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Conserved domains on  [gi|1958769826|ref|XP_038963623|]
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low-density lipoprotein receptor-related protein 6 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 441-476 3.42e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 61.87  E-value: 3.42e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958769826  441 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 476
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1137-1171 5.23e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 5.23e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958769826 1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1171
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 246-286 6.32e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.46  E-value: 6.32e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958769826   246 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 286
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 332-373 8.56e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 8.56e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958769826   332 VLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGR 373
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 307-348 1.02e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.64  E-value: 1.02e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826  307 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 348
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1175-1209 1.39e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 1.39e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958769826 1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDC 1209
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 546-588 3.43e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 3.43e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958769826   546 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 588
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 742-778 6.09e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.41  E-value: 6.09e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958769826  742 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 778
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1-40 7.04e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 58.33  E-value: 7.04e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958769826    1 MYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDY 40
Cdd:pfam00058    3 LYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
503-662 7.06e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 7.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  503 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 582
Cdd:COG3391     60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  583 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 655
Cdd:COG3391    137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                   ....*..
gi 1958769826  656 WTDLDTN 662
Cdd:COG3391    214 VANRGSN 220
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 135-172 2.44e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.87  E-value: 2.44e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958769826  135 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLESGKTC 172
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 24-65 4.03e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 4.03e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958769826    24 VIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNR 65
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1098-1134 9.56e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 9.56e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958769826 1098 CSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDELNC 1134
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1056-1092 2.20e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 2.20e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958769826 1056 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 1092
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 202-242 4.25e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 4.25e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958769826   202 VLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSG 242
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 943-985 1.02e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 1.02e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958769826   943 EVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANR 985
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 676-715 7.07e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 7.07e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958769826   676 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 715
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 374-407 2.51e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 2.51e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958769826   374 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 407
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 807-847 4.36e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.12  E-value: 4.36e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958769826   807 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQ 847
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
817-924 5.54e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 5.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  817 RAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQgftvVVSSVPnqnLEIQPYDLSIDIYSRYIYWTCEATN-------VIDV 889
Cdd:COG3391    113 RGLAVDPDGGRLYVADSGNGRVSVIDTATGK----VVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsvivsVIDT 185

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958769826  890 TrlDGRSVGVVLKGEQdrPRAIVVNPEKGYMYFTN 924
Cdd:COG3391    186 A--TGKVVATIPVGGG--PVGVAVSPDGRRLYVAN 216
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 66-100 1.29e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 1.29e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958769826    66 QAVVKGSLPHP--FALTLFEDTLYWTDWNTHSILACN 100
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
 
Name Accession Description Interval E-value
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 441-476 3.42e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 61.87  E-value: 3.42e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958769826  441 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 476
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1137-1171 5.23e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 5.23e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958769826 1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1171
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 246-286 6.32e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.46  E-value: 6.32e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958769826   246 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 286
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 332-373 8.56e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 8.56e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958769826   332 VLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGR 373
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 307-348 1.02e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.64  E-value: 1.02e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826  307 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 348
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1175-1209 1.39e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 1.39e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958769826 1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDC 1209
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 546-588 3.43e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 3.43e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958769826   546 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 588
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 287-330 3.43e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 3.43e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1958769826   287 KILISEDLEEPRAIVLDPMAGYMYWTDWGEiPKIERAALDGSDR 330
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 742-778 6.09e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.41  E-value: 6.09e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958769826  742 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 778
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1-40 7.04e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 58.33  E-value: 7.04e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958769826    1 MYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDY 40
Cdd:pfam00058    3 LYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
503-662 7.06e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 7.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  503 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 582
Cdd:COG3391     60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  583 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 655
Cdd:COG3391    137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                   ....*..
gi 1958769826  656 WTDLDTN 662
Cdd:COG3391    214 VANRGSN 220
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1137-1171 1.15e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 1.15e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958769826 1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1171
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 135-172 2.44e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.87  E-value: 2.44e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958769826  135 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLESGKTC 172
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 24-65 4.03e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 4.03e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958769826    24 VIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNR 65
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1137-1168 5.88e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 5.88e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958769826  1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDE 1168
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1098-1134 9.56e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 9.56e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958769826 1098 CSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDELNC 1134
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 210-372 4.22e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 59.25  E-value: 4.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  210 HAIAIDYDpveGYVYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 284
Cdd:cd05819     58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  285 MRKIL-----ISEDLEEPRAIVLDPmAGYMYWTDWgeipkieraaldGSDRVVLVNT----------------SLGWPNG 343
Cdd:cd05819    134 FLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADT------------GNHRIQVFDPdgnflttfgstgtgpgQFNYPTG 200

                          170       180
                   ....*....|....*....|....*....
gi 1958769826  344 LALDyDEGTIYWGDAKTDKIEVMNTDGTG 372
Cdd:cd05819    201 IAVD-SDGNIYVADSGNNRVQVFDPDGAG 228
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1175-1206 5.41e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 5.41e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958769826  1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDE 1206
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1097-1131 6.91e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 6.91e-09
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1958769826  1097 TCSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDE 1131
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
210-377 7.56e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 58.17  E-value: 7.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  210 HAIAIDYDPVEGYVYWTDDEVRAIrrSFIDGSGSQFVVT-AQIAHPDGIAVDWVARNLYWTDTGTDRieVTRLNGTMRKI 288
Cdd:COG3391     69 DADGADAGADGRRLYVANSGSGRV--SVIDLATGKVVATiPVGGGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKV 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  289 LISEDL-EEPRAIVLDPMAGYMYWTDWG--EIPKIErAALDGSDRVVLVNTSLG-WPNGLALDYDEGTIYWGDAKTDKie 364
Cdd:COG3391    145 VATIPVgAGPHGIAVDPDGKRLYVANSGsnTVSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT-- 221

                          170
                   ....*....|...
gi 1958769826  365 vmnTDGTGRRVLV 377
Cdd:COG3391    222 ---SNGGSNTVSV 231
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 589-632 2.14e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 2.14e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1958769826   589 QVLVWKDLDSPRALALDPAEGFMYWTEWgGKPKIDRAAMDGSER 632
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1056-1092 2.20e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 2.20e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958769826 1056 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 1092
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1097-1134 4.70e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 4.70e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958769826 1097 TCSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDELNC 1134
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1175-1209 4.75e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 4.75e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958769826 1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDC 1209
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 264-304 8.16e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 8.16e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826  264 RNLYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPRAIVLDP 304
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 202-242 4.25e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 4.25e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958769826   202 VLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSG 242
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 943-985 1.02e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 1.02e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958769826   943 EVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANR 985
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 609-649 1.27e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 1.27e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826  609 GFMYWTEWGGKPKIDRAAMDGSER-TTLVPNVGRANGLTIDY 649
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 548-662 1.22e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 1.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  548 VVEF-GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGGKPKIDR 624
Cdd:cd14952      3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRVLKL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958769826  625 AAmdGSERTTLVP--NVGRANGLTIDyAKRRLYWTDLDTN 662
Cdd:cd14952     79 AA--GSTTQTVLPftGLNDPTGVAVD-AAGNVYVADTGNN 115
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 567-606 3.94e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.15  E-value: 3.94e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958769826  567 NLYWADTGT-NRIEVSKLDGQHRQVLVWKDLDSPRALALDP 606
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 676-715 7.07e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 7.07e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958769826   676 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 715
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 374-407 2.51e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 2.51e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958769826   374 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 407
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 807-847 4.36e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.12  E-value: 4.36e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958769826   807 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQ 847
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
817-924 5.54e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 5.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  817 RAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQgftvVVSSVPnqnLEIQPYDLSIDIYSRYIYWTCEATN-------VIDV 889
Cdd:COG3391    113 RGLAVDPDGGRLYVADSGNGRVSVIDTATGK----VVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsvivsVIDT 185

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958769826  890 TrlDGRSVGVVLKGEQdrPRAIVVNPEKGYMYFTN 924
Cdd:COG3391    186 A--TGKVVATIPVGGG--PVGVAVSPDGRRLYVAN 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 221-261 5.66e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.68  E-value: 5.66e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826  221 GYVYWTDDEVRA-IRRSFIDGSGSQFVVTAQIAHPDGIAVDW 261
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 43-83 8.99e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 8.99e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826   43 RKLYWADAKLNF-IHKSNLDGTNRQAVVKGSLPHPFALTLFE 83
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 66-100 1.29e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 1.29e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958769826    66 QAVVKGSLPHP--FALTLFEDTLYWTDWNTHSILACN 100
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 899-942 2.59e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 2.59e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1958769826   899 VVLKGEQDRPRAIVVNPEKGYMYFTNLqeRSPKIERAALDGTER 942
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 964-1003 3.02e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.75  E-value: 3.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958769826  964 RLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTVFE 1003
Cdd:pfam00058    2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 553-619 4.73e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.76  E-value: 4.73e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958769826  553 LDYPEGMAVDWLGkNLYWADTGTNRIevSKLDGQHRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGK 619
Cdd:cd05819     54 FNEPAGVAVDSDG-NLYVADTGNHRI--QKFDPDGNFLASFggsgdgdGEFNGPRGIAVDSS-GNIYVADTGNH 123
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1-22 4.86e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.43  E-value: 4.86e-03
                            10        20
                    ....*....|....*....|..
gi 1958769826     1 MYWTDWGEvPKIERAGMDGSSR 22
Cdd:smart00135   23 LYWTDWGL-DVIEVANLDGTNR 43
 
Name Accession Description Interval E-value
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 441-476 3.42e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 61.87  E-value: 3.42e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958769826  441 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 476
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1137-1171 5.23e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 5.23e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958769826 1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1171
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 246-286 6.32e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.46  E-value: 6.32e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958769826   246 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 286
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 332-373 8.56e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 8.56e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958769826   332 VLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGR 373
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 307-348 1.02e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.64  E-value: 1.02e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826  307 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 348
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1175-1209 1.39e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 1.39e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958769826 1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDC 1209
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 546-588 3.43e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 3.43e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958769826   546 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 588
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 287-330 3.43e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 3.43e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1958769826   287 KILISEDLEEPRAIVLDPMAGYMYWTDWGEiPKIERAALDGSDR 330
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 742-778 6.09e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.41  E-value: 6.09e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958769826  742 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 778
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1-40 7.04e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 58.33  E-value: 7.04e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958769826    1 MYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDY 40
Cdd:pfam00058    3 LYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
503-662 7.06e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 7.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  503 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 582
Cdd:COG3391     60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  583 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 655
Cdd:COG3391    137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                   ....*..
gi 1958769826  656 WTDLDTN 662
Cdd:COG3391    214 VANRGSN 220
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1137-1171 1.15e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 1.15e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958769826 1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1171
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 135-172 2.44e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.87  E-value: 2.44e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958769826  135 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLESGKTC 172
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 24-65 4.03e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 4.03e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958769826    24 VIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNR 65
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1137-1168 5.88e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 5.88e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958769826  1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDE 1168
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1098-1134 9.56e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 9.56e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958769826 1098 CSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDELNC 1134
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 210-372 4.22e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 59.25  E-value: 4.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  210 HAIAIDYDpveGYVYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 284
Cdd:cd05819     58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  285 MRKIL-----ISEDLEEPRAIVLDPmAGYMYWTDWgeipkieraaldGSDRVVLVNT----------------SLGWPNG 343
Cdd:cd05819    134 FLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADT------------GNHRIQVFDPdgnflttfgstgtgpgQFNYPTG 200

                          170       180
                   ....*....|....*....|....*....
gi 1958769826  344 LALDyDEGTIYWGDAKTDKIEVMNTDGTG 372
Cdd:cd05819    201 IAVD-SDGNIYVADSGNNRVQVFDPDGAG 228
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1175-1206 5.41e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 5.41e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958769826  1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDE 1206
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1097-1131 6.91e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 6.91e-09
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1958769826  1097 TCSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDE 1131
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
210-377 7.56e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 58.17  E-value: 7.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  210 HAIAIDYDPVEGYVYWTDDEVRAIrrSFIDGSGSQFVVT-AQIAHPDGIAVDWVARNLYWTDTGTDRieVTRLNGTMRKI 288
Cdd:COG3391     69 DADGADAGADGRRLYVANSGSGRV--SVIDLATGKVVATiPVGGGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKV 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  289 LISEDL-EEPRAIVLDPMAGYMYWTDWG--EIPKIErAALDGSDRVVLVNTSLG-WPNGLALDYDEGTIYWGDAKTDKie 364
Cdd:COG3391    145 VATIPVgAGPHGIAVDPDGKRLYVANSGsnTVSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT-- 221

                          170
                   ....*....|...
gi 1958769826  365 vmnTDGTGRRVLV 377
Cdd:COG3391    222 ---SNGGSNTVSV 231
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 589-632 2.14e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 2.14e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1958769826   589 QVLVWKDLDSPRALALDPAEGFMYWTEWgGKPKIDRAAMDGSER 632
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1056-1092 2.20e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 2.20e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958769826 1056 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 1092
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1097-1134 4.70e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 4.70e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958769826 1097 TCSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDELNC 1134
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1175-1209 4.75e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 4.75e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958769826 1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDC 1209
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 632-674 8.03e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 8.03e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958769826   632 RTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNR 674
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 264-304 8.16e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 8.16e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826  264 RNLYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPRAIVLDP 304
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
210-398 2.86e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 53.16  E-value: 2.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  210 HAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTMRK 287
Cdd:COG3391     26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVidLATGKVVAT 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  288 ILISEDleePRAIVLDPMAGYMYWTDWGEiPKIerAALDGSDRVVLVNTSLG-WPNGLALDYDEGTIYWGDAKTDKI--- 363
Cdd:COG3391    106 IPVGGG---PRGLAVDPDGGRLYVADSGN-GRV--SVIDTATGKVVATIPVGaGPHGIAVDPDGKRLYVANSGSNTVsvi 179

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1958769826  364 -EVMNT-DGTGRRVLVEDKIPHIFGFTLLGDYVYWTD 398
Cdd:COG3391    180 vSVIDTaTGKVVATIPVGGGPVGVAVSPDGRRLYVAN 216
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 216-407 4.08e-07

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 52.97  E-value: 4.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  216 YDPvEGYVYWTDDEVRAIRRSFIDGSGSQFVVTAQiAHPDGIAVD-----WVARN---LYWTDTGTDRIEVtrlngtmrk 287
Cdd:COG3386     15 WDP-DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADHgrgLVRFDPADGEVTV--------- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  288 ilISEDLEEPRA----IVLDPmAGYMYWTDwgeiPKIERAA-----LDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDA 358
Cdd:COG3386     84 --LADEYGKPLNrpndGVVDP-DGRLYFTD----MGEYLPTgalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADT 156

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958769826  359 KTDKIEVMNTDGTG----RRVLVEDKIPHIF--GFTLLGD-YVYWTDWQRRSIERV 407
Cdd:COG3386    157 GAGRIYRFDLDADGtlgnRRVFADLPDGPGGpdGLAVDADgNLWVALWGGGGVVRF 212
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 202-242 4.25e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 4.25e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958769826   202 VLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSG 242
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 943-985 1.02e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 1.02e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958769826   943 EVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANR 985
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 609-649 1.27e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 1.27e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826  609 GFMYWTEWGGKPKIDRAAMDGSER-TTLVPNVGRANGLTIDY 649
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 210-371 1.37e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 51.51  E-value: 1.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  210 HAIAIDYDpveGYVYWTDD----------EVRAIRRSFIDGSGSQfvvtaQIAHPDGIAVDwVARNLYWTDTGTDRIEVT 279
Cdd:cd14956     16 RGIAVDAD---DNVYVADArngriqvfdkDGTFLRRFGTTGDGPG-----QFGRPRGLAVD-KDGWLYVADYWGDRIQVF 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  280 RLNGTMRKILISE-----DLEEPRAIVLDPmAGYMYWTDWGEiPKIERAALDGSdrvvLVNT---------SLGWPNGLA 345
Cdd:cd14956     87 TLTGELQTIGGSSgsgpgQFNAPRGVAVDA-DGNLYVADFGN-QRIQKFDPDGS----FLRQwggtgiepgSFNYPRGVA 160

                          170       180
                   ....*....|....*....|....*.
gi 1958769826  346 LDyDEGTIYWGDAKTDKIEVMNTDGT 371
Cdd:cd14956    161 VD-PDGTLYVADTYNDRIQVFDNDGA 185
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 505-543 2.71e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 2.71e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1958769826   505 IPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGS 543
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 211-315 1.06e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.85  E-value: 1.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  211 AIAIDYDpveGYVYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEV-----TR 280
Cdd:cd05819    153 GVAVDSD---GNIYVADTGNHRIQVfdpdgNFLTTFGSTGTGPGQFNYPTGIAVD-SDGNIYVADSGNNRVQVfdpdgAG 228

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958769826  281 LNGTMRKILISEDLEEPRAIVLDPmAGYMYWTDWG 315
Cdd:cd05819    229 FGGNGNFLGSDGQFNRPSGLAVDS-DGNLYVADTG 262
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 251-376 1.14e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  251 IAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPmAGYMYWTDWGEIPKIERAAlDGSDR 330
Cdd:cd14952      9 LDGPGGVAVD-AAGNVYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDA-AGTVYVTDFGNNRVLKLAA-GSTTQ 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1958769826  331 VVLVNTSLGWPNGLALDyDEGTIYwgdaktdkieVmnTDGTGRRVL 376
Cdd:cd14952     86 TVLPFTGLNDPTGVAVD-AAGNVY----------V--ADTGNNRVL 118
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 548-662 1.22e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 1.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  548 VVEF-GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGGKPKIDR 624
Cdd:cd14952      3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRVLKL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958769826  625 AAmdGSERTTLVP--NVGRANGLTIDyAKRRLYWTDLDTN 662
Cdd:cd14952     79 AA--GSTTQTVLPftGLNDPTGVAVD-AAGNVYVADTGNN 115
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 552-662 1.74e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.97  E-value: 1.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  552 GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLDGQH--RQVLVWKDLDSPRALALDPAeGFMYWTEWGGKpKIDRAAMDG 629
Cdd:cd14952     92 GLNDPTGVAVDAAG-NVYVADTGNNR--VLKLAAGSntQTVLPFTGLSNPDGVAVDGA-GNVYVTDTGNN-RVLKLAAGS 166

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958769826  630 SERTTLvPNVGRA--NGLTIDyAKRRLYWTDLDTN 662
Cdd:cd14952    167 TTQTVL-PFTGLNspSGVAVD-TAGNVYVTDHGNN 199
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 212-370 3.57e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 47.20  E-value: 3.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  212 IAIDYDPvEGYVYWTDDEVRAIrrsFIDGSGSQFV----VTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRK 287
Cdd:cd14962     60 IGVAIDA-NGNLYVSDAELGKV---FVFDRDGKFLraigAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLF 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  288 IL-----ISEDLEEPRAIVLDPmAGYMYWTDWGEIpKIERAALDGS-----DRVVLVNTSLGWPNGLALDyDEGTIYWGD 357
Cdd:cd14962    136 DIgkrgsGPGEFNLPTDLAVDR-DGNLYVTDTMNF-RVQIFDADGKflrsfGERGDGPGSFARPKGIAVD-SEGNIYVVD 212

                          170
                   ....*....|...
gi 1958769826  358 AKTDKIEVMNTDG 370
Cdd:cd14962    213 AAFDNVQIFNPEG 225
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 567-606 3.94e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.15  E-value: 3.94e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958769826  567 NLYWADTGT-NRIEVSKLDGQHRQVLVWKDLDSPRALALDP 606
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 676-715 7.07e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 7.07e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958769826   676 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 715
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 254-376 1.14e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 45.28  E-value: 1.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  254 PDGIAVDwVARNLYWTDTGTDRieVTRLNG--TMRKILISEDLEEPRAIVLDPmAGYMYWTDWGEiPKIERAALDGSDRV 331
Cdd:cd14952     96 PTGVAVD-AAGNVYVADTGNNR--VLKLAAgsNTQTVLPFTGLSNPDGVAVDG-AGNVYVTDTGN-NRVLKLAAGSTTQT 170

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1958769826  332 VLVNTSLGWPNGLALDyDEGTIYwgdaktdkieVmnTDGTGRRVL 376
Cdd:cd14952    171 VLPFTGLNSPSGVAVD-TAGNVY----------V--TDHGNNRVL 202
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 250-376 1.43e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.39  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  250 QIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTmRKILISED------LEEPRAIVLDPmAGYMYWTDWG--EIPKIe 321
Cdd:cd05819      6 ELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGN-FITSFGSFgsgdgqFNEPAGVAVDS-DGNLYVADTGnhRIQKF- 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958769826  322 raalDGSDRVVLVNTSLGW-------PNGLALDyDEGTIYWGDAKTDKIEVMNTDGTGRRVL 376
Cdd:cd05819     82 ----DPDGNFLASFGGSGDgdgefngPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTF 138
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 522-706 1.58e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.27  E-value: 1.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  522 DNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGkNLYWADTGtNRIEVSKLDGQHRQVLV---WKDLDS 598
Cdd:COG3386     18 DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDPDG-RLLVADHG-RGLVRFDPADGEVTVLAdeyGKPLNR 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  599 PRALALDPAeGFMYWT---EWGGKPKIDRAAMDGsERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLI-----ESSNML 670
Cdd:COG3386     95 PNDGVVDPD-GRLYFTdmgEYLPTGALYRVDPDG-SLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIyrfdlDADGTL 172

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1958769826  671 GlNREVIADDLPHPF---GLTQYQD-YIYWTDWSRRSIER 706
Cdd:COG3386    173 G-NRRVFADLPDGPGgpdGLAVDADgNLWVALWGGGGVVR 211
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 216-378 1.99e-04

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 44.56  E-value: 1.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  216 YDPVEGYVYWTDDEVRAIRR-SFIDGSGSQFVVTAQIA----HPDGIAVDWVARNLYWTDTGTdrievtrlnGTMRKILI 290
Cdd:pfam08450    7 WDEEEGALYWVDILGGRIHRlDPATGKETVWDTPGPVGaiapRDDGGLIVALKDGVALLDLAT---------GELTPLAD 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  291 SEDLEEPRAI----VLDP----MAGYMywtDWGEIPKIERAAL---DGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAK 359
Cdd:pfam08450   78 PEDDDWPLNRfndgKVDPdgrfWFGTM---GDDEAPGGDPGALyrlDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSP 154

                          170       180
                   ....*....|....*....|....
gi 1958769826  360 TDKIEVMNTDGTG-----RRVLVE 378
Cdd:pfam08450  155 ARKIWAYDYDLDGglisnRRVFAD 178
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 523-563 2.00e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.22  E-value: 2.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826  523 NRIYWTDISLK-TISRAFMNGSALEHVVEFGLDYPEGMAVDW 563
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 374-407 2.51e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 2.51e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958769826   374 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 407
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
DUF5050 pfam16472
Domain of unknown function (DUF5050);
222-398 2.60e-04

Domain of unknown function (DUF5050);


Pssm-ID: 465128 [Multi-domain]  Cd Length: 282  Bit Score: 44.54  E-value: 2.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  222 YVYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDgIAVDWVarnlYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPraI 300
Cdd:pfam16472  111 YQHYDNSDGGTLYKIKIDGKEKTKLSDEPISPAS-VSDGWI----YYSGTSDDhYIYKLNTDGDSISKLYDGNSYMP--N 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  301 VLDpmaGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNglaldYDEGTIYWGDAKTD-KIEVMNTDGTGRRVLVED 379
Cdd:pfam16472  184 VNG---DYIYYIDLSNNYALYRMNLSGGEKEVLTDDRVDNYN-----VYGNWIYYQNNGDDnKLYRINTDGSNKEKLAEG 255

                          170
                   ....*....|....*....
gi 1958769826  380 KIPHIfgfTLLGDYVYWTD 398
Cdd:pfam16472  256 NYTNI---NITSDYIYFTD 271
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 210-363 3.88e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 43.74  E-value: 3.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  210 HAIAIDYDpveGYVYWTD-DEVRAIRRSfiDGSGSQFVVT-AQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRK 287
Cdd:cd14952     97 TGVAVDAA---GNVYVADtGNNRVLKLA--AGSNTQTVLPfTGLSNPDGVAVD-GAGNVYVTDTGNNRVLKLAAGSTTQT 170

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958769826  288 ILISEDLEEPRAIVLDPmAGYMYWTDWGEiPKIERAALDGSDRVVLVNTSLGWPNGLALDyDEGTIYWGDAKTDKI 363
Cdd:cd14952    171 VLPFTGLNSPSGVAVDT-AGNVYVTDHGN-NRVLKLAAGSTTPTVLPFTGLNGPLGVAVD-AAGNVYVADRGNDRV 243
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 807-847 4.36e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.12  E-value: 4.36e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958769826   807 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQ 847
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 554-634 4.80e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.81  E-value: 4.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  554 DYPEGMAVDwLGKNLYWADTGTNRIEVSKLDGQH-RQvlVWK------DLDSPRALALDPAEGFMYWTEWGGkpKIDRAA 626
Cdd:cd14956     13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFlRR--FGTtgdgpgQFGRPRGLAVDKDGWLYVADYWGD--RIQVFT 87


                   ....*...
gi 1958769826  627 MDGSERTT 634
Cdd:cd14956     88 LTGELQTI 95
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
817-924 5.54e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 5.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  817 RAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQgftvVVSSVPnqnLEIQPYDLSIDIYSRYIYWTCEATN-------VIDV 889
Cdd:COG3391    113 RGLAVDPDGGRLYVADSGNGRVSVIDTATGK----VVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsvivsVIDT 185

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958769826  890 TrlDGRSVGVVLKGEQdrPRAIVVNPEKGYMYFTN 924
Cdd:COG3391    186 A--TGKVVATIPVGGG--PVGVAVSPDGRRLYVAN 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 221-261 5.66e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.68  E-value: 5.66e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826  221 GYVYWTDDEVRA-IRRSFIDGSGSQFVVTAQIAHPDGIAVDW 261
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 918-959 7.68e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 7.68e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826  918 GYMYFTNLQERsPKIERAALDGTEREVLFFSGLSKPVALALD 959
Cdd:pfam00058    1 GRLYWTDSSLR-ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 520-664 8.74e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 43.08  E-value: 8.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  520 VTD---NRIYWTDISLKTISRAfmnGSALEHVVEFglDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQhrQVLVWKD- 595
Cdd:cd05819    117 VADtgnHRIQKFDPDGEFLTTF---GSGGSGPGQF--NGPTGVAVDSDG-NIYVADTGNHRIQVFDPDGN--FLTTFGSt 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  596 ------LDSPRALALDPaEGFMYWTEWGGKpKIDRAAMDGSERTTLVPNVGRAN------GLTIDyAKRRLYWTDLDTNL 663
Cdd:cd05819    189 gtgpgqFNYPTGIAVDS-DGNIYVADSGNN-RVQVFDPDGAGFGGNGNFLGSDGqfnrpsGLAVD-SDGNLYVADTGNNR 265


                   .
gi 1958769826  664 I 664
Cdd:cd05819    266 I 266
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 43-83 8.99e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 8.99e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958769826   43 RKLYWADAKLNF-IHKSNLDGTNRQAVVKGSLPHPFALTLFE 83
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 552-665 9.20e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.04  E-value: 9.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  552 GLDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGqhRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGKpKIDR 624
Cdd:cd14956    152 SFNYPRGVAVDPDG-TLYVADTYNDRIQVFDNDG--AFLRKWggrgtgpGQFNYPYGIAIDPD-GNVFVADFGNN-RIQK 226

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958769826  625 AAMDGSERTTlVPNVGRANG-------LTIDyAKRRLYWTDLDTNLIE 665
Cdd:cd14956    227 FTADGTFLTS-WGSPGTGPGqfknpwgVVVD-ADGTVYVADSNNNRVQ 272
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 66-100 1.29e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 1.29e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958769826    66 QAVVKGSLPHP--FALTLFEDTLYWTDWNTHSILACN 100
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 516-605 1.71e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.89  E-value: 1.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  516 LDFDVTDNRIYWTDISLKTIsRAFMNGSalEHVVEFG--------LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQH 587
Cdd:cd14963     13 MGVAVSDGRIYVADTNNHRV-QVFDYEG--KFKKSFGgpgtgpgeFKYPYGIAVDSDG-NIYVADLYNGRIQVFDPDGKF 88

                           90       100
                   ....*....|....*....|..
gi 1958769826  588 RQVLVWKD----LDSPRALALD 605
Cdd:cd14963     89 LKYFPEKKdrvkLISPAGLAID 110
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 210-371 1.78e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 41.87  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  210 HAIAIDYDpveGYVYWTDDEVRAIR-----RSFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEV-TRLNG 283
Cdd:cd14957     21 RGIAVDSA---GNIYVADTGNNRIQvftssGVYSYSIGSGGTGSGQFNSPYGIAVD-SNGNIYVADTDNNRIQVfNSSGV 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  284 TMRKI----LISEDLEEPRAIVLDPmAGYMYWTDwgeipkieraalDGSDRVVLVNTS----------------LGWPNG 343
Cdd:cd14957     97 YQYSIgtggSGDGQFNGPYGIAVDS-NGNIYVAD------------TGNHRIQVFTSSgtfsysigsggtgpgqFNGPQG 163

                          170       180
                   ....*....|....*....|....*...
gi 1958769826  344 LALDYDeGTIYWGDAKTDKIEVMNTDGT 371
Cdd:cd14957    164 IAVDSD-GNIYVADTGNHRIQVFTSSGT 190
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 514-606 2.22e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 2.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  514 SALDFDvTDNRIYWTDISLKTISRAFMNGSALEHVVEFG-----LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQHr 588
Cdd:cd05819     58 AGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGGSGdgdgeFNGPRGIAVDSSG-NIYVADTGNHRIQKFDPDGEF- 134

                           90       100
                   ....*....|....*....|....*
gi 1958769826  589 qVLVWK-------DLDSPRALALDP 606
Cdd:cd05819    135 -LTTFGsggsgpgQFNGPTGVAVDS 158
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 12-276 2.52e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 2.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826   12 IERAGMDGSSrfviiNTEIYWPNGLTLDYEERkLYWADAKLNFIHKSNLDGTNRQAVVK-----GSLPHPFALTL-FEDT 85
Cdd:cd05819     41 ITSFGSFGSG-----DGQFNEPAGVAVDSDGN-LYVADTGNHRIQKFDPDGNFLASFGGsgdgdGEFNGPRGIAVdSSGN 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826   86 LYWTDWNTHSILACNKyTGEGLREIHSNIF------SPMDIhafsqqrqpnATNPCGI----DNGGCShlclmspVKPFY 155
Cdd:cd05819    115 IYVADTGNHRIQKFDP-DGEFLTTFGSGGSgpgqfnGPTGV----------AVDSDGNiyvaDTGNHR-------IQVFD 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  156 qcacPTGVKLLESGKTCKDGAtellllarrtdlrriSLDTPdftdivlqledirHAIAIDYDpveGYVYWTDDEVRAIRR 235
Cdd:cd05819    177 ----PDGNFLTTFGSTGTGPG---------------QFNYP-------------TGIAVDSD---GNIYVADSGNNRVQV 221

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1958769826  236 -----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRI 276
Cdd:cd05819    222 fdpdgAGFGGNGNFLGSDGQFNRPSGLAVD-SDGNLYVADTGNNRI 266
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 899-942 2.59e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 2.59e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1958769826   899 VVLKGEQDRPRAIVVNPEKGYMYFTNLqeRSPKIERAALDGTER 942
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 964-1003 3.02e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.75  E-value: 3.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958769826  964 RLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTVFE 1003
Cdd:pfam00058    2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 519-606 3.65e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 3.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  519 DVTDNRIYWTDISLKTISRAFMNGsalEHVVEFG--------LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQHRQV 590
Cdd:cd14963    108 AIDDGKLYVSDVKKHKVIVFDLEG---KLLLEFGkpgsepgeLSYPNGIAVDEDG-NIYVADSGNGRIQVFDKNGKFIKE 183

                           90       100
                   ....*....|....*....|.
gi 1958769826  591 LVWKDLDS-----PRALALDP 606
Cdd:cd14963    184 LNGSPDGKsgfvnPRGIAVDP 204
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
188-276 3.69e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.16  E-value: 3.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  188 LRRISLDTPDFTDIVLQLEDIR-HAIAIDYDpveGYVYWTDDEVRAIRRsfID---GSGSQFVVTAQIAHPDGIAVDwVA 263
Cdd:COG4257    168 IGRIDPDTGTLTEYALPTPGAGpRGLAVDPD---GNLWVADTGSGRIGR--FDpktGTVTEYPLPGGGARPYGVAVD-GD 241

                           90
                   ....*....|...
gi 1958769826  264 RNLYWTDTGTDRI 276
Cdd:COG4257    242 GRVWFAESGANRI 254
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
491-664 4.56e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.77  E-value: 4.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  491 IRRISLETNN-NNVAIPlTGVKEASALDFDVtDNRIYWTDISLKTISR---AfmNGSALEHVVEFGLDYPEGMAVDWLGk 566
Cdd:COG4257     82 IGRIDPKTGEiTTFALP-GGGSNPHGIAFDP-DGNLWFTDQGGNRIGRldpA--TGEVTEFPLPTGGAGPYGIAVDPDG- 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  567 NLYWADTGTNRI-EVSKLDGQHRQVLVWKDLDSPRALALDPaEGFMYWTEWGGKP--KIDRAamDGSERT-TLVPNVGRA 642
Cdd:COG4257    157 NLWVTDFGANAIgRIDPDTGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGSGRigRFDPK--TGTVTEyPLPGGGARP 233

                          170       180
                   ....*....|....*....|..
gi 1958769826  643 NGLTIDyAKRRLYWTDLDTNLI 664
Cdd:COG4257    234 YGVAVD-GDGRVWFAESGANRI 254
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 553-619 4.73e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.76  E-value: 4.73e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958769826  553 LDYPEGMAVDWLGkNLYWADTGTNRIevSKLDGQHRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGK 619
Cdd:cd05819     54 FNEPAGVAVDSDG-NLYVADTGNHRI--QKFDPDGNFLASFggsgdgdGEFNGPRGIAVDSS-GNIYVADTGNH 123
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1-22 4.86e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.43  E-value: 4.86e-03
                            10        20
                    ....*....|....*....|..
gi 1958769826     1 MYWTDWGEvPKIERAGMDGSSR 22
Cdd:smart00135   23 LYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 850-897 5.98e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 5.98e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 1958769826   850 TVVVSSVPNqnleiqPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSV 897
Cdd:smart00135    2 TLLSSGLGH------PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 553-606 6.86e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 40.22  E-value: 6.86e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958769826  553 LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQH-----RQVLVWKDLDSPRALALDP 606
Cdd:cd14954    117 FNYPWGVAVDSEG-RIYVSDTRNHRVQVFDSDGQFirkfgFEGAGPGQLDSPRGVAVNP 174
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 254-370 9.34e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 39.58  E-value: 9.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769826  254 PDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKIL----ISEDLEEPRAIVLDpmAGYMYWTDWGEiPKIerAALDGSD 329
Cdd:cd14963     58 PYGIAVD-SDGNIYVADLYNGRIQVFDPDGKFLKYFpekkDRVKLISPAGLAID--DGKLYVSDVKK-HKV--IVFDLEG 131

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958769826  330 RVVLVNTSLG-------WPNGLALDyDEGTIYWGDAKTDKIEVMNTDG 370
Cdd:cd14963    132 KLLLEFGKPGsepgelsYPNGIAVD-EDGNIYVADSGNGRIQVFDKNG 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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