVDrdEEVkSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEAL 127
Cdd:cd05156     9 GLSNLLYLCSLPDGVVPVggeprkVLLRIYGQilqAEESLVT--ESV-IFALLSERGLGPKLYGIFPGGRLEEFIPSRPL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 128 DPQHVCNPAIFRLIARQLAKIHAIHahngwIPKSN----LWLKMGKYFS-LIPTGFADEDINKRFLSEIPSPQLLQEEMT 202
Cdd:cd05156    86 TTDELSLPEISRKIARKMARFHSLE-----MPISKepkwLFDTMERWLKeALSILFTDEPTKPSKQLELLLSYDLAKELG 160

                         170       180
                  ....*....|....*....|....*.
gi 1958769855 203 WMKEILSSLGSPVVLCHNDLLCKNII 228
Cdd:cd05156   161 WLRSLLESTPSPVVFCHNDLQEGNIL 186
ChoK-like_euk cd14021
Euykaryotic Choline Kinase and similar proteins; This group is composed of eukaryotic choline ...
 57-234 8.10e-18

Euykaryotic Choline Kinase and similar proteins; This group is composed of eukaryotic choline kinase, ethanolamine kinase, and similar proteins. ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC), and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate and displays negligible activity towards N-methylated derivatives of Etn. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270923 [Multi-domain]  Cd Length: 229  Bit Score: 79.23  E-value: 8.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  57 GITNKL----IACYVGDTMDDVVLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEALDPQHV 132
Cdd:cd14021     9 GLTNQVykvsLKDESDSLEPKKVLFRIYGKYLSTLYDREKESEVFKILSEQGLGPKLIYKFDGGRIEEYIDGRPLTTDEL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 133 CNPAIFRLIARQLAKIHAIHAhngwipksnlwlkmgkyfsliptgfadedinkrflseipspqllqeemtwmkeilsslg 212
Cdd:cd14021    89 RNPSVLTSIAKLLAKFHKIKT----------------------------------------------------------- 109

                         170       180
                  ....*....|....*....|..
gi 1958769855 213 SPVVLCHNDLLCKNIIYNEKQD 234
Cdd:cd14021   110 PPVVFCHNDLQENNILLTNDQD 131
PLN02236 PLN02236
choline kinase
 26-234 5.18e-16

choline kinase


Pssm-ID: 177880 [Multi-domain]  Cd Length: 344  Bit Score: 75.85  E-value: 5.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  26 EQRCRDGALSLLQHLRPHW----DPREVTLQLFTDGITNKLIAC-YVGDTMDDV--VLVRIYGNKTELLVDRDEEVKSFR 98
Cdd:PLN02236   12 SGRIPDELKRILHSLASKWgdvvDDEALQVIPLKGAMTNEVFQIkWPTKEGNLGrkVLVRIYGEGVELFFDRDDEIRTFE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  99 VLQAHGCAPQLYCTFNNGLCYEFIQGEALDPQHVCNPAIFRLIARQLAKIHAIHahngwIPKSN---LWLKM----GKYF 171
Cdd:PLN02236   92 CMSRHGQGPRLLGRFPNGRVEEFIHARTLSAADLRDPEISALIAAKLREFHSLD-----MPGPKnvlLWDRLrnwlKEAK 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958769855 172 SLIPTGFADEDINKRFLSEIpspQLLQEEmtwmkeiLSSLGSPVVLCHNDLLCKNIIYNEKQD 234
Cdd:PLN02236  167 NLCSPEEAKEFRLDSLEDEI---NLLEKE-------LSGDDQEIGFCHNDLQYGNIMIDEETR 219
ChoK-like cd05151
Choline Kinase and similar proteins; This subfamily is composed of bacterial and eukaryotic ...
 49-233 1.09e-13

Choline Kinase and similar proteins; This subfamily is composed of bacterial and eukaryotic choline kinases, as well as eukaryotic ethanolamine kinase. ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC), and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. Bacterial ChoK is also referred to as licA protein. ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate and displays negligible activity towards N-methylated derivatives of Etn. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270700 [Multi-domain]  Cd Length: 152  Bit Score: 66.04  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  49 VTLQLFTDGITNKliaCYVGDTMDDVVLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQ-LYCTFNNG-LCYEFIQGEA 126
Cdd:cd05151     1 ITIEPLKGGLTNK---NYLVEVAGKKYVLRIPGAGTELLIDRENEKANSKAAAELGIAPEvIYFDPETGvKITEFIEGAT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 127 LDPQHVCNPAIFRLIARQLAKIHAihahngwipksnlwlkmgkyfsliptgfadedinkrflSEIPspqllqeemtwmke 206
Cdd:cd05151    78 LLTNDFSDPENLERIAALLRKLHS--------------------------------------SPLE-------------- 105

                         170       180
                  ....*....|....*....|....*..
gi 1958769855 207 ilsslgsPVVLCHNDLLCKNIIYNEKQ 233
Cdd:cd05151   106 -------DLVLCHNDLVPGNFLLDDDR 125
PTZ00296 PTZ00296
choline kinase; Provisional
 43-232 3.00e-11

choline kinase; Provisional


Pssm-ID: 240350 [Multi-domain]  Cd Length: 442  Bit Score: 62.21  E-value: 3.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  43 HWDPREVTLQLFTDGITNKLIACYVG-DTMDDV------VLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNN 115
Cdd:PTZ00296  102 RFTEDDVRVNQILSGLTNQLFEVSLKeETANNYpsirrrVLFRIYGKDVDELYNPISEFEVYKTMSKYRIAPQLLNTFSG 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 116 GLCYEFIQGEALDPQHVCNPAIFRLIARQLAKIHAI----HAHNGWiPKSNLWLKMGKYFSLIPTGFADEDINKRFLSei 191
Cdd:PTZ00296  182 GRIEEWLYGDPLRIDDLKNPSILIGIANVLGKFHTLsrkrHLPEHW-DRTPCIFKMMEKWKNQLSKYKNIEKYQRDIH-- 258

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958769855 192 pspQLLQEEMTWMKEI-----LSSLGSPVVLCHNDLLCKNIIYNEK 232
Cdd:PTZ00296  259 ---KYIKESEKFIKFMkvyskSDNLANDIVFCHNDLQENNIINTNK 301
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 50-232 5.00e-06

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 45.96  E-value: 5.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  50 TLQLFTDGITNKliACYVGDTMDDVVLvRIYgNKTELLVDRDEEVKSFRVLQAHG----CAPQLYCTFNNGLC-----YE 120
Cdd:pfam01636   1 TLRPISSGASNR--TYLVTTGDGRYVL-RLP-PPGRAAEELRRELALLRHLAAAGvppvPRVLAGCTDAELLGlpfllME 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 121 FIQGEAL--DPQHVCNPAIFRLIARQLAKIHAIHAHNG---WIPKSNLwlkmgkYFSLIPTGFADEDINKRFLSEIpsPQ 195
Cdd:pfam01636  77 YLPGEVLarPLLPEERGALLEALGRALARLHAVDPAALplaGRLARLL------ELLRQLEAALARLLAAELLDRL--EE 148

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1958769855 196 LLQEEMTWMKEILSSlGSPVVLCHNDLLCKNIIYNEK 232
Cdd:pfam01636 149 LEERLLAALLALLPA-ELPPVLVHGDLHPGNLLVDPG 184
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 36-231 7.56e-04

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 39.71  E-value: 7.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855  36 LLQHLRPHWDpREVTLQLFTDGITNKLiacYVGDTMDDVVLvRIY--GNKTELLVDRdeEvksFRVLQA-HGCA------ 106
Cdd:COG3173    11 LLAAQLPGLA-GLPEVEPLSGGWSNLT---YRLDTGDRLVL-RRPprGLASAHDVRR--E---ARVLRAlAPRLgvpvpr 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769855 107 PQLYCTFNNGL-----CYEFIQGEALDPQ-HVCNPAIFRLIARQLAK-IHAIHAhngwIPKSNLWLKMGKyfsliPTGFA 179
Cdd:COG3173    81 PLALGEDGEVIgapfyVMEWVEGETLEDAlPDLSPAERRALARALGEfLAALHA----VDPAAAGLADGR-----PEGLE 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958769855 180 ------DEDINKRFLSEIPSPQLLQEEMTWMKEILSSLGsPVVLCHNDLLCKNIIYNE 231
Cdd:COG3173   152 rqlarwRAQLRRALARTDDLPALRERLAAWLAANLPEWG-PPVLVHGDLRPGNLLVDP 208
CotS COG0510
Thiamine kinase or a related kinase [Coenzyme transport and metabolism];
195-232 2.39e-03

Thiamine kinase or a related kinase [Coenzyme transport and metabolism];


Pssm-ID: 440276 [Multi-domain]  Cd Length: 156  Bit Score: 37.45  E-value: 2.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958769855 195 QLLQEEMTWMKEILSSLGSPVVLCHNDLLCKNIIYNEK 232
Cdd:COG0510    29 PELLRRLEELERALAARPLPLVLCHGDLHPGNFLVTDD 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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